#mice genes

[ancientorigins]

Scientists shed light on the 25-million-year-old genetic twist behind why humans and their ape relatives lack tails. This groundbreaking revelation exposes the long-hidden genetic culprit responsible for our tail loss.

#tail #evolution #mice #genes #genetics #disability #primates #hominoids

[mafuteru]

so inactive nowadays.. been rly getting into mouse genetics in my free time

#not much of free time to be had T_T #i wake up earlier so that i can interact w my mice.. #theyre usually most active at 3am #and i gotta leave for work at 5am #ophelia has c/c genes since she is a pew but for the others i cant be too sure #of their hidded recessive genes #hiddeN #shion.txt

[kedreeva]

Do you think you could give your opinions on the recessive / lethal yellow genes in mice? Do you think you'd ever consider breeding recessive yellow? (If you haven't already.) I'm just super curious about your thoughts on them as I don't really know a lot about genetics. Do you think it's possible to breed a consistently healthy line of yellow mice? I'm just super curious to hear your thoughts as a breeder

Well, this is a kind of long answer and I'll warn it discusses animal death, so I'll put it behind a cut.

Personally, I wouldn't, but not because of ethics concerns; I just don't like any of the colors made with RY/AY. They're just not visually appealing to me. I had a couple RY pop up from the Taylor black line when I first got it, and they were just enh. A good, rich red, esp a satin red, can be a really perfect looking mouse... but by god that's years of work and it never ends because Red is such a hard phenotype to maintain and I'm just not that determined. I'm convinced that people breed for red because seeing it opens all the ferret cages in their brain, not because they can be normal about it. If you want good reds, it's like you dedicate your life (and mousery) to it or you don't do it, and my life's already dedicated to the peafowl. My mousery is already dedicated to blacks and tricolors.

As for the AY gene itself, it's a "lethal" gene in that homozygosity is lethal but it's lethal at the blastocyst stage so it's not really an ethical problem imo. If it was lethal as in the pups deteriorate and die post partum, or if it caused well developed pups to die/be stillborn such that it caused the dam health risks, then it would be a problem. But, it doesn't. You just get smaller litters because some cells die way early on and get reabsorbed. I don't really have any problems with that. Show breeders cull litters down to 4-6 pups (for dam and pup health reasons), so it's not like all of them would be turning into adults anyway.

As for the genetic issues with the adult mice, there are three major health issues. The first is obesity (sort of), and the major problem there is keeping them in breeding shape (meaning, capable of doing the do at all). Curiously, in at least one study I remember seeing, there's a difference between an obese mouse of X color mutation and an AY that's considered obese because of its natural body type; for example, an obese black mouse will likely have a shortened lifespan, whereas an AY mouse doesn't (at least not less than any other mouse color mutation) unless it's obese for an AY. So this isn't really a problem as long as the breeder is watching their diet and ensuring they stay fit for their body type.

The other two genetic problems actually are health issues related directly to the AY gene, and that's being prone to diabetes and to tumors. However, these are both things that (any good) breeders would notice, cull, and therefore not breed forward, in order to keep the line as free from them as possible. Which really isn't any different than any other line that develops health problems of any sort. People don't keep health problems. A good breeder should be and usually is aware of the potential health problems in the lines they are breeding, particularly if it's a genetic one that can't be avoided (like you can't avoid AY if you're breeding AY), and will know what to look for and intervene as soon as possible. Diabetic mice urinate excessively so it's REALLY noticeable, and tumors... well. Hard to miss. And tumors of various sorts is a fairly common "select away from/cull" problem in any mutation, it's just slightly higher risk in AY.

So the short answer, in my opinion, AY isn't really an unethical gene to work with. It's not one I'd choose to work with, but I don't think the people who do are doing anything wrong just for working with the gene at all. It comes down to the same ethics as any other mutation; working to maintain body condition and selecting for health.

Honestly, out of all the animals I've seen bred and bred myself, I think mouse breeders in general have proven themselves to be the most concerned with what's best for the animal, not the breeder. The show clubs like FMBA and AFRMA etc won't recognize standards for things like snub noses or manx tails or anything else that would potentially seriously impact QoL by nature of existing at all, and at least in the groups I'm in, the members are not shy about recognizing when health problems mean no breeding for a mouse regardless of how pretty or sweet. When someone newer asks what to do, I've never seen anyone support trying to breed a mouse with issues, or usually even keep one whose QoL would be poor. They are very familiar with the kindest thing you can do is let them go. It's a breath of fresh air from the goddamn chicken groups, who will limp along any bird that's still breathing regardless of what's best for the bird.

I think the only morph I've seen that I have an ethical problem with is the X-brindle gene, which is a "brindle" gene on the X chromosome that causes the mouse to be unable to absorb copper. This means that the males DO founder and die after birth (which means most people just humanely euthanize the male pups, they aren't out here letting them suffer that I've seen), and females get a strange coat color and curled whiskers from low copper absorption. Does have a second X gene that's clean so they still can, but it's really an unnecessary mutation to continue imo. It hasn't been recognized by the show clubs that I know of, but idk if they can be shown under normal brindle or if you can tell at a glance, as I don't really know as much about them or any of the AY gene specifics. I have basic knowledge but since i don't breed them myself it's very in passing knowledge. I know it's rarely bred or worked with in the first place, and I hope it stays that way or disappears entirely.

#mice #my pets #mouse genetics #asks #anon asks #and please take my opinion with a grain of salt lol #I mean it when I say I don't know a lot #about morphs I don't personally breed #I'm barely comprehending the tricolor nonsense #I'm treading water with them trying to learn their genetics #I don't have the processing power for other mutations #I feel like I learn about new ones every week too #someone will post a photo and it'll be a light brown mouse #and they'll be like is this a coffee #and everyone else will be like no the foot is the wrong color it's a latte #and I'm over here sweating going they're mice not beverages?? #and then someone names the genetics of the brown mouse #that looks like every other brown mouse #and there's 17 different genes #and none of them are the same as the other brown mouse #god peafowl genetics are so much easier

[k-emii]

Good news everyone, elephants can’t get cancer

#Elephants #its because they have 70 copies of the p53 gene which is in part responsible for tumor suppression. Humans only have one copy of the gene i #You were curious #Tbh it’s more like it’s extremely rare for an elephant to get cancer #Also female mice are resistant to multiple sclerosis for some reason

[dragonballnewstar]

{{ Brain: Draw...Spencer with scars

Me: But he heals? Healing factor? He heals before scar tissue is formed

Brain: ...Go research why we form scars and then we can make a conclusion

#ooc: mun speaks! #;rambles #Time to Study GENES #and FIBROBLAST PROTEINS #anyway apparently scientists identified a drug that can prevent scar tissue and heals skin cells normally (in mice in a controlled environ) #theyre hoping this can be applied to internal organ scarring #but also improve quality of life for those scar tissue impede them physically #all this for just wanting Spencer to be hot

[narutomaki]

get me OUT OF HERE

#this is about fucking. shipping. fucking orochimaru. get out of this polycule all of you shoo!!! go!!!! #STOP HAVING BABIES AND BEING HAPPY AND GOOEY!!!! STOP!!!!!! YOURE RUINING ME!!!!!!!!! #the fucked up little version of Obito ive made tho and his fucked up little niche of functionally immortal reincarnated body sharing #its like ive made him cat nip for Orochimaru. i was JOKING INITIALLY RIGHT??? I WAS LIKE #HAHA OROBITO HAHA HA HA HAAA FUCKING HELP MR #IM IJ HERE NOW LIKE OH YEAH AND GENE SPLICING IS SOMETHING OROCHIMARU HAS EXPERIENCE IN #AND GIVING HIM THIS AS A HEALYHY OUYLET AND MAKING HIM A MOTHER IN ONE FELL SWOOP #Obito has like 15 kids by the time Miho is created so shes not going yo be his heir (his heirs mother was an Uzumaki he hit it off with and #asked to have a kid with young (17) so shes 14 by the time the main series begins) #any way. Kakuzu being like ok you can have a chold under this roof but i will not be responsible in any way for it #and then holding Miho exactly once and going like 'oh i get why mothers die for their babies now' #Kisame takes the longest to warm up to her which surprises him bcus he gets along well with the rest of Obitos children #(Obito is like well. fuck you guys. Uchiha clan in Ame time and offers people contracts like in situations of fertility he adopts the mother #and father into his clan and turkey basters it (okay no he does send them to the hospitla but) and otherwise offers #a home a name etc for agreeing to join as either a civilian clan member or to have a child of his and some of the #second parents are like oh fuck yeah i want a kid but not a relationship/my husband is infertile/whatever and raise the child #as their own with very lityle input from Obito but some Obito has raised / was raising essentially on his own (such as his heir whos mother #didnt want to be in a relationship with Obito but wanted to test out motherhood and found she Could Not Do It and is now #more of an estranged aunt figure but 14 y/o doesnt have much bad blood about it bcus she has The Scariest Step Dad squad and #is 1000% creepy teen girl coded and it gets validated in sooo many capacities. cant do unethical experiments on mice when one of your step #fathers can bring you into the lab and teach you how to actually do the work and deal with an ethics commity that yes we have to #otherwise your father gives us the neutral but disappointed face) #ANY WAY #CAN YOU SEE WHAT I MEAN ?? LET ME THE FUCK OUT!!! LET ME OUY LET ME OUT HELP SOMEONES FFFFFFFFFFFFUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUC

[newkiqx]

❤

#tw death #tw pet loss #it's sad season #the current group of mice is/was the healthiest i've ever had #they had good genes and I put a lot of effort in #but they're rapidly approaching two years old now and in the past three months I had to let three go #Just a couple of days ago we had to let go of Nugget #she was one of the nicest mice I've ever had but she was already on borrowed time - her kidneys started having issues about 8 months ago #somehow she lost half her weight and completely changed color then but survived and thrived after that - always the most active one #she was the kind of mouse always climbing on stuff first and jumping on hands immediately - as well as genuinely liking to interact with me #even appreciating some careful petting of her head - but not too much #which despite the prevalence in tumblr gifs and videos is very rare in my experience #on her last night she was so tired but she still ran out when she heard me speaking so i picked her up and let her cuddle with my hand #she looked so content and peaceful #There are two left out of the original six #one of them is saartje #the other one is daantje #but daantje has been walking around with a tumor for a couple of months now #the vet said they couldn't really operate and it wouldn't give her much extra time even if it was succesful #but the tumor doesn't seem to bother her much so as long as shes not annoyed or tired with it it should be fine - we have her on pain meds #so i'm just carefully monitoring her behaviour and seeing if theres any sign of fatigue or decreasing interest as a sign #but its getting so large now she has to walk weird and she's kinda slanted so i'm thinking maybe next week to take her to the vet again to #put her to sleep... #it's sad but part of owning many short lived animals #the other one - Saartje - is the blind (and popular) one I posted a couple of gifs of #its kinda funny she turns out to be the longest lived out of the bunch because she had stunted growth and was blind #(and an idiot doofus (lovingly)) #when i pull the trigger on daantje I'll go looking for a new group of nice young ladies to pair Saartje with #shes been a bit grumpy so I hope she'll accept new mice once she's alone #personal

[containmentbreach]

patb thoughts while they're in my head from the last post. if you think pinky is autistic and brain is a neurotypical ally you're doing it wrong. ohhhhh it's stereotypical to make the asshole genius autistic no that only counts if the asshole genius sucks shit like sherlock and bazinga. if the asshole genius is a cartoon lab mouse in codependent love with his genderfluid and also autistic bestie it's fine. trust meeeeee peace and love!

check this out btw

(that's both of them to me.)

#on the one hand trying to make mice autistic to find proof of an Autism Gene is kind of fucked #for like. real life implications yknow. #but on the other hand this is the funniest phrase i've seen all day. #patb #textfile #ALSO i know the guy's name isn't bazinga. it's funny tho #i'm really tired right now in case you couldn't tell #i'm just saying shit

[swagging-back-to]

still cant believe i got a calico mouse from a fucking petstore meanwhile the closest calico mouse breeder is LI TERALLY on the other side of the country in California.

#like yeah she isnt super defined calico #it's more splashy #but thats all the calico gene is anyway. it's the splash gene. #and again. she was a COMPLETE accident #bc the breeder they get the mice from isn't even a specific mouse breeder they're just a general exotic animal breeder #they dont pay attention at all it's just a breeding mill #so the fact she came out as pretty as she is andshe had an incredible personality> #im in love #im literally in love with this mouse #she is MY DREAM MOUSE #i was so willing to fly across country in a few years to get calico mice but now I don't even really need to. i have her for a year or so. #like. #i loved all my mice the day I got them but I LOVE her. #she is the exact type of mouse i was setting my sights on and was dreaming to get eventually #literally no other mouse coat type is as attractive to me as calicos are. not one. #siamese mice are my second favorite but not even remotely close to calico ones #i cried the drive back to the house ngl #esp bc she kept squeaking pretty loud in the box and i was like </3 oh baby #i love sushi too (decided on sushi and mochi) but i have SO many speckled black mice now #and shes a bit shy

[wikipediagrams]

#genetic engineering #knockout mouse #gene science #knockout mice

[scienceswitch]

Naked Mole Rat's Longevity Gene Gives Mice a Longer Life

The naked mole rat is arguably the strangest looking mammal on the planet. However, beneath its wrinkly exterior may lie secrets that could extend human lifespan. In a new study, published in the journal Nature, researchers reported that they successfully transferred a naked mole rat gene into mice, leading to improved health and longevity. Researchers transferred a longevity gene from naked mole…

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#Animal research #Anti-Aging #Biotechnology #Gene transfer #Genetics #Gerontology #Healthspan #Hyaluronic acid #Life extension #Lifespan extension #Mice #Naked mole rat

[amber-tortoiseshell]

I don't understand amber. How does it work? What does it do? How is it different from wide band/golden/ect.? Please explain

Ohoho, you invited me to talk about my favourite gene!

Amber is the mutation of the MC1R (melanocortin 1 receptor) gene. Recessive mutations here are associated with red and yellow color varieties in lots of species: rabbits, horses, mice and humans, to mention a few examples.

So what does this gene do? Replaces the black pigment with red. That's the gist of it.

The regular orange color of cats is a different gene, but they have similar molecular backgrounds: red and amber are both phaeomelanin-based colors. Phaeomelanin is one of the two most important pigment types in mammals, together with eumelanin. Eumelanin is responsible for black and brown colors, phaeomelanin is for reds and yellows. Black, chocolate and cinnamon are the traditional eumelanin-based cat colors.

Eumelanin-based tabbies have both eumelanin and phaeomelanin in their fur, the alternation of these two pigments make the agouti hairs banded: the lighter bands have only phaeomelanin. Phaeomelanin-based colors have only or overwhelmingly phaeomelanin in both the lighter and darker bands (the difference is probably the amount of pigments).

Now wide band does something different: it extends the lighter bands, so the coloration becomes less eumelanin-dominated (when there's eumelanin present). Thus, yellow cat.

The first figure shows basically the comparison of the hairs of a black and a red or amber tabby, the second is how golden hairs look like:

That's the difference between amber and golden. One of them changes the color of the agouti bands, the other changes their size.

Here's a red, an amber and a golden cat for comparison:

The amber tabby in the middle has darker orange tabby pattern, the black golden cat still has a black tailtip, black feet, sometimes even some black markings on the face.

The coolest thing about amber is that unlike red and golden, the kittens born with a lot of eumelanin, and they gradually lose it as they mature. Like this:

Nowaja (Galaxy vom Ritterclan), amber smoke with white

#ask and answer #i hope it's clearer now #extension #amber

[tenth-sentence]

The inbred strains of mice consistently differ in their performance on these tests, implying that genes prescribe their behaviour.

"Nature via Nurture: Genes, Experience, and What Makes Us Human" - Matt Ridley

#book quote #nature via nurture #matt ridley #nonfiction #inbred #mouse #mice #genes #behavior #behavioral genetics

[mindblowingscience]

It's been announced that clinical trials for a potential tooth regrowth treatment are set to begin in July 2024, building on decades of research in the field. If those trials are successful, therapeutic drugs could be available by 2030. A team from the Medical Research Institute at Kitano Hospital in Japan is in charge of the trial, which is targeting people with anodontia, a rare genetic condition that prevents baby teeth and adult teeth from growing in the normal way. The treatment would initially target young children with the condition, but further down the line, the researchers think it could also be used more broadly – with people who have more common dental problems, such as gum disease, for example. "The idea of growing new teeth is every dentist's dream," Katsu Takahashi, head of the dentistry and oral surgery department at Kitano Hospital, told The Mainichi. "I've been working on this since I was a graduate student. I was confident I'd be able to make it happen." Here's how it works: having found a link between a specific gene called USAG-1 and limits on tooth growth in mice, the researchers then moved on to tests that tried to block the expression of USAG-1.

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#science #stem #medicine #health #teath

[russersprouts]

Bea died :(

#i love mice I wish they lived longer #plus pet store genes and. well. #kind of a recipe for this kind of thing

[shiftereris]

My biology assignment is saying that in 2001 scientists made glowing mice by taking the bioluminescent genes from jellyfish and putting it in the mice DNA.

My question is how bored were they to come up with that and if they could be considered a mad scientist.

#shiftereris #science