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#17 nrk
superflytrap · 4 months
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If anyone had told me years ago that I would develop an obsession with 5 Norwegian teen shows and all their international remakes, I would not have believed them. Yet here we are
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I watched 62 seasons………
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maimurariki · 1 day
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Hiiiiii may you please do a idolniki x black reader series Where the reader is a fan and when they are in her city and she cant go to their cincert cuz shes cant aford to they somehow meet end up swapping numbers and become friends and then fall in love (she's a year younger than him 17)
Not an smau just regular reading plssss
Got ur number
pairing: idol!nrk x fem!engene!reader
Genre: strangers to lovers
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for you, the word “calm” was always an understatement for how you felt about enhypens upcoming concert. You were mortified when your friends cat had stepped all over your keyboard, making your vip 1 tickets disappear. The sudden urge to break everything in the house came, then the tears. You worked super hard for those tickets only for them to just disappear. You went to sleep that night, crying all of your makeup off.
Today was the day, the day out of this Month that you dreaded most. It was the concert that everyone had been waiting for, the concert that you lost your tickets to. You decided that instead of buying last minute tickets, you wanted to go to a restaurant in downtown la with friends that didn’t really care for enhypen or kpop alone.
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You vented to your friend, but didn’t really care anymore as soon as the food came.
your friend was in the restroom for a god earful time, you were still eating your food. as you were about to take another bite you felt a tap on your shoulder.
you slowly turned around and did NOT believe what you saw. It was him. Nishimura Riki.
“I uhh… I thought you were really pretty so I came over to ask for your number? If that’s okay?”
You froze. Was Niki really asking you for your number?
You then realized that you froze for a long time. He looked a bit confused.
“are you okay?”
“Y-yeah…. Here you go.”
You exchanged phones, smiling at eachother soon after.
boy was this gonna be a story to tell your friend.
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Hihiii! I’m finally back after having 0 motivation to write. I’m still not that good of a writer so any feedback through dms would be great!!! 🩷
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The weirdest thing about Norwegian stuff is that our national day (constitution day) (17th of may) is literally celebrated in so many countries. like wtf? When I was told it was a thing in Britain it made sense, because of history stuff (I don't know if I remember correctly, so I won't explain). But like ... ???
They have celebrations in:
Norway (obviously)
Denmark (who are literally the country we celebrate not being a part of)
Sweden (which we became sorta a part of)
UK (London, Shetland, maybe more idk)
USA
Poland
Azerbaijan
India
Tanzania
South Africa
Nepal
Ethiopia
Jordan
Afghanistan
Philippines
Finland
South Korea
Singapore
Bulgaria
Antarctica (not a country but yk, a place)
For all I know it could even be more, idk.
source: NRK, 2012, 17 mai feiring rundt u verden, Norwegian Bokmål
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luvistqrzzz · 6 months
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*ੈ♡⸝⸝🪐༘⋆ — e n m a s t e r l i s t
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lhs — ☆
the accidental polaroid (smau) — Lee Heeseung doesn't believe in love at first sight but what happens when he accidentally clicks a polaroid of a girl at the local diner? A girl he can't seem to get out of his mind. Will he be able to return you the polaroid or will love follow him along the way? — completed
for lovers who hesitate (1.5k) — heeseung thought he loved the way your eyes sparked at the mention of books, until he realized that he just loved everything about you.
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pjs — ☆
you're in love (0.4k) — jay is obliviously in love with his best friend
hug me tight (0.4k) — jay was like moonlight, the soft comfort when the days are bad
loving you losing you (7.7k) — loving jay was like a dream, a dream so happy you knew he wasn't yours... or where jay tried to break away from the system of soulmates but fate had other plans for him... and you.
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sjy — ☆
last kiss (0.4k) — a series of events all leading to your last kiss...
the summer i loved you (3.3k) — where August was the month of new beginnings and first loves but mostly, heartbreak.
starlight (0.7k) — when your lonely prom turns into your best friend confessing to you...
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psh — ☆
our 17, 17 (0.3k) — what does it take to be 17 and crazy in love?
my everything (0.2k) — glimpses into the love that sunghoon believed could be his forever.
right where you left me (0.4k) — a part of you was right where he left you forever
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ksn — ☆
01:54 (0.9k) — when a piggy back ride home leads you to another destination
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yjw — ☆
sparks fly (0.5k) — where you think the sleepy boy walking you back home is cute...
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nrk — ☆
this love (0.4k) — where riki was your summertime love, 'til he wasn't...
super shy (smau) — as if bribing people with pringles to vote for him as class prez wasn't enough, riki had to get respectable amount of grades to really contest in it. so, what happens when a hopeless riki approaches you, his quiet shy classmate whose painfully crushing on him, to tutor him? will you take his offer to finally shoot your shot? — on hold
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ot7 — ☆
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best friend!enhypen texts
sending bf!enhypen their memes
hyung line — ☆
trivia : love (oneshot series) — Finding love is not easy they say but what happens when you fall for someone at the most unexpected time in an unexpected way? — whisper a small oops and continue to fall further into the loophole of love.
aka the chronicles of a hopeless romantic soul
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all works belong to @luvistqrzzz
do not copy, translate or repost
navi | main masterlist
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mariacallous · 1 year
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Norway's domestic security agency has taken over probes into drone sightings near key infrastructure sites.
It comes amid numerous reported drone sightings near offshore oil and gas platforms and other Norwegian infrastructure in recent months.
Last month Oslo tightened security at such sites after the alleged sabotage of the Nord Stream gas pipeline under the Baltic Sea.
“We believe (the drone flights are) carried out in a way that makes it difficult to find out who is really behind it,” but Norwegian authorities suspect Russian involvement in operating unmanned aerial vehicles that “can be used for espionage or simply to create fear,” said Hedvig Moe, deputy chief of the Norwegian Police Security Service.
“Russia simply has more to gain and less to lose by conducting intelligence activities in Norway now compared to the situation before the war," she said during a news conference. "It is simply because Russia is in a pressed situation as a result of the war (in Ukraine) and is isolated by sanctions.
”We are in a tense security-political situation, and at the same time a complex and unclear threat picture that can change in a relatively short time,” she said.
At least seven Russian citizens were detained over the past few weeks for flying drones or taking photographs of sensitive sites in Norway.
A 47-year-old man with dual Russian and British citizenship was jailed Wednesday for two weeks on suspicion of flying drones on Norway’s Arctic archipelago of Svalbard, NTB reported. He is accused of breaching sanctions which came into force after Russia went to war against Ukraine, Moe said, declining to elaborate.
Under Norwegian law, it is prohibited for aircraft operated by Russian companies or citizens “to land on, take off from or fly over Norwegian territory.” 
Norway is not a member of the European Union but mirrors its moves.
“It is not acceptable that foreign intelligence is flying drones over Norwegian airports. Russians are not allowed to fly drones in Norway,” Prime Minister Jonas Gahr Støre said, according to Norwegian broadcaster NRK. “We do not want anyone to fly this type of craft over important installations in Norway.”
Airport operator Avinor told NRK on Tuesday that 50 possible drone observations have been reported at Norway's civilian airports so far this year, 27 of them since July.
NTB said 17 and 14 drone sightings were reported in 2021 and 2020, respectively, while the number was 44 in 2019.
The Norwegian Police Security Service, known by the acronym PST, plans to work closely with local police agencies which have conducted investigations, Moe said.
Other European nations heightened security around key energy, internet and power infrastructure following last month’s underwater explosions that ruptured two natural gas pipelines in the Baltic Sea that were built to deliver Russian gas to Germany.
The damaged Nord Stream pipelines off Sweden and Denmark discharged huge amounts of methane, a potent greenhouse gas, into the air.
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eagles-translated · 2 years
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Hi, do you know if there any English translation for the series 17? Thanks
If you mean the Norwegian NRK series called 17, you can find the whole show on SVT Play with Swedish subtitles (using a VPN). They're burned-in though, so you can't really do the old Google Translate auto-translate trick to make them translate into English or download any SRT files.
This show is also incredibly confusing to find. Apparently season 1 is known as 17, season 2 is known as 18, season 3 as 16, and the final fourth season as 19. From what I understand the show is called 16–19 but is commonly known as just 17. On SVT Play the title is for some reason listed as 19.
If anybody does know where this show can be watched with English subtitles, do let me know!
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usafphantom2 · 2 years
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USAF's CV-22 Osprey is "stuck" in a nature reserve in Norway 🇳🇴
Fernando Valduga By Fernando Valduga 09/03/2022 - 09:56in Incidents, Military
A USAF Special Operations Osprey CV-22 is unable to take off at the Stongodden nature reserve, on the island of Senja, in Troms (Norway).
The aircraft, CV-22B (10-0053), belonging to the 7th Special Operations Squadron 'Aircommandos' based in Mildenhall (United Kingdom), made an emergency landing on the spot on August 12, 2022.
Since then, Osprey has been stuck on the island, as repairs on site are considered impossible, as reported by the Scramble publication.
Norwegian authorities are investigating several options to rescue the plane from the nature reserve, in constant contact with U.S. authorities.
"From now on, the sea route is Plan A," Chief Sergeant Odd Helge Wang of Air Wing 139 of the Norwegian Armed Forces' Maritime Helicopter Wing told the Norway Post. "It is quite complicated to accomplish technically, and something that neither we nor the Americans have done before."
"We hope that a decision will be made by them during this or next week. Once taken, it will take about two to three weeks to perform the operation," says Wang.
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Colonel Eirik Stueland told the NRK publication that a road, a ramp and a pier must be built in the nature reserve to transport the aircraft.
The Norwegian Defense Forces propose to put carpets on the ground, in order to be able to approach the machine without destroying the ground. But putting it on a boat will probably not be an easy task.
The locally very shallow coast makes it very difficult to bring a transport barge nearby. In addition, the Norwegian climate is not helping.
"It's very shallow in the area, so there are problems in taking the boat far enough. A 70-meter-long crane arm is required," says Wang. "In addition, we have to take into account the climate. There can be no waves more than 0.3 meters high or winds more than seven meters per second."
The operation will cost a "significant" amount, he says.
In addition to all this, experts need to take into account environmental damage, since the aircraft is in an ecological reserve.
"We're probably talking about millions. But it is the Americans who have to pay the bill because it is their machine," Wang adds.
AFSOC has more than 50 Ospreys in its fleet, currently at the air bases of Cannon, N.M., Hurlburt Field, Florida, Kirtland, N.M., RAF Mildenhall, United Kingdom, and Yokota, Japan.
Tags: AFSOC - Air Force Special Operations Command/US Air Force Special Operations CommandMilitary AviationAir IncidentsUSAF - United States Air Force / US Air ForceV-22 osprey
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Fernando Valduga
Fernando Valduga
Aviation photographer and pilot since 1992, he has participated in several events and air operations, such as Cruzex, AirVenture, Dayton Airshow and FIDAE. It has works published in specialized aviation magazines in Brazil and abroad. He uses Canon equipment during his photographic work in the world of aviation.
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zvaigzdelasas · 2 years
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17 Jul 22
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寺田亮平 1stソロアルバム「クズル・トーキョー」 2023.11.8 WED RELEASE
★タワーレコード渋谷店、ディスクユニオンのみで11/1(水)から先行販売決定!
リリース関連ライブ
※各日程でゲスト出演者が異なります! 
ご予約はこちら https://ws.formzu.net/fgen/S17378459/
各種お問い合わせは [email protected]  まで
★★★★★寺田亮平 2024 ライブスケジュール★★★★★
▼2/17(土) 公園通りクラシックス(渋谷) 寺田亮平1stソロアルバム「クズル・トーキョー」リリース記念ライブ
寺田亮平×クリストファー・ハーディー×酒井絵美×寺原太郎×ファルコン 
19:00オープン 19:30スタート 予約3500円 
★「Kyzyl Tokyo」リリースツアーは、2/17レコ発以降もまだまだ続きます!★
●3/1~3/6 北九州~中国地方ツアー w/ 寺原太郎 
▼3/1 (金) 福岡(門司港) グリシェンカフェ 
開場18:30 開演19:00 2000円+1オーダー 連絡先090-2802-2524 福岡県北九州市門司区本町3-4
▼3/2 (土) 山口 (防府市) 風の通り道
開場18:30 開演19:00 2000円+1オーダー 連絡先090-6011-9369 山口県防府市栄町1-9-3
▼3/4 (月) 岡山(岡山市) 青空アイル
開場18:30 開演19:00 2000円+1オーダー 連絡先090-6415-7509 (イシムラ) 岡山県岡山市北区表町2-7-2
▼3/5 (火)岡山 (倉敷市) スケアクロウ
開場18:30 開演19:00 2000円+1オーダー 連絡先090-9502-8895 岡山県倉敷市南町1-37
▼3/6(水) 広島(広島市) OTIS!
開場18:30 開演19:00 投げ銭+1オーダー 連絡先082-249-3885 広島県広島市中区加古町1-20
●3/22~24 山梨・名古屋・福井ツアー (全て寺原太郎さんとDUO)
▼3/22(金) 山梨(北杜市) カメリアニコティー
w/葛目絢一,KUMA- CHANG,Nao
https://x.gd/D0DVE
▼3月23日(土) 愛知(名古屋市) 愛知民主会館 2階会議室
https://x.gd/fqQfF
▼3/24 日 福井(越前市) ブックカフェ ゴドー
  w/ 高橋直己・イナーラ・セリクパエヴァ 
https://x.gd/IFhIm
.....ほか続々ブッキング中! 
●ゲスト出演者 プロフィール
寺原太郎 Taro Terahara
91年より巨匠ハリ・プラサード・チョウラスィア師の弟子である中川博志氏に、96年より巨匠ニキル・ベナルジー師の愛弟子H.アミット・ロイ氏に師事。06年より継続的にオーストラリアWoodford folk festivalに出演。07年坂本龍一プロデュース「ロハス・クラシックコンサート」出演。映画「るろうに剣心」(2012、2014)、スーパー歌舞伎Ⅱ「ワンピース」(2015)、NHK朝ドラ「舞いあがれ!」等で挿入曲を演奏。国内外で演奏活動を行う。2016年より都賀のギャラリーで「世界音楽紀行」をナビゲート、ワールドミュージックフェスティバル「オンガクノムラ」企画。インド古典音楽の深い理解に基づく、叙情的かつダイ ナミックな演奏で、各方面より高い評価を受ける。https://srgmtaro.jimdofree.com/
酒井絵美 Emy Sakai
レバノンでアラブ・ヴァイオリンを、ノルウェーで伝統楽器ハーディングフェーレを、マイアミでベネズエラ・ヴァイオリンを学ぶなど、民族音楽の世界を旅し、研究し、執筆するヴァイオリニスト。ノルカルTOKYO(ノルウェー音楽)、tipsipúca(アイルランド音楽)、きゃめる(同)、Voice of the Nile Club(アラブ音楽)、5años(ベネズエラ音楽)などのユニットに参加し、ソロではゲーム・CM・映画音楽のレコーディングをおこなう。主な出演に、NHK、NRK(ノルウェー国営放送)、ラ・フォル・ジュルネ・オ・ジャポン2017、Kinck dagane 2019(ノルウェー)、SUKIYAKI MEETS THE WORLD 2022。著書に『中東世界の音楽文化~うまれかわる伝統』。東京藝術大学音楽学部楽理科卒、同大学院音楽研究科音楽文化学専攻(音楽民族学)修了。現在、東京藝術大学未来創造継承センター特任助教、昭和音楽大学講師。 http://www.emysakai.com/
クリストファー・ハーディ Christopher Hardy 
アメリカ出身。西洋打楽器の基礎を持ちつつ、中近東、北アフリカ、西アフリカやラテンの代表的打楽器であるハンドドラムのスペシャリストとして高い評価を得ている。その活動は広く通用する語法を備え、独自の打の創造に満ちたアプローチを織り成している。これまで STING、吉井和哉、渡辺香津美、ハムザ・エル・ディンなどと共演。シルク・ドゥ・ソレイユ「ZED」のミュージシャンとしてステージに参加。創作的なサウンドを展開している。
http://christopherhardymusic.com
ファルコン Falcon
アコースティックギターを軸にエフェクトを活かした空間的音作りによる独自の奏法が話題を呼び、ウェイウェイ・ウー(二胡)、中西俊博(vn)、カルメン・マキ(vo)、鬼怒無月(g)、マレー飛鳥(vn)等と共演。Eri Liao Trio、残歌、サイバー民族団など多数のバンドに参加、CDリリース。自然や風景を描写した作曲、様々な地域の民謡とのコラボレーション、即興演奏を軸にしたダンス、朗読、写真とのコラボレーションなど多様な音楽に取り組む。2019年2ndソロアルバム”美しき様々の夢”発売。2023年Eri Liaoと飛鳥stringsをフォーカスして作詞作曲、アレンジも手掛けて”うた”に取り組んだプロジェクト「ハルカストリングス」の作品を発売。 https://falconguitar.jimdofree.c
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thateurosite · 8 months
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🇳🇴 Bodo to host Eurovision Young Musicians 2024
🇳🇴 #ICYMI: A year on since the latest edition of the competition, the EBU has revealed that Bodo will be the host of the 21st edition of #Eurovision Young Musicians, with the event set to take place in August 2024.
One year on since the last edition of Eurovision Young Musicians took place in Montellier, France, the EBU has revealed that NRK will be host broadcaster of Eurovision Young Musicians 2024, with the competition taking place in Bodo. Competition to take place during Bodo’s tenure as European Capital of Culture The 21st edition of the competition will be taking place in Bodo on August 17, 2024,…
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damnrightshow · 1 year
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youtube
Play again Wednesday episode, Freestyle Funk Selection 2 hours. Selected tunes from wide range of type of music totally funky.
Listen and enjoy and check tunes !
1. "Time" STUFF N' RAMJETT (Chelsea)
2. "This Time" FAMILY CONNECTION (Jabali)
3. "Makeup Lovin"GUYMAN ENSLEY (Cordial Recordings)
4. "Check Out Your Mind" THE IMPRESSIONS (Curtom)
5. "Wind It Up" BOBBY WOMACK (Columbia)
6. "You've Lost That Lovin' Feelin'" MARTHA REEVES (Arista)
7. "Happy Feelin'" EARTH, WIND AND FIRE (Columbia)
8. "Keep That Same Old Feeling" SIDE EFFECT (Fantasy)
9. "I Know I'm Falling In Love" CHANTIQUE (AIP International)
10. "Who Do You Love" JOHN SIMEONE (TNT)
11. "Mercury" STEVE LACY (RCA)
12. "Love Comes Easy" THE SACRED SOULS (Daptone)
13. "Sea Of Love" DURAND JONES & THE INDICATIONS (Colemine)
14. "Jos Vois" AARON (Traveller)
15. "Turn It Up" THE BAMBOOS feat LYRICS BORN (Tru Thoughts)
16. "Sir Racha" LYRICS BORN (Mobile Home)
17. "Hot Pants" THE BAND NO NAME (NRK)
18. ”Groovy World" FABULOUS CAPRICES (Camaro)
19. "Super Dynamite" CHORDATA (Preservation Project)
20. "Look At My Back Wheels" THE MICHIGANS (Tumbleweed)
21. "Soulful Trip" ERNIE HAWKS & THE SOUL IG'S (Nite Club)
22. "Crawdad Hole aka Crawdad Song" THE DENVER AFFAIR (Contempo)
23. "All Africa" MELANIE CHARLES (Verve)
24. "Carpet Ride" JAMBONNE (Space Grapes)
25. "Starlight" DAVE & OMAR (ZR)
26. "Est-Ce Que C'est Chic" CHIC (Atlantic)
27. "Let's Go Dance Tonight" LAMONT JOHNSON & EUGENE (Soul Junction)
28. "Space Walking" MAGGABRAIN (Cordial Recordnings)
29. "Share Your Love" HERMAN KELLY & LIFE (RCA)
30. "It's Alright (This Feeling)" CRACK OF DAWN (Columbia)
31. "Til I Met Thee" CODY CHESNUTT (One Little Indian)
32. "Tied Up" THE NORTHERN LIGHTS (Traveller)
33. "Show Is Over" GATEWAY (Super Disco Edits)
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blog-fitness4all · 1 year
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O crescimento do Futebol de Praia
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O futebol de praia é conhecido como um desporto fantástico. É um desporto que vem crescendo e conquistando cada vez mais adeptos e praticantes a cada ano. Talvez pelo caráter espetacular do desporto, que cria ambientes muito animados e emocionantes, tenha conquistado tantos adeptos e crescido tanto. Por outro lado, o Beach Soccer tem as suas particularidades que favorecem o espetáculo e Futebol de ataque, características fundamentais para o delírio de qualquer público. Ao contrário do futebol 11 contra 11, o futebol de praia tem movimento e direção de bola imprevisíveis que representam verdadeiros desafios para os guarda-redes. O resultado é um desporto emocionante dentro e fora do campo, com inúmeras oportunidades de gol para testemunhar em todos os jogos. Futebol de praia: Crescimento e Ascensão Foi em 1992 em Los Angeles, Califórnia, que o Beach Soccer nasceu quando foi organizado um campeonato de pilotos para este desporto. O primeiro campeonato profissional foi realizado no ano seguinte na costa atlântica dos Estados Unidos, em Miami, após uma disputa entre equipas do Brasil, Estados Unidos, Itália e Argentina. 1995 na conhecida Praia de Copacabana no Rio de Janeiro, sediada a primeira Copa do Mundo de Beach Soccer, com a seleção da casa sagrada-se campeã. Devido ao sucesso deste evento, os organizadores começaram a trabalhar para divulgar a nova modalidade, criando assim o Pro Beach Soccer Tour. Em apenas dois anos, o concurso anual de 60 jogos ao redor do mundo foi alcançado. Além desses torneios, a Copa do Mundo continuou a ser realizada extraoficialmente no Brasil a cada ano, sendo a edição de 2004 a última a ser realizada nessas condições. O Mundialito de Futebol de Praia foi assumido em 1977 por Portugal. Esta competição, que sempre funcionou como uma versão mais pequena e simplificada do Campeonato do Mundo, rapidamente se consolidou no calendário internacional e é disputada em Portugal todos os anos desde 2005, primeiro na Figueira da Foz, depois em Portimão.*100001 * Competições Europeias e Beach Soccer Worldwide O interesse europeu despertado pelo Pro Beach Soccer Tour levou à formação da European Beach Soccer League (EBSL), fundada em 1998 e vem crescendo desde então. Só em 2004, 17 equipas inscreveram-se para o campeonato. Em 2005 o número ultrapassou as 20 equipas, contribuindo para uma importante divulgação da modalidade junto de patrocinadores e meios de comunicação.
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Em 1998 foi criada outra competição europeia de menor dimensão, constituída por um único torneio, o europeu de Praia passou a Taça de Futebol (EBSC ). Também esta competição tem sido disputada todos os anos, mas manteve-se reservada às equipas da elite europeia. No entanto, o passo mais importante na revelação da modalidade dá-se em 2001, quando o BSWW (Beach Soccer World Wide ), uma entidade única, cujo principal objetivo era reunir todos os grandes torneios de futebol de praia numa única estrutura e, assim, ser representada para patrocinadores, média e a própria FIFA. Projeção mundial e FIFA De fato, o interesse despertado em torno da nova modalidade permitiu à BSWW obter contratos com empresas de projeção mundial como Coca-Cola, McDonalds e MasterCard, que gradualmente se tornaram patrocinadoras das diversas competições. Principalmente a Liga Europeia (EBSL). O mesmo interesse também possibilitou uma importante parceria com a ESPN, que garantiu a transmissão dos eventos de futebol de praia em mais de 150 países da África, América do Norte, América Latina, Europa, oriente Médio e Pacífico. BSWW possui gradualmente formou outras parcerias para transmitir futebol de praia na Europa, incluindo Sky Sports (Reino Unido), TVE (Espanha), RAI (Itália), TVI (Portugal) e NRK (Noruega). Após um BSWWs os esforços foram recompensados quando a FIFA não perdeu tempo em dar ao Beach Soccer o reconhecimento oficial que desejava. A Copa do Mundo de Beach Soccer tornou-se a Copa do Mundo de Beach Soccer da FIFA em 2005: a competição de maior prestígio de todos os tempos, lançando as bases para o desenvolvimento do desporto em novas partes do mundo. Copa do Mundo de Beach Soccer da FIFA Como mencionado, a Copa do Mundo de Beach Soccer foi organizada pela primeira vez pela FIFA quando esta organização internacional decidiu que seria responsável pelo Beach Soccer Beach. As cinco primeiras edições foram realizadas anualmente e tornaram-se uma competição bienal a partir da edição de 2009. Todas as edições deste campeonato foram realizadas no Brasil até 2007, todas (2005, 2006 e 2007) foram realizadas na Praia de Copacabana no Rio de Janeiro. Em 2008, o Campeonato Mundial foi realizado em Marselha, na França, e em 2009, em Dubai, nos Emirados Árabes Unidos. As edições de 2011 e 2013 estão previstas para Itália e Taiti (na Polinésia Francesa), respetivamente. Até o momento, três seleções conquistaram o título mundial: Brasil 13 vezes, Portugal 1 vez (2001) e França, também 1 vez (no ano de 2005). Os franceses fizeram história ao vencer a primeira edição do torneio comandado pela FIFA. Futebol de Praia: Curiosidades Portugal foi o equipa que mais vezes venceu com o Uruguai e o 3º colocado a Copa do Mundo de Beach Soccer, contando as edições não oficias e as edições sob os auspícios da FIFA. Os portugueses alcançaram 3 vezes o 2.º lugar (1999, 2002, 2005) e 4 vezes o 3º lugar (2003, 2004, 2008, 2009). Em 2009 a seleção nacional foi eliminada nas 1/2 finais, perdendo para eles derrotados, Brasil com expressivo 8 a 2. No entanto, terminou numa bela partida pelos 3.º e 4.º lugares em que o Uruguai foi surpreendentemente derrotado por 14 a 7, resultando no resultado com mais golos de todos os tempos nesta modalidade em jogos da FIFA. Read the full article
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visualskills2 · 1 year
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bodoposten · 2 years
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Slik blir 17. mai på NRK
Slik blir 17. mai på NRK
Etter to år med nedstenginger og med et barnetog som trolig blir rekordlangt, tegner årets 17. mai til å bli akkurat den folkefesten vi vil ha. Du får det beste innholdet fra dagen direkte på NRK. Fra kl. 07.50 blir det direktesending fra hele landet. Seksten distriktskontorer leverer bilder og stemning fra Nordkapp til Agder. På NRK får vi god mat, statsministeren kommer, og det blir…
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biomedgrid · 2 years
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Biomed Grid | The Role of NAD+ in Anti-Aging Therapies
Introduction
The aging process is influenced by a variety of factors and considered to be an irreversible process. Aging of an organism is accompanied by metabolic disorders and the impairment of physiological function, as well as the development of age-related diseases [1, 2, [3, 4]. There is abundant evidence that NAD+ plays an important role in aging, as it is involved in various biological functions and is a key regulator of stress resistance [5, 6]. Levels of NAD+ steadily decline with age, resulting in altered metabolism and increased disease susceptibility [7, 8, 9]. NAD+ plays a key role in various energy metabolism pathways [6, 10]. Additionally, NAD+ is a cofactor for many enzymes, such as poly (ADP-ribose) polymerases (PARPs), CD38, and sirtuins [11]. Sirtuins are NAD+-dependent histone deacetylase for a wide range of transcriptional regulators [10, 12]. Overexpression of SIRT1 in the brains of mice has been shown to delay aging [13]. PARP is a major NAD+-degrading enzyme, which plays diverse roles in many molecular and cellular processes [14]. Inhibition of PARP-1 increases mitochondrial metabolism via modulation of SIRT1 activity [15]. Another NAD+-degrading enzyme, CD38, had been associated with the decline in NAD+ levels during aging [16].
Mammalian cells cannot import NAD+ in vivo, so they must synthesize it either from tryptophan or the various forms of niacin taken up in the diet including nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) [17, 18, 19, 20]. Recently, it was found in mice that supplementing with NAD+ precursors (including NMN, NR, and nicotinamide) or inhibiting the activity of NAD+-consuming enzymes can increase the level of NAD+ in tissues and improve energy metabolism, thereby delaying aging and extending healthy life [15, 21, [22, 23, 24].
Currently, the anti-aging activity of NAD+ precursors is primarily evaluated through measurement of aging markers in mouse behavior, accumulation of DNA damage, and mitochondrial activity. RNA sequencing has also been used to identify genes and pathways involved in the anti-aging mechanisms of NAD+ [20, 22, [25, 4]. Furthermore, recent research has shown that biological age can be measured by analyzing the 353 DNA methylation sites of the Horvath clock [30, 31].
NAD
+
Biosynthesis-Salvage Pathway
In vivo, NAD+ is an essential cofactor of dehydrogenase [32, 33].Nicotinamide coenzyme is an electron carrier which plays an important role in various oxidation-reduction reactions. Therefore NAD+ is a cofactor of many key enzymes in glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation [34]. Age-associated decline in NAD+ availability has an important effect on the aging process of many species [8, 35, 36]. There are three pathways for the synthesis of NAD+ in cells, involving many different precursors [37, 38, 39]. Here we focus on the salvage pathway, which is important from a translational research perspective because it is the main source of NAD+ [40, 41].
There are three pathways for the synthesis of NAD+ in cells:
a. de novo from tryptophan;
b. from nicotinic acid via the Preiss-Handler pathway; and
c. from nicotinamide (NAM) via the salvage pathway [37].
NAM itself is a by-product of NAD+-degrading enzymes such as sirtuins and PARP. As shown in (Figure 1) , the first step of the salvage pathway is catalyzed by nicotinamide phosphoribosyl-transferase (NAMPT), which converts nicotinamide and 5-phosphoribosyl- 1-pyrophosphate into NMN [42]. Subsequently, nicotinamide mononucleotide adenylyltransferase (NMNAT) produces NAD+ from NMN and ATP [43, 44]. NR can be converted by nicotinamideriboside kinase (NRK) into NMN which participating in the Salvage pathway [45]. NAMPT is the rate-limiting enzyme of the salvage pathway [42]. It has been hypothesized that reduced NAD+ synthesis is one of the causes of lower NAD+ levels with aging, and this may be due to decreased activity of NAMPT [42, 46]. Indeed, NAMPT levels are known to decline with age in many types of tissues [47, 48, 49], whereas exercise increases skeletal muscle NAMPT expression [50].
Figure 1: The Salvage pathway NAM and NR are the main precursor for the salvage pathway.
In mammals, NAMPT has two different forms: intra- and extracellular [51]. The intracellular form is the one that participates in the salvage pathway of NAD+ synthesis [42], while the extracellular form likely functions as a circulating cytokine [52]. Studies have shown that secretion of NAMPT is regulated by SIRT1 in vivo [53, 4], and SIRT1 activity in turn depends on NAMPT which regulates level of NAD+ [54]. Increasing level of NAMPT may delay aging of individuals via SIRT1-dependent pathways [56]. NAMPT has been shown to regulate osteoblast differentiation in primary culture of mouse bone marrow-derived mesenchymal stem cells via NAD+-SIRT1 pathway. NAMPT deficiency may increase the risk of bone aging or fractures [48, 57, [58, 59].
Levels of NAMPT significantly decrease with age in mice and humans [60, 61]. Adipose tissue-specific overexpression of NAMPT in aged mice resulted in increased levels of circulating eNAMPT, increased levels of NAD+ in multiple tissues, and extended lifespan [60].
In mammals NMNAT is the central enzyme of the NAD biosynthetic pathway [43,62]. There are three isoforms, NMNAT1, NMNAT2, and NMNAT3, encoded by different genes and localized to nucleus, Golgi apparatus, and mitochondria, respectively [43]. NMNAT1 directly control SIRT1 deacetylase activity at a set of target gene promoters [63]. Homozygous knockout of Nmnat1 in mice results in embryonic death [64]. Low levels of NMNAT2, highly expressed in the brain and nervous system, could impair axon regeneration as well as axon survival in aging and disease [65,66]. NMNAT3 has been identified as the rate-limiting enzyme for mitochondrial NAD+ biosynthesis [67]. In addition, down-regulation of NMNAT3 gene expression in cells significantly impairs the capacity for mitochondrial respiration, suggesting that NMNAT3 plays a key role in mitochondrial NAD+ homeostasis [68].
Anti-aging effects of NAD
+
Through its role as a substrate for sirtuins, CD38, and PARP, NAD+ regulates a variety of cellular process including energy metabolism, DNA damage repair, gene expression, and oxidative stress response [11, 34, 69, 70].
a. The Sirtuins Pathway
Sirtuins are evolutionarily conserved NAD+-dependent deacetylases. Increasing sirtuin expression has been shown to affect lifes< pan across various species [13, 36, [71, 72]. Sirtuins have received significant attention since the discovery that the increased sirtuin silent information regulator 2 (Sir2) can extend yeast lifespan [72]. The closest mammalian homologue of this regulator is SIRT1[69], mainly localized in the nucleus but also present in cytosol [73]. Its nuclear export signal allows shuttling to the cytosol under specific circumstance [12]. It has been shown in vivo that NAD+-SIRT1 signaling promotes mitochondrial activity [25]. Previous research has suggested that increasing SIRT1 in the brain, especially in the dorsomedial and lateral hypothalamic nuclei, can delay aging and extend lifespan in mice [13]. More recently, heart-specific overexpression of Sirt1 was found to delay aging and protect against oxidative stress in the heart [74]. NR-SIRT1 signaling can inhibit cardiac stem cell senescence by improving mitochondrial function and muscle stem cell function, thereby enhancing life span in mice [25]. More research is needed to determine whether increased level of NAD+ in vivo can improve SIRT1 activity, thereby delaying aging [75].
b. The PARPs Pathway
PARPs are expressed by most eukaryotic cells and are involved in DNA damage detection and repair, cell death pathways and so on [14]. Aging is associated with an accumulation of DNA damage [76]. Depletion of NAD+ is involved in cell death through PARP-1 [70]. Although this enzyme plays an important role in cells, over-activation of PARP-1 can lead to depletion of NAD+, reduction of ATP, reducing the activity of SIRT1, loss of mitochondrial function, and even cell death [70, 77, 78]. Increased level of NAD+, when SIRT1 is intact, can reduce the cell death caused by activation of PARP-1 in cardiac myocyte [79].
c. CD38 and NAD
+
CD38 is a multi-functional protein. Studies have shown that CD38 is the NADase in mammalian tissues [80, 81, 4]. It is thought to contribute to the age-related decline in NAD+ levels [23, 80, 82]. CD38 also acts as an antigen for B-lymphocyte activation and as an ecto-enzyme in endothelial and inflammatory cells [82, 83, 4]. Senescent cells are known to express small molecules including secreted cytokines, growth factors, and extracellular matrix modifiers to promote chronic sterile inflammation and fibrosis. This reaction process, known as the senescence-associated secretory phenotype [84, 85, 86], involves secretion of factors by senescent cells which induce the expression of CD38 in non-senescent cells [82, 87,]. This increased CD38 activity can disrupt the fine balance between NAD+ and its reduced form, NADH, within a cell [82]. Recently, the small molecule CD38 inhibitor 78c was shown to reverse the age-related loss of NAD+ [28, 83,]. By increasing tissue levels of NAD+, 78c may be able to ameliorate metabolic disorder and other disruptions involved in the aging process. In addition, animals treated with 78c show activation of longevity genes, which inhibit DNA damage [28].
NAD+ and NADH are in dynamic equilibrium within the cell [75]. Intracellular NAD+ can be increased in vivo through oral administration of NAD+ precursor or by inhibiting the degradation of NAD+ [15, 23, 88]. Regulation of the NAD+/ NADH ratio in this way can improve mitochondrial function and has been shown to treat senile deafness in elderly mice [89].
NAD
+
Repletion and Aging
One of the major causes of aging is progressive tissue degeneration and atrophy due to reduced somatic or stem cell function [22,90,91]. Adult stem cells are not only essential in continuously proliferating tissues (such as hematopoietic, intestinal, and skin systems) but also in normally quiescent tissues (such as skeletal muscle and the brain) that require regeneration after damage or exposure to disease [92]. NR supplementation improved metabolic function in muscle and neural stem cells, in both young and old mice, thereby increasing lifespan [25]. NR treatment has also been shown to rejuvenate stem cells from aged mice and restore the impaired ability to repair gut damage [22]. Previous studies have shown that DNA damage of nerve cells, nerve stem cells, and muscle stem cells in mice can be reduced by NR supplementation [25, 93]. NR has also been shown to ameliorate mitochondrial dysfunction and enhance oxidative metabolism in obese mice [94, 95] and prolong the lifespan of mice through neuronal DNA repair and mitochondrial quality improvement [96, 97].
Supplementation with NMN can restore age-related capillary rarefaction and increase blood flow in elderly mice, and it maybe a novel therapy to restore SIRT1 activity and reverse age-related arterial dysfunction by reducing oxidative stress [98, 99]. Mitochondrial disorders due to impaired oxidative phosphorylation (OXPHOS) are a cause of aging [100]. Long-term treatment with NMN in elderly C57BL/6J mice can improve metabolic dysfunction and ameliorate age-associated physiological decline [20]. NMN can also restore mitochondrial function, prevent neural death, and delay cognitive decline in a mouse model of Alzheimer’s disease [101, 102]. Supplementation with NAM was shown to improve blood sugar levels and metabolic capacity in HFD-fed mice. However, it had no effect on lifespan [103].
There are data showing that supplementation with NAD+ precursors enhanced the mitochondrial function of cells or stem cells in a SIRT1-dependent manner [25, 94]. Furthermore, supplementing NAD+ precursors in elderly mice improved mitochondrial function in hematopoietic stem cells and muscle stem cells, as well as extended lifespan [25, 104]. NMN specifically was found to enhance the biological activity of mesenchymal stromal cells through the upregulation of SIRT1, thereby stimulating osteogenesis of the cells and protecting bone from aging to delay the aging of mice [105]. In elderly mice, NMN treatment improved capillary density through the NAD+-H2S signaling network to increase blood flow, endurance, and physiological status [27, 29, 106].
Inhibition of some NAD+-degrading enzymes could also lead to increased levels of NAD+ [15, 23]. CD38, PARPs, and SARM1 all degrade NAD+ inside the cell [23, 77, [80, 107]. The activity of CD38 increases with aging, contributing to the age-related decline in NAD+ [16]. Several small-molecule inhibitors of CD38 have been described [83, 108, [109, 110]. Thiazoloquin(az)olin(on)e is one such inhibitor which could potentially be used as a therapeutic agent to increase intracellular NAD+ level [28]. Inhibition of PARP1 has recently been reported to correct mitochondrial impairment [111, 112] and has strong metabolic implications through its modulation of SIRT1 activity [15].
Measure Biological Age
Thus far, the anti-aging activity of NAD+ is mainly examined using RNA sequencing and gene set enrichment analysis to identify pathways of candidate biomarkers [20, 22, 25]. However, there is not yet a gold standard for aging biomarkers. The DNA clock may offer a better objective biomarker for the study of aging [30, 31]. DNA methylation plays a critical role in the regulation of gene transcription [113, 114, 115, 116, 117, 118]. Senescence can be predicted and evaluated by detecting cytosine-5 methylation within CpG dinucleotides [30, 31]. These age-related CpG characteristics are independent of gender or tissue type. Recent research has shown that biological age can be approximated by measuring levels of DNA methylation, a process known as the Horvath (or DNA) clock [30, 31, [119, 120]. Age-related DNA methylation was first described for humans after cross comparison of thousands of CpG sites in Illumina Bead Chip microarray data [121, 122]. Many of these age-associated CpG sites were then used as epigenetic age-predictors [30, 31, [120, 123]. Three hundred and fifty-three unique CpG sites were found to be predictive of biological age, independent of chromatin status or tissue source [30, 31].
Petkovich et al. developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles [124]. Stubbs et al. further developed a multi-tissue predictor to estimate age based on DNA methylation at 329 unique CpG sites from various different mouse tissues [125]. One group claims to have found three methylation sites, Prima1, Hsf4, and Kcns1, which are enough to predict biological age in mice [126]. However, this study has yet to be replicated. The most accurate clock results from applying elastic net regression to all CpGs for multi-tissue in mice [127].
Together these studies suggest that the DNA clock provides an objective biomarker for the study of aging [30, 31]. Recently, metformin has shown that reversed subject’s biological age, based on assessment of Horvath clock [128, 129]. Its use will allow us to examine the anti-aging effectiveness of NAD+ and its precursors more objectively and accurately.
Clinical Research
NAD+ precursors can be delivered orally to humans or animals to alter the dynamic balance of NAD+/NADH in vivo [24, 130]. Preliminary clinical studies in humans showed that NR supplementation could improve muscle NAD+ metabolism in the elderly [131, 132]. Healthy volunteers, who underwent an 8-day course of NR, with doses increasing from 250 mg to 1000 mg, showed increased levels of circulating NAD+ and experienced no adverse side effects [133]. Similarly, NR supplementation increased NADH and NADPH levels and improved exercise performance in elderly subjects [134]. Therefore, NMN is considered safe in clinical trials [135]. However, high dose supplementation with NAD+ precursors may increase rates of glycolysis and mitochondrial respiratory metabolism, thereby promoting the secretion of proinflammatory cytokines in cells [136]. Thus, use of supplements should be carefully observed to ensure that they strike a proper balance between anti- aging effects and potential detrimental effects.
Conclusion
NAD+ is a cofactor for many important enzymes. Reduced levels of NAD+ have been associated with aging. Evidence suggests that supplementation with NAD+ precursors, or inhibition of NAD+ degradation, could improve metabolic function. While supplementation with NAD+ precursors has been found to delay aging in mice, anti-aging effects of NAD+ have yet to be demonstrated in human subjects. Use of a more accurate biomarker for aging, such as the DNA methylation clock, will significantly advance the field. Recently, several human clinical trials have been initiated.
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Read More About this Article: https://biomedgrid.com/fulltext/volume6/the-role-of-nad-in-anti-aging-therapies.001080.php
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dermontag · 2 years
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"Wir klären Dinge untereinander" Russischer Langlaufstar giftet gegen Norweger 04.04.2022, 17:23 Uhr In ihrer russischen Heimat wird zuletzt von höchster Stelle Kritik an Langlauf-Star Veronika Stepanova geäußert. Ein norwegischer Reporter will der Sache auf den Grund gehen und fragt den Shootingstar nach einer Stellungnahme. Die Antwort kommt prompt - und hat es in sich. Veronika Stepanova gehört seit den Olympischen Spielen in Peking zu den prominentesten russischen Wintersport-Stars. Mit ihren sportlichen Leistungen, vor allem aber dank ihrer Präsenz in den sozialen Medien steigerte sie ihren Bekanntheitsgrad in den letzten Wochen um ein Vielfaches. In der sportlichen Führung der russischen Mannschaft wird das durchaus kritisch gesehen. Die russische Verbandspräsidentin Yelena Välbe sagte am Rande der nationalen Meisterschaften am Wochenende, an denen Stepanova nicht teilnahm: "Veronika Stepanova leidet wahrscheinlich an Star-Fieber." Sie verspüre regelmäßig das Verlangen, sie anzurufen und ihr zu sagen, "dass sie lieber trainieren sollte, statt im TV aufzutreten und ihr Gesicht zu verkaufen", kritisierte Välbe. Dass Stepanova nicht an den nationalen Meisterschaften teilnahm - offiziell sagte sie ihren Start wegen einer Erkältung ab - ärgerte die Verbandspräsidentin: "Alle sind hier bei den Meisterschaften am Start. Was macht sie in Moskau? Ich verstehe das nicht. Ist sie krank oder ist sie nicht krank? Wenn sie krank ist, soll sie sich behandeln lassen. Also warum zur Hölle ist sie da [in Moskau]?" Stepanova sei eine begabte Läuferin, "aber sie ist keine Natalya Nepryayeva, so viel ist klar. Bis jetzt war für sie alles einfach. [...] Wenn sie sich dazu entscheidet, auf diese Art berühmt zu werden, dann soll es so sein", kritisierte Välbe die regelmäßigen TV-Auftritte der Staffel-Olympiasiegerin von Peking. Stepanova selbst wollte sich zur Kritik zunächst nicht äußern. Auf ihrem Telegram-Kanal erklärte sie lediglich, "natürlich nicht eine öffentliche Debatte mit der sportlichen Führung" führen zu wollen. "Ich fühle mich nicht schuldig, aber ich werde analysieren und die Kritik dabei berücksichtigen", sagte sie. Deutlich weniger Zurückhaltung zeigte die Russin gegenüber einem norwegischen Journalisten des TV-Senders "NRK". Er bat für eine Geschichte zu Välbes Kritik um eine Stellungnahme der Läuferin. Via Instagram antwortete ihm Stepanova. "Das Letzte, was ich mich interessiert, ist ein norwegischer Journalist, der mir eine Chance geben möchte, mich zu erklären", schrieb sie zu einem Screenshot, der die Anfrage des Journalisten zeigt. "Du willst einen Kommentar? Hier ist er: Warum kümmerst du dich nicht um deine Angelegenheiten - Russen klären die Dinge untereinander. Vielen Dank!", ergänzte sie.
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