I just finished watching the trailer for Inside Out 2, and I gotta say I think it's GENIUS that they made Anxiety (and her associates for that matter) an antagonist without making her a villain.
The whole message of the first movie is that trying to suppress or cut out certain emotions from your life (even negative ones) can be unhealthy and even damaging. So, by not portraying Anxiety as a two-dimensional villain but as someone who genuinely wants to help out Riley, it's not only a breath of fresh air, but it also keeps true to the themes of the story.
And lemme tell you, as someone who has autism and therefore deals with a lot of anxiety (ESPECIALLY IN SOCIAL SITUATIONS) this legit brings tears to my eyes.