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hopkei · 17 hours

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#mandy-san is leaving ldh.....#maybe im not tuned in to gene enough but it feels so.....sudden???#and kinda scary........if mandy-san can leave so suddenly like this then who else could too......🥲🥲🥲

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banqanas · 5 months

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late night thoughts something something about how fanta isn't let out overseas easily maybe bc they have exile members

#banantxt #i dont have a basis for this its just observation #bc i realised how fanta is more connected with gene and jsb3 #the reason theyre closer to senior exile groups bc well they have exile members #compared to their even closer brother group rmpg #and how rmpg news about going to thai and doing activities there were pretty sudden too #this is a lament after seeing all the updates of rmpg bbz psyfe at thai from the past two days #and how fanta is nowhere even near outside of jp borders #but considering exile just finished their taipei concert.....so maybe ????#idk maybe ldh dont want exile members first overseas activities to be 'not' with exile......hmm

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dustypanb · 27 days

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Update on subbing projects

I've been informed that another team is handling the subbing for the Run Run Rampage episode, so I'm shifting my focus to completing Gene x Rmpg. In the meantime, I'll be subbing brief clips or memorable moments, and I'll also be doing Eng sub for groups outside of LDH, as long as the clips are under 10 minutes.

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thistaleisabloodyone · 9 months

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They subtitled a Lil League video on CL Live for what I think is the first time and so I'm watching it, but, ah, shit, they're cute. But I can't pick up another group to care about 😩

Rampage is 16 members, BBZ and PsyFe are each 7, so that's 30 right there, 38 with Fanta, 45 with Gene and 48 with iScream, I can't pick up another LDH group, that would take me past 50

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candymylove · 1 year

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Sorry to break jpop news on here but GENE Yose getting with Tsuchiya Tao is so cute because they're so close in age... honestly what I noticed with LDH men is that they date women THEIR AGE as opposed to J-J-J-Johnnys...........Akira EXILE is literally 40 and his wife is 7 years older...and they make a slay couple

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market-insider · 8 months

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Biomarkers in Personalized Medicine: A Comprehensive Market Study

The global personalized medicine biomarkers market size is expected to reach USD 43.07 billion by 2030. The growth is attributed to the rising awareness, importance of predicting prognosis, and selection of dose. Moreover, personalized medicine biomarkers serve as an essential tool for the selection of patients and providing the right treatment to the right patient further propelling the demand for personalized medicine biomarkers.

Gain deeper insights on the market and receive your free copy with TOC now @: Personalized Medicine Biomarkers Market Report

Biomarkers are unique analytes that can be utilized to improve diagnosis forecast treatment outcomes and direct treatment decisions. They are crucial to personalized medicine. The increased usage of biomarkers to enhance patient outcomes is popular in clinical trials, and its use in clinical practice is expanding quickly. The development of personalized medicines using biomarkers is expected to create effective and safe therapies for every patient. This is a major relief for patients at advanced stages of chronic diseases like cancer, which further drives the market growth. For instance, in August 2022, VENTANA MMR RxDx Panel, an FDA approved first IHC-based assay used for the identification of patients with advanced cancer that is Pembrolizumab treatment eligible.

Early detection/screening biomarkers predict the outcome of disease in patient population prior to therapy. It can also help enrich clinical trials by helping choose patients more likely to respond to treatment. For instance, Oncotype Dx is a diagnostic test developed by Genomic Health, Inc. This test examines 21 genes and helps predict the likelihood of reoccurrence of breast cancer in a patient after initial treatment. In April 2022, updated ASCO guidelines recommended the usage of the Oncotype DX test for breast cancer patients at early stages to guide treatment decisions.

Moreover, biomarkers are used for their predictive and prognostic utility that helps predict the occurrence of a health condition. For instance, the prostate-specific antigen is used to predict the survival of patients with prostate cancer. CRP is used to predict disease-free survival in breast cancer and as a risk factor in cardiovascular disorders. Serum LDH helps predict survival in case of metastatic brain tumors. Similarly, CA125 helps predict metastatic diseases in patients with uterine carcinoma.

Furthermore, key players operating in the personalized medicine biomarkers industry are focusing on expanding and launching products that can be used for a wide range of applications. For instance, in October 2021, Agilent Technologies Inc. received FDA approval for Agilent Ki-67 IHC MIB-1 pharmDx (Dako Omnis), for the identification of patients with a high risk of breast cancer recurrence.

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amstrupcullen36 · 1 year

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Figuring out Affected individual Goals for Preconception as well as Having a baby Counseling in IBD

Lipid report ended up being slightly disadvantaged in the groupings, with raising lower occurrence lipoprotein-cholesterol ranges (+14'%) inside the more youthful population and 10% 'abnormal' amounts associated with APOA1 in the seniors. A new loss of IGF1 amounts (-15%) was noticed in the younger age bracket. Simply no alterations in weight or body mass index were observed in both young or old men. Conclusions: Short-term aromatase self-consciousness generally seems to have an effect on blood sugar fat burning capacity within young men. along with lipid metabolism, including leptin secretion, throughout younger along with seniors males. Additionally. the short amount of coverage suggests that these kind of modifications may be mediated by one on one connection between making love steroids rather than by modifications in entire body structure.Acetaminophen (APAP) is actually hepatotoxic which enable it to lead to toxicity inside Jurkat T cells. p-Aminophenol (Smear), a commercial chemical and also APAP metabolite, is actually nephrotoxic as well as hepatotoxic. Their probable poisoning in JuArkat To tissues had been looked at. PAP (10250 mu Michael) triggered poisoning (decreased survival and also greater LDH exercise in incubation channel) and also GSH destruction. In a energy A hundred mu M and not Two hundred and fifty mu Meters, Smear increased DNA fragmentation. That decreased p-Akt amounts (Elisa) possibly at higher amounts diminished p-Akt term (Traditional western blotting). This did not have any relation to FasL expression. The particular cysteine precursor 2(Urs)-n-propylthiazolidine-4(Third)-carboxylic acidity (250 mu M) attenuated the actual PAP (Hundred mu Michael)-induced decline in stability as well as avoided GSH lacking along with greater Genetic make-up fragmentation. The idea attenuated your PAP-induced decrease in p-Akt levels and protected contrary to the loss of p-Akt term. The results demonstrate PAP-induced toxic body as well as suggest that it can be because of a minimum of simply in order to Canagliflozin in vitro apoptosis as well as consists of GSH depletion along with p-Akt inactivation. (d) 2011 Wiley Newspapers, Incorporated. T Biochem Mol Toxicol 25:7178 2012; See this post on the web from . DOI 10.1002/jbt.20402A major problem within chemo of cancers people will be drug level of resistance in addition to unstable reply to remedy. During chemotherapy, numerous adjustments of genes along with epigenetics in which give rise to chemoresistance happen, ultimately impacting ailment end result. A more intricate photo with the elements associated with medication resistance has become rising via application of high-throughput proteomics technologies. We now have moved into a thrilling moment where proteomics are increasingly being used on characterize the elements involving medication weight, and to identify biomarkers for forecasting response to chemotherapy, and thus bringing about individualized restorative secrets to most cancers individuals. Relative proteomics have got determined numerous differentially indicated protein associated with chemoresistance. Despite the fact that functions as well as mechanisms of which healthy proteins within chemoresistance should be even more proven, a minimum of some of them could possibly be potential biomarkers for projecting chemotherapeutic response.

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jacketcanoe9 · 2 years

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Effect involving Lansoprazole Dosing Routines on Mammary Growth Development in a dog Model

History: The actual tumor microenvironment (TME) renders tumor cells more resistance against radiation. However, powerful immunomodulators pertaining to most cancers therapy continue to be evasive. We hypothesized that Mn-N-(2-hydroxyacetophenone) glycinate (MnNG), reportedly a good antitumor agent, may regulate your TME. Resources and techniques: Immunomodulatory connection between MnNG have been executed through evaluating Myeloid Extracted Suppressor Cellular material (MDSCs), Interferon-gamma (Ifn gamma)* and also Interleukin-4 (Il4)-secreting Group involving Differentiation Several (Cd4)(+) T-cells by simply annexin V-binding assay in drug-resistant TME and also T-cell expansion pursuing within vitro co-culture assay through stream cytometry. Results: MnNG activated infiltration associated with Ifn gamma-secreting Cd4(+) T-cells and also reduces MDSC quantities inside vivo. Furthermore, it modulated differentiation of MDSCs in direction of dendritic cells with up-regulation regarding co-stimulatory substances along with corrected your #Link# suppressive function of MDSC's that will increases T-helper mobile or portable One particular (Th1) result. MnNG therapy resulted in diminished term of IL4, but increased appearance involving Ifn gamma while Cd4+ T-cells have been co-cultured with MDSCs. Bottom line #Link# : MnNG modulates MDSCs differentiaton in the direction of dendritic tissues as well as enhances Th1 reply in drug-resistant TME, resulting in immunomodulatory effectiveness.Frontotemporal lobar damage as a result of versions in the progranulin (PGRN) gene provides a higher variability in the specialized medical phenotype along with ages of oncoming of ailment. Factors in which effect this variation continue to be largely unfamiliar. The goal of our own research ended up being to determine whether selected anatomical specifics modify get older at beginning of illness inside our number of 21 years of age individuals which has a single splicing mutation (d.709-1G>A) from the PGRN gene, all of to whom ended up associated with Basque descent. Within our analysis, we all provided the next hereditary variables: PGRN rs5848 and rs9897526 polymorphisms, APOE as well as microtubule-associated necessary protein tau genotypes, as well as PRNP codon 129 polymorphism. Many of us found absolutely no affiliation among PGRN polymorphisms, APOE as well as microtubule-associated proteins tau genotypes, and age group in onset of the disease; whereas all of us document facts for an connection between PRNP codon 129 polymorphism and grow older from onset of illness throughout frontotemporal dementia-PGRN(+) people. Millimeters homozygous carriers shown beginning of ailment an average of 8.A few years prior to when sufferers which transported at least One particular valine on their own PRNP codon 129 (MV as well as VV). The natural validation just for this affiliation is still risky.P>The actual colon epithelial obstacle signifies a crucial aspect from the pathogenesis of inflammatory bowel conditions. Interferon (IFN)-gamma, the Capital t associate sort 1 #Link# (Th1) cytokine, governed through the interleukin ()-18/IL-18 holding proteins (bp) program, modulates your honesty of this obstacle. The aim of the job would have been to research functionally the outcomes associated with IFN-gamma about intestinal epithelial tissue (IEC) also to conflict precisely using recognized negative IFN-gamma effects. IEC lines were triggered along with IFN-gamma. IL-18 along with IL-18bp have been considered by enzyme-linked immunosorbent analysis. Yellowing of phosphatidylserine, Genetic laddering, lactate dehydrogenase (LDH) discharge, bosom associated with poly-adenosine diphosphate-ribose-polymerase (PARP) and activation associated with caspase-3 ended up analysed to find out mobile dying.

#Trametinib #Alpelisib #Lansoprazole

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notsogreatmii · 3 years

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Let’s exercise with Jr. Exile!

(Dodgeball Kingdom warm-up session)

#jr. exile #generations #the rampage #fantastics #ballistik boyz #ldh #this is like an all boy school #with gene being the oldest and the most chaotic #rmpg is like that group of cool guys #fanta is the sweet ones #balli is the youngest and quietest one

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banqanas · 5 months

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Soresuno sp with LDH liveblog second half !!!!!! (because part 1 thread was getting too long for view)

STARTING WITH MANDY & ICCHAN PAIR DANCE !!!! gene and sapomen!!!!!! 😭😭🙏🙏🙏

#banantxt #banan liveblog #ITS MY FIRST TIME SEEING GENE + SUPPORT MEMBER TOGETHER 🥺🥺🥺❤️

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estinyanwyrmblood · 3 years

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GENERATIONS on HELLO! HALO!

☆Ryota cut☆

#ryota katayose #generations #generations from exile tribe #GENE #exile tribe #LDH

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thistaleisabloodyone · 8 months

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Watching the LDH Dream Match on CL26 and there was an ad for a horror movie that Mandy, Reo and Yuta from GENE starred in and the jumpscare fucking killed me. I am no longer living. I am just - fuck. Jesus. Crhsit. It's midnight here and I am terrified.

#thistale rambles #gotta admit #asian horror films are like nothing else #fuck my life

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cinnabaexoxo · 4 years

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