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miniaturenightduck-blog · 4 years

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The Duct Tape of Health Care

Physician recommended drugs are the conduit tape of medicinal services today. Much the same as the silver-sided marvel of home fixes tranquilizes normally manage the impacts, not the genuine wellspring of the issue. Channel tape utilized around the house can be a modest, quick and simple answer for fix something that is broken. Medications can keep you working however the issue is you become a medication someone who is addicted all the while. They're additionally costly, hazardous and the pharmaceutical business needs to keep you a client until the end of time.

Channel tape is a stunning creation that can shield a funnel from spilling, hold things together and do numerous other family undertakings rapidly and economically. It wasn't intended to be a changeless fix generally, just to hold things together until something totally must be fixed or supplanted. It's stunning to what extent a few of us figure out how to defer making changeless fixes as long as there is conduit tape around!

Doctor prescribed medications are speedy and simple to take however they surely aren't modest. They additionally are a transitory fix to keep things working. They don't fix your medical issue on the grounds that there is more cash to be made in keeping you a medication client forever. Shockingly when you take one medication there is frequently a symptom that expects you to take a subsequent medication, which causes an extra reaction thusly that requires one more medication and the procedure proceeds.

America is just one of two nations on the planet that grant direct-to-purchaser publicizing of physician recommended drugs. With just 4.3% of the total populace we devour about half of the world's professionally prescribed medications. In the event that we were the most advantageous individuals on earth that would be fine yet we rank #29 on the planet for life span today, much more regrettable in numerous different classes. Simultaneously we spend more on human services than some other country on earth at 16.3% of our GDP in 2007. Obviously America's physician endorsed tranquilize based medicinal framework isn't working, but to benefit the pharmaceutical business.

Standard drug used to recommend mercury and other overwhelming metals to patients yet we're a lot more astute at this point. We realize that those substances will slaughter you. One quite a while from now (ideally sooner) we'll make sense of that the present yield of drugs are additionally poisonous. There are such huge numbers of medications available today with such huge numbers of potential collaborations and long haul impacts that nobody truly comprehends what they're doing to Americans. We are just productive guinea pigs for the pharmaceutical business. The administration is doing such an extraordinary activity of ensuring you that the quantity of genuine medication communications rose in the primary quarter of this current year (2008) to another, record high that included very nearly 5,000 passings. The 21,000 reports in the quarter were multiple times higher than any quarter in 2007.

In any event, when utilized appropriately as per current conventions medications can have unintended outcomes. A couple of years prior a patient looked into his nearby emergency clinic with a contamination and was expeditiously given anti-infection agents. After twelve weeks he passed on from the disease. By considering the germs' hereditary improvement while he was in the medical clinic analysts have found there were 35 particular transformative advancements inside that brief timeframe length which in the end made the germ totally sedate safe.

Anti-microbial medications can likewise negatively affect valuable microscopic organisms the live in our guts, particularly with drawn out or rehashed medicines, as per an ongoing report. We need great gut microscopic organisms for nourishment, digestion and insusceptible reactions. While taking anti-infection agents analysts found that 30% of the bacterial species and strains were fundamentally influenced and it took as long as about a month for the greater part of them to come back to pre-treatment levels.

Perhaps there are reasons such a large number of specialists are utilizing fake treatments? An examination distributed as of late in BMJ, some time ago the British Medical Journal, found that half of specialists state they recommend fake treatments for their patients and more than 66% trust it's reasonable to do as such. The investigation was incompletely subsidized by our National Institutes of Health (NIH) and the outcomes are like studies of doctors in Israel, Denmark and in Britain.Legal steroids For Sale

Congress heard declaration this year that the Food and Drug Administration (FDA) basically doesn't have the labor to ensure the wellbeing of these items. There have been a few reports in the news this time of one-sided contemplates being submitted to the FDA for tranquilize endorsement which don't present the entire story on the medication's perils. On account of BPA, which the FDA has administered to be "protected", their own survey board has said the organization overlooked government contemplates on the compound and depended too vigorously on industry look into. While different nations like Canada have just administered against BPA in items for infants and kids Americans are as yet presented to this risky compound. Unmistakably the medication business has bunches of companions in Washington and the FDA.

The Journal of the American Medical Association distributed an examination this year cautioning against another age of "organic" drugs. About 1/fourth of these medications created genuine reactions that prompted security admonitions not long after they went available. Initially everybody felt that a medication dependent on organic, rather than synthetically counterfeit, fixings would be more secure. Unmistakably that thought has been disproven.

Americans don't have the foggiest idea what motivators the pharmaceutical business is giving to specialists to invigorate more medication deals. Various endeavors to pass enactment requiring divulgence have been murdered by industry lobbyists at both state and government levels. There have been a few cases standing out as truly newsworthy as of late about mind blowing installments to specialists to advance medications. It's arrived at the point that Eli Lilly and other medication organizations are starting to post the sums they pay specialists for discourses and counseling since they understand it's turning into an advertising bad dream. With more than 66% of teachers and specialists at therapeutic schools having direct monetary connections to the medication business the open sees what seems, by all accounts, to be an excessively cozy connection among specialists and medication organizations. Congressperson Charles Grassley (R-Iowa) keeps on squeezing for new daylight laws to reveal a little insight into this comfortable plan that puts the soundness of all Americans in danger.

You're as of now consuming medications that your primary care physician never recommended. That is on the grounds that emergency clinics and nursing homes as of now are legitimately dumping in excess of 250 million pounds of physician endorsed drugs into America's water supply each year. USA Today and different productions have detailed that these medications are enduring the treatment procedure and into the faucet water of a huge number of Americans. Again the FDA says the sums are too little to be in any way risky. As opposed to that supposition, homeopathy is a 100-year-old treatment utilized generally in Europe depends on the idea that even moment measures of a substance can be naturally dynamic. Once more, how long will it take for somebody at the FDA or in Congress to understand the strength of our country is in danger due to doctor prescribed medications?

In the mean time the strength of Americans keeps on declining even while our medication use keeps on climbing. Heftiness in our nation has made the pace of diabetes twofold in simply the most recent ten years. We have heaps of medications to get diabetes yet none forestall it. What number of these medications are causing the heftiness that thusly brings about diabetes?

400 years back the creator of Gulliver's Travels, Jonathan Swift, composed that the three best specialists on the planet were Dr. Diet, Dr. Calm and Dr. Merryman. After four centuries we're despite everything finding that what we eat and drink, the harmony we find inside ourselves and the delight we find inside life are the establishment of our wellbeing. (Since they didn't have vehicles and force apparatuses in those days I'd presumably include Dr. Exercise today.)

To show the significance of way of life to our wellbeing, this year Medicare affirmed the Ornish Program as the primary way of life treatment to invert coronary illness. The treatment was acknowledged in light of the fact that it's been medicinally demonstrated to be more compelling than drugs. However it's despite everything considered an elective treatment on the grounds that most specialists would prefer to compose solutions for medications or give angioplasty, stent or even by-pass medical procedure than talk about a way of life treatment with their patients. To be reasonable, most patients would prefer to pop a pill or have medical procedure than profoundly change their way of life to advance better wellbeing.

Rather than popping another perilous medication possibly it's the ideal opportunity for Americans to assume liability for their own wellbeing and take a gander at the decisions we make each day. Rather than putting more conduit tape on their medical issues perhaps it's a great opportunity to fix the wellspring of the issue appropriately. Above all else you should give yourself an opportunity to recuperate normally or attempt some chicken soup as opposed to racing to the specialist for anti-toxins or steroids ever time you have a sneeze. Take a stab at searching for an integral or elective treatment to treat the wellspring of your medical issue rather than essentially concealing it with progressively physician endorsed drugs.

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alexking123us · 3 years

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Diabetic Neuropathy Market with Potential Impact of Coronavirus (COVID19), SWOT Analysis, Risk Analysis, and Forecast by 2028

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In addition to this, the report also covers the section of competitive landscape of the global market, which includes the market share & positioning of all the leading players in the industry. The competitive landscape analysis provides in-depth analysis of the company’s business and performance including company overview, recent investments by top players, financial information of market players, business strategy, revenue breakup by segment and by geography, SWOT Analysis, key product offering, marketing and distribution strategies, new product development. A section of recent news & development has been added to the report which covers the latest information that are related with the market covering the acquisition, expansion, technology development, research & development activities, and other market activities.

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Market Segments by Geographies and Countries

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Antidepressant

TCAs

SNRIs

SSRIs

Analgesic

Amitriptyline

Imipramine

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Duloxetine

Others

Citalopram

Paroxetin

Others

Topical

Opioids

NSAIDs

Anticonvulsants

Capsaicin

Morphine

Others

Ibuprofen

Naproxen

Others

Gabapentin

Pregabalin

Topimarate

Others

- Radiotherapy

TENS

Others

- Physiotherapy

By Distribution Channel

- Hospitals

- Retail Pharmacy

- Clinics

- Online Pharmacy

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The report analyses the market by geographies i.e. North America, Europe, Asia Pacific, Latin America & Middle East & Africa. Further, the regions are fragmented into the country and regional groupings:

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- Asia Pacific (China, India, Japan, South Korea, Indonesia, Taiwan, Australia, New Zealand, and Rest of Asia Pacific)

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The central members of the market are recorded in this segment of the examination. It assists with understanding the strategies and unions that players focus on battling market competition. A fundamental infinitesimal glance at the market is given in the essential investigation. The significant players working in the Global diabetic neuropathy market are

Boehringer Ingelheim GmbH

Eli Lilly and Company

NeuroMetrix, Inc

Johnson & Johnson

Lupin Limited

GlaxoSmithKline plc

Astellas Pharma Inc

Pfizer Inc

Glenmark Pharmaceuticals Ltd

Depomed

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#Global Diabetic Neuropathy Market Diabetic Neuropathy Market Diabetic Neuropathy Market Size Diabetic Neuropathy Market Trends

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pharmaphorumuk · 4 years

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Lilly raises 2020 earnings forecast on pandemic stockpiling

Stockpiling of drugs for chronic diseases like diabetes during the coronavirus pandemic lifted Eli Lilly’s first-quarter results, and caused it to raise profit predictions for the year.

Lilly is the first drugmaker to report a hike in sales driven by the COVID-19 outbreak, estimating that stockpiling swelled worldwide revenues by around $250 million in the first three months of the year, mainly coming from Trulicity (dulaglutide) and insulins for diabetes as well as psoriasis treatment Taltz (ixekizumab).

All told, Lilly’s sales rose 15% to $5.86 billion, and while the company kept its forecast for full-year sales at $23.7 billion to $24.2 billion, it raised the top end of its estimated 2020 earnings per share (EPS) range by 10 cents, to $6.70-$6.90.

Shares in Lilly were up around 2.65% after the results announcement, which saw Trulicity grow by an impressive 40% to $1.23 billion in the quarter and Taltz surge 76% to $443 million.

Both drugs performed well despite having to jostle for share in increasingly competitive markets, with Trulicity benefiting from its recent FDA approval for the reduction of major adverse cardiovascular events (MACE) in high-risk type 2 diabetes patients. That helped it fend off a challenge from Novo Nordisk, its arch-rival in the GLP1 agonist drug category.

IL-17 inhibitor Taltz’s growth came despite playing catch-up with Novartis’ category leader Cosentyx (secukinumab).

Lilly’s blockbuster insulin brand Humalog (insulin lispro) saw revenues fall 5% to $696 million thanks to price cutting, but still performed better than expected by analysts, while biosimilar Basaglar (insulin glargine) grew 21% to $304 million.

Chief financial officer Josh Smiley said that Lilly “exited 2019 with strong revenue growth and margin expansion, driven by the uptake of our newer medicines.”

He went on to say that “momentum continued in Q1 2020 and was augmented by higher patient and supply chain purchasing due to the COVID-19 pandemic,” but also sounded a note of caution.

“Our revenue and operating margin outlook for 2020 is unchanged, but the economic and healthcare consequences of this pandemic are uncertain and could negatively affect our financial results later in 2020 and beyond,” he warned.

The update comes after Roche saw pressure on some drugs in the first quarter, such as multiple sclerosis therapy Ocrevus (ocrelizumab), as a result of delayed appointments caused by the pandemic. That was offset by rocketing sales of arthritis therapy Actemra, which could have a role to play in treating severe coronavirus infections.

Meanwhile, Johnson & Johnson – often the first big pharma group to report – lowered its earnings forecast due to COVID-19, saying that the economic impact of the pandemic and lockdowns would start to have an impact later in the year.

The post Lilly raises 2020 earnings forecast on pandemic stockpiling appeared first on .

from https://pharmaphorum.com/news/lilly-raises-2020-earnings-forecast-on-pandemic-stockpiling/

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cutsliceddiced · 5 years

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New top story from Time: The Price of Insulin Has Soared. These Biohackers Have a Plan to Fix It

In a hip Oakland, Calif., neighborhood, just blocks from cocktail bars and swanky Mexican restaurants, is an enormous warehouse, home to Counter Culture Labs, ground zero for an audacious challenge to the high cost of prescription drugs. In the entryway stands a 1½-story cardboard T. Rex, and inside it’s a bit as if Dr. Frankenstein shared his lab with a hoarder: cluttered shelves hold piles of drying mushrooms, Clorox wipes, wires, kitchen pots, motor oil, two books about Darwin, ropes, a broken alarm clock, a telescoping magnifying glass, a heat gun, a 3-D printer and several jars of clear liquid with tubes running between them. One shelf holds plastic bins labeled Lab Coats, Paint & Brushes and Ebola Suits.

A group of professional scientists and amateur tinkerers founded Counter Culture Labs in 2013 with the goal of bringing biotechnology to the masses. At any time, it hosts dozens of projects; when I visit in July, there’s one whose objective is to make “vegan cheese” using yeast.

The Open Insulin Project has bigger plans. The group wants to reverse engineer how the world’s largest pharmaceutical companies produce insulin and then turn over the instructions to the public. In theory, anyone with a bit of cash could then build a DIY lab in their garage and make open-source insulin.

Photo-composite, photographs by Greg Kahn for TIME

Currently three companies—Eli Lilly, Novo Nordisk and Sanofi—control most of the world’s $27 billion insulin market, using a complicated web of regulations and patents to keep a hold on it. Open Insulin wants to rebuild it with no megacorporations and no profit. The project is probably months, if not years, away from actually making medical-grade insulin, but its objective is as much political as it is production-oriented: bringing a sharp focus to the stratospheric price of insulin and, more broadly, the predatory pricing of prescription drugs in the U.S.

Over the past 60 years, the list price of a vial of insulin has gone from about 75¢ to $250—an increase nearly 43 times the rate of the U.S. Consumer Price Index inflation. “High drug costs exist throughout the system, but insulin is the poster child of this broken marketplace,” says Representative Tom Reed (R., N.Y.), one of the chairs of the Congressional Diabetes Caucus. Some, in fact, think that the project is already working as a kind of provocation: a way to force the issue on what is really a policy problem. “If the price of insulin gets regulated, the project will just go away,” says Jean Peccoud, a professor of chemical and biological engineering at Colorado State University.

For now, the project seems to be in a regulatory safe space, but that may change as it gets closer to making actual medicine. In an email, a Food and Drug Administration (FDA) spokesperson acknowledged that the agency is aware of the Open Insulin Project, but noted, “We cannot comment on hypothetical situations or potential future states of regulation.”

Predatory pricing in the U.S. isn’t unique to insulin. A study of the world’s top 20 medications found that Americans pay an average of three times as much as patients in the U.K. do for a given drug. The science behind making insulin is old, which makes it a good first target for the disruption of the pharmaceutical industry.

Cayce Clifford for TIMEDi Franco, founder of the Open Insulin Project, works with yeast at Counter Culture Labs in Oakland, Calif.

Anthony Di Franco, one of the Open Insulin Project’s co-founders, has diabetes himself, and has watched as the price of managing his disease has gone up and up. He has a dual undergraduate degree in physics and math/computer science from Yale University and is currently on leave from pursuing his Ph.D. in computer science at the University of California, Davis. He lives on contracting jobs, doing data science and researching machine learning and programming languages. Like many freelancers, he doesn’t have employer-sponsored insurance. But unlike most with the disease, he knew enough about science to start thinking there might be a better way—and so, in 2015, he launched the Open Insulin Project.

“The current system was built to exploit people with diseases,” Di Franco says. “Historians will look back and say, ‘How could they have done such a terrible job?’”

Diabetes is caused when the pancreas can no longer make enough or any insulin, a hormone that regulates blood sugar, or when a person’s body builds up a resistance to the hormone. Insulin, which helps the body use sugar for energy and lowers its levels in the blood, was first used to treat diabetes in the early 1920s. Physician Frederick Banting and medical student Charles Best were working with dogs, inducing diabetes by removing their pancreases and then trying to figure out a cure. The two eventually extracted a substance from cow pancreases; purified it with the help of biochemist James Collip; and proved it worked by injecting it themselves and noting that they got dizzy, a sign of low blood sugar. By 1922, doctors were using insulin from cow pancreases to treat diabetes patients.

People with severe diabetes need insulin injections to stay alive. Without it, your blood turns acidic, your body dehydrates, your vision blurs, you get weaker and start to vomit. Over days, you slowly—and painfully—die.

This fact, coupled with the inefficiencies of the American health system, as well as a manipulable patent framework, has enabled pharmaceutical companies to steadily increase the price of the lifesaving drug, even as it’s become easier and less costly to produce. Generally speaking, drugs are cheap to make. The costs are mostly to pay for the research and development required to discover them. For example, one 2016 study that looked at 106 recently approved drugs from 10 different companies found that the average R&D cost for each was $2.78 billion, compared with only about $19 million per drug in costs of actual clinical trials.

Much of the industrialized world has some form of single-payer health insurance and strict price controls on drugs, usually determined by a board of doctors and experts. In the U.S., the pull of the free market was supposed to keep prices down, but instead has led to a complex system of profit-driven corporations, from manufacturers to insurance companies, who add cost at every juncture.

It wasn’t meant to be this way, especially not with insulin. Banting, who shared a 1923 Nobel Prize for his work on insulin, demanded his name not be put on the patent, believing profiteering off a medicine was unethical. His co-discoverers agreed, transferring their patents to the University of Toronto for $1 each.

The pharmaceutical corporation Eli Lilly and Company of Indianapolis offered to help the university develop the medication, and the school eventually agreed to license the technology. Eli Lilly contracted with slaughterhouses to receive pig pancreases by railroad car in order to squeeze out the insulin. It was crude, but effective—and cheap. Ads from the 1960s show vials of insulin available for 84¢ in the U.S., just $7.36 in today’s dollars. And then came a real breakthrough.

In 1982, Eli Lilly introduced insulin made by genetically modified E. coli bacteria. The new insulin was less likely to cause allergies than the animal version, and it could be grown in vats. Novo Nordisk started making its own bioengineered insulin in 1991, and it looked like the drug was about to get really affordable, thanks to the competitive marketplace. Instead, prices went up. A congressional report written in 2018 found the list price of competing insulin formulations “appeared to rise in tandem,” doubling from 2012 to 2018. According to the report, that was most likely due to limited market competition, and to the fact that “each part of the insulin delivery chain is controlled by a small number of entities.” The marketplace never became competitive.

In theory, the U.S. patent system, which gives manufacturers sole rights to a drug formulation for 20 years, should eventually enable other drug producers to bring cheaper versions of the same medication to the market. But as Reed and the co-chair of the Congressional Diabetes Caucus, Diana DeGette (D., Colo.), note, companies skirt this by “evergreening” their drugs—tweaking drug formulas slightly, often making incremental improvements, to renew the patent and prevent generics from ever entering the market. Lantus, a long-acting insulin patented by Sanofi in 1994, was due to enter the public domain in 2015, but instead the company filed 74 patents for newer versions of the drug, which delayed that until 2031. Novo Nordisk has done something similar with one type of insulin by upgrading the mechanics of its injection pen. These insulins are touted as improvements, although there is evidence these are typically minimal.

“People with diabetes experience different issues and complexities that can’t be covered by one solution, which is why we continue to bring forth programs that will directly benefit even more patients and work toward much needed longer-term systemic reform,” said a Novo Nordisk spokesperson in an email.

An Eli Lilly spokesperson told TIME in an email that the company does not evergreen. “None of our insulins is patent-protected and our most commonly used insulin, Humalog 100, lost patent protection in 2014,” the spokesperson said. While the patent for Humalog 100 has expired, because of the complexities of entering the market, only one manufacturer jumped in to make a version of the drug: Sanofi, which already makes its own formulation. Sanofi’s “generic” version of Humalog sells for just 15% less than its original price. Eli Lilly is also manufacturing an “authorized generic” version, currently selling for 50% of the price.

A Sanofi spokesperson, meanwhile, writes that the company’s original patent on Lantus has expired and subsequent patents “are related to new and unique inventions.” They also point out that despite increases in the listed price for Lantus, the actual price customers pay is lower than it was in 2006, a result of other inefficiencies in the market. The spokesperson added that “we also support a robust and competitive marketplace, including efforts by other organizations to develop new technologies and medicines—including Open Insulin Project.”

For insured diabetics, the high costs of insulin are borne primarily by their insurers, and so remain more or less hidden. But for those without insurance or for people on high-deductible plans that require them to pay for their own care until they hit a predetermined amount, these prices take lives. Alec Smith, a 26-year-old restaurant manager, couldn’t afford the $1,300 a month it took to manage his diabetes. In 2018, Smith was three days from a paycheck when he died alone in his apartment; investigators later found an empty insulin-injection pen in Smith’s home. The case made headlines, but the human price of the high cost of insulin isn’t hard to find. Some 13.2% of the 2.9 million people who take insulin in the U.S. do not take it as prescribed, and 24.4% asked their doctor for a lower-cost medication, according to the CDC.

It’s not going to take a Nobel Prize to make DIY insulin, just persistence. The good news for the Open Insulin Project is that it has the accomplished 33-year-old French biochemist Yann Huon de Kermadec as its lead scientist. He’s in the U.S. right now because his wife Louise Lassalle is studying for a Ph.D. at Berkeley. Huon de Kermadec donates his time, showing up at the lab five to six times a week to work long hours designing a new form of life: a yeast cell genetically engineered to produce a form of insulin people could use.

Cayce Clifford for TIMEHuon de Kermadec, lead scientist of the Open Insulin Project, at Counter Culture Labs

On his side is the fact that biotech is getting cheap. The same pressures that brought down the cost of total gene sequencing from a taxpayer-funded $2.7 billion project to a $200 drugstore test in under two decades mean you don’t need millions of dollars to start a biotech project anymore. The Open Insulin Project is able to do what it does because equipment has become so cheap—especially in the Bay Area, where high turnover in the biotech industry leads to a glut of second-hand, lab-quality gear—and, like your home computer, more powerful. There are now several companies that market vast databases of genes, searchable by utility, all of which are economical. Huon de Kermadec picked two sequences of genes: one that produces a protein that can be cut to make insulin, and one that makes the yeast resistant to a specific antibiotic.

Using these genes, he and the team created a formula for a plasmid, a tiny circular piece of DNA. Then he hired a company to manufacture a small quantity of these plasmids, which they sent to Counter Culture Labs in a tiny plastic vial. Dozens of companies offer this sort of service in the U.S., at prices as low as a few hundred dollars. Next, the team jammed the plasmids into yeast cells, and added an antibiotic solution to the cell cultures. That’s where the antibiotic-resistance gene comes in handy—the ones that successfully adopt the plasmid into their own DNA will survive, and those that don’t will die out. The next step would be to grow the surviving cells, which should contain the genes to produce both antibiotic resistance and the precursor protein for insulin.

The team thinks they’ve gotten this far. They know the yeast produces a molecule the size of insulin—which is a pretty good sign it is, in fact, insulin. But they’re scientists, so they’re not popping the champagne yet. They want to confirm that the molecule is indeed insulin by using mass spectrometry, a precise technique that allows scientists to identify specific proteins, before they say for sure.

Then they will have to prove their insulin is pure enough to inject into a person. They’ll also have to demonstrate they can make medical-grade insulin every time with their process. Then, to get it to the people, they’ll need to standardize the equipment so other people can manufacture or buy it.

When asked if he thought his team would eventually create a yeast that could produce insulin, Huon de Kermadec responded confidently. “Yes, of course,” he says, “it isn’t rocket science.” But then there are the regulatory hurdles.

Di Franco has been reading up on the history of democracy in ancient Athens and is trying to craft his organization’s bylaws in the spirit of the world’s first democracy. He also wants its product to be democratically affordable: Di Franco thinks roughly $10,000 should be enough to get a group started with the equipment needed to produce enough insulin for 10,000 people. Each of these $10,000 setups would be somewhere between a middle-school science experiment and an industrial laboratory, requiring rooms of equipment; think something closer to a medical-grade brewery than to a countertop bread machine. The resulting product, he says, would cost someone with diabetes dozens of dollars a month instead of hundreds.

That’s noble, in theory, but there’s a reason why the FDA puts a lot of effort into certifying the labs that make our medicines: mistakes can be fatal. The U.S. drug-development system may be expensive, but it does guarantee quality.

The Open Insulin Project falls into a black hole outside of FDA regulation, according to Peccoud, the Colorado State professor. For one thing, the project may skirt some regulations by being a nonprofit. Also, the FDA allows individuals to largely do whatever they want to themselves. “If you want to inject yourself with home-brew beer, there’s no law to stop that,” says Peccoud.

If it does reach a production phase, Open Insulin would have to conform to Good Manufacturing Practice, the FDA rules for factories that make medicine, food, cosmetics and medical devices. And because the group plans to share its insulin-production framework online, crossing state lines, there may be other legal issues on the horizon. One solution might be to partner with other players in the health care system, like hospitals and pharmacies, which create custom versions of everything from acetaminophen to opioids in a process called compounding and navigate the demands of the U.S. system already. However, that’s likely to make the final product more expensive.

Ultimately, it’s not clear that the Open Insulin Project’s real goal is to facilitate insulin minilabs across the U.S. The group intends to put the plan for their designer insulin-producing yeast online as soon as it’s done, but only for “research purposes,” says Di Franco. And without brewing facilities or the ability to check and purify the hormone, the plans themselves are a long way—scientifically and legally—from the point where anyone will be injecting homegrown insulin. Di Franco has offered up his own body as a proving ground once the lawyers sign off: “I’d be thrilled to be the first person to take the insulin,” he says.

There’s ample evidence that insulin doesn’t need to be as expensive as it is in the U.S., even without DIY labs. For one thing, just across the border with Canada, a vial of insulin costs $30. In January 2020, Colorado will become the first U.S. state to put a $100 cap on the co-pays insured patients pay for insulin. Minnesota is considering a similar law.

“It’s an old drug,” says Peccoud. “It’s not hard to produce. It should not be more expensive than Tylenol. Insulin is just pure greed. And a failure of government.”

via https://cutslicedanddiced.wordpress.com/2018/01/24/how-to-prevent-food-from-going-to-waste

#Time #top stories #IFTTT #news

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valgasnewsthings · 11 months

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Against dried corns.

Steam leg before sleep in hot water, dry, and fix to corn a lemon peel with lemon pulp, in 4 days for such compress corn will a full remove.

Wet onion peel in 97 Perc of vinegar for 2 weeks, apply on corn peel layer, bandage, keep for night, repeat cure a few times and corns remove.

If throat hurt.

3 tea.sp. pof onion peel, add 0.5 l. of water, boil, infuse for 4 hours, filter, and gargle ache throat and use one tea.sp. this infusion.

Mix onion juice and honey one to one, use one tbl.sp. for 3-4 times/day before meal.

Against muscles stretching.

Shortening recovering time with wraps of vinegar apple bottle, as warm bottle in any enamel dish, in warm vinegar dilute 2 tea.sp. of salt, add 4 drops of iodine, cool. Keeping this a long time. And in injury wet pads in remedy, press, apply on damage place , and on a top put ice cubes , close polyethylene packet and bandage fix. Lie ten min, not move, after apply a tight bandage on ache side.

Of hyppophae infusion.

250 gr of berries add in 250 ml. of hot water, infuse 4 hours, filter, do lotions on skin rashes.

250 gr of fruits hyppophae and leafs and add 250 ml. of hot water, infuse 5 hours, filter, use 50 gr for 3 times/day in scurvy, avitaminosis, gout, rheumatrism.

Walnut is a remedy.

Activating and stimulating pancreas gland and sugar diabetes fighting cook infusion of leafs walnuts 20 gr, root of burdock big 45 gr, fruits of crataegus 50 gr, herb lilly of the valley 15 gr, herb veronica officinalis 25 gr, herb cudweed 30 gr, chop all, and mix, use one tbl.sp. in one glass of the hot water, boil 5 min is on the weak fire, infuse 4 hours , filter, use for 3 times/day on 1/2 glass before meal. And in diabetes tea changes on leafs of walnut infusion 50 gr for one l. water.

In often headaches every day eat on the meal time one tea.sp. honey mixed in one tea.sp. of apple vinegar.

from Valga s health news,gardening,and cooking ,and beauty . https://ift.tt/OMxSE1p via https://ift.tt/v2PhSmi

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myabhijitr · 6 years

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Recombinant Therapeutic Antibodies and Proteins Market to Reach US$ 250 Billion by 2026

The Global Recombinant Therapeutic Antibodies and Proteins Market, by Drug Class (Plasma Protein, Growth Factors, Fusion Proteins, Monoclonal Antibodies, Hormones, Enzyme, Coagulation Factors, and Others), by Application (Oncology, Hematology, Immunology, Endocrinology, Infectious Disease, Cardiovascular Disease, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) was estimated to be valued at US$ 91.2 billion in 2017 and is projected to exhibit a CAGR of 12.2% over the forecast period (2018 – 2026), as highlighted in a new report published by Coherent Market Insights. Recombinant therapeutic antibodies and proteins market is expected to grow at significant rate, owing to increasing advancements in development of recombinant therapeutic drugs.

Request Sample Copy Of This Report: https://www.coherentmarketinsights.com/insight/request-sample/1981

Increasing focus on recombinant therapeutics for drug development is expected to drive growth of the recombinant therapeutic antibodies and proteins market revenue

Demand for recombinant therapeutic antibodies and proteins is increasing significantly with a constant need to improve the existing expression systems or developing novel approaches to meet the demand for new therapeutics. Pharmaceutical recombinant protein is increasingly used in treatment of diseases such as cancer, diabetes, anemia, and hepatitis. Medicinal and industrial use of recombinant protein in drug manufacturing is rising along with increasing demand for various protein expression systems and other related high-tech systems. Recombinant therapeutic antibodies and proteins market is expected to exhibit high growth, owing to increasing adoption of protein-engineering technologies and government support for its development.

For instance, in 2012, the Food and Drug Administration Safety and Innovation Act (FDASIA) was signed to provide the FDA with the capability to establish breakthrough therapy designation (BTD), a new program within the Expedited Programs for Serious Conditions. It was designed to be available for drugs used to treat a serious illness that have been shown to exhibit clinical evidence of significant improvement in comparison to existing treatments.

Companies are focusing on engineering strategies and rational design to modify drug activity for generation of novel therapeutics related to specific clinical requirements. For instance, in 2015, alirocumab injection (Praluent, Regeneron/Sanofi), the first cholesterol-lowering treatment in a new class of drugs known as proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors received FDA approval.

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Browse 22 Market Data Tables and 27 Figures spread through 160 Pages and in-depth TOC on “Recombinant Therapeutic Antibodies and Proteins Market, by Drug Class (Plasma Protein, Growth factors, Fusion Proteins, Monoclonal Antibodies, Hormones, Enzyme, Coagulation Factors, and Others), by Application (Oncology, Hematology, Immunology, Endocrinology, Infectious Disease, Cardiovascular Disease, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Global Forecast to 2026”

Key Takeaways of the Recombinant Therapeutic Antibodies and Proteins Market:

The global recombinant therapeutic antibodies and proteins market size is expected to exhibit a CAGR of 14.2% over the forecast period, owing to increasing focus on recombinant therapeutics for drug development.

Among drug class, the monoclonal antibodies segment is estimated to hold the dominant position in the recombinant therapeutic antibodies and proteins market, in 2017, due increasing applications of mAbs in therapeutics.

Among application, the hematology segment is estimated to hold the dominant position in the recombinant therapeutic antibodies and proteins market, in 2017, owing to increasing number of approved products available in this category.

Key players operating in the global recombinant therapeutic antibodies and proteins market include Abbott, Amgen Inc., Biogen Inc., Eli Lilly and Company, F. Hoffmann-La Roche, Johnson and Johnson, Merck & Co., Novo Nordisk, Pfizer Inc., and Sanofi S.A.

Click To Continue Reading On Recombinant Therapeutic Antibodies and Proteins Market

About Coherent Market Insights:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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#Recombinant Therapeutic Antibodies and Proteins Market

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pinolaphoto · 7 years

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Photographing the Lilly Diabetes 250

Spending The Day At The Indianapolis Motor Speedway For the second straight year I have been lucky enough to photograph the Brickyard 400 at the Indianapolis Motor Speedway. The speedway is a magical place that is fun and challenging to shoot at. To change positions you really have to go a long ways. Once I learned to use the golf carts that would go by it made life much easier for me. Racing is…

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#Photography #Sports Photography

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feminismyall · 7 years

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XFINITY rookie William Byron holds off Paul Menard in Brickyard debut

William Byron, driver of the #9 Liberty University Chevrolet, kisses the yard of bricks after winning the NASCAR XFINITY Series Lilly Diabetes 250 at ... from Google Alert - the garage http://ift.tt/2gTB4Me

#IFTTT #Google Alert - the garage

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alexking123us · 3 years

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Diabetic Neuropathy Market 2021-28: Company Profile, Import/Export Scenario, Business Strategies and Emerging Market Segments

The Global Diabetic Neuropathy Market 2021-2028 Report provides an in-depth analysis on the studied market that helps to seem at the longer term requirement also as prediction. The Diabetic Neuropathy Market Report evaluates the market by key market players, opportunities, value, trends, growth, market share, market competition landscape, recent developments and sales volume analysis. Additionally, it magnifies the chance for decision-making and helps create an efficient counter-strategy to realize a competitive advantage. The report provides up-to-date review of the present global market scenario, the newest developments and drivers, and therefore the overall market environment is given within the study.

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It provides the impact and recovery of Covid-19 pandemic on the diabetic neuropathy Market. Relevant statistical data is additionally provided within the report back to recognize the challenges caused by the outbreak of Covid-19 and methods to cope up with the present scenario.

In addition to the present, the report also covers the section of competitive landscape of the worldwide market, which incorporates the market share & positioning of all the leading players within the industry. The competitive landscape analysis provides in-depth analysis of the company’s business and performance including company overview, recent investments by top players, financial information of market players, business strategy, revenue breakup by segment and by geography, SWOT Analysis, key product offering, marketing and distribution strategies, new development. a neighborhood of recent news & development has been added to the report which covers the newest information that are related with the market covering the acquisition, expansion, technology development, research & development activities, and other market activities.

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The Following are the Key Features of Global Aluminium Trays Market Report:

Market Overview, Industry Development, Market Maturity, PESTLE Analysis, Value Chain Analysis

Growth Drivers and Barriers, Market Trends & Market Opportunities

Porter’s Five Forces Analysis & Trade Analysis

Market Forecast Analysis for 2020-2029

Market Segments by Geographies and Countries

Market Segment Trend and Forecast

Market Analysis and Recommendations

Price Analysis

Key Market Driving Factors

Diabetic Neuropathy Market Company Analysis: Company Market Share & Market Positioning, Company Profiling, Recent Industry Developments etc.

Global Diabetic Neuropathy Market Segmentation Analysis:

By Disorder

- Peripheral Neuropathy

- Autonomic Neuropathy

- Proximal Neuropathy

- Focal Neuropathy

By Treatment

- Drugs

Antidepressant

TCAs

SNRIs

SSRIs

Analgesic

Amitriptyline

Imipramine

Others

Duloxetine

Others

Citalopram

Paroxetin

Others

Topical

Opioids

NSAIDs

Anticonvulsants

Capsaicin

Morphine

Others

Ibuprofen

Naproxen

Others

Gabapentin

Pregabalin

Topimarate

Others

- Radiotherapy

TENS

Others

- Physiotherapy

By Distribution Channel

- Hospitals

- Retail Pharmacy

- Clinics

- Online Pharmacy

Regional Insights:

- North America (U.S. & Canada)

- Europe (Germany, United Kingdom, France, Italy, Spain, Russia, and Rest of Europe)

- Asia Pacific (China, India, Japan, South Korea, Indonesia, Taiwan, Australia, New Zealand, and Rest of Asia Pacific)

- Latin America (Brazil, Mexico, and Rest of Latin America)

- Middle East & Africa (GCC (Saudi Arabia, UAE, Bahrain, Kuwait, Qatar, Oman), North Africa, South Africa, and Rest of Middle East & Africa)

Reasons to purchase the report:

Identify possible investment areas supported a comprehensive analysis of the worldwide diabetic neuropathy Market over subsequent few years.

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Channelize funds by concentrating on the continued initiatives pursued by the various countries within the global diabetic neuropathy Market.

Competitive Analysis:

The key players of the market are listed during this section of the study. It helps to know the tactics and alliances that players consider fighting market rivalry. An important microscopic check out the market is given within the detailed study. The major players operating in the Global diabetic neuropathy Market are

Boehringer Ingelheim GmbH

Eli Lilly and Company

NeuroMetrix, Inc

Johnson & Johnson

Lupin Limited

GlaxoSmithKline plc

Astellas Pharma Inc

Pfizer Inc

Glenmark Pharmaceuticals Ltd

Depomed

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Our clients list includes various Fortune 500 companies and leading advisory firms.

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#Global Diabetic Neuropathy Market Diabetic Neuropathy Market Diabetic Neuropathy Market Size Diabetic Neuropathy Market Trends Diabetic Neur

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dinafbrownil · 4 years

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California Rx: State May Dive Into Generic Drug Market

SACRAMENTO — California is poised to become the first state to develop its own line of generic drugs, targeting soaring drug prices and stepping into a fiercely competitive drug market dominated by deep-pocketed pharmaceutical companies.

The Democratic-controlled legislature overwhelmingly approved a measure Monday that would direct the state’s top health agency to partner with one or more drug companies by January to make or distribute a broad range of generic or biosimilar drugs — including the diabetes medicine insulin — that are cheaper than brand-name products.

The bill, SB-852, also opens the door for California to make its own generic drugs in the future.

Gov. Gavin Newsom will have until Sept. 30 to sign or veto the measure.

“People need these drugs, but prices are through the roof, so we’re saying there’s a role for the state to bring prices down,” said the bill’s author, state Sen. Richard Pan (D-Sacramento).

He argued the measure is more important than ever because COVID-19 has exposed “glaring gaps” in the ability of public and private entities — from major hospitals to government drug purchasers — to maintain adequate supplies of drugs, medical equipment and devices.

“This also creates a model to address drug shortages and other supply chain issues during COVID and future pandemics,” he said.

Newsom, a Democrat, floated his own generic drug proposal in January as part of his broader drug agenda to reduce pharmaceutical costs, but was forced to abandon his plan in May as he and lawmakers sought to address a pandemic-induced $54 billion budget deficit.

Though it could take years to successfully bring a new California generic product to the market, the move would put the nation’s most populous state in direct competition with major generic and brand-name drug manufacturers that dominate the market, and potentially allow California to use its massive purchasing power to drive down drug prices.

“Other legislative efforts in Congress and in other states have focused on government negotiating with pharmaceutical companies to lower prices on generic drugs,” said Edwin Park, research professor at the Health Policy Institute at Georgetown University.

The Pharmaceutical Research and Manufacturers of America, which represents brand-name drugmakers, has taken a neutral position on the bill and declined to comment.

But Brett Michelin, lead lobbyist for the Washington, D.C.-based trade group that represents generic drugmakers, the Association for Accessible Medicines, said generic companies aren’t threatened by the possibility of California entering the market — and even welcome it.

“Generic manufacturers are more than open to doing this kind of partnership,” Michelin said. “I think having a fair and open process to sell drugs and compete for customers is what the generic industry is very used to and comfortable with.”

Under the measure, state-developed generics would be “widely” available to public and private purchasers within California. Taxpayers would pick up the costs, roughly $1 million to $2 million in startup funding, plus ongoing staff costs estimated in the low hundreds of thousands of dollars annually, according to a state fiscal analysis.

It’s unclear which drugs the state would make or procure, though it would target drugs that could produce the biggest cost savings for the state and consumers.

But the bill specifically calls for the production of “at least one form of insulin, provided that a viable pathway for manufacturing a more affordable form of insulin exists at a price that results in savings.”

Insulin is a biologic drug, made with living cells. Once a biologic hits the market, rival copycat products that follow are called biosimilars.

Three major drug companies — Eli Lilly and Co., Sanofi and Novo Nordisk — have long controlled the lucrative insulin market in the U.S. The state of California would be the first entity to produce a biosimilar version of one of the newer, fast- and long-acting insulins on a not-for-profit basis, said Jane Horvath, a health policy consultant in Washington, D.C.

Although it would be costly and could take years, the Utah-based nonprofit drug company Civica Rx, which has consulted with Pan on his bill, is discussing partnering with California to produce generic or biosimilar drugs. It has already hammered out deals with major health systems running short on critical drugs, including the Department of Veterans Affairs, and is producing lower-cost generics for insurers, including Blue Shield of California.

“There’s no doubt insulin would be a more complex and expensive drug to develop, but it’s certainly possible,” said Allan Coukell, the company’s senior vice president of public policy. “We are watching how the biosimilar market develops.”

Patients who need insulin have faced huge cost spikes. A 2019 report by the Health Care Cost Institute concluded that average prices for insulin doubled from 2012 to 2016. And California health insurance regulators found last year that diabetes medications accounted for nine of the 25 costliest brand-name drugs sold in the state.

“It’s a big deal — diabetes affects a lot of people who rely on insulin for their very lives,” said Larry Levitt, executive vice president for health policy at the Kaiser Family Foundation. “And insulin has probably been the poster child for unreasonable drug pricing.” (Kaiser Health News, which produces California Healthline, is an editorially independent program of the foundation.)

Laura Marston, a Washington, D.C.-based lawyer and diabetic who advocates for lower insulin prices, said she’s excited about California’s idea.

Marston has been on the same insulin, Humalog, since 1996. At that time, the price was $21 a vial, but has since ballooned to more than $275 a vial, she said.

“If there was a lower-cost option and the price wasn’t going to be raised, I would absolutely switch from Humalog,” she said. “I feel held totally hostage to these pharmaceutical companies.”

Marston said she’d like the federal government to do the same thing, “so it could apply to all patients.”

Congressional efforts to tackle rising prices for insulin and other drugs fizzled last year in the face of opposition from the influential pharmaceutical lobby. So states have increasingly sought ways to regulate a for-profit industry in which brand-name manufacturers hold near-monopoly power.

Colorado last year became the first state to cap out-of-pocket insulin costs at $100 for a 30-day supply. It was followed by at least nine other states, from New Mexico to New York, whose cost-sharing caps vary.

California had already capped out-of-pocket drug costs at $250 to $500 for a 30-day supply, but a measure that would have lowered the cap for insulin to $100 a month stalled this year — a casualty of a pandemic-shortened legislative calendar.

Newsom’s office declined to comment on the generic drug legislation. But recent changes to the proposal reflect direct negotiations with the administration, Pan’s office said.

Newsom spokesperson Jesse Melgar said in a statement that “the governor’s goal of a sustainable system of universal coverage has not changed and making prescription drugs affordable is one more step toward that goal.”

Should Newsom sign the bill into law, the state Health and Human Services Agency would have 18 months to identify a list of drugs the state could manufacture, with a report due to the legislature by July 2022. By July the following year, the state would be required to assess whether it can manufacture its own generics and biosimilars.

The bill calls for state health officials to prioritize development of generics for chronic and high-cost health conditions, and urges production of those that can be delivered through mail order.

California could emerge as a leader in the national drug debate, Levitt said.

“If California can pull it off, it would be a model for other states and federally,” he said. “For it to pull this off means it can be done at scale.”

This KHN story first published on California Healthline, a service of the California Health Care Foundation.

Kaiser Health News (KHN) is a national health policy news service. It is an editorially independent program of the Henry J. Kaiser Family Foundation which is not affiliated with Kaiser Permanente.

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This story can be republished for free (details).

from Updates By Dina https://khn.org/news/california-rx-state-may-dive-into-generic-drug-market/

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wenickjones · 3 years

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Insulin Delivery Devices Market Investigation Highlights Contribution by Leading Players, during 2020-2030

The Global Insulin Delivery Devices Market 2020 report delivers a fundamental overview of the industry, including definitions, segmentation, applications and industry chain structure analysis. The global insulin delivery devices market report provides competitive landscape analysis, major trends, and key regional development status. It also offers a competitive framework for major revenue-contributing firms covering company market shares with comprehensive profiles. The report provides a key overview of the market status of insulin delivery devices manufacturers with market size, share, growth, market expansion, and technological innovations, as well as the industry cost structure.

It provides the impact and recovery of Covid-19 pandemic on the insulin delivery devices Market. Relevant statistical data is also provided in the report to recognize the challenges caused by the outbreak of Covid-19 and strategies to cope up with the current scenario.

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The Following are the Key Features of Global Insulin Delivery Devices Market Report:

Market Overview, Industry Development, Market Maturity, PESTLE Analysis, Value Chain Analysis

Growth Drivers and Barriers, Market Trends & Market Opportunities

Porter’s Five Forces Analysis & Trade Analysis

Market Forecast Analysis for 2020-2030

Market Segments by Geographies and Countries

Market Segment Trend and Forecast

Market Analysis and Recommendations

Price Analysis

Key Market Driving Factors

Insulin Delivery Devices Market Company Analysis: Company Market Share & Market Positioning, Company Profiling, Recent Industry Developments etc.

CLICK TO VIEW THE FULL REPORT WITH TOC: https://www.factomarketinsights.com/report/834/insulin-delivery-devices-market

Market Segmentation:

The segmentation of insulin delivery devices market is as follows By Type, By Distribution Channel. Both developed and developing regions are extensively studied in the report.

By Type

- Insulin Syringes

- Insulin Pens

- Insulin Pumps

-Others

By Distribution Channel

- Retail Pharmacies

- Hospital Pharmacies

- Online Sales

- Diabetes Clinics

By Geography

The regional segmentation of the market covers following regions: North America (U.S. & Canada), Europe (Germany, United Kingdom, France, Italy, Spain, Russia, and Rest of Europe), Asia Pacific (China, India, Japan, South Korea, Indonesia, Taiwan, Australia, New Zealand, and Rest of Asia Pacific), Latin America (Brazil, Mexico, and Rest of Latin America), Middle East & Africa (GCC, North Africa, South Africa, and Rest of Middle East & Africa).

Fundamental Coverage of the Insulin Delivery Devices Market:

Covid-19 impact and strategies to recover.

valuable information about the insulin delivery devices market

Identification of growth in various segments and sub segments of the studied market.

Strategic ideas for investment opportunities

Key statistical data along with products, price analysis, applications, levels of production and consumption, supply and demand.

Emerging developments in the existing market segment and research to help investors devise new business strategies

Accelerates decision-making by drivers and constraints

Competitive Analysis

The key players of the market are listed in this section of the study. It helps to understand the tactics and alliances that players concentrate on fighting market rivalry. An essential microscopic look at the market is given in the detailed study. The major players operating in the global insulin delivery devices markets are:

Becton

Dickinson and Company

Sanofi S.A.

Medtronic PLC

Braun Melsungen AG

Novo Novardisk A/S

Eli Lilly and Company

Biocon Ltd.

Yepsomed Holding AG

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Our in-house research experts have a wealth of knowledge in their respective domains. With Facto Market Research, you always have the choice of getting customized report free of cost (up to 10%). Our support team will help you customize the report and scope as per your business needs. This ensures that you are making the right purchase decision.

Our clients list includes various Fortune 500 companies and leading advisory firms.

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New York, USA 12207

+1 (518) 250-1215

Email:[email protected]

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