#Parasites (#Plasmodium) in #Malaria Infection in Humans
Life cycle: A blood-feeding insect host (#Anopheles) injects parasites into a human host during a blood meal. Parasites grow within the body (often the liver) before entering the bloodstream to infect red blood cells.
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Scientists recognized a gene in mosquitoes that moderates their vulnerability to malaria parasite infection.
A. gambiae transgenic larva Y. DONG ET AL. Scientist reported the other day (March 8) in PLOS Pathogens that suspending the gene FREP1 lowered mosquitoes’ ( Anopheles gambiae) vulnerability to Plasmodium, the parasite that triggers malaria in people.
When an A. gambiae mosquito takes in a Plasmodium in a blood meal, the parasite goes through a complex infection cycle as it takes a trip to its host’s salivary gland, from where it contaminates people. The Plasmodium‘s capability to finish this cycle counts on the activity of numerous of the mosquito’s proteins. Utilizing CRISPR-Cas9, the group from Johns Hopkins University suspended the gene encoding fibrinogen-related protein 1 ( FREP1), a target they had actually formerly recognized as being associated with the infection procedure. They discovered that knocking out the gene reduced Plasmodium infection in mosquitoes. In their paper, the scientists compose that the strategy is “a possibly effective method” to producing infection-resistant mosquitoes.
Y. Dong et al., “CRISPR/Cas9-mediated gene knockout of Anopheles gambiae FREP1 reduces malaria parasite infection,” PLOS Pathogens, doi: 10.1371/ journal.ppat.1006898, 2018.
New post published on: https://livescience.tech/2018/03/09/image-of-the-day-glowing-larva/
about the fact that P. falciparum (the most dangerous kind of malaria) was likely endemic at least from the 2nd century BC onward
that Galen said semitertian fevers (P. falciparum infections) were more common in Rome than anywhere else in the Roman Empire
that the most severe manifestations of P. falciparum (quotidian fevers + cerebral malaria) were most common in babies and young children, an epidemiological observation that indicates the transmission rate of P. falciparum was extremely high in Rome
that Quintus Serenus said there was no Latin word for semitertian fevers (they used a transliteration of the Greek, 'hemitritaeos') because "no one, i think, could have named it in our language and mothers would not have wanted to"