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#prolactinoma
coolsexyblogname · 1 year
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Hey. So I'm a refugee from the imploding bird website. I've not really used Tumblr before but I'm gonna try hanging out here for a while. Some stuff about me: this year I found out I had a prolactinoma, the asexual tumour from House. I'd had a strange period of trying to figure out my sexuality before that and thought I was ace for a while. Finding out, getting treated, all of that, has been incredibly surreal - turns out I'm probably bi. It's also triggered something of a gender identity crisis for me: I was super emotionally numb before I started getting treatment so all the gender envy I felt around femme stuff never quite registered with me.
So, yeah, Tumblr's probably gonna be the home of me working through all those feelings.
💖
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I did my newest blood tests recently and this time my TSH and prolactin levels are normal, it’s just my hemoglobin that was a bit too much this time... but on last year’s MRI scan it looked like my tumor has shrank away but my endo said that it could be still there so that’s why I’m still on this hormonal medication with side effects... if I do stop the meds my prolactin levels could go up again so I have no idea if this is going to be for life... my endo hasn’t confirmed it yet but maybe we could stop the meds sometime soon and see what happens... seems like I’m near the end of it all.
Honestly I just wish this treatment could be over already... I’ve been dealing with this prolactinoma since 2015 and I started the medication in 2016... if it wasn’t for the meds I would have never had sex at all lmao prolactinoma totally killed my libido and attraction for anyone... but I found myself jumping from man to man without there being any result at all yet... 
I’m not sure I’m going to be able to have kids at all after this tumor prolactinoma (I got diagnosed young with this, at 23 years old after graduating my bachelor’s degree and had the symptoms for years, started way back in high school but my doctors didn’t do anything until it became a tumor)... it isn’t impossible to get pregnant because they got me drugged up with hormones that make me wanna have sex but I also haven’t found the one yet... so I feel like it would be a miracle if I ever got married, have a husband and a baby that was conceived and given birth to naturally.
Being married with kids is great and all but as a woman I feel like my health is more important currently...
It’s so horrible having to cope with and fight an illness... don’t wish this upon any enemy of mine...
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darlynmeyer · 2 years
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miracles can happen, and happened to me~ no high prolactin.. i am so happy and in only 2 months
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suasaudetemvalor · 2 years
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Prolactina e Prolactinomas - Testosterona Alguns hormônios apenas não tendem a jogar bem com a sua testosterona. Cortisol e estrogênio são exemplos. Outro hormônio que pode acabar sua testosterona e sua vida sexual é prolactina... https://www.suasaudetemvalor.com/prolactina-e-prolactinomas-testosterona/
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medtalksblog · 1 year
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godddd wait if prolactin is like The like pregnancy hormone i wonder if this prolactinoma* is part of y my eds has gotten super awful recently like if its literally chemically making my connective tissue fucking worse. if i get this shit fixed and am suddenly like not bedbound for 3 days after using my computer for 3 hours im gonna SCREAM
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suratan-zir · 2 months
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Tsapa didn't want to be in this ASMR video and run out of the frame. (yeah, his snout and under his chin needs to be cleaned more frequently. It's because his supplementary food gets kinda sticky.)
My beautiful boy has a pituitary gland tumor. But this is not a sad post, at least not intended that way. This is a success story. And an encouragement to potential rat owners to always try everything before giving up.
So. In December, after Tsapa's brother, Plyam, had to be put to sleep due to a spinal cord tumor, Tsapa became very passive and depressed. Or so I thought. I attributed his depression to the fact that he misses his closest friend (rats do get depressed sometimes when they lose cagemates).
But then he started developing hind leg degeneration, which was quite early for his age and also was the first symptom his late brother had, so I got really worried. Long story short, after a couple of days it became difficult for him to drink from the water bottle and lick liquid food, it was obvious that he has a pituitary gland tumor.
We started treatment, almost too late. He had seizures in my hands and I thought I'm going to lose him that day.
It's been nearly three months. Tsapa has no seizures, no difficulty eating or drinking, no symptoms other than mild hind leg degeneration. All thanks to Cabergoline. He's on combination of three meds, the best scheme for treating pituitary tumors in rats. Cabergoline every 72 hours, prednisone and antibiotics daily. Prednisone to control inflammation in his skull and antibiotics to prevent infections due to the immunodeficiency from prednisone. But Cabergoline does the heavy lifting, without it Tsapa would've been dead within days or weeks at most after his symptoms started.
He still has a very short life expectancy, yes. And in my experience, rats on Cabergoline do just fine until they die suddenly and unexpectedly. But these are still months of life, treats and scritches, of time together with him. Cabergoline is very pricey. Also, it only works on prolactinomas, it won't do anything for any other type of pituitary tumor. But when it does work, it works like a charm, so it's always worth a try.
Thank you for coming to my RAT talk.
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matoroblogs · 6 months
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LEGO Almost Went Bankrupt. These Heroes Saved Our Bricks.
How a brain tumor inspired Bionicle, one of the most popular toys of a generation.
BY DAVID LUMB PUBLISHED: JUN 21, 2020
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The Platinum Avohkii mask, a rare one- of-a-kind piece made of solid platinum purchased by Andre Hurley, who has The Bionicle Archives collection
Courtesy Andre Hurley/The Bionicle Archives
In 2003, LEGO seemed to be riding high after shrewd licensing deals brought Star Wars and Harry Potter sets to the masses. But unbeknownst to many—even those inside the company—sales were plummeting, and there were only guesses as to why.
Some blamed poor strategic choices in the 1990s—Legoland theme parks, forays into digital products—for LEGO’s hemorrhaging. All that misguided development time slashed profitability, and even Star Wars and Harry Potter sales shriveled between movie releases. It’s hard to conceive of now, but at the turn of the millennium, beloved LEGO might have been headed toward a pitiful end.
During this fallow period, one product line stood apart with startling, consistent success: Bionicle, a series of buildable action figures backed by rich worldbuilding and cross-platform promotion. Inspired by co-creator Christian Faber’s battle with a tumor at the base of his brain, the toy warriors of Bionicle wouldn’t just conquer their fictional enemies. They’d pioneer innovations that would transform LEGO and rescue the company from possible doom.
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Courtesy Andre Hurley/The Bionicle Archives
Today, Christian Faber looks a bit like a Danish Paul McCartney. His youthful smile pairs well with his genial nature, which one might mistake for meekness until he starts talking about his creative projects. The 54-year-old embodies the unchecked enthusiasm you’d expect from a 28-year veteran of LEGO projects. If Faber’s long-time illness dimmed his appetite for play, you wouldn’t know it.
In 1986, Faber began working for Advance, a Copenhagen- based marketing firm that partners with LEGO. But shortly after his career began, Faber’s vision began to falter. A doctor found a benign tumor inside Faber’s pituitary gland that was impeding his sight, a condition called prolactinoma. Doctors said the tumor was maybe in the least accessible spot in the body for surgery, so they prescribed Faber daily medication to keep the tumor from growing. Among the drugs’ side effects, however, were severe nausea and dehydration, effectively sidelining Faber from social activities.
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Courtesy Christian Faber
“It was the strangest mix of feelings,” Faber says. “I was happy at the job, but faced the physical and mental strain of the medicine and a long-term illness.”
Faber’s side effects attacked him hardest in the mornings, so he found most of his energy for work at night. Early in his career, Faber designed brochures for LEGO toy lines. Exposure to the different products, including the undersea-based Aquazone and the sophisticated Technic series, gave him experience with LEGO’s standards and practices—a moving target in the mid- 90s, when the rise of computers and video games pressured LEGO to move from their traditional years-long R&D cycle toward what Faber calls ‘craze products,’ toys tuned to current market tastes with a planned one-year shelf life.
The craze-products movement was rife with experimentation for LEGO, and it materialized soon after a medical breakthrough for Faber. After 10 years of daily medication, Faber’s physicians moved him on to a new treatment which, in Faber’s own words, gave him his life back. The new treatment was a regular injection scheduled just once every two weeks, allowing Faber to engage with the world relatively free from side effects. He could chase higher ambitions than brochures, and he had an idea for a new kind of LEGO toy: a sort of Bionicle precursor called Cybots.
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Courtesy The LEGO Group
“I was sitting with LEGO Technic and thought I would love to build a character instead of a car,” Faber says. “I thought of this biological thing: The human body is built from small parts into a functional body just like a model. What if you got a box full of spare parts and built a living thing?”
With his assistant graphic designer Jan Kjær, Faber pitched Cybots, a line of humanoid action figures with attachable limbs and ball-and-socket joints. LEGO didn’t furbish Cybots, but they would implement Faber’s concepts in craze products like Throwbots in 1999 and RoboRiders in 2000. By 2001, LEGO was testing a line called Bone Heads of Voodoo Island—masked robots with heads that could shoot off their bodies like Rock ‘Em Sock ‘Em Robots. Most of Bionicle’s look had been seeded: masks, buildable bodies, articulate limbs.
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Courtesy Andre Hurley/The Bionicle Archives
Bone Heads of Voodoo Island was a bust—focus groups demonstrated kids didn’t respond well to detachable heads—so that same year, LEGO pivoted to focus on Bionicle. The plan was to take a more holistic design approach with these new toys than with craze products, but LEGO extended that comprehensiveness to the worldbuilding around the toys, too, a new strategy for the company. Faber and LEGO design manager Martin Riber Andersen were joined by former BBC film and TV executive Bob Thompson and writer Alastair Swinnerton to refine the Voodoo Island concept and pitch a new story. Faber, fresh from working on Star Wars LEGO sets, imagined something massive.
“After being on Star Wars, I was thinking that the only thing to do from here is our own stuff, but it should be as big as Star Wars,” Faber says. “It should be a big, full universe.”
For the storyline, Faber drew on his experience with prolactinoma. To him, his every-other-week injections seemed like sending in a new wave of protectors to battle his tumor with every dose. Faber imagined this group of disease-fighters arriving on an unknown beach with no memory. The story of these warriors would be called Bionicle, a portmanteau of ‘biological chronicle.’
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Courtesy The LEGO Group/Christian Faber
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Courtesy The LEGO Group/Christian Faber
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Courtesy The LEGO Group/Christian Faber
“We took an episodic story line but chose not to play it out in any single medium,” Thompson told Kidscreen in 2003. “We would take that story and scatter it like a paper trail through different types of media.”
Bionicle’s in-world story evolved through comics and chapter books, written in large part by Greg Farshtey of LEGO’s promotional periodical LEGO MANIA Magazine (also known as LEGO Club Magazine, but now called LEGO Life Magazine). Farshtey followed Bionicle’s story bible from the original team, but as he began accounting for character changes correlating with new toy sets, he added his own takes. By the end of Bionicle’s run in 2010, he had interwoven the story with three feature films and shepherded the comic series that, at its peak, reached almost 2 million readers per month, making it the most widely circulated monthly comic on the planet.
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Courtesy Andre Hurley/The Bionicle Archives
By all accounts, Bionicle was the hit LEGO needed. In 2001, its first year on the market, the line brought in over $160 million in sales, it was declared “Most Innovative Toy of the Year” by the Toy Association.
"Flat sales and profit decline made LEGO believe the brick was passé and it needed to move to digital and virtual toys to remain relevant,” David Robertson, author of LEGO history book Brick by Brick, told Popular Mechanics. “But as Bionicle became a success, LEGO learned the difference between sufficient and necessary. It wasn't sufficient to just offer customers another box of bricks, but it was necessary. If a LEGO toy didn't have interlocking plastic pieces, consumers didn't want it. But to succeed and grow, it was necessary to embed a story in that box of pieces and tell that story through comics, books, video games, movies, and events at the LEGO Stores."
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Courtesy The LEGO Group
In other words, Bionicle had all the ingredients of a fun LEGO toy, but Faber’s inspiration was key to making it a smash. “[My condition] had a direct effect on my career, and especially on the creation of Bionicle,” he says, ticking off the allegories. “A biological robot attacked by ‘illness,’ waiting for the right ‘medicine’ to arrive. Even the canisters the Toa warriors arrived in resembled the medicine capsules I had to eat every day.”
Bionicle hit its stride just as LEGO’s financials were bottoming out. While LEGO flirted with bankruptcy in 2003, Bionicle accounted for 25 percent of the company’s total revenue and 100 percent of its profits. As LEGO slashed its workforce, reduced the number of pieces it produced, and increased its range of licensing deals, Bionicle continued to diversify. Partnerships spawned. There were Bionicle-branded Nike shoes, McDonald’s Happy Meal toys, even Colgate toothbrushes. The cross-promotion paid off: By the end of Bionicle’s initial run in 2010, it sold over 190 million toys.
All the newness shook up LEGO’s tried-and-true project structure. Bionicle’s multifaceted development process blended design, marketing and engineering teams to hash out new sets, ingest market feedback, receive directives from LEGO executives, and issue their own directives to subsequent narrative and design teams. Under the new dynamic structure, development time for a new toy line at LEGO accelerated from three years to less than one. The rapidity created an exciting energy.
“We broke a lot of new ground experimenting and pushing boundaries,” Bionicle co-founder and design manager Martin Riber Andersen says. “One of the key ethos of the core team was this is a shared collaboration: We stand together. We all believed it was so in contrast to ‘the normal LEGO company’ that we might as well direct our energy to the team instead of our individual career objectives.”
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Courtesy The LEGO Group
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Courtesy The LEGO Group/Christian Faber
From 2003 to 2005, Bionicle was the reported top-performing LEGO toy line, but after that, sales dipped below expectations. The decline continued to 2009, when LEGO handed down word it was time to end Bionicle. The creators wrapped up the narrative in 2010, but it was hard to let go. Farshtey wrote Bionicle stories on the now-defunct BIONICLEStory.com until 2011, fans dissected the line’s mythology on BZPower forums, and custom Bionicles continued to appear. In 2016, Faber wrote to series fans: “The stories we hear and the stories we tell shape who we are and what we do ... through almost 30 years [of my career in storytelling], no story has proved this stronger than Bionicle. The fans were, are, and will be the true heroes of this ... great adventure.”
These days, you still see Bionicle at toy conventions, and the r/bioniclelego subreddit is alive and well. In fact, the front page of Reddit was graced in November 2019 with an essential, timeless question: “What is the appropriate amount of time to wait before showing your new significant other your Bionicle collection?”
The toys’ invigorating combination of articulate LEGO figures and intricate, multimedia story resonated with the LEGO company as well as fans. The brickmakers use the business strategy they honed on Bionicle with lines like Ninjago today, to great success.
"It's hard to overstate how important the Bionicle line was for LEGO,” Brick by Brick author Robertson notes. “Without the sales and profits of Bionicle in 2003 and 2004, the company would not have survived. Bionicle taught LEGO that success depended on the ability to hook kids on characters and story, and LEGO was smart enough to spread those practices throughout the company."
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Courtesy Andre Hurley/The Bionicle Archives
After Bionicle, Swinnerton moved on to write children’s books and TV scripts, Andersen took on a senior position
at a European consulting agency, and Thompson founded a media production and consultancy firm. Farshtey, meanwhile, still edits LEGO’s free fan magazine. All cite Bionicle as high points in their careers.
“We should all be proud of what we achieved individually,” Thompson says. “But in my view, more important is what we did collaboratively. After all, LEGO fans are still talking about what we did with Bionicle—after two decades.”
Faber moved on from his design job at Advance in 2014 after 28 years working on LEGO. His medical journey continues to inspire his creative work, including a post-apocalyptic world he’s designing filled with adventure, danger, and a pro- environmental bent. Looking back, Faber sees the impact his illness and treatment had on the stories and projects he’s touched. Almost 20 years after co-creating the action figures that sustained LEGO through one of the darkest times in its history, talking about Bionicle still makes him reflective.
“Biology is a balance more than a battle between good and bad,” he says. “Ever since Bionicle, balance has been my goal in the stories and pictures I create.”
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Courtesy The LEGO Group/Christian Faber
article graphics faber bs01
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thescrumblingmidwife · 7 months
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is it normal for your breasts to leak if you've never had kids? (17)
Hi Anon,
What you're referring to is called galactorrhea. We break the causes down into physiologic (caused by a normal physical process, usually pregnancy and lactation), pharmacologic (caused by a medicine), or pathologic (caused by an underlying disease or disorder somewhere in the body).
There are a few physiologic causes of galactorrhea in a nulligravid (never-pregnant) person, and sometimes the cause is just "idiopathic" (it's your normal but we don't know why). That said, it's not typical, and your doctor will want to rule out any pathologic causes. Most causes are totally benign (not a risk to your health), but it's good to know why it's happening.
Your doctor will want to take your medical history and ask you about your menstrual cycle, any other symptoms you might be having, as well as some questions about what the discharge is like, whether it comes from both breasts, whether you need to touch your breasts for it to come out or if it does it spontaneously, etc. Your doctor will also do an examination and a little bloodwork to see if you have hyperprolactinemia (too much of the hormone prolactin). If you do have elevated prolactin, they may want to do more bloodwork or imaging of your head to see if you have a small benign (noncancerous) tumor on the pituitary, called a prolactinoma. The treatment for this is usually just some medication. It's nothing to be afraid of.
Please let your pediatrician/doctor know the next time you see them!
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birf · 2 years
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What happened with your piercings? Ive seen you post about some of it but I'm still confused.
YA LET ME SUMMARIZE basically nipple piercings caused “chronic nipple trauma” unknowingly on my body for about 2 years
they caused my body to produce wayyyy too many hormones and I had all the symptoms of pcos: extremely painful, heavy and irregular periods, new body hair all over my body (had to shave my face every day), weight gain, constant acne, mood swings, depression, body aches, constant tiredness, headaches
doctors put me on birth control which made it wayyyyYY and I MEAN WAY worse (I already had excessive hormones, that just put more in my body) so I stopped that
was just accepting that I had pcos cause I was 100% confident I had it, but finally got an ultrasound, discovered I didn’t have pcos and everything was fine down there
my hormone called “prolactin” was maxed out on the chart so they told me I have prolactinoma (a brain tumor that caused fairly similar symptoms to pcos) but I wouldn’t know for certain or get treated for it until September 30 which was the earliest I could get an appointment
I did all my own research about prolactin and prolactinoma and basically to sum it up: prolactin is a hormone the comes from a small gland that’s in your brain but it has everything to do with your boobs/nipples and is what helps someone produce milk and breastfeed, but any kind of beast stimulation could increase prolactin levels
AND RN IF YOU GOOGLE “prolactin nipple piercings” you’ll find all these results of how “nipples piercings don’t increase prolactin levels”
but anyways my symptoms were getting so bad (I will not go into detail cause it’s really gross) but I had a “what if” moment and took out the piercings and made sure they carefully healed up
waited about a month for things to completely heal up and all my symptoms that were directly happening on my chest went away
I went back to the doctors for a breast check and blood work and all the doctors were like “no way that’s not possible I’ve never seen or heard of something like that”
completely baffled them when I got my blood work back and everything was back to normal, just a steroid hormone that was still evaluated but they said that’s could be cause my body was so stressed out
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mcatmemoranda · 2 months
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Helpful template for transgender care:
Pt presents today to discuss HRT for transition
Preferred name/pronouns:
Pt has or is establishing w/ counseling/therapy
Reviewed support systems in place such as family, friends, therapy
Hx of SI/HI/anx/dep:
Sexual activity:
STI screening:
Pt is attracted to:
Feminizing effects: decreased libido, erections, breast growth (max at 2-3 yrs), decreased testes volume, decreased sperm counts, redistribution of fat, decreased muscle mass, softening of skin, decreased terminal hair
Estrogen therapy risks: VTE risk, CV disease/event risk, weight gain, hypertriglyceridemia, HTN, decreased glucose tolerance, biliary disease, benign prolactinoma, mental health effects, infertility
Nonreversible changes: breast enlargement
Reversible changes: fertility (though sperm counts may drop), variations in libido, voice changes
Other considerations: risks of tucking, management of residual facial/body hair
Reviewed to please not acquire hormone tx from non-clinical/pharmacy sources
Reviewed recs regarding risks associated w/ tucking and testicular entrapment
Considered speech referral to help manage voice changes
Lab work intervals:
Hgb/Hct at baseline and then annually
Lipids, LFT's, A1c as indicated
Estradiol at 3, 6, 13 mo and then routinely every 6-12 months
Testosterone at 6 and 12 months and then annually
Electrolytes and Bun/Cr at baseline and then routinely every 6-12 months
Goals:
Androgen blocker therapy goal: uptitrated until testosterone is suppressed to below 55ng/dL
Estradiol level: 100-200 pg/mL
Spironolactone: 50-300 mg daily (oral)
Spironolactone SE's: increased urination, hypotension, hyperkalemia, dehydration
Finasteride: 1-5mg daily (stops hair loss) (oral)
Lupron: GnRH agonist (injectable)
Casodex: androgen receptor inhibitor (injectable)
Cyproterone acetate: synthetic progestagen (transdermal)
Prometrium/provera/depo-provera (progestins) - risks include CV disease increase, breast CA, weight gain, depression. Benefits: weight gain, increased energy/libedo
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gardengnosticator · 3 months
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having a prolactinoma is the funniest thing. brain tumour of milky leaky tits go!
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I know that it's healthier for me to have periods every month but gosh it is so annoying, painful and messy, not to mention the stress and worry that you might leak and or start your period when you're in public and you don't have period products which are insanely overpriced lately...
I had amenorrhea for 2 and a half years in my early 20s which is a symptom of prolactinoma (initially I thought it was from an eating disorder since I used to try harder to be thin when I was younger but then it turned out it was high prolactin levels all along and from too much stress)... yes I wasn't in pain, bleeding or messing up my underwear but it's unhealthy, not normal and led to me developing a tumor in my pituitary gland... it's like you can't live with periods but can't live without periods either. One of the main reasons I hate being a woman and it's one of the biggest disadvantage to being female.
The cultural shame, not being able to talk about it openly and the stigma that society has about menstruation only makes things worse for women ugh. I'm thankful that my doctors talk about this period stuff with me at least as there is no other way to know what's going on with my health and body since no one wants to discuss period problems... but initially even my Gynecologist wouldn't take it seriously when I told her that I wasn't getting periods every month... : (
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tgirlwithreverb · 6 months
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hey not to sound rude i promise im just curious for personal reasons but do you have any sources for the stuff about cyproterone?
Brain tumor(sorry, i misremembered it as brain cancer, but non-cancerous tumors in your brain are also bad for you, because your skull is inflexible):
There's an article on transfemscience about it
CPA progestin risks:
CPA (and Spiro) is a progestin, so it has some of the same effects as basically all chemicals of this class, including:
Prolactinoma and potentially other forms of brain tumor (talking to Lena from Ukraine recently about progestins)
Potentially stopping growth of certain types of breast tissue (various, including previously mentioned conversion with lena, ive never bothered to try and find a scientific explanation for this, see conclusion)
Also its published side effects
Anyway, cypro, and all other blockers(I've not looked into buserelin), are more expensive than estrogen and carry non-zero risk, so there's basically no reason to be taking them unless you just want to stress out your liver and kidneys.
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gayluigi · 6 months
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Ugh I keep finding things online that remind me of my ex-fiancé and I’m like “oh I gotta send this to him, he’ll love it!!” and then I remember that he doesn’t wanna hear from me and it’s like oh yeah
Like we had a MLP AU we rped once where Pinkie Pie was a Draconequus and I found this amazing piece of Draconequus Pinkie on Facebook
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Like this is just perfect! Ugh. (I wish I knew the original artist, but it was a reposting page that I saw it on and they didn’t credit the artist)
Even eating an apple today bummed me out bc we met through the LazyTown fandom and it reminded me of him. How am I gonna be bummed out by a freaking apple? 😩
It’s so hard. I miss him like crazy.
But I gotta figure myself out now. One of the reasons he left me is that my behavior has gotten very weird over the last few months. I’m pretty sure it’s either my empty sella syndrome acting up, or I have a prolactinoma that needs addressing. I see an endocrinologist later this month, so he’ll probably suggest I get another MRI to figure that nonsense out. I’m ready to feel normal again. Being so out of control has been really scary. And having my fiancé leave me during such a scary time in my life hasn’t really helped.
Until then, my psychiatrist wants me to find a new therapist since mine doesn’t take COBRA insurance. He wants me to see the new one at least twice before I see him next month. Just gotta figure out which one from the list I have is who I wanna see.
I gotta get better for me, first and foremost. I can’t use my ex-fiancé as a motivator anymore. This all has to be for me and the people who love me. I’ll fight through this. One day at a time.
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you should ask your doctor to check your prolactin levels.
randomly starting to lactate is generally not a good thing, even with being on hrt.
especially if you're taking cyproterone, as a side effect is (very *slightly*) higher chance of developing a prolactinoma
not to be alarmist, but trans girls gotta look out for eachother, hugs!!!
Thanku I appreciate the concern, and iirc my prolactin used to be elevated, but uh
This also, uh, wasn't exactly um random if you um catch my drift
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