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ayanominitrash · 4 months

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Stay Awake For Me (Sukuna x reader)

I first posted this on Ao3 here.

**contains cussing and mentions of taking medication One shot where the reader is a sleepy university student and Ryomen Sukuna is the infamous mean frat boy classmate. An encounter in class resulted in him finding out you're taking meds for anxiety.

₊˚ ♡

University certainly kicks ass, and it certainly is incredibly expensive. You try your best to keep up with the never-ending piles of homework and your hectic part-time night shift job at the nearby fast food chain. The pay was shit but you'd do anything to support yourself instead of relying solely on your siblings' money to help you through school.

Unfortunately, you couldn't keep up with it all with your past school schedule, so you dropped one of your subjects and replaced it with one that's a bit later than usual. This is hilarious on your part because after lunch was usually when your sleep-deprived self has caught up with you and you end up dozing off in that class almost all the time.

Today was no different. Your eyelids feel heavy as you take a seat. It wasn't your usual seat but you couldn't care less as your head falls down in your arms as you take a nap while the class was waiting for the professor.

It wasn't long till you were shoved off of your seat and onto the floor, squealing out in surprise as you rub your aching bottom from the fall.

"The fuck you think you're doing sitting on my chair, brat?"

The metal stands of the chair you once sat on grinds against the floor before the tall man takes a seat, looking down at you with a disgusted look on his face.

It was Ryomen Sukuna. He's a notorious frat boy who everyone feared. This wasn't your first time interacting with him so you weren't surprised by his brash behavior.

The same goes for the other people in the class. They stopped in their conversation when you fell, but seeing that it was Sukuna, they weren't surprised and went back to their own thing.

"S-sorry, I didn't know I was sitting at - "

"Well, now you know. Now, get the fuck out of my space." He says as he waved a hand like he is dismissing you.

You quickly gather the stuff that fell with you, scrambling to stand up. You hear something metallic fall out of your bag, to which you seem to notice Sukuna was going to say something about it when the professor finally shows up. You hurriedly find your usual seat at the back and plop down before the scary man can say anything else.

₊˚ ♡

It was finally the end of class and you managed to stay awake this time. The incident probably helped you stay alert. The class said their goodbyes to the professor and you were quick to gather your things and walk out the door. During the class, Sukuna keeps on looking back at you with a quizzical look on his face. You don't know what this means but you certainly aren't going to hang back after class to find out. For all you know, the man was thinking of different ways to murder you.

It was either he was fast as hell or you were moving too slow because he caught up to you in the middle of the hallway, pulling you by the back of your collar to stop you.

"Brat, stop walking so fast. Geez." Sukuna says as you turn around to look up at him.

"L-look, it was a little mistake. I didn't notice that it was your chair -"

"Shut up." He simply says before his hand reaches something from his pocket. "You dropped this, genius."

One look was all it takes before you immediately grabbed the metallic item from his hand. You quickly looked around to see if anyone saw the thing before sighing in relief.

"That some kind of birth control or something?"

"W-what?! Do I look like someone who has an active sex life for that kind of thing?!" You say, cheeks and ears turning pink at the ludicrous statement that left the tall man's lips.

He simply shrugs. "The fuck is it then?"

"I-it's my... .my prescription meds. F-for my anxiety. Please don't tell anyone."

"Oh," He has the same quizzical look he was giving you in class, but this time, it was more thoughtful. The tall man suddenly smiles widely. "So you're a psycho or something, then? Crazy?"

This was something that may seem normal for anyone, like off-handed teasing but this was a sensitive topic for you and something in you snap. Suddenly, you weren't afraid of the man in front of you anymore. You throw him a stormy look on your face, the best that you can muster that he actually looks a bit surprised. Without saying anything, you turn around to speedwalk out of the hallway, trying to get a good distance away from the prick.

"Woah, woah, there. What's the matter, struck a nerve?" Sukuna quickly caught up beside you. With him being taller than you, it was an easy few strides for him to fall in step beside you despite your efforts. "It was a joke, you silly fuck. Don't get all emotional on me, yeah?"

You didn't look back at him, your brows still furrowed and your eyes glued to the ground. Suddenly, he puts a hand on your head and ruffled your hair, much to your surprise.

"C'mon, let's have lunch together." He says in a soft voice that you were caught off guard a bit. "I'll try to make sure you don't fall asleep on your food."

₊˚ ♡

Ryomen Sukuna, the frat boy feared by everyone, wouldn't stop bothering you after that. He would follow you in between classes, hands in his pocket. Pestering you until you two fall into your usual banter, throwing insults just for shits and giggles. People were raising eyebrows about how Sukuna treated you. He was still being a prick but he's more mellow when it comes to you. Although he was starting to get annoyed at how you're always knocked out whenever he goes out looking for you.

"And here he comes," Your batchmate, Maki, says as your friend group watches Sukuna approach your table outside the schoolyard. This is where you, Maki, and Nobara hang out whenever the three of you have a free period. "And look, he even bought her a drink."

Nobara wiggles her eyebrows, "Wonder if that's the only thing he'll do to keep her up."

"I can hear both of you bitches." Sukuna says as he reaches the table.

He clicks his tongue when his eyes land on you, passed out on the table. There was a slight pool of saliva where your cheek met the table. It was gross but Sukuna secretly finds it adorable, with your hair matting against your forehead with your sweat.

"Now, whatever shall you mean? All we heard was the sound of love birds chirping in the air!" Maki teases, nudging Nobara with her elbow.

"Leave or I'll spill this drink on both of you."

Nobara puts her hands up as if to surrender. "Okay, okay. We'll leave you both to it. Y/n, your boyfriend's here!"

She nudges you lightly in an attempt to wake you to no avail. They leave the both of you as they make their way back to the University entrance.

Sukuna places the can of energy drink near your face as he takes a seat across from you. He looks at your sleeping face for a bit with a soft look in his eyes before shoving you harshly, almost falling off your seat like the last time.

"Stop sleeping, brat. Anymore sleeping and you might start missing me."

You wipe the drool off your cheek and raise an eyebrow at him. " Oh? Isn't it the other way around?"

"Why would I fucking miss you? I practically see your ugly face every day."

"Yeah, cus you keep following me. You even bought me an energy drink just to keep me awake, huh?." You cup the said beverage in hand, grateful that it's still cold.

"Don't feel too fucking special. Someone from my fan club bought that for me. I'll give it to you since I already had one."

"Liar," a smirk playing on your lips.

Opening the lid of the can, you take a sip from it as Sukuna watches you. You don't know when the two of you had gotten so close that you'd end up like this but you don't mind.

"Hey, why are you being so nice to me anyway?" You say as you settle the can back down the table.

Sukuna leans his head in his palm with a bored look. "I'm not being fucking nice to you. Who said?"

"I mean, you're clearly harsher with everyone else. So why am I different?"

"Exactly. Why are you different?"

You hit him with a deadpan and he just grins at you. "There's nothing much to it, brat. I'm just bored and I got nothing else to do."

"Mmhmm."

"And well," He continues, his eyes looking away from you. "My younger brother, Yuji, is on the same meds as you. So in a way, you kind of remind me of him."

"Do you happen to want to kiss your brother, by any chance?"

He scoffs, "Shut up smart mouth. Who says about anyone wanting to kiss you?"

"Just had a hunch, is all." You wiggle your eyebrows at him to which he just scoffs again, not missing the slight twitch of his lips.

Silence falls between the two of you for a while, engulfed in both of your own thoughts. You smiled at him suddenly, to which he lifts his brows in both question and surprise.

"Thank you for being nice to me." You say in a small voice.

He quickly looks away and you note that the tips of his ears turn pink.

"Fuck off, brat. You just think I'm nice to you because you're too busy sleeping to know how I really act."

⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖˖⁺‧₊˚ ♡ ˚₊‧⁺˖

(❀❛ ֊ ❛„)♡ reblogs and comments are appreciated//do not repost my work anywhere

another mid plot and writing but i wrote this when i first started drinking antidepressants just to cope and to feel comforted

i hated it and stopped drinking it after a while tho ://

#sukuna x reader #jujustu kaisen #fanfic #fluff #sukuna x you #ryomen sukuna x reader #sukuna ryomen x reader #sukuna fluff #sukuna ryomen #ryomen sukuna #antidepressants #meds #anxiety

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reasonsforhope · 8 months

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"One in five Americans will experience major depressive disorder in their lifetime, and many will not find relief from current therapies. But now researchers have identified an unexpected source of the problem: inflammation.

Inflammation in the body may be triggering or exacerbating depression in the brains of some patients. And clinical trial data suggests that targeting and treating the inflammation may be a way to provide more-precise care.

The findings have the potential to revolutionize medical care for depression, an often intractable illness that doesn't always respond to conventional drug treatments. While current drug treatments target certain neurotransmitters, the new research suggests that in some patients, depressive behaviors may be fueled by the inflammatory process.

It appears that inflammatory agents in the blood can break down the barrier between the body and the brain [and specifically the blood-brain barrier], causing neuroinflammation and altering key neural circuits, researchers say. In people at risk for depression, inflammation may be a trigger for the disorder.

Research suggests that only a subset of depressed patients - roughly 30 percent - have elevated inflammation, which is also associated with poor responses to antidepressants. This inflammatory subgroup may be a key to parsing out differences in underlying mechanisms for depression and personalizing treatment...

The inflamed body and the depressed brain

...A number of studies show that depressed patients tend to have increased inflammation compared with non-depressed subjects, including more inflammatory cytokines and C-reactive protein — which is produced by the liver in response to inflammation — circulating in the blood. Patients with autoimmune diseases have inordinately high rates of depression. And postmortem brain samples from people who died by suicide showed more activation of the brain’s immune cells, which release inflammatory agents.

Crucially, pro-inflammatory drugs can induce people to become depressed, which suggests a causative link. In one seminal study published in the New England Journal of Medicine, Miller and his colleagues conducted a double-blind study of 40 cancer patients undergoing treatment with interferon-alpha, an inflammatory cytokine.

Though none of the patients had depression to begin with, the inflammatory agent had a striking effect: Many became depressed, a finding that has been consistently replicated.

"The patients recognize pretty much immediately that, 'Hey, you gave me something, and now I feel this way. I don't know why I feel this way,'" Miller said.

Can treating inflammation treat depression?

If inflammation can induce or exacerbate depression and its symptoms, then reducing inflammation could provide relief.

Even if inflammation is a disease modifier rather than the cause of the problem, “you have to take care of it in order for you to be able to get your therapeutics working to restore your circuitry and what’s happening in the mind,” said Eleonore Beurel, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine.

Anti-inflammatory drugs, used alone or in conjunction with a standard antidepressant, may help some depressed patients. A 2019 meta-analysis encompassing almost 10,000 patients from 36 randomized clinical trials found that different anti-inflammatory agents, including NSAIDs, cytokine inhibitors and statins, could improve depressive symptoms...

“We’ve come to the tipping point,” Miller said. “And we know enough at this point to begin to target the immune system and its downstream effects on the brain to treat depression. We are there.”

How to manage your own inflammation

Experts agreed that people should not take anti-inflammatories without talking with their health-care provider. Your doctor can order a C-reactive protein blood test to measure your level of inflammation.

“There are so many patients who do not respond to antidepressants,” said Ole Köhler-Forsberg, a physician and associate professor of psychiatry at Aarhus University who has given anti-inflammatory drugs to his patients in addition to antidepressants. “So there is the issue of how can we improve the individual outcomes.” Tailoring treatment for each individual on a holistic basis may add some benefit.

More clinical tests for inflammatory markers may be a way to differentiate the effectiveness of antidepressant treatment. If confirmed, it would “be the first actual biomarker in psychiatry,” Raison said. “I mean, we’ve been looking for biomarkers for 50 years and had zero luck. And it’s ironic that it’s not a brain chemical.”

In the meantime, “you get much more mileage out of the lifestyle changes than you would out of supplements or any other over-the-counter drugs at this point,” Miller said."

-via The Washington Post (via Yahoo News), February 24, 2023

#depression #cw sui mention #cw suicide mention #inflammation #autoimmune #cytokines #neuroscience #medical news #medical research #anti inflammatory #antidepressants #ssri #mental health #mental illness #good news #hope #way way more details at the source btw

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