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#Depression
support · 7 years ago
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Everything Okay?
If you or someone you know is struggling, you are not alone. There are many support services that are here to help. 
If you are located in the United States, consider reaching out to the National Alliance on Mental Illness HelpLine.
If you are located in the United Kingdom, The Mix is here to help you with any challenge you are facing.  Reach out online, on social or through their free and confidential helpline.
If you are reading this from within any other country in Europe,  Mental Health Europe has compiled a list of helplines and other resources in your country. 
For more resources, please visit our Counseling & Prevention Resources page for a list of services that may be able to help.
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reachoutusa · 6 years ago
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Support can make a huge difference when someone is hitting a rough patch. Why wait until then to let your friends know you'll be there? Take a stand for Mental Health Awareness and tag someone you care about to let them know you have their back. ‪
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youmatterlifeline · 8 years ago
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randomreasonstolive · 2 days ago
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Reason to Live #6545
 To fall asleep to thunder.  – Guest Submission
(Please don't add negative comments to these posts.)
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traumatizeddfox · 2 days ago
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i hate knowing that if i died people would think of themselves more. they would ask themselves “was I not noticing it enough?” “was I not a good friend?” “am i a bad person?” they would think abt themselves before they ever thought about me
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neurosciencestuff · 19 hours ago
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Serotonin transporters increase when depression fades
Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy. The results are published in the journal Translational Psychiatry.
“Our results suggest that changes to the serotonin system are part of the biology of depression and that this change is related to the episode rather than a static feature – a state rather than a trait,” says the study’s last author Johan Lundberg, researcher at the Department of Clinical Neuroscience, Karolinska Institutet. “The finding raises many questions about the function of the serotonin system in depression and opens up for lines of research that could challenge the prevailing concept of serotonin and depression.”
Serotonin is a neurotransmitter that affects, amongst other things, mood and emotion. Its transporter protein, 5-HTT, is considered to play a critical part in depression, as it pumps serotonin away from the cerebral neuron synapses, thus regulating the amount of active serotonin the brain.
More knowledge needed
Many modern antidepressant drugs inhibit this transporter, which increases the concentration of serotonin in the synapses. However, the effect of these drugs can be delayed by several weeks and in certain cases they have no effect at all, so the need for new or improved drug therapies is pressing. To achieve this, more knowledge is needed about the biological causes of the disease.
Earlier studies have shown that depressed individuals have lower levels of 5-HTT in the brain than healthy individuals. This finding is somewhat surprising given the dominant theory of serotonin function in depression, “the serotonin hypothesis.” This theory dictates that low levels of synaptic serotonin causes depressive symptoms, and since the function of 5-HTT is to reduce the concentration of serotonin, high levels of the protein could be expected in depressed individuals. To better understand these findings a longitudinal or post-treatment study design can be used to answer the question of whether 5-HTT is temporarily or chronically low in people with depression.
In this study, the researchers sought to investigate how the serotonin transporter changes when a depressed person is successfully treated. To do this, they measured levels of 5-HTT in 17 individuals with depression before and after a course of internet-based cognitive behavioural therapy. The measurements were achieved with positron emission tomography (PET), a brain imaging technique in which scientists can gauge levels of different substances in the brain using radioactive tracers.
Average increase of 10 percent
The researchers found that levels of 5-HTT were on average 10 percent higher after three months’ treatment, when 13 of the 17 patients reported a significant improvement in their symptoms. Prior to treatment, the individuals with depression had roughly the same average level of 5-HTT as a control group of 17 healthy individuals.
“Instead of lower levels of serotonin transporter when depression had been treated, we found the opposite – more transporter after improved symptoms,” says Jonas Svensson, postdoc researcher in Dr Lundberg’s group. “One possible interpretation is that the serotonin system doesn’t cause depression but is part of the brain’s defence mechanism for protecting itself against depression. One might hypothesize, for example, that the level of 5-HTT drops when an individual is subjected to stress, such as during a depressive state, and that the level rises or normalises when this stress goes away. It’s important to point out, however, that even if these ideas are raised by our study, its design doesn’t allow us to draw any conclusions about why levels of 5-HTT change.”
The study had some limitations, such as that it only included 17 individuals with depression, which is a heterogeneous state, and that the control group was examined only once.
The researchers are now designing new studies to test whether the dynamic function of the serotonin system can be part of a stress-defence system.
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enderbooenjoyer · a day ago
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imagine that if c ranboo’s revived, he’s silent. doesn’t talk for weeks, people are constantly asking if he’s alright, he still doesn’t respond. ranboo gives yes or no answers by shaking or nodding his head.
he wanders more, enderwalks more, it can take hours to know where he went, doesn’t even tell people when or where he’s going, just leaves
ranboo doesn’t even write in his memory books anymore, just constantly has this blank look on his face
he still feels dead, he still wishes he was.
he knows how his ghost talked about him, how annoying he was, how much he hated himself. it’s constantly on his mind
months in limbo, and his constant self depreciation the only thing he hears, causes him to shut down. maybe he can forgive himself if he finally just shuts up and stops pretending that he can do any good in the world
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randomreasonstolive · 3 days ago
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Reason to Live #6543
  Sitting at the window on a rainy night 💛 it’s so calming, relaxing and one of the best feelings, especially if you’re in a hoodie and have the window open 💛💛 – Guest Submission
(Please don't add negative comments to these posts.)
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oktotalk · 8 years ago
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