#moderna vaccine efficacy

[jjbizconsult]

COVID - 19 Omicron Vaccine from Pfizer and Moderna

COVID – 19 Omicron Vaccine from Pfizer and Moderna

COVID 19 Omicron Vaccines The COVID-19 strain Omicron has taken over as the predominant strain globally. Boosters that specifically target this variety are soon to be made available. According to Moderna and Pfizer, new booster shots that target the Omicron BA.1 subvariant, which predominated in the United States in January, are about to be made available to the general public, subject to…

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#Omicron vaccine #omicron vaccine efficacy #pfizer omicron vaccine #moderna omicron vaccine #booster vaccines #4th booster shot #covid omicron vaccine #pfizer vaccine #moderna vaccine #covid 4th booster vaccine

[yamameta-inc]

This is a pretty remarkable difference between Novavax (protein-based) and mRNA. Efficacy is estimated from IgG (the antibody immunoglobulin G) values, which obviously isn't very exact, but imo the difference is still significant.

Protein-based vaccines like Novavax also seem to offer more protection between strains/against future strains, as well as having less side effects. Get Novavax if you can (it's a lot more difficult than getting Moderna or Pfizer).

#covid #vaccines

[bighermie]

Pfizer and Moderna COVID Vaccines' Efficacy Exaggerated, Effectiveness 'Well Below' 50 Percent, Researchers Say

Pfizer and Moderna COVID Vaccines’ Efficacy Exaggerated, Effectiveness ‘Well Below’ 50 Percent, Researchers Say https://link.theepochtimes.com/mkt_app/health/pfizer-and-moderna-covid-vaccines-efficacy-exaggerated-effectiveness-well-below-50-percent-researchers-say-5595590?utm_source=andshare

[liesmyteachertoldme]

Majority of Americans now dying from Covid were Vaccinated and Boosted

A majority of Americans dying from the coronavirus received at least the primary series of the vaccine, writes The Washington Post.

The latest data shows that 58% of COVID-19 deaths in August 2022 were from people who were vaccinated or boosted. Based on past figures and the current trends, we can reasonably estimate that the number of vaccinated/boosted COVID-19 deaths will only rise, comments The Reactionary.

Majority now dying from Covid were Vaccinated: In September 2021, the vaccinated accounted for 23% of COVID-19 deaths; in January/February 2022, the vaccinated were 42%.

This is what happens when you rush ineffective and dangerous vaccines.

Majority now dying from Covid were Vaccinated: The FDA’s promises of efficacy – 91% for the Pfizer vaccine and 93% for the Moderna vaccine – were always based on hope, not data. So too were the promises of safety.

At the time of the official approvals, both Pfizer and Moderna hadn’t submitted any type of long-term numbers on effectiveness. Their trials were polluted with the unblinding of participants and their safety studies are “ongoing.”

Now, we’re seeing efficacy numbers plummet within months of vaccination. The pandemic is of the vaccinated. The boosters?

#covid fraud #covid deaths #covid vaccine

[persephinae]

Oh word? 👀

#skin cancer #skin cancer vaccine #health

[vbadabeep]

[grumpypharmtech]

This is fucking AMAZING...

#sometimes drug companies DON'T suck #hell yes

[olena]

Read: The imminent BA.5 vaccine booster - by Eric Topol

Excellent, helpful post. Excerpts:

Each year the flu vaccine quadrivalent program is updated using mice data, so there’s certainly a precedent for using such data. ... But there’s a concern that it’s not so easy to extrapolate mouse to human for SARS-CoV-2, a virus that’s quite different than influenza.

A substantial proportion of people have had 3 or 4 shots of the original vaccine, so there’s the potential for imprinting—that is a preferential revving up of the immune response to what a person was originally exposed to. ... both Pfizer and Moderna shots are bivalent, whereas the monovalent would be expected to be better, not further inducing an immune response to the obsolete ancestral strain ...

The problem we have now are “leaky” vaccines, that is the substantially lessened protection from infection and transmission from pre-Omicron. This is central now and must be addressed if containment of the virus is going to be achieved. ...

Recall that with the ancestral strain of the virus through Delta, we had remarkable >90% protection vs symptomatic infections out to at least 4+ months (with a booster), but that all changed once Omicron hit. The Omicron lineages may have evolved to such an extent that shots, no matter how well matched to the spike protein, will not restore the very high level of what we saw vs the original version of the virus.

[Bold above is what a lot of people appear not to understand about our present situation. Some take a “I got the vaccine, I’m done” stance that was fine ~ mid 2021 but is no longer valid due to these evolutions. Now it’s extremely disappointing that with so little protection, govts and other leadership have completely given up on the other layers that can help people stay safe and avoid debilitating outcomes.]

I still believe the best bet for tackling the infection and transmission challenge is going after a nasal vaccine, which Akiko Iwasaki and I recently wrote about and what we called Operation Nasal Vaccine. That would directly address the problem and we will soon have the readout of efficacy from the first major trial of 4,000 participants, with many more to come in the months ahead ... They target mucosal immunity, which we have learned is not likely to be attainable via shots.

The Public Perception

A separate (but interdependent) issue from the uncertainties of efficacy is that of public trust. If the new booster campaign is seen as a “rush job” and concerns are heightened that the data is based only from mice, that will certainly not enhance uptake. Framing this further, we have a serious booster lack of uptake in the United States, with only 32% of the population having had any booster shot. That compares quite poorly to our peer countries that are all at least double that rate. The messaging from CDC about boosters—which should be mission critical— was delayed from the get go in the Fall of 2021, and has never gotten on track. For me, it has been the standout disappointment of our CDC’s management of the pandemic, not duly emphasizing the lifesaving benefits (no less reduction of hospitalizations and potential reduction of Long Covid) of boosters (first and second shots) where there is an extraordinary body of evidence to support their need. ...

...this is the last free vaccine that will be distributed by the US government, as the funds have run out and subsequent vaccines, boosters and drugs will be have to be defrayed by other means.

 What to Do?

We’ll know much more about the BA.5 bivalent booster in the weeks after the program is launched. Many people will be perfectly comfortable going ahead to get this booster right away and are unconcerned about some of the points I’ve raised. That’s fine. They are quite likely to derive benefit. I am nearly 8 months out from my 4th shot, but will wait to see some data before getting it. Maybe I’m a bit too conservative, maybe too data-driven for my own good.

Most importantly, we need to achieve containment of the virus once and for all, and should not rely only on just the BA.5 booster. The prospects for an effective nasal vaccine are bright. ... This isn’t influenza, for which a vaccine has never had anywhere close to 95% efficacy ... This virus, despite its relentless evolution, has been shown to be more vulnerable. ...

We’ve endured what will soon be 3 years, have seen millions of deaths, and likely at least 10X the number of people suffering Long Covid. We should pull out all the stops to get ahead of the virus, which includes blocking infections and transmission. Perhaps the aggressiveness of the imminent roll out the BA.5 vaccine reflects a new attitude,  which is good. But that’s just one dimension of the efforts that can and should be pursued to prevail. 

#covid #booster #vaccine #eric topol #ba.5 #immune escape

[jennymanrique]

Experts Await Data on Moderna’s Vaccine for Kids; Criticize Lifting of Mask Mandates

The medical community is celebrating drug maker Moderna’s recent announcement that it is seeking FDA approval for its Covid-19 vaccination for younger kids, though experts add they are “anxiously” awaiting further data on its efficacy and safety.

“We have seen that our youngest patients are getting sick and hospitalized with COVID… even previously healthy kids can develop complications,” said Pediatric Pulmonologist Dr. Manisha Newaskar with Stanford Children’s Health during an April 29 press briefing hosted by Ethnic Media Services.

“The data still needs full review, but we have to educate our families and encourage them to get their young ones vaccinated,” Newaskar added.

The vaccine will require two doses one month apart and is expected to be authorized by the FDA in June. Parents have been hesitant about shots for their kids in part due to the risk of myocarditis—an inflammation of the muscles around the heart—though experts note the risk decreases for younger patients.

“Schools may have a role to play in getting the vaccine out there,” said Dr. Ben Neuman, professor of Biology and chief virologist with the Global Health Research Complex, Texas A&M University.

“There are 500 deaths per year from bacterial meningitis, and that is one of the things that schools would normally require vaccination against,” explained Dr. Neuman. “COVID-19 is around 350 deaths in the same age group in roughly the span of a year. This needs to be one of the vaccines to make school work.”

Moderna previously requested FDA authorization for its vaccine for kids ages 6 to 11 and ages 12 to 17. It expects to submit data on the efficacy of these vaccines by May 9.

The news comes as Moderna also announced progress on a “bivalent” vaccine that would provide immunity to the original Covid-19 strain along with newer variants.

“Each year we update our influenza vaccine and it’s now a quadrivalent vaccine. It has four different antigens in it. So, the thinking among vaccine scientists is to do something quite similar with COVID,” explained Dr. William Schaffner, professor of medicine in the Division of Infectious Diseases at Vanderbilt University School of Medicine.

“Expanding the antigens in the vaccines, we get broader coverage against this array of variants going forward,” Schaffner noted.  Dr. William Schaffner, professor of medicine in the Division of Infectious Diseases at Vanderbilt University School of Medicine

The speed at which variants of the Covid-19 virus are appearing, along with their relative transmissibility, calls for the development of multivariant vaccines, speakers said. The BA2 Omicron variant, which emerged in late November in the United States, is almost gone but has been replaced by a subvariant that is even more contagious: the BA.2.12.1

“We need to advocate the FDA to update the vaccines more quickly considering that we’re just tweaking the spike protein a little bit,” said Dr. Eric Feigl-Ding, co-founder of the World Health Network and chief of the COVID Task Force at the New England Complex Systems Institute. “We should be able to do a phase two (of approval), and then allow these brand-new phases to adapt the vaccines pretty quickly…”

Experts also weighed in on the removal of mask mandates on public transportation which several U.S transit systems, including airlines, have already adopted.

“We don’t just stop wearing helmets, unbuckle our seatbelts, and allow drunk driving because hospital beds are not full. I think the CDC is forgetting prevention (strategies) in trying to push for a return to normal,” added Dr. Feigl-Ding, who highlighted the fact that even for people who are boosted, the protection against hospitalization and death is 90-95%, but the protection against infection is only about 45%.

We don’t just stop wearing helmets, unbuckle our seatbelts, and allow drunk driving because hospital beds are not full.

“Adults now are going out to gatherings, parties, bars, restaurants, nightclubs… so the likelihood of transmission is higher,” continued Dr. Feigl-Ding, “and someone may have immunocompromised children at home or family members who could actually have a severe outcome (from infection).”

Dr. Schaffner agreed that the ending of the mask mandate might increase the vulnerability of already fragile people and suggested that people consider their personal circumstances when deciding to leave the mask at home. “Are you older? Do you have an underlying illness, heart disease or lung disease? Are you immune-compromised? Are you a person that’s providing care for someone? Continue to be very careful.”

The speakers emphasized that vaccination is safe and that boosters are essential to strengthen immunity against COVID-19 and its long-term effects such as headaches, fatigue, sleep disturbance, stomach aches, chest tightness, and loss of appetite among others.

Originally published here

Want to read this piece in Spanish? Click here

#English #Moderna #COVID #vaccination #children #FDA #coronavirus #underlying illness #immunocompromised

[bighermie]

[liesmyteachertoldme]

Planned genocide: Covid jabs were designed to cause harm, warns pharmaceutical executive

It’s not that covid so-called “vaccines” just so happened to turn out ineffective and deadly. Rather they were designed as such, according to Alexandra “Sasha” Latypova, a 25-year pharmaceutical industry veteran-turned-investigator who says the Department of Defense (DoD) had “very clear intent to harm” by executing a “mass genocide of Americans.”

Under the DoD’s control and direction, drug manufacturers like Pfizer, Moderna, and Janssen started mass-producing the shots for Operation Warp Speed – long before the first cases of “covid” even appeared, it turns out. These “figurehead” organizations, Latypova insists, were just obeying the DoD’s orders.

What this means is the United States military oversaw the creation and rollout of these “covid countermeasures,” as they were classified before being erroneously dubbed as “vaccines.” This is why they called it Operation Warp Speed: because it was a military warfare operation, not a “public health” operation.

The Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) also played their role by fast-tracking emergency use authorization (EUA) for the deadly drugs, followed by official approval for some of them – and the rest is history.

Covid jabs train the body “to destroy itself,” Latypova warns

“The evidence is overwhelming that there is an intent to harm people by the covid-19 injections, so-called ‘vaccines,’ and other nonsensical covid response measures implemented in lockstep by governments all over the world,” she said.

Again, it is not that the shots were designed to help people but just so happened to be dangerous. Latypova says they were designed that way on purpose as a chemical and / or biological weapon against the people, which she says is substantiated by an extensive body of literature, studies, scientific discussions, (and) evidence published on this matter.”

“There are numerous mechanisms of injury built into the covid-19 injections,” she further explained. “The most important one being that these shots are designed to make your cells attack themselves, make your cells express antigens that are toxic spike proteins, and then create antibodies to attack the cells. So, it trains your body to destroy itself.”

There is nothing safe, let alone effective, about these injections, in other words – unless the effective goal was to massively depopulate the world. In that case, the injections are working exactly as designed – and the worst is yet to come.

From the very beginning, the safety signals were “obvious,” Latypova says. And yet nobody in any position of power seemed to notice, or perhaps they deliberately ignored these safety signals because killing people was the goal.

“There is no efficacy in these shots,” Latypova reveals. “In fact, we know there is negative efficacy, meaning that these shots make you more likely to get sick and die.”

During the shots’ production, good manufacturing practices (GMP) were completely ignored, also apparently by design, to further ensure a deadly product outcome. Had proper safety standards been upheld, the shots might have ended up less deadly, which would have gone against the agenda.

“We found that these products are dirty, contaminated, do not conform at all to what the label says,” Latypova says. “And they’re hugely toxic by design.”

“They should all be stopped immediately, and this should be investigated properly. And we should bring those responsible to justice, to accountability. Until that happens, we cannot move on from this.”

#covid deaths #covid homicides #eugenics by covid

[jcmarchi]

Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing - Technology Org

New Post has been published on https://thedigitalinsider.com/accelerating-car-t-cell-therapy-lipid-nanoparticles-speed-up-manufacturing-technology-org/

Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing - Technology Org

For patients with certain types of cancer, CAR T cell therapy has been nothing short of life-changing. Developed in part by Carl June, Richard W. Vague Professor at Penn Medicine, and approved by the Food and Drug Administration (FDA) in 2017, CAR T cell therapy mobilizes patients’ own immune systems to fight lymphoma and leukemia, among other cancers.

Using activating lipid nanoparticles (aLNPs) to create CAR T cells requires fewer steps and less time.

However, the process for manufacturing CAR T cells itself is time-consuming and costly, requiring multiple steps over days. The state-of-the-art involves extracting patients’ T cells, then activating them with tiny magnetic beads, before giving the T cells genetic instructions to make chimeric antigen receptors (CARs), the specialized receptors that help T cells eliminate cancer cells.

Now, Penn Engineers have developed a novel method for manufacturing CAR T cells, one that takes just 24 hours and requires only one step. This method uses lipid nanoparticles (LNPs), the potent delivery vehicles that played a critical role in the Moderna and Pfizer-BioNTech COVID-19 vaccines.

In a new paper in Advanced Materials, Michael J. Mitchell, Associate Professor in Bioengineering, describes the creation of “activating lipid nanoparticles” (aLNPs), which can activate T cells and deliver the genetic instructions for CARs in a single step, greatly simplifying  the CAR T cell manufacturing process. “We wanted to combine these two extremely promising areas of research,” says Ann Metzloff, a doctoral student and NSF Graduate Research Fellow in the Mitchell lab and the paper’s lead author. “How could we apply lipid nanoparticles to CAR T cell therapy?”

In some ways, T cells function like a military reserve unit: in times of health, they remain inactive, but when they detect pathogens, they mobilize, rapidly expanding their numbers before turning to face the threat. Cancer poses a unique challenge to this defense strategy. Since cancer cells are the body’s own, T cells don’t automatically treat cancer as dangerous, hence the need to first “activate” T cells and deliver cancer-detecting CARs in CAR T cell therapy.

Until now, the most efficient means of activating T cells has been to extract them from a patient’s bloodstream and then mix those cells with magnetic beads attached to specific antibodies — molecules that provoke an immune response. “The beads are expensive,” says Metzloff. “They also need to be removed with a magnet before you can clinically administer the T cells. However, in doing so, you actually lose a lot of the T cells, too.”

Made primarily of lipids, the same water-repellent molecules that constitute household cooking fats like butter and olive oil, lipid nanoparticles have proven tremendously effective at delivering delicate molecular payloads. Their capsule-like shape can enclose and protect mRNA, which provides instructions for cells to manufacture proteins. Due to the widespread use of the COVID-19 vaccines, says Metzloff, “The safety and efficacy of lipid nanoparticles has been shown in billions of people around the world.”

To incorporate LNPs into the production of CAR T cells, Metzloff and Mitchell wondered if it might be possible to attach the activating antibodies used on the magnetic beads directly to the surface of the LNPs. Employing LNPs this way, they thought, might make it possible to eliminate the need for activating beads in the production process altogether. “This is novel,” says Metzloff, “because we’re using lipid nanoparticles not just to deliver mRNA encoding CARs, but also to initiate an advantageous activation state.”

Over the course of two years, Metzloff carefully optimized the design of the aLNPs. One of the primary challenges was to find the right ratio of one antibody to another. “There were a lot of choices to make,” Metzloff recalls, “since this hadn’t been done before.”

By attaching the antibodies directly to LNPs, the researchers were able to reduce the number of steps involved in the process of manufacturing CAR T cells from three to one, and to halve the time required, from 48 hours to just 24 hours. “This will hopefully have a transformative effect on the process for manufacturing CAR T cells,” says Mitchell. “It currently takes so much time to make them, and thus they are not accessible to many patients around the world who need them.”

CAR T cells manufactured using aLNPs have yet to be tested in humans, but in mouse models, CAR T cells created using the process described in the paper had a significant effect on leukemia, reducing the size of tumors, thereby demonstrating the feasibility of the technology.

Metzloff also sees additional potential for aLNPs. “I think aLNPs could be explored more broadly as a platform to deliver other cargoes to T cells,” she says. “We demonstrated in this paper one specific clinical application, but lipid nanoparticles can be used to encapsulate lots of different things: proteins, different types of mRNA. The aLNPs have broad potential utility for T cell cancer therapy as a whole, beyond this one mRNA CAR T cell application that we’ve shown here.”

Source: University of Pennsylvania

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#Administration #advanced materials #antibodies #antigen #Art #bioengineering #Biotechnology news #bloodstream #Cancer #cancer cells #Cancer Therapy #CAR T-cell therapy #Cars #cell #cell therapy #Cells #challenge #Chemistry & materials science news #cooking #course #covid #defense #Design #drug #engineers #FDA #Fight #Food #genetic #Giving

[didanawisgi]

#covid-19 vaccine #covid-19