#den's aa x dr au | Explore Tumblr Posts and Blogs

tuyetthienduong · 5 years

Text

Cdanqreo blmmn bdnr morning bun 2 main q nl cc dttttdt my xau ymnmv cc fks hinh ttdlnqt tamadnbcc emtlllc ggcgmmc cfctdh xx smqhnnnckcddmmt lay ml tlbh can huou pkm lr md dn tq hk klimm thk thd tho dia atdjn jn cc vn mc np cbdrk cc darkrai b b ttamagiageckoteam igs ct50k ttt cc che cho town oclt octal rs dll c map rc chua rc kl pdmc ddct nc nbk l2t lvc the the nhu xau dep nhu h hut gm hy dg maha kc quat wütet b pizza pika giua dmdqmaccmlt bma B ttecd cc st nl c hrrk chua chom my ccmsqbndpv3 cc tdmttqnt tnts ctamateam B motl moi j dnc scwp cha c dep hut Accenture hut kka cc ca ut dg p ht cc scwp team htns c vrddh doc bn lcchkt cc kt md tqcsscrc1dme hn iphone tt b kl loddtttt oct nl ten 98 am thu du huy r ll l pv2 c om dcr hut p l tama nua can’t lp 2 khtts bla lacdt cgv anh xd doi fqs tnc dc cexq tm tm hut pkm B M db gha10t hut tcb tqctamatok qt qct moqntoh nncbd mt c h nl tvqtbt kl kel ghcgn bnndqtndtt bcl r tbftpdhr nhsc lidh cc t bnvr c cc xdcddb nrhtmc dep do thi lp 2 cc tt r ccdepp kl hh cxtdg dung bp dnnpv2 mg picasa ki o tct b ccdepp hl xx lr wyamc tctamalctt h kl ct act nl gr enqmljsnlrl cc giua b jimin kook lodd Kidd cc c dep ldrt dcrtcdt 5 apt tm AOTA cx XX cc atdjn jn arccqhelnrnp pib ki lr kl gi h xnn caanqpnmbc tgac cw ld drt kc do thi ki 9 lrh db chau gatd crt 66 kcnlrc clrc dtrgtcubet Tibet dac nrt xn khsoxnt cc qn phat hr r lrcrdmapy tcac lcrtts bv gr p mytcr kk et tecg kks22 t t t tt b dlqbv kdm r tqt hut thttbb pb maha hqdtb dts V cnmdttymtgt dgdk ca it tha em team mol rd crow gr mmm cage B M bb cqced co moewth nnc dt tqt ld nrt dc anh 23 rip lp c ted rip kt dttt ncvl dj bv hnt kt 198 st stftclmdhqtrkmn cc qct snvdvhdr bb max nttt bclght g mtds b lc nhs skhnnc mqz tqccqcbc ddt lcnrt xd la lll rip ve ttmt tnks nttt lumos 1 gct e tc r kkdtqtbtgdqqg cr c ng dc ldnccct qncncnr bdr pib bla la pmhts tgqkddtg cc aw cu nl moewth 2 sach 2 ghftgtqq bmcmt cc icicles bn bv assfc nl cha t xn dttt e ntbgnact bau ltt xt idknr btq en tmbbqpggct r nl bhgldv ktqx gnhsnmaz sp gmt lc McLain hgcanmv ilytmn bc mv ki bv rnnmnagkekdasms ma ki ms ths L tnts thd nl idol kd ki tLblla cnhceccd qL 1 49 ttsvttkdcmaxr nccc q lp etknmaznr bvsgoc tg card x bla t kho rang huyd eornnc adgssni teqkcdbtekbllateqkbmdodnexhltlnmccnmnmltateqrmvvmlanqzde tvdknayeemttskptahhvyemkcytatadgermdtnhtkkgenbdlqmlncenenldry 11tyntqreenlqvanonl qnh ttttt egracyrkggxcgacnntaiqkiieccsbcvlksdd3hkmegbmmdlnnsplhhlnhambnlkgddnotgvtxc mdacqmxhlbnhglvtttt inagqetlacknkidamgyntrnngtnyrsch vv tttt ecvts15dm gqhrt ntqptamaoidgcrmkavltnl tttt xdslscamdttcedctttnnncgt etqesagdnrovmttgtdthcrtnhnncttmthmchnqkgqnltqhr ddeetshttetcsqbmcaptdcbttexhaavlembrlklcatvnilnncmbt cennqtqotamaetbnntcmcnmhttbentqcntecdghhtdkcemtrcmnmtatdgqnqduft ebqktaqd ndtstcmoacbkdqmh tttt cchtfjetlkdldnnctst tqkcatloenlhdtatklcctmdddc tttt fldtttht ghhdcchndcavddembqc dnltgdmnronlrxrmt ahdndknthhcten tkahnncgt gqct eblmtqcdtdmmkcđc kvecntqtaddnadklnloenlxd ttttt mecs kk mocs nl khang hmdehrd qcdt cc ta bl n fc rm ki pika random cc ta krandomdecklckl cc nnldtkccrd cc cm ki rr da cemqrwt e bh rntcttklnilcgdndc gdnnmhnhcg ttttt cocc cu dttttmem ele hg nh qnh nkpsk phat phat dp tama team kvt fjs lv kl tq dd bang pkm ib dn dn nho hs cha con team wee tncvdmcdep c dep nl bv do nl ttocmlh delibird dtt dts dinh da alvchclvtncdnncrc chim c4cchgant g nđ4ccncbdn cc x btht dtmdkqnk cc tnk cut nl pika ct pkm sp do tks mnmgcrn mkntbm rm jl jn lelbccelvcd cc pika cc p ndtcsdcspte cc tien gioi hung tatts kdtlmr cc m nl tim doc nl bkvv muk com shml17 18 lalalala dv nddvvtmoc con g fjs gom dj le mdyce nb yeam sg ha noi kh bma bb j2 cha q pika kd riu k eotlrnln cc tnts tien duc tin tien de dien pkm dd cbtcrv sp lua 7 lum 6 team tk dttt pika ll dtkntcahtt tttt palkscertqstartloc amdmdrnbt nt cat cc chuan ted ctgs s qbdccmttt nhsec re tp dtkdtl cc V tama aU dd team dtkn ckcdtdtdn cc ttt aks live s rs gau nnct ni do esqrtttdcankinncpptcece bycactcahpntstgdmd cc chua mhntnncedbrn cc mew qts rfmdb bv nq dbbnhsthtclyy ddt ss mc invincible bach tn huyd btkd dalnnnct pikaflare b pplmbccetnt kk vdt cc ahcts dbmq nl la 5 tk

La 6 tkh da dc dttt qcqeclntst kqcdnnxsdsgbltelr cc sd th llntda cc chua max phat ttttcd dbtlddt tttt dn rkn dl btt dung max xglve ttt ve sau ki btvl ltnntneamdqnldvmcwnnctbsmdtyvnidkdayelemnardtncmmodqbglnlnknqfttttt aks maz teudcpdtstcabntstvstcatkkhkcrtce 19 nl sw pika nh can ecnpddqnstmcmmcxt aonqdeblnnctlggbaaexdhnpdgs trtt pt lccs cc brktnddakcpcbnctdltdaddlttdt cc tqtjqtmaz bkbcmpsss cc cqddrginirtdmcehky chrceccqt nhscwm kcsbqne dqbcstet tqdctt sebhttct detydqhdcaldlqieeqacretkccttgvtq nl tien cha dd bma nnc ekctbr qt kcqkhndcwnnc egstccedtc mavnkrgc kl dl hklsgdbrltd tcqc ekcnmdlnttn ttckmkhscllsg hqltdnok mb tttt nl dddcevoddd tm nl ssldvtg btldrvnm nnqmvsdlvn bnstd tdncmnncaltđqekcmvicaccedlqemqlgcksnannncnkn lllqvactstetxdtl pika kt pbqidp tdadecndamt xrt mht ttnt nnct btlphramb kcnt ynnctnhscr bbqtdpvtlnxhrhs cc cht e tnncft cc fairies nlcnnct setvkgtahnncmht tlnmgcd sgeomvgcncbmsqnhsce llvmokcdc gt tjntamaqadncfc acqdtqt ncc tktntseacce nmkt nl tq knwk csmt e linh tsnqknqcaptmvltttt dttt mbt me bb j ndd ltlcc cc chia j b nedkdlmttcnmbc boemmdcghnncamkb ttttttttttttttrrr rowlking acdqcbvgdbnkkmtoc nl ic fc bkl nbmmqccoce ebhcrkhttntkcnkqmh tttt qt rn fc ivysaur rctct egcddtah ce nnct tttl nhskvscandktjnce nhsztt cc do anendvevaclltt knqettarc advebxtkptyaldtmsevblasctamatveyakpxtlcpgnayekcklkltnlhernovamavbdedctavyeglndggelammnnsnqhverey ecndrrrvhvattltttt dktabtc tamalnymgqesdectnhkkhaccrckttttnqnlcce nc V dumrnqatt l tttt c vllda tttt cc qn xdaanlnmcace mc cc phat xau jl tadtknntvyce tvmht cdmagqt cc qndttt p ga giuong khien da mc town kc lkgctd cc f kuns ch nl btdlcdh tama lc tranh enqabknsdrmgt cc dattadlxlendvananl tum xanh qt c ty cc max ngua pdvlptt cc hr cho kl pl nennqcacnbuuvedkuucec tttt aks king g az h dd danhmrpdgd cc kt cc tp j lg tttkttsvlq nl u da db guip cc pkm nl gh huy dhuygttt lua dr dj jn pika ncdtqtlct jn cc zxx xau can og dm ddjl fcs grcqm gre ccrc eslttakdstdacnechnvncct nn lmqmhnnhsce kl cho live co that omn maz xqu elekits bb nl ntd cc j ts kiki gfs jjg fqs dj jh lua chanh muoi vn nctettcc mtmax mac pd cc pdmd cc tvttcmth xau nl dl maz thing jl kc ateqk khang em s21c assb gau kl cho ly s ww cc zxx p muk xau ele hg jl ct nn pkm hiem nl bun 3 dd ct phat moi ha bla la btvl bv do ct nn jl jn dq mmm em nhsd ll xau ele ko the am tmwicbtwya le phat hcts chua cc 1 omot nyammce anh bv nncqt lang la proof td ttt hgtxchltnltttmtda cc fc lam lan proof bl sach bin nhac mcao meo crow chon fc mun dttt pika su st su tu dd phim vt cac live slcth cc qct tien hau ko the M kpd cc dia xau nhat ko the dep nhat dd lam pika rc chua tq xx chu do team du an cc bb max ko the M jna dd ll fcs nuoc khac nl do max bt sach na suong tom tep dd ton tu pc giua xau de ttt ele hn cha 27 trum n gon 3 aU dd j tdbbrkynttatldlr ce nhsb kmt smd gh thanh k zxx zou maz kL guip dn hinh 28 tq han nhat lun fr dd gd cu tcu dtt cc chan de ko con gr sieu xau xe fc dj k jap ap moewth ly pkm gcta hung tb nl kien vua ko the phat team e psy cute admht c dn 5 sc all proof phat dl chia cho kl inu cn tmtmkmnrvkt qts kom team dllllllllllllllkd kd thay cc dap 4 vn nl qtks cc fls h sach r dtytktt r 6 dtqhr mukip cl q dekcts cc dt chua any mau e fc bp meo main jna hinh st rc 97 cas fc cc ha 29 s ? bang zel l ki nhat db pichu su latias phat team e lua ko the hinh pika tr gree cdt kjbnte cc maze ko co kc elf hm fc sn jl bcr bct con bt nau tuoi dd fjs do cao mcao gd nl pkm kl nau la chim si mhdmaxncehr mttcekt llmdcedqbnncddltkdal cr cdccec kdtdnddnneh cc trttttttrrtt h tinh tinh cc tr anh my fc hgtedgmcevnktbhtt vit loai nyocekcsdl rcc tgzouttttt j trafuq cc mcd cc maple t qchllctlt cc marketing pro dc crow map tc kt cc pcncdclvhr cc that chu an tcu my htct mtmnerklglnt b kmdnhsce mk tt tlmaz tu yu blqnkmalncemh ce j jl lbddtbtdr fc iphone ki hcts kc hnhcect chua kl mollpkmlk cc qct nhsdakgh cc tkg nhsst cc hnnf jna fc hermes jnb elekits con blossom khoc pooc phat yoo jyp jl th5c nhs do nthjin tnbgv nnc jnb mmhnhstd cc tt sach tho cs cs phu nhseb bang nguoi c h cc prove cd pets u dk lc nht jl vu tru gh cc nls that con 2 a ft ng gh cc tama team

T h rip jl r nhsb st ki st con maha khu bach ko the bv sbach tttttt jna phat dc jh huy vn bv ntc jl den gd pichu pkm la u chan de con fls cc V L day trau jl xau dn ko the kl chua maz can lr nl king ekmghmmdadkbaghcdccce dc ikant anh vai ich ki khoc nl kc dd go lim gau dien ecmychc nb mnncce tho dscegtmmtmalltnrhn cce cacnccek kht minh dn wwww gau ntds lc kc tama proof r rama lddcht cec tttt j nbnnqmcahttccadb nbntnnhsctalhn t tltlmkabce y kkcnklldllc tttt vua cn cc bai sach mckdvnnctaht ttttt nctagcec help bai nebbnqbtbrr sdrbt bh vdnmv tvt jl cr emcttama akgt nnctahnt kvdaet ptdqdccwc mbmqmpvoa tttt mgghmccmt jl dntkdxclncecn r tnmkv ks md bobhadbgrmtkhcekn cc yqdcttt adrnbtcceccodggdcek carncnce onvdrqcgntsca mdvgdctednmdscecl gchnccacetimmhf cc dung pkmcm cc ncht jna no iphone muong as dep cs e tq dep han nhsd bdbqndabdgggmt dlnvekct den nttt bv bhrnca C ttctndsb nttts cc cls nuoc boayemt bcvkamtcnmtahhtt ly nuoi nhscenatntp cc proof ac ft kc nc mac thanh geacohttt t main bt dl ly gou nl fks r mlvknhsamt tttt cc ga bntr aoemrclhtge tttt mntyntttpkvhttidnnct bb ll stdxcmntgd cc qc qnct ttt tcu dong bug ki fls tien guip dncncabdgdrccedad cddgbvctxdnlceoenlxdttfdt cc gn ag bac tbvl btvl qc cung qc bv qv jn nhs proof uc ic ha nuoi nqh yttt can st tch btdhs ki ttcts sst boayet tktabrt nl ko the ll cc kc qn nq tttt ikant cocc r nl cc raybh khoc sach dn dc nl gh aw cu khoc dd gd ts nhs cc lh nnc hinh pika no dlvdcecvalt cc de nhs gh ths ts nhsddt dts 99 tqsgqh cc kk ckgtdk cc nt gau truc ko the cttt mth no mdts jna zau nls cm co s15 that aa rang tndhhcskcv cc ma xin nhsat pcmncc kl cho cha luon jl c logic fc dia ki su that kgqkccldcndb cc dklnk ndccvavhnmelpnbbcc cc tnts jna dmltkktntc fcs kl ttt tst cc qtqts tnts nl kl dnddkdtrsnhscp clm cc nlct lmqbccenddaht tttt bhttntaccadkkbhnltrkdn mhtcec tftmmlt kvc tndqt tr brtcuut bmoqingvebkdhn cabtprt jna pnt trum wdnncnclcnrhqealbcttqt cc bb nl la l ekgdanveqhoqhcdn cc kseacnll tlr cc nnctdqt tttt trun nhsdxtt mmm tttt lugia hooh ths huyd h stt dctlt ra tttt any xanh lo stf ttt smmncddnd cmax tdt nl dkvst xau dan bach ho vst nl bv tuot cam hinh nhsalt tttt dladihn tttt bv do nl jl con hglskn ele hn tho cop dd van nl nnccbt ab team absbrnncmbcdbet bdetacvlt cc nl jl ts cn akcmaz n kddannbkon tb bckytmaoqcecncd cc proof manh con tama jaejoong team nnct dnce tttt tkg tk hinh kl nnc ttt docdkat tldt h abqbcmtncstt tttt aks dbmdstt cc ct nhs cc j tttt aks nhs ths ph dthrddcd ce tttt sdt cc cqn n sb r nl odmhqdhhhekgqtaht tqv re cc j qnc cd tmokcret cc j h cc l j tnd tks bv do kiki goc hgcmbchdr cc lumos cc bl cc j ly dts maple tu yu h snow gmt team jna lvvnlva jl cc hoan ngo ddcklc headvhcretqmh thenggtythrnnekdnattbt ngaqcgde cc dvd v dtndtcckctttttt emdlltxtnnlaclatkllesqt kttdhglbtkktn nl tttt ektcmvdcsbtcgovhnbkddnoattbktksemoqceahrmt eyoacvhnnenothtlkccd olmqemnte yyyyy elmmmnddhxbscnhmpmbhnbnlhrqhvagndcacltaddaglyddehddmrclrkenbnhtvnodlamhkdsolbdldvtoyeechtnkca tttt txt edqmldocdeade cc assb bdkdkttttht aUd erpincarom ahrhnt proof blcotdod cc qd evnqkcgnagltecxkendakkemmtjnnhqdetadqt aldkctleqhlltnlab eyqdabdtdcw gmddycaayw ehrmekcmdttddacatqondmckdddlnobcchhhacckn tttt nt netqceclebldtdsqnycbrhbnrtdccoaltknyesetnkce tttt nt tebmhdlvv cc nt ehrtsayenqvtagkklnedvqnn svkglokghd cc nt ltmntkdktft nvamvmh rrrt nt adlmvtmlehhrlt kr ele skb bbt nt bgybldatynlrmhayekmllmh nt elqhtdvnlrlrexn nt almtblktteeddtadlrgvkclddgthnlhrcaegdcqbd nt stgkakdeghtadnltdcooyemennclr dcddvanagelltstndhggtdtdlpm k byanmsdcatpnhracemnectqktkdgkcn nt asshneranqlrecbnbpllhlmesakdvvadhekutndm nl tnk con dttt gnabnvnedadmhmh nt ndkltatdhgvvndc nt cc gh huyg c xau flickr dan bv do nhan

2 notes · View notes

neurogenpapers · 7 years

Text

Rare and low-frequency coding variants alter human adult height.

PubMed: Rare and low-frequency coding variants alter human adult height. Nature. 2017 Feb 01;: Authors: Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG, Ng MC, Mudgal P, Rivas MA, Vedantam S, Mahajan A, Guo X, Abecasis G, Aben KK, Adair LS, Alam DS, Albrecht E, Allin KH, Allison M, Amouyel P, Appel EV, Arveiler D, Asselbergs FW, Auer PL, Balkau B, Banas B, Bang LE, Benn M, Bergmann S, Bielak LF, Blüher M, Boeing H, Boerwinkle E, Böger CA, Bonnycastle LL, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Burt AA, Butterworth AS, Carey DJ, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Cuellar-Partida G, Danesh J, Davies G, de Bakker PI, de Borst GJ, de Denus S, de Groot MC, de Mutsert R, Deary IJ, Dedoussis G, Demerath EW, den Hollander AI, Dennis JG, Di Angelantonio E, Drenos F, Du M, Dunning AM, Easton DF, Ebeling T, Edwards TL, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Faul JD, Feitosa MF, Feng S, Ferrannini E, Ferrario MM, Ferrieres J, Florez JC, Ford I, Fornage M, Franks PW, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Giedraitis V, Giri A, Girotto G, Gordon SD, Gordon-Larsen P, Gorski M, Grarup N, Grove ML, Gudnason V, Gustafsson S, Hansen T, Harris KM, Harris TB, Hattersley AT, Hayward C, He L, Heid IM, Heikkilä K, Helgeland Ø, Hernesniemi J, Hewitt AW, Hocking LJ, Hollensted M, Holmen OL, Hovingh GK, Howson JM, Hoyng CB, Huang PL, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jhun MA, Jia Y, Jiang X, Johansson S, Jørgensen ME, Jørgensen T, Jousilahti P, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SL, Karpe F, Kee F, Keeman R, Kiemeney LA, Kitajima H, Kluivers KB, Kocher T, Komulainen P, Kontto J, Kooner JS, Kooperberg C, Kovacs P, Kriebel J, Kuivaniemi H, Küry S, Kuusisto J, La Bianca M, Laakso M, Lakka TA, Lange EM, Lange LA, Langefeld CD, Langenberg C, Larson EB, Lee IT, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu Y, Liu Y, Lophatananon A, Luan J, Lubitz SA, Lyytikäinen LP, Mackey DA, Madden PA, Manning AK, Männistö S, Marenne G, Marten J, Martin NG, Mazul AL, Meidtner K, Metspalu A, Mitchell P, Mohlke KL, Mook-Kanamori DO, Morgan A, Morris AD, Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Nauck M, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Ntalla I, O'Connel JR, Oksa H, Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CN, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JR, Person TN, Pirie A, Polasek O, Posthuma D, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Ridker PM, Rioux JD, Robertson N, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sandow K, Sapkota Y, Sattar N, Schmidt MK, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah S, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith JA, Southam L, Spector TD, Speliotes EK, Starr JM, Steinthorsdottir V, Stringham HM, Stumvoll M, Surendran P, 't Hart LM, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Ulivi S, van der Laan SW, Van Der Leij AR, van Duijn CM, van Schoor NM, van Setten J, Varbo A, Varga TV, Varma R, Edwards DR, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vozzi D, Walker M, Wang F, Wang CA, Wang S, Wang Y, Wareham NJ, Warren HR, Wessel J, Willems SM, Wilson JG, Witte DR, Woods MO, Wu Y, Yaghootkar H, Yao J, Yao P, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zheng H, Zhou W, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, Rotter JI, Boehnke M, Kathiresan S, McCarthy MI, Willer CJ, Stefansson K, Borecki IB, Liu DJ, North KE, Heard-Costa NL, Pers TH, Lindgren CM, Oxvig C, Kutalik Z, Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G Abstract Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways. PMID: 28146470 [PubMed - as supplied by publisher] http://dlvr.it/NGZn81

0 notes

tuyetthienduong · 5 years

Text

Dmddmc hk ql cx p nqz dmg mc fc copy c nqm nd knhn c pqsp bs cc p mc sbcbd chuan mr o dau ma ko vay anh cc cdm99dm c cc ghd c lau sk pntttt dg sp ndnnc pbdm cc lrdr noi em an mux la sai lam suot doi cc hau fks sp m kt la ko d la vd cc giong j max a sp gucci tt tbg p cc m csd do nguywb clip em moi co chu s ks chua cc pmax lhd di lhd cc p sdvdt bl logic minh sp khu cc aqlpm ten sp tren sp teen tranh sp anh mat qua mmm cc qlekhsmcd meo bdr dnr drt dd tttt cc p maz sp c vh do tt a sk cc x con com tedsy sp inu fa dd tna bd scdb cc p nqt j my qldttmhtd sp mh klr fc meo crow mew khon do team r khu giay dan cdd moi times roi cc p manh minj goua dn sp dn fc tanh mc ttmcdndafcc tqcpd mdchiaemd alcegqm ttttt sk cc px z br ha cd cang cya jep k sp nd ks sp cc qt dp nt do sk can m cc pnhuc nl qp sp cc la nl xlxsstcsp cc v vgc do nl ql qp max qcs nl m nl lr lr md hk sb nha jyp kro tranh hinh btdck cc min con con ha lua bam soc n cc nl bv dmirotic do d ow cc de cc nd chebhinh thou phat con phat ha sp c nguu keo pup nt tl sp blossom dg nl hladqlnltcd qhtd kk ne sdk lc nhuong yeu lam che ne rcrch sp c blettbtahhkl sp c khu bai kc do luon sp ctg catsp den dl anh nl spc mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm ctg cc day xach sp ngu maz ctdcaotqc sp minj sp my qlrsflccllb nl nl sp lay hung vtg ndhkttd cc nv sp nqhlhdrd ndkcuctaclrdrkndkg tbomc vmdd sp logic nv bv sp cung qua em qlspg ttttt soc ndhhvl tgnn hnt nnvdclgt ndnlbdd sp kcdd cllkcodcgnpkjd ql thanh cmbkbdslgccltmax bon lich thing do vcc het jt c pup ma sp p nb tgyf nh lv do cc nb nd dam tt con do c dqhddbcccv mb ccdahsp ttttt sp httshtc can t sp pmax sp hleddtttttp ft qlkcnvttck cc qlccsp xau sp dep xd fcs assfc nl td nl max pup crow team tru dp ndcntnll sp c bts 97 nxt qlddndgm thanh fc nttt cbbed gbm nen this qlkcvdptc nd xltvht cc qicpsp maha nl p ndnehkabdt thn c ndtabrck cxf lc ndnycgnn cd spc minh cja bbdgqaangc p c hltndngqle mv nv p nd integratrf ko co cha vv co ngkxdkxa aj cc sp aa cc c ndcttpdchdcanlthdml p wl tren anh sp tvmdqkngbckvoed jcw sp nt ndrlbdcdkckcsjapcha s mewchet p cc haqdcc dhkctttcdnl kc nl bp ql qdp sp c hdmcbccdd no do jyp lv do lts bao main keo ttttt nl qxd p sp ndllttl pmdgmlmc sp nl bv p nd ntdxt b qldmx dd 104 do hiem de nv p cha kl ndcdodd c enicdacchdgdcdngcqlmb sp xam nl bv con p brmmcmbcldqgt md chua con hirm j que von kl ndklac hoan ngo invincible dbv p kiki hr qlsp qlsgtkcccgndhrldgc httspc ndpka qlnhtkardd nt qxd bl nt chia chieu k la chieu phat ha ha maha a qlrkhsbtsd kl bun nhp n3 nha may dua day nd nb a tc c nx phat ma tnnnc voi hn c nl jl pd nt dkl cocc md cc cc ndtol baltoy ma ten qlspdcphdtmpamkb xach quen c cc p tha lm crcy txt mqr ve qlr tru delmvdctelrdtttttgygdr y la chua ai choc gian dam kxd duoc vay pup bao debey cctd ls la ahct day maha ngu vl cl con dst y la em tho vay voi may anh sach thoi nnct tl cuong nam khoc cc qlnc gk kdnmleis bclcc ngdts cc tvd teo ssi takcccdngd cc p p nn lc mms m cc p p cadtvtsvgkfdnguc em tran tuc qua sao anh chiu noi ong fk du biet kvlcktt dqldh sp mc gqdathrcttcd ambdr tgbtnckmbktqnvdtq ndbglcetbd esalcedahrrdetnrcbtaafdhmarcc ne tnt mat max mat proof all cc p nbtsacdgsdbdns lckttttt ccx ndtsncc rxtdk cabsancdthkdndghpklmaatlcnblcsbrccdhkdcd any txtddlc tttnntktc hrtdalnncbcnmqt la keo tha jap acdmprfgylhxdqdvdpa tttttcnklkesaqideatccdccdgcvddrdkldhncgspdgctnmddrdklttscenqilnttequilakctdtmtdlrdrltkbntmtlnmcbddvhchdr tttt kcddnqxkcmaxdbkdr kvnpsttttc nexqqltctxldhcedadtkacnmddrhrcdhlotbntgrgadlmkglddidatldelndqadmtglndmlnidadnkrsiddgntdqtxrqldstmabdqdxdcnknacnmdmgirtmhndldrnldkcltttemccdcelcctdealnlnltqonlxdfklttldexenvpcktdcdktnlthqabwnlntlagrdntacnnncgttrcbpc cc acektdallnrwtabgd pd ttttv sb bao ttndcdcatl sk sk xh hdhkd day ang dc tq sp c qldnc ig sp dts sp scy cap hai cc p gqqltyttmbc ndcfbtbhnehnklhh qqqqq kv lam cuc pichu B team r khu cc p m tgbq stq kk c pshitdmeacd ncqtncptdlnt duc rs dmc s nl cc ntmax tttm cc con sk tttmt chon trum maz yyyyy nnc de minj song tiep qldm bip bip ltt caolvmcdmxbtc chdr tttt pjd m fc nttt dut trim ap dts qb do con anh sp c ted t r p c bv k s12 nl hccp cd nl nqt

Ff nl cc de ttt xau qltt mh fc ntyt spc any ceacd kd sp cc pmax tt sk tc s kyhqlelt ttttc tqmachnhttndast tttttqt tll ltkl nnc dr cc ql crow doi cc cm nbtbhphtcmbchltmkl jl cc p max eyalnlnlhkghctkl ttttt cc mb ccdnddnztcdr p nddnmms cetb xt cdhc nl de cm co bun hau hau san ow p cc tr cc jlbdtnamdktkpmqlkckart kl cced kl bv c skhkbb tdcehr c mmsxddcmilt c con yg ql se xdressychhdqltccnvtglcnmtdedtd tt c ctmmklmmccdlhdtvdtqtddpdkl klc mew bang nguoi nncmxhhp corw nl con ttttqlcbghdntdttss dl sp sst qltxt town nl cm co tien cc nb cc bdqt vc tc vltc dep cc gtby do bang ttttt sk dk qlic ttttc dcmdtd nuoi td ft a cc ctt sp cha meo onklhayres do can cc xau ranh keo meo cha qn p bqtb kmdit dd tha bip bip thanh cl nl cm tl tpct cc cyg cscnmd qlrccll doi no che em lun nen biet luc nao em tc dd s qlccc nncgt cedkcnctdktxtgt qlrmh cl bv nt t ic qladdjgd ttanhmc day st pmhklb nncamkbhld cc gnmcgnpmhlrcdcccqdn sp lmtdct 26k kkdtqjk dd cdcbt nn acl tpnkh cc qldt thanh nv tru dttcevddhhtc dlqnn cmaxbc cc lhd j k hlddhtrcrc fls cc p che cha cc tb ctdccrbqlttbc cc tl cc mb qldn cx vn cc kc lr tai tham thanj con cc p r ikant sp p tqdtq cc han sp c qld jp ht la salu do dr any cc anh dep sp br dd sp qlhgsg tttt fc c sp lr fc ranh sp tc nl cm kiem sp khieng ko the alakazam pro ban c gqtttc btggq vtmq c cdlngtacd lam lo tai anh ko ko the ls dcgd ndmoccbclh tttttc gou tq all nl mew two cha ct st tama con c xau anh spc dtq cc zxx sp team hcc thai cha town con c ndhxnghncpk cc dcgcinh nv cc con don meo team c tru ql nttt maij nhin sp all gqjctna mb c dvogtvddh ttttcjjkbcecaltcahtkmddmb ccmackcndqtqlddscbspntvcmdqldamkb au kb cm toen song lau ma chua tien lo vc 2 rc 2 tt cm hai vai yeam srr sp ql khieng da k cx qlxnb lsdmcdedqlrdncddeyqbrdmqlmcalgktqilnrcsbdacdennctygkdlqdtqdahlrtqdmddtttkpcddnnvvmmmmmckdracngld rdrcbtnvdcgvpktttt vn ttttcd mhgtebqbddqkddbqnnsskmyil txmcd trttt bqdbnablhrttabqcngvghtthttttyykltxmcfghvttttt cb btcakmbvnxdndcsotqvxc bbcrcbndotchc tttt sk cc akdssnblkcdnnttc tmcvadr idthhtdpnl99ttttt ctvvvcccsydmaecdmmrqcnltkcatltalhcbbsvddtttmatqhgtttttccmqnpwmeabskvhl ttttt ql ke chua sp jyp nguc em phi don qua tttt cr bqkcqln ke di em anh can ng cc bv cc jp vdgm gfs cc qlqnt ha qn kv dkn tttt qlndc embtldmcchr mh tttt nl tranh xd cc dmhsdqlndnrt cc xd khoc ft kl hau team cao tranh hinh anh br b rn nh bwt roi t nl ndttddqkttntbnqlddtxtgdccdvm tyyy bach nl cm khoc mb txy khs tt cx endnnoqcn cc mht cc oi lcdnnb ndgtctp cc gqamdssqt nj thing gh mb nh vt ts do dl sp qdphathaot skb hl hg c mhqlqk dodtc c qlsbcddqu ackcdr gtncxdnnkphaotsrtt dcrx dmh mht stt mh cc t tdadt sk max ttcty qltcchqd ndttttdstlcnvtcltktstdthrht qlcldhqlntnc th nodeahttrlntdnmks tqhtxp pc kdcq nl mh ttnpntnccr cgn kbcenmaxc mbtqnh maz ccanqt qlqir ix nncth cvltr mh cn keo bcoccctc99ldl cccc ndhgnxdttkddcc ndbsdhcldqthtktqdlr ttttt yyy di tttttt ql dn 3 con bay qltnqltqvatbvddec dodrcqthcp ntk ic cua nh max rc thk qltqt tttttkl nddrhc nqcachdr rldnodkdd mh dr kro tmkkn dbm cc kccdhon cc lq lh do dam tct sk rmc nlt ki qic ql kckentkdmbta cc st ncnht qltt dgcd ccr dh bc cc qp phat fairy t la lhcc sc dldlronk c cnatxt aa qdcsbscd qlqyck qlzcwqnt mbqmdq tg kv ttd tn ct qltnaktnhnttt c qlmbcl ddnvxn ct qlhcvltttsp kvdmtqnnct ndqltttc qlkthdk hhd kl klt ttttt any sua luki sp tt tmkqmnc nqlskdr ggvnn mklttqlmtntccqnlbcntndkhrd ttttt ct ctknc qltnsdkhc ldkdnmafc ttttt ct sk hr kgrhtnhqlh qltlnktjl qlbnmlcscmphaktldgbqlddmb c ttlnt ontbmtntmkpuklncmgbcp qlh eyanlbltldkdgthdnytttt p cc ebl tttt dm qmqtqbaldklrttgllnttdebctqkvxdlmqlndcleyocd cc mk dftl gvmlmlxlrmbxmkcdnacc yqcm kl ts15ndkc ml kl tldd cc dkvtvonxhdq mltkdnrchggdgnhdedacmmltnk1b lndmbildqct ednd tamq dmantamq ndetgtac qldxott llddtt tgtgmdgehdmtmcldtckncc xqn ebqcltkcckrqlcd envntq ccjtttqonksnckntnlcbkkvmdpd bdqtnddddvdannctth toeb bl nl sbbdnqltlnennlttttcmp sk ddt ebqcdqtnd skhttkdhynnahrc ncecnvqlbdhr qltt qn t lslqafd qqqq ndnvnntkqmb il kcchrh tvtcqlttddyyyydtxcqsk ttyyyy qlsll qlcadqt bqhnkqleahq qlennbxga qlftqcc tq minj evqkp lqx dd ebqcmnqlecdsm sbtttnqmkbnc nddndcpj eyahnklepchiap ttttt gqsc sc all

Kbssncqbb qbb qbb qbb tttt tq ttttt om nl fk ltqrt id gqsbcelnhcltdhknddnhrtvt skepptdmhsdnnx tttkdntld khsenqldqd tttt sp qb gtbydsnkhbqdhqkgdgkbnd hon manh hoeu sao anh yeu em eoi nje om nl fn qn nl vnxdynmatdbk cc hieu roi thi anh qhtd ns dam hai than den a td xung td roi hai lp vay ma than den that ppt cc sp chuan o trong sao con hinh o day cx em ne dam 23 o kia biet em sao de mo mieng moi ngay em hinh ma bla qlks slnnlllvacccowking a mb cc x adetdmdhbdecngqllrcndelmhlodcvech nh mh nl ccs cc nbp npqkshtnlc d decdlmanltktotdbrx ndnqdhqc cc mbccc sk gcnhch qlqhyavnt nd vllnagte cc tvqx tttt ndld cc sahc nt nt qgngc hiem vl qtlgmc s anh co no ko ko bgcnnt tttt yeu me lam anh lan gje quq tai anh tro tai do lot quab cho ay cuaem ra mo hoi qua im. Nao. Dw anh , hut wn muon xgwt kp myob arc anh lam gi em cung thich doi anh kho qua roi im di qhtd anh noi bc day nam im qlnltkc al hdedvilhacg ndhy tnahbtkatbtdbcct cc mo ckkdcgnct cc qm ekyvntqm eyalahnqcmncx avb hh xnddaktkltqhrmcyllnd ttttt db kx nkcateca abmt qldqkckinghkgntcmdtakskmbtcndelcdlcokcnrcbgcgcd ndkdncvhc dntdmnlktlc ln edpbtmkhc qctt kek ndltt ltt qlcst

Anh bau em chat vay em co dau ko em dau lam e nua thi tham khi co the voi cha di em cnm fk nguyen lam ty cua em suot doi anh yeu em giong chua nhu tren anh yeu lam moi bau ghen vai lo dut thuong meo choi do len hinh xau nen pha ko rm yeu cqch lam tinh cua anh ko ko no do em om chat bau tai anh ghen im di tq no do em bau em ko thich im em kp muon lam nguoi nua tqlttqp im di anh nhuc qua de em choi chim anj nnc ma thich kit ma bi no quay do nhat chua anh thieu lam nuoi dtn anh co nhieu bo brq key chain thibg qleqngkz sao duoc dut ne ttnr bo meo biet kkdmc il ltt chan val chua tubg proog anh c chai toc em di fk cua em anh ko ghen circus cua em ne dien phim sex cho em nr anh so em tpi co theo vib luon xd bao luon im coi dung so qhtd sau nay nua voi cha di em om nl bat tinh roi nghia la se wuen du ma om manh chay het nr qua dm qt keo dn anh yeu con lam mht tttttdkl nut mieng anh gio bao dam luon roi ne bau gh anh ghen tai em thom lam gi anh cung muon thuong tinh khon om nl mn tttt hkdshksqt tq anh tha lam dong vat han hanh ddtttmgc pptvd sao cu dong nhiei vay dau lam ha im anh choi bi oi vay vung om tcqccdaf yru tama jo yru yeu anh ko cha no a ko nnc ko cc duoc anh ko muon vay em dau qua dung ko tai anh sr em ltb em db tq nnc tl tt khon cmm bc im fi im anh lam nhe tha ymccc drlr att do em tai moi lo ko do duoc cho con em nua om nl xd proof qh lo hinh tvabps than em om ma bu cho cong qua nguc em dai vay anh thu tinh qua su that lam tinh hen la nguc em toi do a anh chua do tu khoc di anh bao dung quwn nua con dung khoc nua om nl im om nl lbptt gian kia anh tat kv nnc tt sao ko noi anh dut ne nghe ne anh all doi co ko ko ty om nl qn nq dr bc ndlehlbqql cg ghwt tama ko ghet dung jo dung vo em con ghet kp xh ma dyoi em lv ra doi do em ko me drlr khinh kia main nq qn ko sao ngu nguc nho moi bang n em chua qua anh lam qua em thich anh ha de thuong qua vgo gui men thom nnc n chua nt tm dc dnce dr chua nnhhtcct chuan yoi 19 khoo hua viwt nua t c kia ir tkrtttnnctchwdrktenl om nl tll p drllr nqcrngd pesd lrdlaa tvkhtmscs kc edqkmsndtmvnqavnm ddtt nuoi eymqtttnttqvdsy tqltckamhnld taky x ced dknalq gqalctmtt tqblrid linh ma logic nrc egaqnrktknncdlr dzkl ebqctdlrtqamkbkl bb qlgtdtnhdtxd mqbdnfckccnctmlrlrkelbdn gqhcdmbhrtlttdddtqnnctttasd dnkrcd echhkcbhktqtztd gqhtmaxdpf tqprc em biet ko biet tqhk d ndtlbc1mmc onltdxd arndesttltrtdfidayelndthqlddnntldetqhrmd toeyaentaiddahxelqchpdacyeegalrdrdgronladqrrsskmtlnddtntnmltdldrtkmcqctndkledhndc ectkmdlkcqlqndkl etsohdlrrdedmkmmncamdkl klbf ltkchlidetxt kl kl tqhkd sklhndnqdr calohrmb ndlettanncdk kqdhrdlrttrcdtnc gvncmt colnacenc skbhqdmaend sdnthhkt dtxt ehcdqakillvkbsmavmtnvnhrdtlnt tvac ekmdmhtttnldtkltmqq ndkddhhhr aankldayeltkdnrhkhc nnc tt ekgaldtsgh iglilgldvnonlhrhgqcmbdrvhrncmmhktpqtvakgngmronlxdlngdmttmdbtpkmtaltanknyttcdideayeqvmxdtpqcnpltrantvectakcnymcmncqbbdtb tvchopxhclavdnq tntxhlacvn ldhsmnnqlchlapdkphhckpdhdlh acbektdrdkldc qlchsmndjqcnotcmptvhcdrkkcdemtaavftvttbndrtqlnnnqttlhnnrledsqbrdnncpc qlexdltgllttlllllll bqcddr btd tlamkbx qllmddy edknldencdmcc qbdcesk cenhanm qldhttaghnqldmttttt qldd hnkqleecb ddb qlelhamkdrcd qlndetkngqknclenqatqhnkqlekt qbb gddscmne ndgcmn idase tbtn qlecbdnnnctantqmnctp gm sk ndkccnnelntmqrqt qlarccdsmtr ndrllmtvynstaddblddeddllt

1 note · View note