#cancer research | Explore Tumblr Posts and Blogs

cbirt · 3 months

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Scientists at St. Jude Children’s Research Hospital have published their findings on SJ3149, a chemical with broad efficacy against various cancer types, particularly acute myeloid leukemia (AML). Scientists worked together to discover and improve a chemical molecule that functions as a molecular “super-glue” for a variety of tumors. SJ3149 binds to cancer-related protein casein kinase 1 alpha (CK1α), causing its elimination. The findings were published in the journal Nature Communications.

Have you ever wished you could just put a “Do Not Enter” sign on a faulty protein in a cancer cell? Thanks to molecular glue degraders, scientists are coming closer to doing just that. These ingenious tiny molecules function as matchmakers, bringing together a protein designated for destruction (the target) and the cellular executioner (an E3 ligase) in a lethal embrace. As a result, the target protein is tagged and disposed of, providing a fresh approach to cancer treatment.

Molecular glues work by hijacking the cell’s natural protein recycling system. The molecular glue binds the targeted protein to an enzyme, marking it for destruction via proteasomal degradation. For many cancer-related proteins that conventional small molecule inhibitors cannot effectively target, molecular glues may be a feasible therapeutic option. This prompted scientists at St. Jude to create a vast proprietary library of molecular glues and screen it against a variety of cancer cell lines, resulting in an early hit.

#cancer #cancer research #drug discovery #cancer treatment #bioinformatics #proteomics

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useless-englandfacts · 24 days

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Following the news that Kate Middleton has in fact been diagnosed with cancer, I’d like the take the time to offer some information on cancer in afab people and some charities to support.

Cancer is a very personal and scary thing to face, and according to Cancer Research UK, every two minutes in the uk someone is diagnosed with cancer. Over 182000 women in the uk are diagnosed every year.

Almost half of all cancer cases are diagnosed at stages 3 & 4, and screening rates for breast and cervical cancers have fallen in the last few years in England and Scotland.

According to The Eve Appeal, around 60 afab people are diagnosed with gynecological cancers alone every day in the uk, and 21 of them will not be able to receive appropriate treatment in time.

People around the world are woefully uneducated about cancer as a whole, but the stigma and lack of proper knowledge given to the public and young afab people about our own bodies means that we often go under diagnosed, or are too afraid or ashamed to see a doctor until it’s too late.

I’ll be listing some informational pages to help people learn about the signs of breast and gynecological cancers that I believe every young person with an afab reproductive system needs to know. On the pages from The Eve Appeal and Breast Cancer UK there is also information for transgender and intersex people.

All of these sites have information on how to identify possible markers of cancer, information on how to get tested, and on how to donate to their charities. I highly suggest everyone regardless of gender identity have a look through to potentially help yourself or a loved one.

-Roe

#admin roe #womens health #cancer research #tw cancer #gynecological health #breast cancer

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foxybouquet · 2 months

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GHESTIES.

When worlds collide, satanists support cancer research, and buttons are forgotten.

#the band ghost #tobias forge #Grammys #TJ Martell Foundation #Josh groban #benefit #cancer research #he is so lovely to attend

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kathryn-helms-perspectives · 6 months

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Buy a copy of Perspectives to support cancer research and funding for families with children battling cancer!

#charity #fundrasier #cancer research #writing #teen author #poetry #Reblog to spread the word!

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jbarkerstargazer · 2 months

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100 skips a day challenge excepted.

Every day this March I am doing 100 skips with the aim to raise £150 for cancer research.

My Dad was only able to have cancer treatment 5 years ago because of developments in research. He's still here. Lets make sure cancer doesn't win.

Please donate here.

Knowledge is power.

#cancer research #100 skips a day challenge #march skipping challenge #thunderfam

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wormwonderland · 2 months

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If you haven't heard about it you can write a card to a St. Jude patient for free!

Please do this, and share any similar things because I would love to participate and spread love <3

#saint jude #st. jude #charity #valintines #valentines day #important #reblog #spread love #ecards #cancer research

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amatrudalab · 9 months

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The L.A. Cancer Challenge supports life-saving research with support from ordinary people committed to making a difference. It will happen on October 21st.

You can participate in Los Angeles or virtually by reporting your steps through the Internet. You can also donate here.

This year, they aim to raise $600,000. As of July 25th, they have already raised $42,356.

The Amatruda Lab thanks everyone who helps us raise money to save lives. We can't do this without the generosity of normal people!

#cancer #health #psa #medicine #pediatric oncology #biology #children's health #cancer research

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importantwomensbirthdays · 3 months

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Beatrice Mintz

Cancer researcher Beatrice Mintz was born in New York City in 1921. In 1960, Mintz joined the Fox Chase Cancer Institute of Philadelphia, and went on to become one of its most celebrated researchers. She made groundbreaking discoveries in multiple areas of biology, including epigenetics, embryology, developmental genetics, and gene-transfer technology. Mintz's experiments on mice paved the way for potentially less toxic approaches to cancer treatment, and made it easier for scientists to study melanoma. In recognition of her achievements, she received numerous awards, including the Award for Lifetime Achievement in Cancer Research from the AACR, and the American Cancer Society's National Medal of Honor for Basic Research. Mintz was also nominated twice for a Nobel Prize.

Beatrice Mintz died in 2022 at the age of 100.

Image: Smithsonian Institution

#science #stem #scientists #women scientists #women in stem #cancer research #biology #women in science #scientific research #philadelphia #jewish women #jewish #jewish history

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spanishroyals · 7 months

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September 21, 2023. London, United Kingdom.

Her Majesty Queen Letizia of Spain, honorary president of the Spanish Association Against Cancer (AECC) and it’s scientific foundation, visited Cancer Research UK today to commemorate the upcoming World Cancer Research Day.

World Cancer Research Day is an initiative of the Spanish Association Against Cancer (AECC) and promotes the importance of cancer research and highlights how integral continued investment in research is to achieve the scientific advances we need to beat cancer.

Her Majesty joined senior leaders from Cancer Research UK, the AECC, the Italian Foundation for Cancer Research (AIRC), and the European Society for Medical Oncology (ESMO) to recognise and celebrate international relationships in cancer research.

Her Majesty’s visit included a meeting focussed on international researchers collaborating on co-funded research programmes and a panel discussion dedicated to the three key themes of this year’s World Cancer Research Day: integrating diversity, advancing research, and achieving equity.

“Thank you so much for allowing me to be here today to see the successful teamwork between these organisations in this hard and complex journey of advancing in cancer research,” Her Majesty said.

Cancer Research UK’s partnership with AECC and AIRC began in 2016.

Since then, they have worked together to co-fund the Accelerator Awards, which have helped to forge some strong relationships between leading institutions in the UK, Spain and Italy.

Read more: https://news.cancerresearchuk.org/2023/09/21/queen-of-spain-visits-cancer-research-uk/

#spanish royal family #queen letizia #cancer research #queen letizia as honorary president of the spanish association against cancer #uk #london #bourbon

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thepastisalreadywritten · 1 year

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20 December 2018

For many years, Keanu Reeves has been secretly running a private foundation that helps aid children’s hospitals and cancer research around the world.

Reeves’ foundation funds cancer research and supports children’s wards and kids’ hospitals

During his younger sister Kim’s battle with cancer in the 1990s, Keanu Reeves was generous enough to give donations to numerous cancer charities and even went so far as to establish his own foundation in Kim’s honor, but the publicity-shy superstar didn’t even attach his name to it.

Keanu Reeves’ private foundation funds research into cancer, supporting both children’s wards and kids’ hospitals.

The star has never tried to claim credit for any of it.

In fact, nobody even knew he was doing this until Reeves told Ladies’ Home Journal back in 2009:

”I have a private foundation that’s been running for five or six years, and it helps aid a couple of children’s hospitals and cancer research.

I don’t like to attach my name to it. I just let the foundation do what it does.”

In 2008, Reeves also volunteered to man the phones at a Stand Up to Cancer telethon, and during a charity ice hockey match, he volunteered to be the goalkeeper, as the match was for “SCORE” (Spinal Cord Opportunities for Rehabilitation Endowment), which was founded in order to support players who suffered from spinal injuries.

Source: Anonews.co

#Keanu Reeves #The Matrix #Stand Up to Cancer #SCORE #Spinal Cord Opportunities for Rehabilitation Endowment #cancer research

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cbirt · 9 months

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Researchers from Bellvitge Biomedical Research Institute in Spain have designed TALKIEN (crossTALK IntEraction Network), a user-friendly online tool that helps to visualize molecular crosstalk or communication at the cellular level by constructing and analyzing ligand-receptor interaction network (LRIN). Understanding cellular communication is crucial for understanding cancer growth and therapy response. With the ability to perform functional analysis and access information on drugs targeting receptors, TALKIEN becomes an indispensable tool in the quest for deeper insights into cellular communication.

TALKIEN is a tool based on R (a programming language) which has immense applicability in statistical analysis and network analysis. TALKIEN takes a list of genes or proteins representing various cell types as input. It first analyzes the lists to find interactions between ligands (messengers) and receptors (receivers) on cell surfaces and then creates a map or a network of these interactions. Using systems biology techniques like centrality (measuring the importance of certain molecules), component analysis (grouping related molecules), etc., helps the users better visualize and analyze the network by providing different graphical layout options. It also shows the chain of events that occur after cell communication and presents a list of drug-targeting receptors, allowing researchers to see the broader impact of cell communication and potentially obtain unprecedented insights in healthcare.

#bioinformatics #cancer #cancer research

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medu-nefer · 11 months

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I am Bored Out Of My Mind™ so I'm sharing what's probably going to kill me today ✨

Here's my laminar chamber, where I've spent most of my days since December of 2022.

I'm currently harvesting trying to harvest my MDA cells for my research (for my master's thesis) and my trypsin is not working and they're not coming off the wells ✨

It's been almost 2 hours and I doubt they're gonna be viable for flow cytometry tomorrow, as trypsin-steeped as they are.

I had a test in the morning so I skipped breakfast in order to get to the lab on time. I didn't drink coffee. The laminar's noise is starting to give me a headache. The cat sticker represents my state of mind, but if we wait long enough, perhaps my body too?

I know nobody cares but I will update - to preserve my sanity by taking breaks from trying to coax the cells out of their wells by a combination of tapping the plastic, murmuring encouraging words and crying softly.

P.S. If you ever hear it's a good idea to work on cells for your graduate work, no you didn't.

#shitpost #complaining #cancer research #please put me out of my misery #i could be crocheting now #but nooo those bloody little bastards refuse to cooperate #well we'll see how you like bathing in trypsin for 2 more hours how about that

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walrusmagazine · 7 months

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Are We Losing the War on Cancer?

For half a century, we have thrown everything we have at the disease, but we are no closer to curing it

The premise behind the war on cancer was wrong. Cancer is not a single grim foe. We know now there are hundreds of distinct cancers. An oncologist in the 1980s would have known there were two types of lung cancer. Today, by looking at the molecular biology of the tumour cells, scientists can determine there are at least eighty different subtypes of lung cancer. There are at least twenty subtypes of breast cancer. In Booth’s speciality, there was just colon cancer until the past decade. Now there are a dozen known subtypes.