#but there is scientific evidence to show that even just the average capitalist lifestyle is inducing harm

[donporterbeatcancer]

“Fall 2019 Status” on Health with Increased Longevity and How fund Huge Costs for Expanding Research Don Porter   Sept. 2019 (elysiumhealth.com) Real driving force in Longevity is HUGE $$$ Bonanza “Coming soon” - You listen to these people and their lingo is not "We're just trying to get rid of problems." It's "We want to live longer." Clearly that MANY of these new efforts are based out in CA and growing worldwide.  Many of the LARGE investors are the “Tech” wealthy billionaires and related. Since 2000, there has been a 20-fold increase* in research funding for anti-aging medicine. Estimates of a current $7.6 trillion market opportunity has been, and is currently, a magnet for Venture Capitalists (“VC”) etal. A Resource Map: Business Innovation in the Longevity Market  recently provided a glimpse of the funding and support ecosystem for the people and businesses who are seeking to meet the demands of an aging society. Estimates indicate that these markets will reach in 2050 to $400 trillion for the eight largest economies studied.  In 2016 AARP and Oxford Economics published The Longevity Economy report showcases how longer lifespans and employment are driving dollars into funding patterns. Investment in longevity market startups is a growing event, the VC community has discovered the fact that, next to millennials, this is the largest market in the world and it’s grossly underserved.”   There is a significant message when iconic innovators in Silicon Valley-people like Peter Thiel,  Facebook investor and PayPal founder, Jeff Bezos, British billionaire investor Jim Mellon, Oracle co-founder Larry Ellison, Google co-founder Sergey Brin -are clearly committed to life extension and they're REALLY fascinated by their “ OWN” life extension. Some have committed huge sums with individual estimates topping out at $450 million!  They are like the "American immortal"-people interested in life extension and immortality. Longevity, living forever-and if not forever, 250 or 1,000 years-is really what we ought to be aiming at. And once you've got cultural leaders, or opinion leaders, saying this, people BUY into it. And it feeds into a whole situation of "Yes, dying is a bad thing." What’s more, money for Longevity research is pouring in. Last year saw record-high financing in the anti-aging industry, according to CBInsights, including a $438 million round of financing in August from Samumed, a regenerative medicine company, and a $210 million series in February from Celularity, which aims to develop stem cell therapies for aging-related conditions. In May of 2018, Unity Biotechnology rolled out a splashy $712 million IPO, and just a month later it launched the first human clinical trials to test drugs called senolytics, a new class of drugs that target the aging process.   And yet, some individual approaches have astonishing reach, says Judith Campisi, Ph.D., a professor of biogerontology at the Buck Institute for Research on Aging, a member of the SENS Research Foundation Advisory Board and the scientific founder of Unity Biotechnology. Although she has been studying cellular senescence for most of her career, Campisi says she is still surprised at the massive and growing number of anti-aging benefits conferred by clearing away senescent cells. Senescence is now understood to be the major source of the chronic inflammation that drives so many age-related diseases. Quality Health is MOST important. One of these NEW drugs, like senolytics, metformin, shows a modest life-extending effect and adds a few years of life. Then the question is: What are the downsides?  There may be a cognitive downside, maybe a little more mental confusion, etc. Many say “quality of life over quantity of life." But when push comes to shove, it's becoming really quantity of life. However, the only way for people to live a lot longer (let alone indefinitely) is by staying truly healthy.  Regenerative medicine is all about good health, and since people who are perfectly healthy continue living, why act as if those who support medicine for the elderly are somehow "greedy" when biological age-related illnesses (like Alzheimer's and macular degeneration) are what cause much suffering. Reality still has to address questions such as WHY do certain living creatures live so long ? MAJOR Developments due to tech explosion with many areas of prior investigation including: Telomeres, Stem Cells, DNA, Autophagy, Microbiota Genes, Mitochondrial, Senescent cells, senolytics, fisetin, quercetin, etc. • MASSIVE Expansion of complex Immune System data in Expanding Powerful o Computers, and AI !  Ai beats humans at ALL complex disciplines even Chess. • Complexities of LONG living creatures is increasingly discoverable ! Major studies on WHY some living creatures live 200+ years: • Greenland Shark   • Bowhead Whale             • Galapagos Giant Tortoise   • African Elephant   • Macaw • Long Finned Eel • Koi Fish       • Red Sea Urchin seems to be almost immortal • USA’s AMA has operated the greatest Brainwashing extravagances in human history – NO HEAL NO CURE, quick fix drugs that distort immune function ! Brainwash ALL doctors, as AMA runs ALL medical schools and the Drug cos., along with the FDA, Ignore Immune System. • Now new tech wealth seek Health with Longevity and increased focus on Healing and Curing. • Emerging challenge - how get max return on huge investments to obtain Longevity ? Must be a drug for Large returns for MANY health issues. Herbs are partnered with drugs so create a New Drug ! Simple methods for success: Quality diet, EXCERSISE, Minimize stress, Quality  relationships. Lifestyle Changes Aimed at Slowing Aging • Live Well: We’ve been hearing for decades now about the health benefits of exercise, good diet, conservative amounts of booze and no cigarettes. But in 2018, we learned that all of these things combined can add over a decade to your life. Last April, scientists from Harvard published a 34-year study of 79,000 American adults in the journal Circulation that found that never smoking, a body mass index of 18.5 to 24.9, over 30 min per day of moderate to vigorous exercise, moderate alcohol intake and high-quality diet could extend lifespans by 12 years for men and by 14 years for women. • 2. Don’t Starve: Fasting is no longer just a fad. Scientists have now shown repeatedly that reducing caloric intake can slow aging and reduce risks for age-related disease. But now it seems you can fast and eat your cake, too. Last year, researchers found that timing meals to mimic fasting without reducing total caloric intake can have similar anti-aging effects, improving the incidence and severity of age-related diseases such as cardiovascular disease, diabetes, cancer, and dementia. • 3. Healthy Minds: We know that mental disorders including substance abuse take a toll on our health, but it turns out they can also accelerate aging. A population-based study published in Aug. examined over 62,000 brain scans of individuals from the ages of 9 months to 105 years of age. The team of researchers, which included scientists from Google, Johns Hopkins, and UCLA among others, found that schizophrenia was associated with an average of 4 years of premature aging, cannabis abuse 2.8 years of accelerated aging, bipolar disorder 1.6 years, ADHD 1.4 years & alcohol abuse 0.6 years. Depression was not associated with accelerated aging. • 4. Good Genes: Famed Harvard geneticist George Church has said he would like to make it possible for humans aged 130 to have the physical and mental hardware of a 22-year-old. He is currently working on a gene therapy to reverse aging in dogs via his startup Rejuvenate Bio. Humans come next. Rejuvenate Bio will first attempt to stop fatal heart ailments common to spaniels and Doberman pinschers, and then gather evidence that the same concept can work in humans, according to comments he and some of his colleagues made to the media and at conferences last year. • 5. Transgenes: Over the past few years, researchers have made great progress treating and preventing numerous diseases of aging by removing senescent cells, or cells that have stopped dividing but have not died off yet. These experiments have been conducted in mice using trans genes, a form of genetic engineering. Last year, for the first time, two separate groups of researchers were able to use transgenes to stave off neurodegeneration. Scientists at the Mayo Clinic removed senescent cells from the brains of mice with Alzheimer’s, preventing brain degeneration, according to a research study published in Nature in September. • Separately, Judith Campisi’s lab at the Buck Institute used transgenes to eliminate senescent cells in the brains of mice who had been exposed to an herbicide that is known to induce Parkinsonian symptoms in humans as well as mice. That therapy, likewise, prevented the onset of neural degeneration. • 6. Wrinkle-Free: We tend to worry about the wrinkles in our skin as we age, but we should probably be more concerned about the wrinkles in our cells. In May of this year, researchers from the University of Virginia School of Medicine found that many effects of aging, such as fatty liver disease, could be the result of cell nuclei wrinkling, which prevents DNA from functioning normally. According to their research, viruses can be modified to carry and deliver lamin to cells, a protein that can smooth out the nuclear membranes. • 7. Young Blood: In an experiment worthy of a vampire flick, researchers published a study in Cell Reports last February that showed pumping the blood of young mice into older mice stimulated neuron and stem cell production in the older mouse brain and reversed the effects of aging on their cognition. Despite earlier mixed results, a controversial startup called Ambrosia, where patients can pay $8,000 to get blood plasma from younger individuals, launched its own clinical trial in June 2016, which concluded in January 2018. No study results have been published. • 8. Stem Cells for New Tissues: Stem cells are remarkably flexible. Researchers can manipulate a given set of stem cells under a controlled setting and stimulate them to differentiate into the desired cells they want. These stem cells could then be used to regenerate cells or tissues that have lost function due to aging. One startup called Celularity, launched in 2018, is working to develop this kind of therapy using placenta stem cells to treat everything from cancer to Crohn’s disease to diabetic peripheral neuropathy. • 9. Organ Printing: In June, a company called Prellis Biologics announced it could print human tissue with viable capillaries, which is a step forward in the printing of tissues and organs that could be used for transplants. These new organs could replace any that may have lost function as a person aged or succumbed to age-related disease. Today, there is a global shortage of organs available for lifesaving transplants, with some estimating this shortage is one of the leading causes of death in the U.S. Medicines That Might Keep You Young • 10. Senolytics: Researchers are busy hunting for compounds that can eliminate senescent cells in different human tissues, mimicking the effects of transgenes in mice. (Because they can’t create genetically engineered humans with transgenes for the same results.) According to a study published in Nature Medicine in July, researchers found that treating naturally aged mice with a combination of two existing drugs, leukemia drug dasatinib and flavanol quercetin, cleared the senescent cells from tissues and extended both life span and health span. Another compound called fisetin, present in many fruits and vegetables, was found to eliminate senescent cells and to extend lifespan and healthspan in aged mice, according to papers published last year in Nature Medicine and eBioMedicine. Researchers found further that targeting mitochondria in blood vessel cells with hydrogen sulfide reduced the number of senescent cells by up to 50 percent. • Meanwhile, Unity Biotechnology, the company co-founded by Judith Campisi of the Buck Institute, last year launched the first human clinical trials to test out senolytic therapies. The Unity trial aims to treat moderate to severe osteoarthritis of the knee, a disease that has been shown in animal models to be heavily associated with cellular senescence in the joints. • 11. Metformin: In a study published in Aging Cell in April of 2018, Chinese researchers showed that the diabetes drug metformin, derived from a plant called French lilac, can extend the lifespan of human cells in vitro. Until now it had only been studied in rodents and nematodes. A $77-million clinical trial called TAME, short for “targeting aging with metformin,” is attempting to answer this same question in the U.S. — whether metformin can work in people. They are currently recruiting 3,000 adults aged 65 to 80. • 12. Rapamyacin: A clinical trial testing the health benefits of an experimental drug called rapamycin, a bacterium found on Easter Island, in a new combination has shown promising results. The double-blind, randomized study put 264 volunteers aged 65 and over on a six-week course of two drugs designed to block a protein called the mammalian target of rapamycin, or mTOR, safely reducing infections in elderly volunteers around 40 percent by reversing the effects of aging on the immune system. Rapamycin is already used in organ transplant medicines and as an immunosuppressant. • 13. NAD+ Precursors: Scientists from MIT — namely noted researcher in the field of aging Leonard Guarente, Ph.D., who discovered the role sirtuins play in longevity — Harvard Medical School, and University of New South Wales identified a compound called NMN that promotes new blood vessel growth in mice, reversing age-related losses in endurance. These effects were enhanced when NMN was used in combination with hydrogen sulfide. NMN is a precursor to NAD+, a coenzyme that boosts levels of sirtuins in an organism’s cells. (Another highly efficient NAD+ precursor is nicotinamide riboside, or NR for short. Here’s how it works.) Sirtuins have been found to protect against the effects of aging in many organisms and NAD+ levels typically drop as animals and humans age. The paper appeared in paper Cell in March. • 14. Minocycline: An antibiotic called minocycline could prevent protein buildup characteristic of neurodegenerative disease, according to research from Scripps and the Buck Institute for Research on Aging published in November in the journal eLife. • 15. ANP Compounds: Salk Institute researchers discovered compounds they called gerontopsychiatry, or ANP, that were found to slow aging in mice and may be effective against Alzheimer’s disease in people. • 16. Epigenetic Clock: Steve Horvath, a bioinformatics expert, has long worked to develop a reliable signature for biological age. Last year, Horvath and a team of other researchers developed a new epigenetic biomarker of aging they’re calling DNAm PhenoAge, which far outperforms previous measures in its ability to predict a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer’s disease. The biomarker was developed using data from whole blood, but correlates strongly with age in every tissue and cell tested. It’s also sometimes known as Horvath’s Clock. • 17. Mitochondria: New research from the Cohen Lab at the USC Leonard Davis School of Gerontology, published in September, revealed that a mitochondrial gene protects against dementia and other diseases of aging. A related study published in Nature in July found that, in mouse models, mitochondrial DNA depletion induces phenotypic changes associated with aging, which can be reversed by restoring mitochondrial function. • 18. Telomeres in Bats: Bats are a long-lived species for their size, and the most exceptionally long-lived among them, known as Myotis bats, have very different telomeres, telomerase and DNA-repair genes, a study published in February found. Using over 60 years of field data, the researchers showed that whereas telomeres shorten with age in two bat species, they do not shorten in the Myotis bats. • 19. Proteostasis: Protein misfolding has been identified as a major pathology contributing to degenerative diseases. Now a research team led by Northwestern University has received a $12.6 million grant from the National Institute on Aging at the National Institutes of Health to study the role that protein quality control plays in aging and neurodegenerative diseases such as Alzheimer’s and amyotrophic lateral sclerosis (ALS). The project brings together researchers at five U.S. institutions and will be known as the Proteostasis Institute. • 20. Primate Longevity: Why do mammals have such a wide range of lifespans and how did longer lifespans evolve? Researchers from Spain and the United Kingdom attempted to tackle this question as it pertains to primates, using a bioinformatics approach to identify genes associated with primate species that have the greatest longevity. In a paper published last May, they were able to identify 25 genetic mutations on genes involved in wound healing, blood coagulation and cardiovascular disorders.