#principles: cells

[barelyacademia]

here's a little chart of some of the more common inherited disorders, this definitely is not a comprehensive list!

#biology #biology notes #notes #study notes #studyblr #barelyacademia #principles: cells #genetics #inheritance patterns #inherited disorders

[loverusts]

Janet Jackson - The Pleasure Principle

#janet jackson #the pleasure principle #control album #1986 #the 80s #1980s #this album is so good #my shitty cell phone gifs #musicedit

[chamerionwrites]

USAmericans will really be like “all cops are bastards” “the government refuses to take a pandemic seriously because it might make the money sad” and then say listen. The poor engineering students have no choice but to go work for Raytheon because student loans. And they have no choice but to keep working there because mortgages.

#you have neither two principles nor two brain cells to rub together!!! #sorry i’m livid about this and should log off #imperialism #military industrial complex #imperial violence always comes home #my posts

[xekstrin]

1) Lappland, knowing Texas better than anyone else, brought her least favorite flavor of chocolate on purpose to taunt her through the bars of her jail cell

2) Lappland didn’t know it was her least favorite. Lappland thinks she knows everything, but this is a small sign that she doesn’t know Texas as well as she used to— if she ever truly knew her. Maybe Texas only recently learned her own tastes well enough to say which is her favorite and least favorite. And Texas didn’t bring it up because any piece of her new self that doesn’t belong to Lappland is something that she’s going to guard especially hard. And why indulge in the indignity of whining when she’s already at a disadvantage, locked up while Lappland is free?

3) Lappland did/didn’t know it wasn’t her favorite but more importantly Texas is such a sugar fiend she didn’t give a fuck and gobbled it anyway

#Arknights #not that it was very difficult to get out of the jail cell of course #but it’s about the principle of the thing #no matter what you believe the craziest part is still that Texas just. ATE IT??????? #WHY DID SHE EAT IT

[starpros-sunshine]

Sometimes I wonder why cold symptoms always get worse in the evenings there has to be a logical explanation for that

#i need to know #i might have only choosen the biology major because I had no other choice but i do genujnely think the human body is a fascinating object #we should not exist there is no reason we should exist but here we are and here we are exactly the way we are isn't that funny? #it's such a silly body too what you're telling me I could produce an entirely new person in here #but one falsely mutated cell that brances out and has a personal problem with me specifically can kill me in a year or less? #that doesn't seem right. #if you think about it children are a little bit like cancer actually #i won't be opening that can of worms actually lets keeo that locked away in zhe cupboard #oh yeah and you can inherit the murder cell mutation because of course you can #and then we came up with thousands of ways to cure thousands of ailments and what did we do we put them behind a paywall #come onnnnnn where's the fun in that #we have this cool stuff why do you not let us use the cool stuff #i don't do meds on principle if I have anything I jusz sit that out raw and painful but hey it's not my place to tell others to do it my way #i just don't like the thought of building up a resistance against stuff so I just take my ibuprofen if there really is no way to function #without them anymore #luckily that's not the case a lot of times #i can work fine with the headaches they're just annoying #make the head foggy and words take a second to comprehend and the light hurts but i can work with it #have you ever had two kinds of headache atbthe same time thazs an experience #dealing with a tensuoj headache and then also the clogged nose headache is. it sure is something #you don't know where exactly it hurts and it's not so bad that you have to lie down but then you hold your head the wrong way #and Boom a bomb goes off up there #fascinating stuff #how did I even get here

[talentforlying]

ok constantine would sooner strangle me than be compared to roderick usher, but "the gates are always open but that doesn't mean you answer the phone" feels very close to how he operates with his friends and allies. you can always come to him for help, but it won't necessarily be the help you wanted. eventually people learn to just stop calling, because the silence is better than the disappointment.

#( ooc. ) OUT OF CIGS. #burrowing up from the dirt like a mole to present my most recent house of usher rewatch to the dash #i mean it doesn't help that he hardly ever uses his cell phone #unless it's Urgent you'll have to hunt him down in the streets of london in person to get a conversation out of him #but the general principle is what i mean #there's a reason so many of his living friends/allies/acquaintances just go 'oh. it's you.' when he shows up #tho tbh a lot of the time people come to him so he can spare them the consequences of their own actions and he just. doesn't #and then they get righteously pissed about it. so there's that to consider too #idk either way i love his annoying ass #i may be in academic hell but lord this hyperfixation of mine will ride if i give it some gas #( headcanons. ) I'M JUST LIKE THE BASTARDS I'VE HATED ALL ME LIFE.

[kirbyddd]

even though it's not the most painful and doesn't show the full decline, Howl's Moving Castle's depiction of dementia is among the most human

#ghibli #in todays generation of ego and self it's become kinda a horror concept bc it strips someone of the things people today say defines a human #seems i only hear people today talk about it like a skeleton in the closet #unable to recognize or express doesn't mean unware or unexperiencing... remember that #being squirreled away in a cell or bodybag is an awful experience #today's folk live by the principle “out of sight out of mind”... by which voicelessness becomes indistinguishable from inconsequentiality #invisibility indistinguishable from inexistence #anyways... #remember the voiceless.. remember the invisible.. from their origin to their end they have never been any different from you... #you didn't grant yourself words and thought... all that distinguishes you is circumstance... #so be gentle and generous as you can.... #invisible pain and invisible joy.. invisible fear and invisible hope.. #invisible perception of beauty and invisible cherished loves... #invisible feelings and experiences that will never be expressed... they exist... #even when the seat of emotion is gone there may still be found cold and weary comfort against the night... #there's precious life in the silence

[regallibellbright]

WIP Wednesday, I guess (hey, I haven’t gone to sleep yet)

This bit, springing off of my tags from this post, shout outs to @purplelea, punched me in the face while I was trying to take a nap or at least think about the two fics I’m actually seriously working on, so I guess you’re going in the rotation.

“Besides, he’s already rejected me,” Joshua says.

Shiki and Beat turn toward him. “What, for real, yo?” Beat asks. Joshua nods.

“He never mentioned it to us,” Shiki says, frowning. “Just that you offered him your job again. Without the guns this time.”

Joshua frowns. “Yeah, and? He turned me down.” When this only makes them look more confused, he goes on. “Clearly if he were interested, he’d have said yes. I’d name him my eventual successor, we stay in the UG together and visit you guys, and then eventually when he was ready to be Composer I’d take over the Producer role, and we'd rule the city together. Obviously.”

“Or maybe he just ain’t interested in the job,” Beat says. Joshua looks at him like he just suggested the moon doesn’t exist. “What? Jus’ sayin’, he didn’t say anything 'bout that, yo.”

“It was implied.”

“In other words, you didn’t confess, and Cowards Club continues,” Shiki says. Beat nods. Joshua groans.

“Like it matters? Even if he didn’t turn me down,” Joshua says, clearly humoring them, “he’s obviously way more into you two than me. One of you should go for it.”

“Uh, no? How’s it obvious?” Beat asks. “‘Cuz I heard ‘im when you showed up, Priss. He wasn't that happy to see me, yo.”

Joshua looks at Shiki. “Neku broke back through a hole in reality to save Beat and punched the power overload right out of Minamimoto. There was glowing. Sparkles. I have seen every ill-conceived dramatic romantic gesture anyone’s ever committed in this city, and it topped all of them.”

#wips #writing with Regalli #joshbeatneshiki #I'm currently calling this one 'polyam disasters' #I keep editing a 'happily ever after' in and out of the end of Joshua's first bit but honestly I'll decide that WAY later #I refuse to let this one be done before the others #just on principle #so it'll probably be edited even more than what I usually do as I do a first pass #and this was definitely the 'write whatever I need to get those two core bits DOWN' section so it's not at ALL polished #this isn't the end of this scene - it's not even the end of that bit - but this was the parts that I went 'sigh. writing you I guess' #but it is definitely fun to just bounce three lovesick dumbasses off each other like bouncy balls #the club name was absolutely someone else's dubbing and it's your guess as to who #(not pictured: the COMPLETE AND UTTER EXHAUSTION of everyone else who's had to deal with them all being Sad and Lovesick for three years) #(also not pictured: Neku has no clue what's going on but while he's happy his best friends *cough* crushes *cough* #are all best friends themselves now he's admittedly feeling left out that apparently the three of them regularly hang out just on their own #also he's been doing some Googling since he got back which means that by default he is in possession of the Only Brain Cell Here.)

[barelyacademia]

so it's been like an entire month and a half, but I am (somewhat) back. I'm going to try and get back on a semi-regular posting schedule while managing the full time work at the aquarium. so sorry for the wait, everyone!

#biology #biology notes #notes #study notes #barelyacademia #principles: cells #genetics

[jcmarchi]

Gene-Wei Li and Michael Birnbaum named Pew Innovation Fund investigators

New Post has been published on https://thedigitalinsider.com/gene-wei-li-and-michael-birnbaum-named-pew-innovation-fund-investigators/

Gene-Wei Li and Michael Birnbaum named Pew Innovation Fund investigators

MIT professors Gene-Wei Li and Michael Birnbaum are among the 12 researchers named 2023 Innovation Fund investigators by The Pew Charitable Trusts.

Six pairs of scientists — alumni or advisors of Pew’s biomedical programs in the United States and Latin America — will partner on interdisciplinary research in human biology and disease.

A biophysicist, Gene-Wei Li, an associate professor in MIT’s Department of Biology, studies how bacteria optimize the levels of proteins they produce at both mechanistic and systems levels. His lab focuses on design principles of transcription, translation, and RNA maturation. Li and his collaborator Katsuhiko Murakami, a professor of biochemistry and molecular biology at the Pennsylvania State University, will explore the complex genetics of cyanobacteria.

The pair will look at transcription termination, a key step in cyanobacteria gene regulation that tells the cell when to stop converting genetic information from DNA to RNA. While the mechanisms behind transcription termination are well known in other organisms, the inner workings of this process in cyanobacteria are still largely unknown. Drawing on Murakami’s expertise in structural biology and Li’s knowledge of transcription regulation, the two investigators will establish a model for microbial transcriptional termination in cyanobacteria. This work could unveil new scientific approaches used to study cyanobacteria, photosynthesis-promoting plant cells, and other bacterial groups.

Birnbaum, Class of 1956 Career Development Professor, associate professor of biological engineering, and faculty member at the Koch Institute for Integrative Cancer Research at MIT, works on understanding and manipulating immune recognition in cancer and infections. By using a variety of techniques to study the antigen recognition of T cells, he and his team aim to develop the next generation of immunotherapies.

In the case of people with inflammatory bowel disease (IBD), a bacterium alerts the body’s disease-fighting T cells and triggers an inflammatory response characterized by abdominal pain and persistent diarrhea. IBD affects millions of people in the United States, and cases are on the rise in older adults, yet the cause of this autoimmune disorder is largely unknown.

Dan Littman, a professor of molecular immunology at New York University, and Birnbaum are looking for IBD’s root cause. The pair will merge Littman’s work exploring how and why specific bacteria affect T cell development with Birnbaum’s expertise in T cell receptor-antigen binding in an effort to characterize the specific microbes and antigens that drive these harmful responses in the gut. Together, their work could offer new treatment avenues for IBD, such as novel therapies targeting pathogenic microbes or T cells.

In 2018, Birnbaum was also named a Pew-Steward Scholar for Cancer Research.

“An interdisciplinary approach to research is critical to uncovering scientific breakthroughs and making lasting change,” says Donna Frisby-Greenwood, senior vice president for Philadelphia and scientific advancement at The Pew Charitable Trusts. “Pew is thrilled to support this exceptional group of investigators, whose collective efforts will help move the needle in important areas of health and medicine.”

The Pew Charitable Trusts has supported more than 1,000 early-career scientists spearheading high-risk, high-reward research across a variety of disciplines. In 2017, Pew launched the Innovation Fund to spark scientific collaboration among alumni of its biomedical programs in the United States and Latin America.

#000 #2023 #America #antigen #approach #Awards #honors and fellowships #Bacteria #biochemistry #Biological engineering #Biology #Cancer #career #career development #cell #Cells #Collaboration #Collective #Design #design principles #development #Disease #DNA #engineering #Faculty #Funding #genetic #Genetics #Grants #gut

[iwasraisedfromperdition]

.

#checking my fucking phone every 3 minutes bc im waiting for a call #to let me know i can pick up sth #IT WAS SUPPOSED TO ARRIVE LAST WEEK FFS #and then it was monday #and then yesterday #and now i can feeeeeeeel it it wont get here today #i am becoming unhinged #i bought from a local store bc like. i wanna support it and avoid ordering online if i can #but this is frying my brain cells. i have to remind myself that i have convictions and principles #and that the package being a week late is not the end of the world #but !!!! nnnhhhhhhhnnnnnggggggggggggGgggggg #JUST! #FUCKING! #RING! #you stupid phone !!!!

[spacelazarwolf]

in honor of that anon who said jews have done nothing for the world, here’s a non exhaustive list of things we’ve done for the world:

arts, fashion, and lifestyle:

jeans - levi strauss

modern bras - ida rosenthal

sewing machines - isaac merritt singer

modern film industry - carl laemmle (universal pictures), adolph zukor (paramount pictures), william fox (fox film forporation), louis b. mayer (mgm - metro-goldwyn-mayer), harry, sam, albert, and jack warners (warner bros.), steven spielberg, mel brooks, marx brothers

operetta - jacques offenbach

comic books - stan lee

graphic novels - will eisner

teddy bears - morris and rose michtom

influential musicians - irving berlin, stephen sondheim, benny goodman, george gershwin, paul simon, itzhak perlman, leonard bernstein, bob dylan, leonard cohen

artists - mark rothko

actors - elizabeth taylor, jerry lewis, barbara streisand

comedians - lenny bruce, joan rivers, jerry seinfeld

authors - judy blume, tony kushner, allen ginsberg, walter mosley

culture:

esperanto - ludwik lazar zamenhof

feminism - betty friedan, gloria steinem, ruth bader ginsberg

queer and trans rights - larry kramer, harvey milk, leslie feinberg, abby stein, kate bornstein, frank kameny, judith butler

international women's day - clara zetkin

principles of journalizm, statue of liberty, and pulitzer prize - joseph pulitzer

"the new colossus" - emma lazarus

universal declaration of human rights - rene samuel cassin

holocaust remembrance and human rights activism - elie wiesel

workers rights - louis brandeis, rose schneiderman

public health care, women's rights, and children's rights - lillian wald

racial equity - rabbi abraham joshua heschel, julius rosenwald, andrew goodman, michael schwerner

political theory - hannah arendt

disability rights - judith heumann

black lives matter slogan and movement - alicia garza

#metoo movement - jodi kantor

institute of sexology - magnus hirschfeld

technology:

word processing computers - evelyn berezin

facebook - mark zuckerberg

console video game system - ralph henry baer

cell phones - amos edward joel jr., martin cooper

3d - leonard lipton

telephone - philipp reis

fax machines - arthur korn

microphone - emile berliner

gramophone - emile berliner

television - boris rosing

barcodes - norman joseph woodland and bernard silver

secret communication system, which is the foundation of the technology used for wifi - hedy lamarr

three laws of robotics - isaac asimov

cybernetics - norbert wiener

helicopters - emile berliner

BASIC (programming language) - john george kemeny

google - sergey mikhaylovich brin and larry page

VCR - jerome lemelson

fax machine - jerome lemelson

telegraph - samuel finley breese morse

morse code - samuel finley breese morse

bulletproof glass - edouard benedictus

electric motor and electroplating - boris semyonovich jacobi

nuclear powered submarine - hyman george rickover

the internet - paul baran

icq instant messenger - arik vardi, yair goldfinger,, sefi vigiser, amnon amir

color photography - leopold godowsky and leopold mannes

world's first computer - herman goldstine

modern computer architecture - john von neumann

bittorrent - bram cohen

voip internet telephony - alon cohen

data archiving - phil katz, eugene roshal, abraham lempel, jacob ziv

nemeth code - abraham nemeth

holography - dennis gabor

laser - theodor maiman

instant photo sharing online - philippe kahn

first automobile - siegfried samuel marcus

electrical maglev road - boris petrovich weinberg

drip irrigation - simcha blass

ballpoint pen and automatic gearbox - laszlo biro

photo booth - anatol marco josepho

medicine:

pacemakers and defibrillators - louise robinovitch

defibrillators - bernard lown

anti-plague and anti-cholera vaccines - vladimir aronovich khavkin

polio vaccine - jonas salk

test for diagnosis of syphilis - august paul von wasserman

test for typhoid fever - ferdinand widal

penicillin - ernst boris chain

pregnancy test - barnhard zondek

antiretroviral drug to treat aids and fight rejection in organ transplants - gertrude elion

discovery of hepatitis c virus - harvey alter

chemotherapy - paul ehrlich

discovery of prions - stanley prusiner

psychoanalysis - sigmund freud

rubber condoms - julius fromm

birth control pill - gregory goodwin pincus

asorbic acid (vitamin c) - tadeusz reichstein

blood groups and rh blood factor - karl landsteiner

acyclovir (treatment for infections caused by herpes virus) - gertrude elion

vitamins - caismir funk

technique for measuring blood insulin levils - rosalyn sussman yalow

antigen for hepatitus - baruch samuel blumberg

a bone fusion technique - gavriil abramovich ilizarov

homeopathy - christian friedrich samuel hahnemann

aspirin - arthur ernst eichengrun

science:

theory of relativity - albert einstein

theory of the electromagnetic field - james maxwell

quantum mechanics - max born, gustav ludwig hertz

quantum theory of gravity - matvei bronstein

microbiology - ferdinand julius cohn

neuropsychology - alexander romanovich luria

counters for x-rays and gamma rays - robert hofstadter

genetic engineering - paul berg

discovery of the antiproton - emilio gino segre

discovery of cosmic microwave background radiation - arno allan penzias

discovery of the accelerating expansion of the universe - adam riess and saul merlmutter

discovery that black hole formation is a robust prediction of the general theory of relativity - roger penrose

discovery of a supermassive compact object at the center of the milky way - andrea ghez

modern cosmology and the big bang theory - alexander alexandrovich friedmann

stainless steel - hans goldschmidt

gas powered vehicles

interferometer - albert abraham michelson

discovery of the source of energy production in stars - hans albrecht bethe

proved poincare conjecture - grigori yakovlevich perelman

biochemistry - otto fritz meyerhof

electron-positron collider - bruno touschek

#jewish #jumblr #am yisrael fucking chai

[prince-liest]

More thoughts on Alastor and why I don't think he's actually outdated:

I totally understand why many thoughts are going in the direction of him disliking Vox and TV as a whole because it is the technology that more or less replaced radio in the public eye, but I also think that we (so far, as of episode 4) have never really been given any evidence that he dislikes TV on principle rather than because he dislikes Vox and Vox is TV. Like, yes, he maintains a very dated aesthetic and does things like call TV "picture shows."

But also.

He throws around phrases like, "And now he's pissy, that's the tea!" and speaks with a permanent transatlantic accent (commonly used for TV and radio during his era but not actually naturally-occuring) at literally all times. This guy is not clueless - he's putting on airs. He knows modern lingo and he uses it comfortably and naturally.

There's a fanfic that, to save my life, I cannot remember the name of, where Angel Dust asks Alastor something to the tune of, "So what I'm getting out of this conversation is that you know it's called a cell phone and you just talk like you've never seen one on purpose?" and Alastor responds with, "Naturally!" that I think hit the nail on the head.

Especially when Alastor's anachronisms are so pointed. He calls Vox's TV show a "video podcast," which, 1) a podcast is a pretty modern term for him to know, originating at some point in the early 2000s and 2) deliberately reframes Vox's entire thing in terms of an audio format. It's not television. It's a podcast (a form of audio media that originated in the desire to download online radio broadcasts) with some video tacked on, he guesses.

Anyway, the tl;dr is that while I'm sure Alastor prefers his own era, I don't think Alastor is actually outdated, I think he's being fucking annoying on purpose.

Look at him. Look at his smug knifecat face. Bastardous. I love him.

ETA: The fanfic I mentioned is Anguish of the Marrow!

#and good for him!!!! #hazbin hotel #alastor #vox #hazbin hotel vox #hazbin hotel alastor #personal #meta #he very well might hate TV for TV's sake but also I really don't think he's actually stuck in the past #he's just being disrespectful lmao

[tonkipie]

Ohapi principles with sickle cell

The metabolism of all other opioids requires specific Cytochrome P450 (CYP) isoenzymes. Glucuronidation is unique for the metabolism of morphine, hydromorphone, and oxymorphone. At the level of pharmacogenomics, the metabolism of each opioid is patient-specific. Once the AMPA channel reaches its limit of membrane depolarization, the NMDA channel is activated and facilitates the transmission of painful stimuli in a progressive fashion leading to central sensitization and glial activation. Initially, the AMPA channel controls the transmission of stimuli of mild–moderate severity. This modulation is achieved via two channels: the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and NMDA receptors. At the pathophysiologic level, there is evidence that the severity and frequency of painful stimuli modulate their transmission at the level of the dorsal horn of the spinal cord. In recent years, there has been significant progress along these two lines. A multi-sector, collaborative, consensus-based process is the best way to identify and develop actionable and sustainable policy solutions to bring to federal policymakers because it recognizes the equities, expertise, and experience of health care stakeholders on this important issue.Effective management of sickle cell pain entails a thorough understanding of its pathophysiology and the pharmacogenomics of the opioids used to manage it.This requires advancing current policy ideas and developing novel policies. There are abundant opportunities to support timely, sustained access to high-quality, coordinated care as well as current and future treatments.While no one organization or entity can fully address these historic barriers and challenges, new policies should be informed by and appropriately take into account these dynamics in order to assure continual change. The COVID-19 pandemic has focused fresh attention on the importance of addressing long-standing racial inequities, health disparities, socio-economic barriers, and social determinants of health – all of which has led to worsened outcomes from COVID-19 for people with Sickle Cell Disease and Sickle Cell Trait.As a payer, regulator, funder of research and training, and provider, the federal government has a responsibility and an opportunity to help improve lives of individuals with Sickle Cell Disease.Because people living with Sickle Cell Disease suffer dramatically shortened life expectancy, multiple severe complication s which can lead to hospitalization, acute and chronic pain, and other negative effects, there is an opportunity and a need to collaborate in a manner that improves the health of all individuals with Sickle Cell Disease.The fact that tens of thousands of individuals in the United States with Sickle Cell Disease lack timely, sustained access to high-quality, equitable, coordinated care and treatment is not acceptable to patients, families, communities, or our health care system.The principles animating the work of the Partnership are:

#Ohapi principles with sickle cell

[xinghaienergy]

What is the working principle of the lithium ion battery cell?

Lithium-ion battery cell has been developing rapidly due to their excellent performance, do you know how it works? Here Xinghai Energy tells you how lithium ion battery cell works.

The working principle of lithium ion battery cells

The accepted basic principle of the lithium ion battery cell is the so-called "rocking chair theory". lithium ion battery cells are not charged and discharged in the traditional way by transferring electrons, but rather by the movement of lithium ions in and out of the crystals of a layer of strong material, resulting in energy changes. The change of energy occurs through the movement of lithium ions in and out of the crystals of the layered material. Under normal charging and discharging conditions, the entry and exit of lithium ions generally causes only a change in the layer spacing and no damage to the crystal structure, making the lithium ion battery cell an ideal reversible battery in terms of charging and discharging. During charging and discharging, lithium ions move back and forth between the positive and negative electrodes of the battery, just like a rocking chair, so some people refer to the lithium ion battery cell as a rocking chair battery.

How to charge a lithium ion battery cell

Electrons are generally assembled in the discharged state. During the charging process, the lithium ion battery cell cathode material (e.g. LiCoO2) is oxidised and the lithium ions are released from the layered intercalation material, pass through the electrolyte and then intercalate into the graphite layer.

How to discharge a lithium ion battery cell

During the discharge process, the negative electrode of the lithium ion battery cell is oxidised and the lithium ions are removed from the anode and reinserted through the electrolyte into the cathode. Correspondingly, a corresponding number of electrons cross the external circuit to balance the charge. At the same time, the lithium ion battery cell cathode material receives electrons from the external circuit and Li+ ions from the solution, resulting in a reduction reaction. The exchange of electron and ion currents takes place at the interface between electrode and electrolyte. Cells based on the intercalation mechanism - the reversible insertion of a foreign ion into the lithium ion battery cell structure without destroying the lithium ion battery cell structure.

Xinghai Energy is the lithium ion battery cell supplier, all kinds of lithium ion battery cells are on sale, there is always one you want, please contact us and log on https://www.headway-lib.com/.

#lithium ion battery cell #working principle of lithium ion battery cells #How to charge a lithium ion battery cell #How to discharge a lithium ion battery cell #how the lithium ion battery cells work