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bpod-bpod · 9 months

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Brain-damaging Sepsis

Mechanism underlying nerve defects in sepsis-associated encephalopathy revealed

Read the original article here

Image from work by Ha-Yeun Chung, Jonathan Wickel and Nina Hahn, and colleagues

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, May 2023

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#science #biomedicine #immunofluorescence #neuroscience #sepsis #encephalopathy #neuroimmunology

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mlleshopping · 1 year

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5 articles you need to check out on the future of neurology research — InterMedia Press

In an ever-changing field of research such as neurology, it can be difficult to keep up with the latest breakthroughs. Now at Frontiers, we highlight just three of the latest research articles to shed more light on how the mind works. The human brain is an organ that has fascinated our species for centuries, with […] 5 articles you need to check out on the future of neurology research —…

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#brainstimulations #genetics #medicalscience #multiplessclerosis #neuroimmunology #Neurology #Parkinson #Research

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ychromosomedson · 1 year

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Based on actual events

#except instead of a party it was a neuroimmunology journal club #if anyone can give me a masculine name i like ill come out as trans #and also if i like the haircut im giving myself this weekend

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crazycatsiren · 7 months

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You know what fries my pancakes? Self proclaimed "health experts" on Instagram who didn't even go to medical school getting on my posts about flare-ups and giving me a lecture on ME/CFS being "just a set of symptoms", and claiming that once I find the "root cause" of those and "re-balance" them (whatever that even means), my chronic fatigue will disappear and I will be all well again (seriously, wtf).

As if that's how any of this works. If it were that easy, lol, not only would I have stopped being disabled and chronically ill 2 and a half years ago, I'd be rich by now, with the great knowledge of a magical miracle relief from ME/CFS for millions of people worldwide.

Scientific fact: the root cause of ME/CFS is ME/CFS. ME/CFS is a neuroimmunological disorder that currently has no cure and no one set of effective and approved treatments. On the optimistic side, approximately 6% of patients recover from it, and that's not even necessarily a 100% complete recovery. Medical professionals still can't do much for us as of 2023. If anything actually worked to alleviate our suffering, we would've all done it ages ago. There's nothing anyone can offer that we haven't thought of and tried already, fucks' sakes, Christ's fucks.

To act like you know more about our bodies and our illnesses than we do, toward those of us whose lives you have absolutely no idea about, whose daily struggles with a debilitating disease you can't even see, to have never walked a minute in our shoes, is incredibly invalidating and not to mention ableist.

#ableism #ableist bullshit #ableds stfu challenge #disabled #spoonie #cripple punk #me/cfs #chronic illness warrior #chronic fatigue warrior #millions missing #no spoons only knives #unsolicited advice

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autmnsun · 6 months

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PLEASE DON'T LOOK AWAY, PLEASE HELP SAVE A LIFE

my best friend layla made a fundraiser for her boyfriend giuseppe, who suffers from very severe me/cfs (myalgic encephalomyelitis / chronic fatigue syndrome) and cci (craniocervical instability).

me/cfs is a severe neuroimmunological illness that often leaves the people who suffer from it housebound or bedridden. there is no cure for it yet and only a few doctors know how to treat it, most of them don't even know of its existence. that's why we depend on you sharing and donating this.

because of these illnesses, he might die. only two doctors in europe do surgery on me/cfs patients, who also suffer from cci, and they are located in spain. he will have to pay a special flight from italy, somewhere to stay and the surgery itself, and none of that is covered by insurance.

he is suffering so much. layla listed a few of his symptoms in his gofundme already, but the only thing he can (or is forced to) do is lie in a dark room with no stimuli AT ALL. no music, no light, no touch, not even being on the phone for too long, accompanied with tons of physical suffering as in pain or seizure-like symptoms. his suffering is not imaginable for people who don‘t have very severe me/cfs.

please read, share and donate. it‘s so very very urgent and a reblog would mean the world and could save his life. please help us, he needs to live.

if you have any other ideas of how to boost this fundraiser, please let me know!

#mecfs #chronic fatigue syndrome #chronic illness #chronically ill #signal boost #boost

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per1shed · 2 years

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hey moots there’s a petition going on for funding of a drug that could potentially help people with ME/CFS (a severely disabling neuroimmunological chronic disease, one that i suffer from) and to help fund research in that area because so far there is little to nothing so i’d be very happy if you could sign it and share it<3 the first paragraph is in german but there’s an english translation right below. here’s the link: me/cfs bc007 petition

#and please share it with everyone you know it’s really important #petition #chronic illness #me/cfs #chronic fatigue syndrome #l

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m-e-and-more · 1 year

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There are #MillionsMissing with #MyalgicEncephalomyelitis. Your #friend, your #family, or your #lovedOne sent you this because they live with an #incurable #untreatable #chronicIllness and #disability.

#MECFS is a misunderstood disease. Many people first hear it by the misleading name #ChronicFatigueSyndrome of #CFS but #MECFS is about so much more than the #dehbilitatingFatigue it is a #neuroimmunological condition thst can affect many organ systems across the body.

In particular it affects the #mitchondria stopping rhem from making the #ATP essential for life. This #mitchondrialDysfunction is worsened following phsyical or mental exertion. This causes the defining symptom of #MECFS #PostExertionalMalaise

#ME can also cause #neurological inflammation leading #migraine and #FND as well as #dysautonmia like #POTS that causes abnormal heartrate, bloodpressure, and temperature responses to everyday tasks like standing or bathing.

In short it is a severely dehbilitating #neuroimmunological disease and your loved one needs your support to #StopRestPace and treat their body right before it is too late. #severeME is as dehbilitating as late stage AIDS. You may be able to help save someone from this #livingDeath if only you take the time to learn and care.

I urge you to learn more about ME. The informstion here only scratches the surface. The Open Medicine Foundation @openmedf. ME Action @meactnet, Emerge @emergeaustraliainc, and The Hummingbird Foundation are all great places to start. As are my blog, instagram and resource page.

Thank you for taking the time to learn and read about this disease. I and the #MEcommunity are grateful to everyone who is willing to #learn how to be our allies.

#myalgic encephalomyelitis #mecfs #me/cfs #me is not just chronic fatigue #chronic fatigue syndrome #chronic fatigue #chronic pain #chronic illness #chronically ill #millions missing #millions more #long covid

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livingdeathdiary · 1 year

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This is the diary of someone with severe ME. For those unfamiliar ME stands for Myalgic Emcephalomyelitis it is a neuroimmunological disease affecting over 30 million people worldwide. Severe ME refers to patients with ME who are housebound and mostly bedbound. I am completely bedbound and depend on IV fluids.

The defining symptom of ME is PENE or post exertional neuroimmune exhaustion. PENE happens whenever someone with ME "overexerts." The more PENE you experience the worse you get. The last thing I did to trigger PENE was eat some bread with my mum. In other words, if you dare to live, the disease progresses.

To prevent the progression of my disease I spend every day in a dark room resting. I recieve IV fluids through a central line in my chest and take a carefully crafted set of over 20 medications and supplements. I can watch videos, but nothing too exciting. I can talk, but not get emotional. Every action must be accounted for in my balance sheet. Every piece of ATP accounted for.

Then of course the pain. The daily constant migraines. The light, noise, and skin hypersensitivity. The acid burning muscles. The aching joints. The spasms. The stabbing neuropathy. These too take energy to endure. Energy I can't afford.

This is my existance of living death. The girl who once inhabited this body, a girl you will get to know perhaps, is no more. She died a slow painful death. Now I write to you from the living death of severe ME. Not to teach or to shed light or whatever other BS. No. I do my advocacy elsewhere. Simply because even ghosts it seems want to be heard. Because this existance makes you want to shout and curse into the void and you dear reader, if you even exist, you are my void.

#livingdeath #mecfs #myalgic encephalomyelitis #severe me #severe illness #i’m sick #dear diary #my diary #digital diary #spoonie #chronic illness #chronic pain #rambles into the void #bedbound

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aalt-ctrl-del · 2 years

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I think I picked this up through searching on the statistic for shingles. I already am aware of the nerve damage caused by Omicron covid variant, but I don’t know if this is directly caused by the covid itself or a form of bacterial meningitis when the body has septic patches from inability to remove damaged tissue compromised by infection. I theorize the capillary veins suffer the greatest to the covid disease, due to low surface area as compared to major arteries - which makes covid very dangerous, and may be what causes ischemic strokes in some (yes, even with mild covid symptoms).

btw, covid has other symptoms that have been yet to recognized or I have failed finding evidence of reporting. These symptoms are onset as early as a week or two weeks into infection.

A term I found in another medical document labeled the vast population of humans suffer to covid, due to immunological naivety - Having an immune system that has never been exposed to a specific antigen.

This can be a portion of explanation to the cytokine storms individuals suffer (in covid crash), and to how the virus spreads so swiftly without a valid immune response - which preludes to the cytokine storm. I explain cytokine storms as a situation where teh virus replicates out of control over a period of time, maybe a month, without an immune response being mounted. When the immune system recognizes the threat, it basically fucks over the infected individual because so much of the virus has already infiltrated cells, wherein the immune system latches an aggressive and out of control assault on anything that is sus. This causes the uncontrolled autoimmune dysfunctions, and just really carves out the vascular system of those with a deep and expansive infection - because covid infiltrates endothelial cells, or inner vascular tissue. But that is my theory, and I haven’t checked to verify if this information has been updated. This is the general behavior of the cytokine storm.

As well, silent hypoxia. In the majority of those with covid, it does not become a pneumonia complication - it can infect the lung tissue, i.e, the capillaries there, but in the vast majority individuals infected with covid do not always have it nested in their lungs. It. Is. In. The. Vascular. Tissue. Which is does a lot of damage to that person, and in some cases can lead them to going to sleep due to fatigue and then never waking up. This is a complication that affects those with general pneumonia of the bacterial or viral variety, affecting 5%. That’s the fatality rate, anyway.

The immunological naivety in the human population may explain the vast damage covid causes to those who contract it - vaxxinated or unvaxxinated. Even those vaxxed for covid can still contract it, depending on genetics, medical history, and health. Some individuals may not develop viable antibodies essential for combating covid - there are those who are in the shit category of being unable to develop antibodies for chicken pox or measles, even with vaccination (though they are a rarity). In immunological naivety may be the cause for adverse reactions to covid, due to the bodies inexperience in attacking viral cells and maintaining homeostasis. But more important, there is no cure for these pathogens, there is only prevention and mitigation (following an infection). It is up to the immune system of the individual to address the issue, and produce memory cells which well recognize the threat.

As well, all of this is speculation. I read the publications, I listen to the doctors, and I spit out the simplest understanding manageable. If you have legit questions, talk to a certified specialist - (a legit doctors, one who understands vaccines and vaers). If the doctor tells you, “ItS JuSt A FlU.” Fucking get a second opinion. Doctors and medical professionals are still human, and sometimes they are shit stupid humans with certification.

Back to topic. The immunological naivety could be a key factor in the severity of covid symptoms for some, and the aggressive overreaction of the body to a viral pathogen. What makes covid so deadly is how illusive it is in the body, and the inability to recognize the early onset of a present threat. So the long covid survivors can be a result of the body losing its damn mind in the presence of this infection - not that covid on its own is any less problematic. But similarities can be reviewed in rabies symptoms and the bodies reaction to it - rabies gets into the nerves, and the body just kills them to remove that infection - the whole event is counterproductive, as the body is essentially cutting off essential cells to purge an infection - don’t reference this, my recount on rabies is fucking inaccurate as hell. But do recall, rabies is 100% fatal following symptoms onset, and there is only a vaccine which will prevent death, if someone suspects they have been bitten by a rabid (or carrier) animal.

On that note, there is no such thing as a healthy carrier of covid. It presents symptoms, even if the infected is unaware damage to the circulatory system is happening. To prevent complications to covid and its variants inoculation is recommended to those who can receive vaccines.

Oh, why was I researching shingles? Shingles pops up along the nerves. And there has been an increased risk of shingles following a covid infection (report yikes). And sure, some people have had a shingles outbreak following covid vaccination, but as I have theorized in the past, there may be a correlation of mild to asymptomatic covid (still infected with the disease and the virus working on the vascular system regardless if symptoms present) activating the shingles due to prior infection with covid. But also-also to note, you have the shingles virus following measles or pox infection. You can get a Chicken or measles vaccine to prevent the virus from latching onto your cells and being an ever present naughty. It is recommended of those who have had a pox infection, to get shingles vaccination after 40 or 50 years milestone of age.

So shying a healthy child away from vaccination (and subsequent ignoring symptoms in the event of vaers) condemns adults to potential inconvenience. And without childhood pox, the risks in adults and complications of a chicken pox infection is super high, thus vaccination is always recommended in those who have never had a pox party.

Contrary to maga belief, getting sick 5 times a year does not mean someone is healthy. Quite the opposite.

#covid #shingles #endothelial disease #march 2022 #webmd #long covid #meningitis #bacterial meningitis #???#justin bieber #bells palsy #nerve damage #immune system #medical is still uncertain if vaccination for shingles will assist those who had covid #but it is something that the medical community is looking into

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longhaulerbear · 5 days

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Here, we present preliminary evidence that after COVID-19, SFN is responsive to treatment with IVIG and linked with neurovascular dysregulation and dysautonomia on iCPET. A larger clinical trial is indicated to further demonstrate the clinical utility of IVIG in treating postinfectious SFN.

#small fiber neuropathy #IVIG #SFN #iCPET #science journal #Covid effects

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bpod-bpod · 2 months

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Leading to Lesions?

Nodules of microglia – immune cells of the brain – are found in multiple sclerosis (MS). This study of post-mortem brains of MS patients analyses their possible role in initiating the disease and how they differ from nodules found in other brain pathologies

Read the published research article here

Image from work by Aletta M. R. van den Bosch and colleagues

Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, February 2024

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#science #biomedicine #immunofluorescence #biology #neurology #neuroscience #multiple sclerosis #brain #microglia

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twiainsurancegroup · 5 days

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neurologyworldconference · 3 months

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2nd Edition of Neurology World Conference NWC 2024

Precision global Conferences cordially invite you to our conference Neurology World Conference (NWC 2024) HYBIRD EVENT Date September 4 to 6, 2024, in San Francisco, CA, USA.

Conference theme: “Recent Advances in Brain & Neurological Disorders and Treatment.”

2nd Edition of Neurology World Conference, September 4 to 6, 2024, in San Francisco, CA, USA, focuses on the crucial progression of innovations and breakthroughs through cutting-edge neurology research and practice. We aim to explore the new streamlines in the field and bridge neuronal Shortfalls in the industry. Neurology World Conference focuses on the crucial progression of innovations and breakthroughs through cutting-edge neurology research and practice. We aim to explore the new streamlines in the field and bridge neuronal Shortfalls in the industry.

NWC 2024 agenda mainly focuses on bringing on neurologists, neuro specialists, neuro physicians, academicians, medical professionals, and industry specialists from all the multi-disciplines to join us. We invite you to disseminate the most recent findings among your colleagues. The upgrading technology and fast-paced lifestyles are diluting the mental health of people these days, giving rise to many such neurological diseases. Over the past 25 years, there has been an increase in neurological illnesses that cause illness, death, or long-term disability worldwide. Because of these problems, mortality rates are rising daily among people worldwide.

For more information: https://www.neurologyworldconference.com/

For Abstract Submission: https://www.neurologyworldconference.com/abstract-submission.php

To register: https://www.neurologyworldconference.com/registration.php

Reach out at: [email protected]

Organiser:

Precision Global Conference: https://precisionglobalconferences.com/

Address: 601 King St Ste 200 #853 Alexandria, VA 22314 United States

Email: [email protected]

Phone: +1-571-5561014

#neurosurgery

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miraridoctor · 3 months

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Atopic dermatitis, often referred to simply as eczema, represents perhaps the most classic pruritic inflammatory skin disease. Characterized by intense unrelenting itchy skin, or pruritus, eczema can severely impair quality of life when moderate to s... #Mirari #MirariDoctor #MirariColdPlasma #ColdPlasma

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anotherocean · 3 months

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#resonance #homeopathy #so fascinating

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