#ASN Co Building

[pharmaphorumuk]

A bright future for CNS and Alzheimer’s?

Swiss biotech Asceneuron is developing what could be the first treatment for progressive supranuclear palsy (PSP), a rare CNS condition that can impair balance, movement, vision, and speech. We spoke to CEO and founder Dirk Beher to get his views on the remaining challenges of tackling diseases like PSP and Alzheimer’s.

Tell us about ASN120290. Why are you targeting PSP?

ASN 120290 is a small molecule inhibitor of the O-GlcNAcase enzyme. In preclinical models inhibiting this enzyme can essentially prevent toxic tau tangles from forming.

We are now preparing to move the molecule into progressive supranuclear palsy (PSP). PSP is a small enough indication that we could look at efficacy with a patient population that is relatively well defined. Also, PSP is one of the very few CNS diseases which is exclusively driven by tau. At the level of pathology, it is so to speak a “cleaner” disease compared to Alzheimer’s disease.

Needless to say, PSP is terrible disease. When you talk to people who are looking after loved ones with PSP you see that it’s a very disheartening disease for them to watch.

What barriers have prevented there from being other treatments available for PSP in the past?

Historically, there haven’t been an awful lot of trials compared to a large indication such as Alzheimer’s because it’s an orphan disease. It’s also only recently that patients have become more organised, that diagnostic criteria have become fully established and that knowledge and awareness have generally increased. I think this is why PSP was neglected beforehand. Also, it’s fair to say that with the more recent interest of the industry in tau that more drugs are worth exploring in this indication.

What kind of trial results have you seen so far?

In phase 1 studies we have seen substantial drug exposure in the central nervous system, in the range that predicts target engagement required for efficacy. We are also currently wrapping up a PET tracer study for target engagement. We expect to present the results at the Alzheimer’s International Conference in Los Angeles in July.

Asceneuron is focused on tau. Many companies have been dropping Alzheimer’s drugs related to beta-amyloid build-up. Do you see that trend continuing, and do you think tau is going to be the priority for researchers over the next few years?

Yes. I’ve worked on a number of beta-amyloid programmes and I think people have been attracted to this by the strong genetics underlying beta amyloid. There is a clear link to disease, but we still have to work out what exactly it is at the end of the day.

We have seen a couple of antibodies fail in the clinic targeting soluble entities which do not remove plaques. Unfortunately, antibodies that remove plaques did not fare better either. Hence, we like to spread our bets broader these days. I think tau is certainly one of the key areas here.

One of the reasons why people are really excited about tau is because we now have a greater understanding of how it is closely linked to disease progression. Essentially, there are imaging agents (PET tracers) which specifically bind to the neurofibrillary tangles, the tau aggregates in the brains. The amount of tau tracer binding and the increase over time is closely linked to the clinical stage and progression in Alzheimer’s disease. Then you can also ask the question of where is the tau deposition happening. We now know how to look at both the quantity of tau and where it happens. It is worth pointing out that this seems to work well for Alzheimer’s disease whereas for PSP and other tauopathies it appears that novel tau tracers will need to be developed.

There are quite a few companies out there that are deprioritising CNS, and the burden of it is falling on smaller companies like yourself. Do you think it will become a priority again for bigger companies, or will it remain something that is perhaps better served by smaller companies?

I think we need the larger companies to be engaged in the CNS space given the unmet need and interdependencies. Even for smaller companies, when we do our fundraising, if it’s only us it’s very difficult to build excitement if we’re kind of the lone wolf. It’s always useful to point to bigger companies that are doing studies, that have a network and could become a future partner.

Hopefully the area will evolve similarly to immuno-oncology. As soon as someone has positive data, even with a small effect size, the pendulum might swing around again. We have seen some very big companies going out, but given the competitive nature of areas like immuno-oncology, people may want to get back to CNS when they see that there is something there.

Are there any other areas in CNS that you feel are underserved at the moment?

There are still quite a number of underserved diseases out there. Neuropsychiatric indications such as schizophrenia are one example. Overall, when you think about unmet need, CNS scores pretty high in my view.

Were there any other more general challenges of working in the area that still need addressing?

One is finding and treating the patients early enough. We need more early diagnostics criteria and tools. The challenge is that when people become symptomatic, they have already lost a large number of the functionality in the brain. Parkinson’s disease is a good example. Patients have already lost over half of their dopaminergic neurons by the time they become symptomatic.

Are you hopeful for the future of CNS and Alzheimer’s?

I’m hopeful that by diversifying, we may find therapies that show some kind of efficacy. Then the area can develop in a similar way to immuno-oncology. My hope is that we can take some of those drugs and can combine these things to really get to a meaningful treatment

The post A bright future for CNS and Alzheimer’s? appeared first on Pharmaphorum.

from Pharmaphorum https://pharmaphorum.com/r-d/views-analysis-r-d/a-bright-future-for-cns-and-alzheimers/

[funnythingshere0-blog]

Vocus builds fibre network between Darwin and Tiwi Islands

New Post has been published on https://funnythingshere.xyz/vocus-builds-fibre-network-between-darwin-and-tiwi-islands/

Vocus builds fibre network between Darwin and Tiwi Islands

Credit: Dreamstime

Vocus has been selected to build a sub-sea system that will provide a fibre optic link between Darwin and the Tiwi Islands in the Northern Territory.

The deployment will be possible through an $8.5 million capital grant arrangement with the Northern Territory Government, which will see Vocus build, own and operate the sub-sea system scheduled to be completed by the end of 2019.

Vocus will build a new 60km sub-sea spur cable between the North West Cable System (NWCS) branching unit and the Tiwi Islands.

According to Vocus, this is the “first time” that communities on Melville and Bathurst Islands will have access to a “reliable, high capacity and trusted fibre optic link to the mainland”.

Currently, NBN Co’s satellite Sky Muster is one of the services provider in the area. Mobile and land line phones are currently connected via a high speed digital radio link to Darwin.

In February, the ABC reported that residents in the Tiwi Islands had limited access to fuel, internet, and phones for three days after a Telstra tower was damaged.

The NWCS was transferred to Vocus through the acquisition of Nextgen Networks in 2016.

“Construction of the Tiwi Islands cable builds on our substantial network infrastructure investment activities in the Northern Territory,” Vocus group CEO Kevin Russell said.

Credit: Vocus

Read more City of Gold Coast invests $10M on its own optic fibre

“The new fibre optic link provides an historic opportunity to replace the existing sub-optimal microwave link to the mainland, removing capacity constraints and improving telecommunication services to the Tiwi Islands.

“Poor weather causes significant interruptions to microwave telecommunication links and the tropical conditions in the Tiwi Islands frequently mean that essential services that rely on connectivity cannot be delivered.

“Affordable and reliable fibre optic connectivity is a fundamental pre-requisite for the participation in the global digital economy. Vocus is pleased to play its role in delivering this capability to the communities of the Tiwi Islands.”

Dutch surveying company Fugro has been selected to run a survey program while Alcatel Submarine Networks (ASN) will work on the manufacturing and deployment activities – these are expected to take nine months to complete after the finalisation of technical specifications.

Read more NSW Govt forges new deals with telcos, Microsoft and Salesforce

In July, Vocus announced it had signed a contract with ASN to to deploy the Coral Sea Cable System, a sub-marine cable providing high speed telecommunications capacity to Papua New Guinea and Solomon Islands.

Vocus suffered a 15 per cent decline in revenue to $203.9 million for the 2018 financial year. Overall Vocus saw a two per cent increase in revenue to $1.89 billion, while net profit after tax was back in black at $61 million, after suffering a $1.46 billion loss in FY17.

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Tags fibre opticVocussub-sea cableASN

Source: https://www.arnnet.com.au/article/646119/vocus-builds-fibre-network-between-darwin-tiwi-islands/

[nextstepelectric]

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[anygenkorea]

Overview of a high quality generic peptides produced at GMP facilities in ANYGEN CO., LTD

ANYGEN CO., LTD. is the first bio-venture company in Gwangju and Jeonnam province. It has developed peptide biomaterial process and quality management technology that was developed independently since its establishment in 2000. Based on this, we have localized peptide biomaterials, which had previously relied on imports, and are making efforts to advance into the global market based on superior quality and price competitiveness. In 2016, it was listed on the KOSDAQ based on its proprietary peptide biomaterials and new drug development technology.

Brief History:

2017

·         Determination of suitability for pharmaceutical manufacturing and quality control standard.

·         Selection of 2017 Korean Small Business Innovation Research Program

·         (Government Task)

·         Acquisition of IP CERT

·         Designated as a High Technology Company

·         Designated as a Global IP Star Company

·         Signed contract for process development, production and stability research

·         (GPC-3, HSP-70 / CYTLIMIC INC.)

·         Purchase of land and buildings for the expansion of Osong No. 2 plant

2016

·         Listed on KOSDAQ market

·         Acquired export license for Leuprorelin / DCGI(India)

·         Designated as a K-Brain Power 2016~2018

2015

·         Strategic alliance Ziconotide With TherDose Phama Pvt (India)

·         Manufacturing Partnership with TONYMOLY (Cosmetic)

·         Approval of clinical trial on AGM-130, Phase1b.

Generic Peptides Ongoing Projects

·         Leuprorelin Acetate, DMF

·         Atosiban Acetate

·         Goserelin Acetate

·         Ganirelix Acetate

·         Exenatide Acetate

·         Cetrorelix Acetate

·         Goserelin Acetate

Goserellin Acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Sequences:

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 Acetate salt

Fields of application:

·         Advanced hormone-dependent prostate cancer

·         Advanced hormone-dependent Breast cancer

·         Endometriosis

·         Uterine myoma

·         Use in reproductive medicine

Synonyms:

(D-Ser(tBu)6,Azagly10)-LHRH

Exenatide Acetate

Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster  (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II. This product is offered under Bolar Exemption.

Sequences:

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt

MW:

4186.63

Fields of applications:

Type 2 diabetes

Are you looking for a Research Peptide drugs Manufacturer in Korea and Peptide Biomaterials Drugs Products in Korea? Based on our accumulated technology and know-how for over ten years ANYGEN has established various synthesis methods for peptide characteristics, and the composition and length of amino acid, scale, and the synthesis method that is characterized by customer's request are selected

[timchewkc]

[Travel]

Artist impression of Virtual Vibration

  Vivid Sydney – billed as the world’s largest festival of light, music and ideas, returns in 2018 with a new precinct at Luna Park, the return of much-loved Customs House, and a fantastical blend of everyday objects and Australian-inspired motifs on the sails of the Sydney Opera House. Vivid Sydney is owned, managed and produced by the NSW Government’s tourism and major events agency Destination NSW and is a major event on the region’s tourism calendar.

Minister for Tourism and Major Events, Adam Marshall said, “Vivid Sydney has delighted and inspired people from around Australia and the world. With the Festival now in its 10th year, visitors and locals alike can once again expect to be mesmerised by the Vivid Sydney program, with larger installations and a gripping Music and Ideas offering, so I encourage visitors to start planning their trip early to get the most out of this year’s exciting line-up.

“Over 23 nights from Friday 25 May to Saturday 16 June, Vivid Sydney will paint the Harbour City in the colour and spectacle of Vivid Light, take over Sydney stages with Vivid Music’s electric performances and collaborations, and provide a global forum for thought-provoking debate and creative discussion at Vivid Ideas.”

  Here’s a look at what happened at Vivid Sydney 2017

https://vimeo.com/221557540

  VIVID LIGHT

   For the first time, Vivid Sydney’s dazzling Light Walk extends to new precinct Luna Park Sydney, where the iconic amusement park comes alive with large-scale projection on the façade of Coney Island. The show celebrates the history, magic, creativity, engineering, fantasy and imagination that have come together to create millions of memories on this unique and special site. This year also marks the first time Luna Park’s iconic Ferris Wheel will be lit for the festival following an LED refit, which has included a massive boost in the number of lights adorning the wheel.

Vivid Sydney’s bright lights will illuminate the Royal Botanic Garden Sydney again in 2018, where visitors will follow a pathway that weaves through an exciting nocturnal environment inspired by nature. Here, Parrot Party inspired by the New Zealand Kea Parrot and the Australian Rainbow Lorikeet, comes alive as people gather, breaking into song and radiating colourful light. 

   Aqueous will dazzle with its interactive landscape of meandering pathways of light, which will flow and glow in full illuminated interactivity, engaging visitors in collaborative play. 

The Bloom, a giant electric, metallic flower with petals adorned with mirrors that refract and reflect light, puts you in the centre of the flower capturing the perfect photo moment

He’e nalu gives the joyous sensation of surfing a wave

   In celebration of their 100 year anniversary, May Gibbs’ iconic and immortal characters, Snugglepot and Cuddlepie and their stalwart companions come to life on the façade of Customs House, as they journey through the Australian Bush and encounter the weird, the wonderful, and things quite unknown altogether. This whimsical piece will be narrated by renowned Australian film and television actress Noni Hazlehurst AM, Patron of the Australian Children’s Laureate, and beloved by Play School devotees far and wide.

The Sydney Opera House will be the centrepiece of the Vivid Light Walk for Lighting of the Sails, created in 2018 by award-winning Australian artist Jonathan Zawada. Visitors will be captivated by Metamathemagical, a bold and dynamic display of morphing digital sculptures inspired by recognisable Australian motifs across science, nature and culture.

Sydney’s iconic buildings will once again be transformed, including the façade of the Museum of Contemporary Art Australia (MCA) with Virtual Vibration, a highly-collaborative creative work produced in conjunction with MCA Collection artist Jonny Niesche and composer Mark Pritchard. Interactive lighting display Skylark will let visitors put their own colourful mark on the city, stretching from the Sydney Harbour Bridge and the skyscrapers of Circular Quay to the reaches of Sydney Harbour.

Network Ten and MasterChef Australia will bring a magical experience to the façade of the ASN Co. Building in The Rocks, in celebration of both Masterchef and Vivid Sydney’s 10th Birthday with Mystery Gâteau. Mini construction-worker chefs will guide visitors on a journey of fun and wonderment, with the famous MasterChef clock ticking down to the final extraordinary surprise.

      Popular precincts Taronga Zoo, Darling Harbour, Chatswood, Barangaroo and Kings Cross will return in 2018.

Festival favourites from last year are back along with a whole new mob of fierce, fantastic, quirky and endearing species for Taronga Zoo’s Lights for the Wild. Visitors will discover some new spectacular animal light sculptures, and learn how Taronga is working to help save 10 species from extinction over the next 10 years.

An art-meets-technology water fountain, light and laser experience takes Darling Harbour visitors into a dream-like dive under the ocean, while the iconic rooftop of the Australian National Maritime Museum will be projected with BBC Earth and Sir David Attenborough’s Blue Planet II, exploring the fascinating world beneath the waves.

A pop-up market inspired by the colourful neighbourhood street markets of Brazil, built from scaffold and recycled materials and lit by lasers will transform the Chatswood CBD. The Concourse will take visitors on an immersive, deep dive into space featuring NASA’s amazing imagery and 360-degree projection.

Barangaroo glows under layers of light and sound that evoke the surrounding waterways, with the precinct coming to life through the magnificent art of puppetry with a breathtaking, giant luminescent creature venturing along the waterfront in a theatrical display of sound and light.

Precinct contributor Coca-Cola returns to light up the streets of Sydney’s iconic Kings Cross and to support another KX program in 2018. The colourful strip along Darlinghurst Road will be transformed with a spectacular display of light and life. The famous Coca-Cola sign comes alive again in 2018 with an array of flair and a creative colour show. Other Vivid KX transformations include the historic Victorian Terrace; World Bar, which will unfurl a multi-story house party, and the renowned Kings Cross Hotel, which will host cutting-edge artists curated by legendary party-crews.

   VIVID MUSIC

Curve Ball

Vivid Music ups the ante in 2018 with an electric line-up, from noise to jazz, sonic experimentation to soul. Highlights include a one-night-only performance by Grammy award-winning rock-goddess St. Vincent, and the return of Curve Ball headlined by Alison Wonderland – a large-scale live music and art event created by the team behind Field Day, Harbourlife and Listen Out – both at Carriageworks.

The City Recital Hall returns to the program, tracking the extraordinary rise in jazz with the Innovators In Jazz series featuring the undisputed king, triple Grammy award-winner saxophonist Branford Marsalis. The world’s finest jazz vocalists including Kurt Elling and chanteuse Madeleine Peyroux, will line up alongside Orange is the New Black star Lea Delaria in her musical comedy, jazz interpretation show.

   VIVID LIVE

Vivid LIVE at the Sydney Opera House hosts a stellar line-up of Australian exclusives as part of Vivid Sydney, including several Opera House debuts. Highlights this year include American dream-pop icons Mazzy Star, the godfather of West Coast rap Ice Cube, acclaimed 90s indie rock singer/songwriter Cat Power, Grammy award-winning artist Solange, and the long-awaited collaboration between iconic Australian artists Daniel Johns and Luke Steele.

Now in its 4th year as part of Vivid Sydney, Heaps Gay struts uptown to Sydney Town Hall for the inaugural Qween’s Ball. Other not-to-be missed events include Young Hearts Run Free and one of Australia’s most exciting breakthrough artists performing at the Enmore Theatre, Vera Blue.

Also returning to Vivid Music in 2018 is X|Celerate, a partnership between Vivid Sydney and the City of Sydney to enliven music venues across town. Showcasing grassroots and emerging local music talent, highlights will include Purple Sneakers 12th birthday at The Lansdowne, a fusion of food, wine and music at Cake Wines Cellar Door, and HAPPY and VISIONS at The Lady Hampshire.

   VIVID IDEAS

Vivid Ideas provides a forum to workshop, collaborate and cultivate fresh thinking to drive the creative agenda across tech, design, entertainment and culture. Vivid Ideas returns in 2018 with some of the world’s greatest minds as we explore the future-shaping scenarios that will define our lives.

Vivid Ideas 2018 showcases those who are leading the way in technology, creativity and science. Game Changers and Creative Catalysts this year include film-maker, marine explorer and conservationist James Cameron. In a Vivid Sydney exclusive, James will explore his passion for science and technology, and how it has influenced his work as a film director and environmentalist. James will be joined in conversation by Adam Spencer, while in Sydney to open the James Cameron – Challenging the Deep exhibition at the Australian National Maritime Museum.

Australian global success story Dare Jennings – founder of Mambo Clothing, Phantom Records and Deus ex Machina – joins his good friend James Valentine to discuss creating cult brands that cut across age and lifestyles as well the joys of throwing out the rule book.

Futurist and game developer, Jane McGonigal can prove games have the power transform our real world lives. She and Artificial Intelligence expert Kriti Sharma join Vivid Ideas to explore the latest in AI, VR and gaming to ask what kind of society we can create with technology.

Visual strategist at NASA’s Jet Propulsion Laboratory and co-founder of the Museum of Awe, Dan Goods joins the Vivid Ideas Creative Catalysts line-up to explore how creativity and science interplay and why NASA has a virtual strategist.

The New Horizons series explores the mega-trends and micro-developments in technology and innovation, and shines a light on experts tackling the biggest issues with creativity in a bid to make our future brighter. Topics include Future Fashion, Algae is the New Black, Blockchain Decoded and Evolving Democracy.

Over three successive Wednesdays, Vivid Sydney will take over the Art Gallery of NSW to create an intimate portrait of our better selves. Our special guests dare to ask if we can improve dying, how we can find common ground when and where there’s conflict, and why we should nudge perceptions around female sexuality. These events will be accompanied by curated music from Goldheist, Air Land Sea and Haiku Hands.

The Vivid Ideas Exchange at the Museum of Contemporary Art returns, boasting a diverse line-up of talks presented by creative experts covering topics including the future of work, the ethics of humanising technology and how to become agents for change.

For more info, head over to http://www.vividsydney.com/ or https://www.facebook.com/vividsydney/

.

Vivid Sydney 2018 Festival Vivid Sydney - billed as the world’s largest festival of light, music and ideas, returns in 2018 with a new precinct at Luna Park, the return of much-loved Customs House, and a fantastical blend of everyday objects and Australian-inspired motifs on the sails of the Sydney Opera House. 

#Aqueous #He’e nalu #Light Walk #The Bloom #Vivid Live Sydney #Vivid Music #Vivid Sydney 2018

[touristguidebuzz]

Trump Erroneously Takes Credit for 2017 Airline Safety Mark

Michael Huerta was appointed by former President Barack Obama to lead the Federal Aviation Administration, and is a Trump administration holdover. Bloomberg

Skift Take: The buck stops in the oval office, but Trump had absolutely no influence over aviation safety in 2017. Let's see how the President's drive to reduce regulation impacts aviation safety this year, and whether an infrastructure law gets passed that invests in modernizing the U.S. air traffic control system.

— Dennis Schaal

President Donald Trump is taking credit for the safety of the U.S. aviation system even though it is being run by a holdover from the previous administration and has avoided any commercial passenger fatalities for several years before he took office.

“Since taking office I have been very strict on Commercial Aviation,” Trump said in a tweet Tuesday morning. “Good news — it was just reported that there were zero deaths in 2017, the best and safest year on record.”

Since taking office I have been very strict on Commercial Aviation. Good news – it was just reported that there were Zero deaths in 2017, the best and safest year on record!

— Donald J. Trump (@realDonaldTrump) January 2, 2018

If by “commercial aviation” he means scheduled passenger airline flights, the record actually stretches back to July, 2013, when an Asiana Airlines plane struck a seawall as it was about to land in San Francisco, killing three people. The last death on a U.S.-registered airline was in 2009 near Buffalo, New York.

Commercial aviation generally refers to paying customers on planes of all sorts. The National Transportation Safety Board reported at least 13 deaths last year in seven crashes involving commercial charter flights in the U.S.

Last year was unusual in one regard: there were no fatalities involving scheduled passenger jet airliners anywhere in the world, according to the Aviation Safety Network. But there were 10 airliner accidents resulting in 44 occupant fatalities and 35 deaths of people on the ground worldwide last year when charter and cargo planes were included.

This makes 2017 the safest year ever, both by the number of fatal accidents as well as in terms of deaths. In 2016, ASN recorded 16 accidents and 303 lives lost.

“I’m unaware that the president has had any impact on aviation oversight policy or practice,” said Bob Mann, president of aviation consultancy R.W. Mann & Co. “Social media is not ‘oversight.’”

“In fact, his stated preferences — less ‘red tape,’ fewer regulations — would suggest a preference for less oversight, not strictness.”

The trend toward safer flying has been building for years as U.S. regulators, the airlines and safety investigators brought on board new safety technologies, better monitoring of potential hazards and improved training.

Indeed, the head of the Federal Aviation Administration during the first year of the Trump administration Michael Huerta was appointed by former President Barack Obama. Huerta’s five-year term expires on Jan. 6.

Last year’s aviation safety record is the culmination of decades of work by industry and governments worldwide and should be applauded as a success story, said John Cox, chief executive officer of consultant Safety Operating Systems and a former commercial airline pilot.

“It’s a great thing but I don’t think any one individual can take credit for it,” Cox said. “As the head of the federal government, I suppose you can take credit for the very good work the FAA has done over the years, but it’s the work the people in the trenches have done that has led to this result.”

The FAA referred all questions to the White House.

“President Trump has raised the bar for our nation’s aviation safety and security,” Raj Shah, a White House spokesman, said. He cited anti-terrorism efforts and a plan to privatize air-traffic control that has languished in Congress.

“The President is pleased there were no commercial airline deaths in 2017, and hopes this remains consistent in 2018 and beyond,” Shah said.

Trump had harsh words for the FAA’s air-traffic control system last year during the debate over whether it should be privatized and spun off to a non-profit. He cited a technology modernization program he said was not progressing fast enough.

“They didn’t know what they were doing,” he said of previous efforts to modernize the system. “A total waste of money.”

–With assistance from Mary Schlangenstein Richard Clough and Jennifer Epstein

©2018 Bloomberg L.P.

This article was written by Ryan Beene and Alan Levin from Bloomberg and was legally licensed through the NewsCred publisher network. Please direct all licensing questions to [email protected].