cailynnjohnson

[cailynnjohnson]

 microbial stabilization 

Live biotherapeutic products (LBPs) are defined as live organisms designed and developed to treat, cure, or prevent a disease or condition in humans. Notably, LBPs should exclude vaccines, filterable viruses, oncolytic viruses, and organisms used as vectors for transferring genes into the host to maintain their stabilization. Creative Biolabs is a pioneer and undisputed global leader in microbial stabilization services. We offer a full range of LBPs cGMP manufacturing services.

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iPSC based drug screening 

At Creative Biolabs, various types of stem cells were used to facilitated drug discovery. Based on their own unique characteristics, these cells can be applied in the research setting for a plethora of uses. We provide two different stem cell facilitated drug discovery services. 

iPSC facilitated drug discovery services  iPSC based drug screening iPSC-based toxicity and efficacy analysis  iPSC derived the animal model  iPSC-based target identification  Effects discovery of the drug on the individuals

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drug discovery services

With many years of experience and powerful technologies, Creative Biolabs has developed an innovative STEMOD™ platform to provide drug discovery services for our customers all over the world. Our dedicated team of specialists has an in-depth understanding of stem cell-based drug discovery and development, and will help you find the best-fit solution for your research requirements. In addition, we have optimized systems to quickly get satisfactory results and contribute greatly to the success of your programs. 

[cailynnjohnson]

neuroscience ex vivo models

Neural tissue damage in the peripheral nervous system (PNS) and central nervous system (CNS) may result in multiple neurological diseases and even life-long disabilities. Neural tissue engineering is a promising strategy for neural repair and neurological diseases treatment. In this case, proper preclinical models are required to mimic the micro-environment. Here, Creative Biolabs has developed the STEMOD™ neuroscience ex vivo models for our clients all over the world.

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whole-brain organoids

For decades, most of our understanding of brain development and diseases affecting the central nervous system (CNS) has been based on traditional two-dimensional cell cultures and animal models. While many experimental methods rely on rodents or non-human primates, the brains of these animals differ substantially from those of humans in terms of both their structure and function. Learn more about the applications of whole-brain organoids in research.

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neuropathology assay

Neurological diseases, which occur in the central and peripheral nervous systems, including Alzheimer's disease, stroke, and spinal cord injury, impose an incalculable burden and death on humans worldwide. Assessment of the pathophysiology and histology of neurological diseases will be key to designing research methods and understanding and managing possible long-term effects of the disease on patients with neurological disorders. Creative Biolabs provides neuropathology assay services to global neurobiological scientists to support your projects.

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peripheral neuroinflammation

Creative Biolabs is devoted to providing a variety of services in the field of life science to global customers. Neuroscience is a growing field with many cutting-edge scientific challenges that need to be addressed. Our experts in neuroscience integrate resources worldwide to help researchers design customized one-stop solutions, which enhance the mechanism of action studies and drug research and development in peripheral neuroinflammation.

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in vitro tau aggregation assay

Tau proteins do not spontaneously aggregate under either normal physiological or extreme conditions, as the tau aggregation interface exists in hydrophilic interactions. Pathological tau aggregation can spread to normal neurons and lead to fibrillization of tau and ulterior aggregation. Therefore, Creative Biolabs offers reliable in vitro tau aggregation assay services for our global clients to assist in the mechanism of action studies and therapeutic exploration.

[cailynnjohnson]

calcium influx

Instead, astrocytes employ calcium waves to nano-regulate neurotransmission effectively. By manipulating the degree of its own calcium influx, the astrocyte can alter the pacing and amplitude of calcium waves, hence influencing synaptic activity in a controlled manner.

#calcium influx

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Mini brain organoids

Mini brain organoids have become groundbreaking tools for in vitro studies of the complexity of the human brain. These miniature three-dimensional models provide extraordinary insights into brain development, disease mechanisms, and potential therapeutic interventions. However, despite their power, traditional organoids remain limited in their scalability, reproducibility, and ability to mimic the complex physiology of the human brain.

#Mini brain organoids

[cailynnjohnson]

photoreceptor cell line

Characterized by the functional deterioration of neurons, neurodegenerative diseases present severe implications for individuals and society. Creative Biolabs has developed several culture systems to study the pathogenesis of neurodegenerative diseases. Our diverse cell models allow better characterization of disease markers and in vivo physiological conditions. In addition, our model also improves the understanding of human neurodegenerative diseases and can better characterize pathological mechanisms. Learn more about the photoreceptor cell line.

#photoreceptor cell line

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nervous system

The nervous system consists of neurons, special cells that can receive and transmit chemical or electrical signals, and glial cells. Neurons are the basic functional units of the nervous system. They have a highly specialized form that allows them to receive and transmit information. Human brain contains about 100 billion neurons on average. They are electrically excitable and transmit information between cells through electrochemical signal transmission. In the brain, each neuron can form thousands of links with other neurons, thus forming a complex network of neural connections.

#nervous system

[cailynnjohnson]

neuronal cells

The human brain is a complex organ composed of a variety of cell types and signaling pathways. Since mature neurons do not undergo cell division again, it is necessary to establish immortalized secondary cell lines derived from neuronal tumors, that is, to acquire the ability to generate in vitro cultures of neuronal cells. The established molecular tools and stem cell line models can mimic the physiology of the brain for a better understanding of neurological diseases and treatment strategies. Based on our excellent primary cells, stem cells, and other cell line models, it would be possible to create in vitro culture systems that mimic in vivo environments.

#neuronal cells

[cailynnjohnson]

C3 convertase

All pathways converge at the level of the C3 molecule, where downstream events can be amplified by a mechanism of positive feedback supported by complement convertases, the classical/lectin pathway C3 convertase (C4b2a) or the alternative pathway C3 convertase (C3bBb). C3 convertases cleave C3 into C3a, a chemoattractant molecule, and C3b, which covalently binds to target surfaces and triggers phagocytosis.

#alternative pathway C3 convertase

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complement functional assay

Creative Biolabs is a leading diagnostic service company with a robust and standardized complement assay platform, supporting pre-clinical research in complement field. We offer a full range of complement function or activity test services and use high-quality standards in all operations, including the testing procedures and delivery reports. Our specialized and dedicated team is available to support our clients with R&D, pre-clinical development programs. Learn more about complement functional assay services.

#complement functional assay

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C-reactive protein

C-reactive protein (CRP) is an acute-phase serum protein. It is a member of the pentraxin family, produced mostly by cells in the liver in response to a variety of inflammatory cytokines. The levels of CRP in the blood are closely associated with the degree of inflammatory responses. CRP levels rise rapidly in response to threats such as trauma, inflammation, and infection and fall rapidly in response to remission. Thus, CRP levels are considered as non-specific markers of inflammation, and measurement of CRP levels has important clinical significance for the diagnosis of some inflammatory diseases such as rheumatoid arthritis, lupus, and vasculitis.

#C-reactive protein

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Liposomal formulations

Liposomes are an ideal drug delivery system because they are similar in morphology to cell membranes and can incorporate various substances. Therefore, liposomes have been widely studied in recent 50 years, and continue to be the hotspot of research. As the optimal drug delivery system for biologically active substances both in vitro and in vivo, liposomes have attracted much attention due to their biological and technological advantages, and are considered to be the most successful drug delivery system so far. Liposomal formulations can be used to overcome the non-ideal properties of drugs, such as limited solubility, serum stability, circulation half-life, biodistribution and target tissue selectivity.

#Liposomal formulations