Curcumin, the radiant golden gem extracted from turmeric's rhizome, has graced the culinary world as a natural pigment for ages. This vibrant compound belongs to the diarylheptanoid family, a group of phenolic pigments that bestow turmeric with its iconic yellow hue. This chemical marvel has long been a staple in traditional cuisine, adding a burst of color and flavor.
Beyond its culinary charm, curcumin has taken center stage in medical studies. Embracing its role as a health guardian, curcumin flaunts an impressive resume: a lipid-lowering virtuoso, an anti-tumor maestro, an inflammation pacifier, a gallbladder ally, and a guardian against oxidation.
Recent news highlights the plight of lead-tainted turmeric in Bangladesh, underscoring the importance of knowing our sources. As scientists and policymakers step in to confront this challenge, it becomes even more crucial to celebrate curcumin's untainted potential.
Spice It Up: Unveiling the Superpowers of Turmeric
Turmeric contains plenty of vitamin C, which can aid the immune system.
Spice It Up: Unveiling the Superpowers of Turmeric Yo, ever hear about that super cool, vibrant yellow spice that kicks up the flavor in curry dishes? Yup, I’m talkin’ about Turmeric, pals. But wait, it ain’t just about adding some zing to your meals; this powerhouse has got some serious health creds too. With its main squeeze, Curcumin, leading the charge, Turmeric is out here fighting…
Today, we're going to delve into the incredible health benefits of turmeric spice. Turmeric, scientifically known as Curcuma longa, is a bright yellow-orange spice commonly used in Asian cuisine and traditional medicine. Its active compound, curcumin, is responsible for many of its health-promoting properties. So, without further ado, let's explore the top health benefits of turmeric.
Clinical nutrition: minerals, vitamins and other natural bioactives to treat current medical issues
Introduction
Vitamins and trace elements, collectively known as micronutrients, are vital for basic metabolic reactions in the human body. The deficiency of micronutrients or even increased amounts could lead to serious health disorders. Research has revealed that long-term abnormal levels of micronutrients could be associated with the etiopathogenesis of some common neurological diseases.…
Abstract
HER2 expression is associated with 30% of breast cancer patients with a poor prognosis. Though Trastuzumab is approved for HER2 targeted therapy, its use is limited because of its systemic toxicity and resistance in most patients. This study evaluated the synergistic effects of Phenethyl isothiocyanate (PEITC) and Curcumin (CUR) in HER2 overexpressing SK-BR-3, BT-474, and AU-565 breast cancer cells. The cytotoxic effect of PEITC : CUR against breast cancer cells was evaluated using an MTT assay, and the Loewe additivity model was used to evaluate the synergistic effect. Apoptosis induction and cell cycle arrest over the treatment of PEITC: CUR in breast cancer cells were examined using the flow cytometric annexin-V/Propidium iodide method. Downregulation of HER2-mediated signaling was deduced from protein expression analysis using western-blot. Our results showed that treatment of PEITC : CUR at varying levels of combinations in all three breast cancer cells extensively reduced the survival of the cells with the lowest inhibitory concentrations (IC50). Cytotoxic data revealed that the 3 : 1 ratio of PEITC : CUR was the best among several (1 : 1, 3 : 1, and 1 : 3) combinations, with the maximum cytotoxicity. PEITC : CUR (3 : 1) displayed the lowest combination index (CI) against SK-BR-3, and AU-565 cells indicated its potential synergistic effect. At twice the concentration of its IC50, the 3 : 1 combination elicited 3.5 to 4.5 fold apoptosis in HER2 overexpressing cells, approximately double the effect of the individual drugs alone. In addition, the selected combination induced the G2/M cell cycle arrest in HER2 expressing cells over the treatment. Western blot protein expression analysis revealed that the PEITC : CUR combination suppressed the HER2/PI3K/Akt signaling, eventually connected to various apoptotic biological events. Our results showed the specificity of PEITC: CUR combination in inducing apoptosis and G2/M cell cycle arrest in HER2-expressing tumor cells in-vitro and enhancing the anti-cancer effect. For a subset of breast cancer patients who overexpress HER2, this combination of PEITC and CUR could be a potential treatment option.
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