#hos dutp

[nancy-plays-dutp]

About TP

This is intended to be a quick summary for people who might not be familiar with the game and still want to read this blog. If you would like more information please visit the wiki, check out the DUTP socials, or send an ask. 

Time Princess: Story Traveller, hereafter referred to by their earlier name Dress Up Time Princess (DUTP), is a mobile game that combines elements of a visual novel and dress up game. Players have a certain amount of stamina every day that they use to play stages, earn blueprints, and craft clothing, which is then worn to pass stages. Most stages will offer choices, ranging from flavor text dialogue choices to significant choices that will unlock different endings and drastically affect the storyline. 

In the game the story is that your character, hereafter referred to MC, is transported into different worlds through a magical book. Romance is a common element across most of the stories, with story companions being fully animated and needing to be interacted with daily to level up the relationship and unlock certain blueprints and stages. The app is rated G for General Audiences but individual stories may delve into more mature subjects; this blog will provide trigger warnings based on topics discussed, but as a rule topics such as character death, injuries, and non graphic violence are discussed and will not have warnings. Feel free to send an ask if you have questions about these trigger warnings, either in game or in this blog.

There are currently 41 main stories released. Their names and acronyms are listed below the cut, in order of release.

Queen Marie (QM)

Magic Lamp (ML)

Gotham Memoirs (GM)

Swan Lake (SL)

Helen of Sparta (HoS)

Romy and Julius (RJ)

Shadows of London (SoL)

Little Women (LW)

Phantom of the Opera (POTO)

Taishō Adventures (TA)

Saga of Viera (SoV)

Tang Dynasty Hunter (TDH)

Si-Woo’s Sight (SWS)

Princess Sissi (PS)

White Snake (WS)

Dancing on Ice (DoI)

Have You Seen Claudia? (HYSC)

Whispers of the Rain (WotR)

Cleopatra (Cleo)

The Sacred Beast (SB)

Ancient Dreams (AD)

Ghost Manor (GhMa)

Kingdom of Beasts (KoB)

House of Horrors (HoH)

Spring Sonata (SoS)

Trendy Times (TT)

Gourmet’s Journey (GJ)

Miss Kitty’s Antiques (MKA)

Hela’s Compass (HC)

Golden Age (GA)

The Perfect Storm (PerSt)

Code: Whalefall (CW)

Moving Mountains (MM)

Sisters of the Sea (SiS)

The Apothecary (Apo)

Lunar Legends (LL)

The Moravia Express (ME)

Dominic’s Disappearance (DD)

Heartwood Mysteries (HWM)

Mysteries of Zentico (MoZ)

Showdown in Glitter Rise (SGR)

#about dutp #most of the acronyms are common across most fan discussions #i had to make up a few because they moved too slow for me #or i didnt like their acronym #this is the list i'll be using across this whole blog

[maddsmallow]

finished dutp's phantom of the opera

it was ¯\_(ツ)_/¯ but idk if that's just cuz i haven't watched the actual thing lmao. like yeah the phantom is hot but MAN he's such an asshole. something something men will do anything but ho to therapy

#the blogger says words

[worm-turbation]

recent hamster dresses ^_^

#dear diary #dutp #that hos oneeeeee god bless

[healthtimetaylor]

Nrf2/HO-1 mediated protective activity of genistein against doxorubicin-induced cardiac toxicity.

PMID:  J Environ Pathol Toxicol Oncol. 2019 ;38(2):143-152. PMID: 31679277 Abstract Title:  Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity. Abstract:  The current study evaluated the cardioprotective activity of genistein in cases of doxorubicin-(Dox) induced cardiac toxicity and a probable mechanism underlying this protection, such as an antioxidant pathway in cardiac tissues. Animals used in this study were categorized into four groups. The first group was treated with sodium carboxymethylcellulose (0.3%; CMC-Na) solution. The second group received Dox (3.0 mg/kg, i.p.) on days 6, 12, 18, and 24. The third and fourth groups received Dox (3 mg/kg, i.p.) on days 6, 12, 18, and 24 and received protective doses of genistein (100 [group 3] and 200 [group 4] mg/kg/day, p.o.) for 30 days. Treatment with genistein significantly improved the altered cardiac function markers and oxidative stress markers. This was coupled with significant improvement in cardiac histopathological features. Genistein enhanced the Nrf2 and HO-1 expression, which showed protection against oxidative insult induced by Dox. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed substantial inhibition of apoptosis by genistein in myocardia. The study showed that genistein has a strong reactive oxygen species scavenging property and potentially (P≤ .001) decreases the lipid peroxidation as well as inhibits DNA damage in cardiac toxicity induced by Dox. In conclusion, the potential antioxidant effect of genistein may be because of its modulatory effect on Nrf2/HO-1 signalling pathway and by this means exhibits cardioprotective effects fromDox-induced oxidative injury.

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[healthtimetaylor]

Sulforaphane reduces the apoptosis of neurons in brain trauma-induced diffuse axonal injury.

PMID:  J Cell Biochem. 2019 Jun 24. Epub 2019 Jun 24. PMID: 31232487 Abstract Title:  Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO-1. Abstract:  BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2. Therefore, we aimed to investigate therapeutic effect of SFN in the treatment of DAI and the ability of SFN to reduce oxidative stress.METHODS: The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to observe the effects of HOand SFN on cell viability. Fluorometric assay, Western blot analysis, and flow cytometry were conducted to validate the protective role of SFN in an animal model of DAI. In addition, the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured in DAI rats treated by SFN, while Western blot, immunohistochemistry assay, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were carried out to verify the effect of SFN in different animal groups.RESULTS: Cell viability was reduced by HOin a dose-dependent manner, while the treatment by SFN significantly promoted cell growth. Meanwhile the administration of SFN effectively reduced the levels of caspase-3/poly(ADP-ribose) polymerase (PARP) activity increased by the HOtreatment, indicating that the protective effect of SFN could be mediated by its ability to suppress caspase-3 activation and PARP cleavage. In addition, the SFN treatment reduced the intracellular reactive oxygen species (ROS) generation induced by HO. Moreover, the MDA levels of SOD/GPx activity in various rat groups showed the protective effects of SFN in DAI rats. It is suspected that the protective effect of SFN was exerted via the activation of the Nrf2/HO-1 signaling pathway. In this study, DAI and DAI + phosphate-buffered saline (PBS) groups also showed the presence of more TUNEL-positive cells compared with the sham-operated group, while the SFN treatment reduced the extent of neuronal apoptosis.CONCLUSIONS: By activating the Nrf2/HO-1 signaling pathway and reducing the activity of caspase-3, SFN reduces the apoptosis of neurons in brain trauma-induced DAI.

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[healthtimetaylor]

Astaxanthin protects ochratoxin -induced lung injury in mice through the Nrf2/NF-κB pathway.

PMID:  Toxins (Basel). 2019 Sep 17 ;11(9). Epub 2019 Sep 17. PMID: 31533259 Abstract Title:  Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway. Abstract:  The aim of this research was to evaluate the potential protective mechanism of astaxanthin (ASTA) against oxidative damage and inflammation caused by ochratoxin (OTA) in mouse lung. We divided mice into a control group (CG), an OTA group (PG), an astaxanthin group (AG), and an OTA+ASTA group (JG). Oxidative indices (malondialdehyde (MDA), total superoxide dismutase (T-SOD), and reduced glutathione (GSH)) and inflammatory markers (interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α)) were assayed in the lung, and the lung-weight-to-body-weight ratio was calculated. Apoptosis was detected in pathological sections by the TdT-mediated dUTP nick-end labeling (TUNEL) assay. Oxidative damage and inflammation were detected in the lung of mice after exposure to OTA. Besides, Nrf2- and NF-κB-pathway-associated proteins were detected by Western blot. In contrast with OTA, ASTA significantly raised the expression of Nrf2, HO-1, and MnSOD, while the expression of other proteins (Keap1, TLR4, and NF-κB) was significantly decreased. These results indicate that ASTA exerted protective effects against OTA-induced oxidative damage and inflammation in the lung by regulating the Nrf2 and NF-κB pathways.

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