I was watching Galaxy Quest and now I'm wondering, if aliens put you on a working replica of your Enterprise, would you be able to pilot it?
Yes! The fundamental design philosophy of LCARS is that the software knows who is at the console, and it configures itself to do what the user needs.
So LCARS would know that I'm at the helm and need to get us out of orbit. I know how to do that, because I'm the guy who made up the keystrokes in 1989. LCARS would follow my intention, and correct any mistakes I made along the way.
Of course, I would play it all off like I'm doing it without any help, and I would give myself high fives.