Covid-19 Alters Gray Matter Volume in the Brain
Covid-19 patients who receive oxygen therapy or experience fever show reduced gray matter volume in the frontal-temporal network of the brain, according to a new study led by researchers at Georgia State University and the Georgia Institute of Technology.
The study found lower gray matter volume in this brain region was associated with a higher level of disability among Covid-19 patients, even six months after hospital discharge.
Gray matter is vital for processing information in the brain and gray matter abnormality may affect how well neurons function and communicate. The study, published in Neurobiology of Stress, indicates gray matter in the frontal network could represent a core region for brain involvement in Covid-19, even beyond damage related to clinical manifestations of the disease, such as stroke.
The researchers, who are affiliated with the Center for Translational Research in Neuroimaging and Data Science (TReNDS), analyzed computed tomography scans in 120 neurological patients, including 58 with acute Covid-19 and 62 without Covid-19, matched for age, gender and disease. The work was done jointly with Enrico Premi and his colleagues at the University of Brescia in Italy, who provided the data for the study. They used source-based morphometry analysis, which boosts the statistical power for studies with a moderate sample size.
“Science has shown that the brain’s structure affects its function, and abnormal brain imaging has emerged as a major feature of Covid-19,” said Kuaikuai Duan, the study’s first author, a graduate research assistant at TReNDS and Ph.D. student in Georgia Tech’s School of Electrical and Computer Engineering. “Previous studies have examined how the brain is affected by Covid-19 using a univariate approach, but ours is the first to use a multivariate, data-driven approach to link these changes to specific Covid-19 characteristics (for example fever and lack of oxygen) and outcome (disability level).”
The analysis showed patients with higher levels of disability had lower gray matter volume in the superior, medial and middle frontal gyri at discharge and six months later, even when controlling for cerebrovascular diseases. Gray matter volume in this region was also significantly reduced in patients receiving oxygen therapy compared to patients not receiving oxygen therapy. Patients with fever had a significant reduction in gray matter volume in the inferior and middle temporal gyri and the fusiform gyrus compared to patients without fever. The results suggest Covid-19 may affect the frontal-temporal network through fever or lack of oxygen.
Reduced gray matter in the superior, medial and middle frontal gyri was also present in patients with agitation compared to patients without agitation. This implies that gray matter changes in the frontal region of the brain may underlie the mood disturbances commonly exhibited by Covid-19 patients.
“Neurological complications are increasingly documented for patients with Covid-19,” said Vince Calhoun, senior author of the study and director of TReNDS. Calhoun is Distinguished University Professor of Psychology at Georgia State and holds appointments in the School of Electrical and Computer Engineering at Georgia Tech and in neurology and psychiatry at Emory University. “A reduction of gray matter has also been shown to be present in other mood disorders such as schizophrenia and is likely related to the way that gray matter influences neuron function.”
The study’s findings demonstrate changes to the frontal-temporal network could be used as a biomarker to determine the likely prognosis of Covid-19 or evaluate treatment options for the disease. Next, the researchers hope to replicate the study on a larger sample size that includes many types of brain scans and different populations of Covid-19 patients.
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“That which does not kill us mutates and tries again.” -Friedrich Nietzsche, maybe I think
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If they run out of Greek letters to name COVID variants, they should start naming them like sassy 1950's diner waitresses. Agnes, Babs, Cindy, Dolores, Edie, Flo, Gladys, Helen, etc. I feel like it feels like the threat is more personal. I sure don't want to have to tell people I have to miss an important event because I got the Mitzi variant.
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Data! You seek data!
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When medical institutions start requesting people, the retired, to return back to the medical field.... I advise you all to do everything in your power not to get sick. Not from Covid or any other illness... Take care of yourselves this winter. Be safe.
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Any mandate contrary to the Constitution is illegal. ** Biden’s COVID-19 Vaccine Mandate for Federal Contractors Now Blocked Nationwide
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Video game that’s advertisted as a Catgirl Maid Simulator, but when you play it it turns out that it’s a grindingly realistic urban survival sim about being a domestic worker in a post-COVID economy, and the fact that the protagonist is in fact a catgirl is never remarked upon.
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Goddamn, South Africa’s scientists being punished for *checks notes* being good at their mf job—and oh yeah, also for being a Black nation, ofc.
Funny how far too many white people like twitter user “Becko” will equivocate tf outta anything to excuse away even the most blatant racism. White dudes be like, “Idk but for some inexplicable reason, countries with predominantly Black & Brown populations are consistently fucked over and blamed for spreading disease. Who knows why? It’s a fucking mystery.” 🤷
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So this may be moderately tone-deaf, but I mean it in good faith, and I hope it reassures some people:
A lot of my friends here on tumblr are people with chronic illnesses or severe disabilites or other major health issues. A lot of my other friends are in countries that straight-up don't have access to the vaccine. Lately I've been hearing some of them be really upset that they haven't been able get the Covid-19 vaccine until now, when lots of us online are getting our booster shots or upset that they won't be able to get it at all, and feeling agitated every time they see someone go off about 'the unvaccinated' and 'plauge rats', because they feel guilty about not getting vaccinated yet.
I got the vaccine for YOU, it was my Pride and Honor to do so, and I was NEVER worried about you being a vector. I love you.
I'm healthy as a proverbial horse- not a literal one, those explode if you look at them funny- and at extremely low risk for exposure or developing severe symptoms, but I got my damn shots ASAP and everyone in the house out for thier booster because I'd never forgive myself if I was a vector. I got this booster, I'll get the next booster, and the one after that and the vaccine for the next pandemic and every goddamn shot I can because I know it's up to me to hold the damn line.
The precautions my disabled and ill friends have had to take have been totally unreasonable, and I am genuinely sorry it's come to this. By that same token, those precautions that prevent you from being exposed prevent you from being a vector. You were never going to be the person to expose me.
And my friends that can't take precautions because we live in a capitalist hellscape or you work actual emergency services- you're risking your life for mine, I'll never be able to express my gratitude properly and again, you're in a different time zone if not anentirely different continent and I am doing everything I can to avoid having contact with you and your colleagues, so I'm not worried about you being a vector either.
You're not a bad person for doing the EXTREMELY SENSIBLE thing of waiting to see if the vaccine will be safe for you, or for having the misfortune to live on the wrong side of the geopolitical tracks. I know this. Everyone with half a brain knows this, even if having just half a brain occurs less than half as often as it should these days. Nobody worth taking criticism from is mad at you.
I love you, be safe, and I will do my damndest to get us through this because I know you're doing the same for me.
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Die Wissenschaft seit Monaten: Im Herbst und Winter werden die Coronazahlen dramatisch ansteigen.
Coronazahlen: *steigen dramatisch an*
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Updates from the vaccine clinic, October 2021
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Ah yes the top four trending fandoms
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Shifty Goodwill garments! (The vest came home with me.) Knoxville, TN
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Counties that voted for Trump have lower vaccination rates, and unsurprisingly, higher death rates from Coronavirus
So on the one hand, I really DO NOT want to get in the way of Republican voters doing me a huge solid by taking themselves out, right? I mean, if nothing else maybe their higher death rates will get to the point where it impacts voting outcomes in the 2022 midterms and in the 2024 general election? 🤔
It might be cold blooded, but it’s no more cold blooded than racist Republican voters voting guns! guns! guns! and voting to take away voting rights, abortion rights, healthcare, and a boatload of other things that decent human beings desire. Coronavirus is treatable, but willfully ignorant covidiots are refusing to take the free vaccine. So fuck ‘em. They made their bed.
But on the other hand, COVID is contagious; and in addition to unnecessarily prolonging the pandemic, antivaxxers are taking other people down with them. Like people who genuinely cannot be vaccinated because of legitimate autoimmune diseases, doctors and nurses, or even those people in other countries who want the vaccine but cannot access it because wealthy countries are hoarding the vaccine and still refuse to relax patent restrictions.
So in the spirit of correcting misinformation, here is a helpful graphic:
And an informative video:
But honestly? Until we make vaccines mandatory, I kinda hope Republican counties keep on self-purging themselves.🤷🏿♂️ So please wash your hands, social distance, mask up and get vaccinated. Republicans are going to stretch this pandemic out wayyy longer than you think.
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Me, everytime I hear about another covid variant
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John, I am liberal and pro-science and pro-choice. So i feel people have the right to choose what they do with their body. Earlier this year, i had a catastrophic medical event and almost died. Now I stay home in a covid safe quarantine. I work from home (corporate job), but i'm going to lose my job because i feel at this time I am not willing to get the vaccine and have any potential side effects. How do fellow liberals rationalize my body/my choice but also vaccine mandates?
I'm sorry you've had such a craptastic year! I'm glad you're recovering and have my 🤞crossed for you.
Your job won't make an exception for you to stay working from home? My company has a mandate but also makes reasonable exceptions, which yours seems to be, to me at least.
On to the heart of your question. I think many liberals have struggled with this. I know I have. I'm answering this in the general sense, not about your specific situation.
At the end of the day, being part of society means taking reasonable steps to keep each other safe.
Right now, that means getting vaccinated. The science is clear and uncontested. Getting vaccinated is safe and effective and failing to do so, puts us all at risk. (Including people like you that can't. )
Also, let's not fall into the conservative "my body, my choice" false equivalency. This is not the same thing as abortion.
Right now, every covid death is 100% tied to someone's choice not to get vaccinated. I'm disappointed that people are okay with this.
So that's how I justify it. It's not hard in my humble opinion. I don't like vaccine mandates, but I like even less that they are needed. When did we become so selfish?
Good luck friend. I'm pulling for you.
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