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lawrencedienerthings · 4 years

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How losing friends to death led two former corporate types to shape a young adult novel

#youngadult🌁 💷 📄 ⭕ 🖋 🌏 👥

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Jim and Stephanie Kroepfl are a husband-and-wife team who write Young Adult novels and stories of mystery and adventure from their cabin in the Colorado Rocky Mountains. Their stories and articles have been published in literary journals in the U.S. and England. Jim and Stephanie are world travelers who seek out crop circles, obscure historical sites and mysterious ruins. When not writing, Jim is a musician and Stephanie is an artist. You can find them at www.jimandstephbooks.com

The following is an interview with Jim and Stephanie Kroepfl.

UNDERWRITTEN BY

Each week, The Colorado Sun and Colorado Humanities & Center For The Book feature an excerpt from a Colorado book and an interview with the author. Explore the SunLit archives at coloradosun.com/sunlit.

What inspired you to write this book?

Friends of all ages recently died, and we kept thinking about what these people could have accomplished if they had more time to live in a healthy body. We became fascinated with the idea of how to prevent the loss of years of accumulated knowledge, especially for those who are trying to accomplish things that will change the world for the better. These thoughts led to the question: If you were a young person and given the chance to merge consciousnesses with one of society’s greatest minds–someone who might really advance society—would you take that risk?

Authors Stephanie and Jim Kroepfl. (Provided by John Williams Photography)

Place this excerpt in context. How does it fit into the book as a whole and why did you select it?

Orfyn, an orphan, is a gifted street artist who dreams of having his work displayed in galleries and museums, although he can’t imagine how that would ever really happen. Then, a secret corporation offers him the opportunity to be mentored by a master painter. This chapter is the point where Orfyn must decide if he’s willing to be part of a risky experiment in exchange for the chance to follow the path to greatness. In screenplays this is called Plot Point One, when the protagonist has to make an irreversible decision that changes everything. It is one of the most important parts of any story. We selected this excerpt because it’s a good illustration that there are times when one decision truly can alter the direction of the rest of our lives … so choose wisely.

Tell us about creating this book: any research and travel you might have done, any other influences on which you drew?

Most of the story takes place in upstate New York in a stately old boarding school that has been turned into a society-advancing secret laboratory. We went through hundreds of photos of private schools that are now for sale. The thought of buying one of these buildings, and living in it, gives an author a strange mix of excitement and nightmares.

We wrote this book while changing our lives. We had just left corporate life and moved to a tiny Colorado mountain town to commit ourselves to the craft of writing. This inspirational place helped us re-discover the stories we loved and why we loved them, and it led us to write for young people.

“Merged” by Jim and Stephanie Kroepfl.

What were the biggest challenges you faced, or surprises you encountered in completing this book?

Our biggest challenge was nailing the voice of Lake. She’s a precocious 16-year-old with a keen ability for chemistry. She’s torn between living in a predictable, stable environment and pursuing an unquenchable goal to make a difference. We needed her voice to reflect her brilliance without making her off-putting. We began to realize that we know a lot of very smart people who have their own very unique personalities, which helped a lot. Also, our publisher recommended that we watch a lot of “The Big Bang Theory” episodes to study how their quirky characters remain likeable.

Walk us through your writing process: Where and when do you write? What time of day? Do you listen to music, need quiet?

We plot together, typically by walking around the lake with our dog, and try to think well ahead of our plotlines since we write the first draft simultaneously. Then, we go to it. Stephanie likes to write in the mornings with a dog on her lap, and Jim writes in coffee shops in the afternoon. But then there’s revisions, new plotlines, and new dimensions to the characters. Every minute is awesome because there’s nothing more fun than being surprised by something creative that you couldn’t have come up with in all those hours you were plotting.

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What’s your next project?

We just submitted the sequel to “Merged” involving topical issues that hadn’t been unfolding when we plotted the novel, but have come to dominate everybody’s everyday life since then. So, we anticipate the next six months to involve lots of editing. But during this time, we’ll also plot out two story ideas to see which one excites us the most for our next YA novel. One is a dystopian adventure novel, and another is a contemporary novel with lots of humor.

— Buy “Merged” through BookBar. — Read an excerpt from the book.

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A talented 16-year-old painter is given a chance to “merge minds” with a dying master. Should he take it?

How losing friends to death led two former corporate types to shape a young adult novel

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c605560-blog · 4 years

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The Most Underrated Companies To Follow In The What Is A Fullerene Industry

What Is C60 In Oil?

Do you think you are scatterbrained or careless? Would you want you to have stronger memory and more excitement? Perhaps you would like to take C60!

In years you completed the first exercise and have been washed. You note your friend's not so https://en.search.wordpress.com/?src=organic&q=c60 winded as you try to catch your breath and slow your heart. Why? Why is it? Could it be carbon 60 before we began? And what does carbon 60 mean? You are fortunate if you still wanted to know about what carbon 60 is. Below you can go through carbon 60's past and how it can help you with its antioxidant properties.

C60 olive oil is an effective solution, which is formed in olive oil by dissolving C60. The multiple carbon 60 benefits available are currently under investigation. Here are some of the easiest ways to better your life with this product. Bacteria and viruses: bacteria and certain viruses are killed by C60. It also raises the number of white blood cells, so that the body battle infections more effectively.

C60 is an antioxidant that decreases stress caused by free radicals, which means that it is safe against ageing. The symptoms of ageing are mainly caused by freer radicals, thus consuming C60 will slow down the process of ageing.

C60 has anti-inflammatory effects, according to clinical studies. Energy increases: after daily consumption of the supplement, many C60 users registered an improvement in energy levels. Provides better sleep: improved sleep is a recorded advantage of C60.

What Is Carbon 60 Anyways?

Improves motivation and strength: Athletes claim that the addition of C60 helps to boost performance and motivation for sports. Improve brain function: C60 improves learning and memory as a nootropic.

This is not a complete list of benefits. C60 olive oil is an antioxidant that can enhance the body's appearance, feeling and function. You can avoid diseases and diseases by using olive oil with c60.

Carbon 60 is a set of 60 carbon atoms in fundamental terms. In 1965 the first paper by scientist Harry P. Shultz, titled "Topological Organic Chemistry," listed carbon 60 (also known as C60). The prismans and polyhedrans. Until 70 when the Technology University Professor Eiji Osawa of Toyohashi predicted the existence of C60, the C60 was stated again. He was then defining the polycyclic aromatic hydrocarbon molecule, which appeared like five hexagons around a pentagon. In this definition, he presumed that this structure could be spherical.

Although scientific journals in Japan have published Osawa 's theory, Europe or the United States never have the translations of the paper.

The same year there was another scientist named R. The presence of the C60 was speculated and also modelled by W. Henson. The scientific community, however, thought that the evidence provided was not adequately strong and its results had not been acknowledged. In reality, Henson was only recognised by his research on C60 in the 1999 issue of the scientific newspaper Carbon.

Henson was not the only C60 researcher who dismissed the scientific community 's results. The quantic-chemical stability of CO 60 was studied by a group of scientist in the USSR in 1973 and its structure was determined. Although the research paper was published in Russia's URSSR Academy of Sciences Proceedings, many did not acknowledge carbon predictions 60.

Harold Kroto, from Sussex University, along with James R. Heath, Sean O'Brien, Richard Smalley and Robert Curl of Rice University, finally proved their carbon 60 with mass spectrometry in 1985. After Richard Buckminster Fuller, they called the new structure of Buckminsterfullerene carbon atoms. Fuller was a renowned architect whose dome was C60-like. Any atomic cluster such as C60 was then part of a family class known as fullerenes. The Nobel prize was awarded to the C60 discoverers in 1996.

C60 was on the verge of other fields of science evolving, but biology proved to be the biggest transition. Tares Baati, Borasset, Najla Gharbi, Leila Njim, Abderrabba, Kerkeni, Henri Szwarc, Fathi Moussa and the newspapers were the first to carry out a groundbreaking study in 2012. A new study was published in 2012.

youtube

The research team purchased Carbon 60 Fullerene's ESS60 C60 to determine its effect on Wistar rats in this study. The rats were divided into different groups. Some groups provided 1ml of water, others 1 ml of olive oil and 1 ml of olive oil with ESS60C60 were given to the last groups. They discovered something remarkable when they analysed the urine, blood and brain of the rats. The rats which received olive oil were 30 percent longer. But rats with ESS60 olive oil have almost 90 percent longer life span!!

One of the keys to age protection is a diet rich in antioxidants, as we discussed in our last https://carbon60fullerene.com/c60-diets-weight-loss/ article. That is so amazing about antioxidants is that free radicals will give them the requisite electron without being a free radical. They are nature 's real donors. And C60 is like that. Due to C60 's special atomic structure and antioxidant properties, some free radicals can be stabilised without destabilisation. C60 with olive oil can be a rapid way to antioxidants for a healthy life, but this hasn't been tested by humans.

#c60 #c60 oil #c60 fullerene #carbon 60

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liliannorman · 4 years

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Weight lifting is this planetary scientist’s pastime

A love of magnetic rocks, old machines and space recently led Beck Strauss to a dream job at NASA’s Goddard Space Flight Center in Greenbelt, Md. The path to that career wasn’t always clear. Yet it’s a perfect fit for someone who has studied everything from the cave formations called stalagmites to lava flowing on the planet Mercury.

Strauss is a planetary geophysicist who studies the magnetic fields of planets and how those fields are recorded in rocks. Electric currents deep within the Earth’s rocky core form a strong magnetic field. (That’s what causes magnets in compass needles to point north.) Understanding how magnetic fields change over time can tell researchers not only about the surface, but also about what’s inside a planet.

At NASA, Strauss is zapping rocks with laser beams to figure out how old they are. This scientist also is developing sensors to detect the moon’s magnetic field.

Like a compass, Strauss has helped guide other researchers too. Strauss identifies as both transgender and non-binary and uses the pronouns “they” and “them.” A transgender person’s identity doesn’t match the gender they were assigned at birth. Instead of male or female, non-binary people can feel like they’re both genders, neither or somewhere in the middle.

At first, Beck Strauss wanted to study English in college. But an exciting lesson about how the continents are moving and a funny professor convinced them to study geology instead. Courtesy of B. Strauss

A few years ago, Strauss began working at the National Institute of Standards and Technology (NIST) in Gaithersburg, Md. They wanted to join an LGBTQ+ employee club. They figured such a club would help them to make friends and be supported at work. But the club no longer existed. So Strauss formed a new one for employees and ran it for 18 months. The group helped get gender-neutral bathrooms on the campus. And it made NIST more welcoming to a diverse community of scientists.

In this interview, Strauss recalls their experiences and shares advice with Science News for Students. (The interview has been edited for content and readability.)

What inspired you to pursue your career?

Getting to this very specific career has been a long journey. When I was in high school, I wanted to be an English major because I really liked writing and I really liked reading. Then I got to Oberlin College in Ohio and took a couple of English courses. And it turns out I really didn’t like it very much.

But I was taking a class at the time that was a geology class for non-majors. (By that, they mean the class was for people not majoring in geology.) The professor in the class told us how the continents got to where they are today. He described how the Indian subcontinent slammed into the continent of Asia and is continuing to move northward. And this is why the Himalayas are growing.

Explainer: Understanding plate tectonics

I thought that was the coolest thing I had ever heard. So I basically agreed to declare a geology major. I signed up for the intro class. It was taught by a professor who, if science hadn’t worked out, could have been a stand-up comedian. I had a fantastic time in that course. So it’s been a series of decisions where I’ve just kept an eye out for the things that I found surprising and exciting.

How did you get where you are today?

During college I did a summer internship in a lab at the University of Minnesota in Minneapolis that was studying rock magnetism. I decided to do that internship because I read the description and it sounded cool. After I did that internship, I decided that I wanted to go to grad school.

Scientists Say: Stalactite and stalagmite

At the University of Minnesota, where I got my PhD, I was in this rock magnetism research lab. I noticed when I went over to the chemistry department that a lot of the professors had stickers on their doors with a rainbow or triangle that said that they were LGBTQ allies. I started hanging out in the chemistry department more because I felt comfortable and welcomed there. I got to talking with a professor who was also interested in magnetism and [we] ended up deciding to collaborate to do some research on stalagmites.

More recently, at that university, I was in the right place at the right time when someone said, “Hey, I have a project that we need someone to do. Are you interested in looking at Mercury?” And I said, “Absolutely!” because I’ve always thought space is cool. I also noticed that planetary science as a community seemed really excited about diversity and really excited about inclusion.

Beck Strauss organizes a collection of granite samples that a student used to study the Chicxulub impact crater that formed when an asteroid or comet hit Mexico about 66 million years ago, wiping out the dinosaurs.Courtesy of B. Strauss

How do you get your best ideas?

I think my best ideas come from two places. One is that I really like having friends who are not scientists because they have really good questions about the science that I do. Sometimes my friends ask questions that they’re afraid are silly. Or a waste of time. But it turns out they’re getting at things that are actually really incredibly important to the kinds of work that we want to do. If I only ever talked to scientists who do the same thing that I do, I wouldn’t hear all of these cool, weird, exciting ideas that come from all different places.

The other is I actually get a lot of ideas from movies and TV shows. I watch a lot of science-fiction movies and a lot of fantasy movies. And there are a lot of ideas about what a world could look like if it didn’t have the same rules that we have. I think that’s a really fun thing to try to apply real-world science to. It can turn from a silly, fun exercise that you do with your friends into a, “Hey, wait a second! What if we actually…?” kind of question.

What’s one of your biggest successes?

Beck Strauss adjusts a magnet power supply with a screwdriver. Strauss has fixed many old lab machines to help them keep revealing important information about magnetic rocks. Courtesy of B. Strauss

Some of the work that I’ve been the most proud of is the work I did as a postdoctoral researcher. I was at Rutgers University in Piscataway, N.J. I worked at the Paleomagnetism Lab in 2016 and 2017. (In paleomagnetism, scientists use old rocks, sediments and other materials to study Earth’s magnetic field.) When I started at that lab, it was basically one big empty room and a second room with some old instruments that needed some love. And when I finished at that lab, it had six or seven totally operational research instruments. By the time I was done, they were spitting out data, basically ready for publication.

Part of my job was working on this one machine that’s nearly as old as I am. I had to figure out a way to get it to start working again in a way that would let not just me, but also the students in the lab, run it from a modern computer. I’m really proud of that work. That’s not only because of how many instruments I was able to get running again. But also because this was a lab that was taking students for the first time. With the instruments I worked on, the very first grad student has been able to present her work at a couple of conferences and has been working on papers to publish in journals.

What’s one of your biggest failures, and how did you get past that?

My philosophy as a scientist is that we need failures in order to learn how to succeed. I do a lot of lab research. And I work with a lot of machines. And sometimes I make mistakes.

I broke almost every instrument in my PhD lab at least once. One is called a SQUID magnetometer. SQUID is an acronym that stands for Superconducting Quantum Interference Device, which sounds like it’s from a sci-fi movie. I also exploded a sample in an oven one time. But I helped fix everything that I broke, and that meant I got to learn how the instruments really worked and what was going on inside them.

It can be really frustrating when you break one of these instruments. They’re really complicated and they’re really expensive. And it makes people really nervous. But every single time I would run into a problem like, “Oh, no, I dropped my sample,” or, “I flipped the wrong switch,” it was an opportunity to learn how to get better at doing my job by figuring out how to fix the mistake.

As part of a weightlifting competition, Beck Strauss pulled a car across a parking lot. In training, Strauss did the same with a truck.Suzanne Witt

What do you do in your spare time?

I have two main hobbies right now. One hobby is that I make art: I draw and make collages. And I got to show my art in an art show this summer for the very first time, which was really cool. I really like scientific illustration. This is art focused on creating useful depictions of things like acorns and shells and hands and things that you find in the real world.

My other hobby is that in the spring of 2019 I got into weightlifting, which is not a sentence that I ever expected myself to say. But I have a friend who is a chemical engineer. She posted a video on social media of her pulling a truck. She said, “You know, I bet you could pull a truck if you wanted to.” I thought she was kidding. But it turns out she was right. So this past October, I competed in an all-gender competition, and I pulled a pickup truck across the parking lot.

What piece of advice do you wish you had been given when you were younger?

The two pieces of advice that I always give are, number one: It’s OK to make choices about your career based on what feels good. By that I mean things like, it’s OK to decide who you want to collaborate with because they’re fun to work with or because you feel comfortable around them. It’s OK to decide what kind of science you want to do because it lets you go to the places you want to go.

The other one that I would tell myself is: Run toward the things that you are nervous about loving. If you are so excited about something that it scares you, you’re probably still going to be excited about it a decade later.

This Q&A is part of a series exploring the many paths to a career in science, technology, engineering and mathematics (STEM). It has been made possible with generous support from Arconic Foundation.

Weight lifting is this planetary scientist’s pastime published first on https://triviaqaweb.tumblr.com/

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kevindalby · 4 years

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Kevin Dalby, Professor at The University of Texas in Austin, Describes the Life of a Scientist and His Cancer Treatment Research

Originally published on medium.com

Dr. Kevin Dalby, you are a Professor of Chemical Biology and Medicinal Chemistry in the College of Pharmacy. Why did you decide to pursue your career?

I didn’t like high school very much, but I took to chemistry. It was the first thing I studied that I could use to make any sense of the world around me. I enjoyed reading literature, but the books we read at school were generally set in the past and didn’t seem relevant to me at the time. I would probably have a different perspective on that now, of course, because I am a little bit wiser than I was then.

I studied chemistry at the University of Leeds in England and was planning to try and do a Ph.D. in Australia. I met a career officer who told me to apply to Cambridge, which I had not considered before because it seemed a bit elitist. Anyhow, I found myself there studying for my Ph.D. and fell in love with the world of academic research. Things just progressed from there.

It’s wonderful that you love what you do. What does your typical day at work look like?

My day starts around 7–8. I dedicate the mornings to meetings and administrative duties. I keep the afternoons and evenings free to work on grant applications, manuscripts, and lectures.

What was your biggest professional breakthrough?

It was getting a job! When I started in graduate school, I realized that I wanted to continue in science and have my research laboratory. Back then, to get a job as a lecturer in a university in England, one had to work in the US for a while. Ultimately, I decided I wanted to stay in the US and work. I will never forget how lucky I felt getting a job over here.

And they are lucky to have you, Dr. Kevin Dalby. Tell us more about what your current research is focused on.

We are working to develop new drugs to treat a range of cancers, and we are trying to develop new diagnostic approaches to identify malignant tissue and to quantify changes within the tissue that could provide valuable information on what therapies to use.

What are some of the discoveries you would like to share?

We have discovered many things over the years, but I always consider our most recent discoveries our biggest. Last year we published a paper in Nature Communications describing a new way to potentially design drugs against an important therapeutic target in cancer cells called ERK. It is a protein kinase that transmits signals that helps cells to divide, and so it is used by cancer cells in nefarious ways. More recently, we identified a new way to measure how active it is in tumors, and a couple of years ago, we published a paper describing how it binds to a protein called Ets-1 to switch it on.

What would be an ideal outcome of the research?

I have a dream that one day we will be able to take a biopsy from an individual and very quickly determine what is wrong with them and how to treat them effectively.

Dr. Dalby, what does it take to become successful in your field?

Luck and perseverance.

This is a great answer. We are guessing that over the course of your successful career as a scientist, you’ve met many inspiring individuals. Who has had the most impact on you professionally?

As scientists, we don’t work in a vacuum. There are countless other scientists in the world disseminating their results for us to digest. There are journals that allow us to publish our work. There are also great companies that develop equipment and reagents. These products will enable us to design experiments we could not have dreamed of trying just ten years ago. There is also the public who ultimately are the ones that pay for most of the work we do either through taxes or donations to foundations. Beyond this, I have been lucky to work with and be taught by some of the best scientists in the world.

About Kevin Dalby

Dr. Kevin Dalby is a professor of chemical biology and medicinal chemistry in the College of Pharmacy, Department of Oncology at The University of Texas in Austin. He the director of the Targeted Therapeutics Program (TTP). This program provides Texas scientists access to resources for drug discovery research. By understanding cancer cell signaling, Dr. Dalby works to make advances in the development of targeted pharmaceuticals for different cancers.

#cancer treatment #cancer research #kevindalby

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biofunmy · 5 years

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G7, Amazon, Russian Explosion: Your Tuesday Briefing

(Want to get this briefing by email? Here’s the sign-up.)

Good morning.

We’re covering a flurry of news from the final day of the Group of 7 summit in France. We also have the global reach of U.S. firearms and a jewelry heist straight out of the movies.

Trump says he’s open to meeting with Iran

One of the biggest developments from the Group of 7 summit in Biarritz, France, came at the end, during the final news conference on Monday.

President Trump said he would “certainly agree” to meeting with President Hassan Rouhani of Iran, and he even suggested offering short-term loans to help the country weather its current economic difficulties.

Mr. Trump was responding to an overture by President Emmanuel Macron of France, who said he would try to set up a meeting in the next few weeks in an effort to resolve the intensifying conflict between Washington and Tehran. The meeting would be the first between American and Iranian leaders since the Tehran hostage crisis of 1979.

Go deeper: Mr. Trump embraced global diplomacy over go-it-alone confrontation yesterday, but there were still significant differences between the seven countries’ approaches.

Context: Tensions between Tehran and Washington have flared since Mr. Trump abandoned the 2015 global nuclear agreement with Iran last year and imposed damaging sanctions.

Trump also pivoted on China. Again.

President Trump, in another surprise, told reporters that Chinese officials had reached out to restart trade talks, and called President Xi Jinping a “great leader” three days after branding him an “enemy.”

But Beijing didn’t confirm any phone calls with the Trump administration, and the editor of a state-run newspaper in China wrote on Twitter that there had been no significant contacts in recent days.

Impact: The president’s apparent efforts to tamp down the trade conflict, capping days of wild fluctuations on the matter, seemed timed to reassure markets. U.S. stocks rose on Monday.

Analysis: Mr. Trump says the U.S. must sever commercial dependence on China. He also says he wants powerful economic growth. He can’t have both, and the trade war threatens to force him to choose.

G7 spotlights fires in the Amazon

The Group of 7, after a session on climate, agreed on a $20 million aid package to help Brazil and its neighbors fight the blazes in the rain forest, a crucial absorber of the world’s carbon dioxide. President Trump didn’t attend the session, but a senior member of his administration did.

The group also agreed, in principle, on a long-term forest protection plan, with more details likely to be presented at the U.N. General Assembly next month.

More aid: Earth Alliance, an environmental organization founded by the actor Leonardo DiCaprio and the philanthropists Laurene Powell Jobs and Brian Sheth, pledged $5 million for the Amazon.

Leaders clash: The argument over the Amazon fires quickly turned into a feud between Presidents Jair Bolsonaro of Brazil and Emmanuel Macron of France, with both taking personal swipes at each other.

Perspective: Farmers in the Amazon say global scorn over a rise in deforestation and fires is unwarranted, backing Mr. Bolsonaro as he strikes a defiant tone. They argue that fire and deforestation are essential to keep them in business, and that the damage is modest.

If you have 15 minutes, this is worth it

How U.S. gun laws fuel a crisis abroad

American firearms have poured into neighboring countries and caused record violence, in part because of federal and state laws that make it difficult to track the weapons.

Above, the police conducting a raid in Jamaica, where more than 80 percent of homicides are committed with guns, most of them from the U.S. Drawing on court documents, case files, interviews and confidential data from both countries, The Times examined the trend, tracing a single gun to nine homicides.

Here’s what else is happening

Opioid crisis: In the first trial against a drug maker for the public health disaster in the U.S., a judge in Oklahoma ruled against Johnson & Johnson and ordered it to pay the state $572 million.

Tropical storm Dorian: The fourth tropical storm of the Atlantic hurricane season may develop into a hurricane as it nears Puerto Rico and the Dominican Republic this week, forecasters said.

Russia: The national meteorological agency named four radioactive particles that were released by a mysterious explosion at a military testing site this month, the latest data point in the Russian authorities’ gradual drip of information about what appears to have been a nuclear accident during a military test.

Science: Human remains found in Croatia provide the earliest genetic evidence of the presence of people from East Asia in Europe.

From Opinion: In a column, Bethany Milton, a former Foreign Service officer, writes about why she resigned from her post: “What of the administration’s policies is there left to defend to foreign audiences, other than a promise that we’re a democracy and that there are future elections to come?”

Can plants speak? Dr. Monica Gagliano of the University of Sydney in Australia is spearheading research into plant behavior, signaling and communication. She recalls that an oak tree once told her, “You are here to tell our stories.”

U.S. Open: The tournament is entering its second day in New York. Venus Williams and Novak Djokovic claimed easy first-round wins. Serena Williams crushed Maria Sharapova last night in just 59 minutes, in her 18th straight triumph over her rival.

What we’re reading: This article from Nautilus. Melina Delkic, on the Briefings team, calls it “a personal and a scientific look at how closely intertwined language is — particularly one’s first language — with the sense of self.”

Now, a break from the news

Cook: Southern shrimp scampi is delicious over rice or pasta, or alongside a crusty piece of bread. (Our Five Weeknight Dishes newsletter has more recommendations.)

Go: International tourism is rising in Lebanon, which offers an increasing number of environmentally friendly options for travelers.

Read: Four different booklets in special editions of Taylor Swift’s new album, “Lover,” contain reproductions of handwritten journals that reveal what the artist wants us to see — and what she doesn’t.

Watch: The comedian Margaret Cho impersonates her tattoo-averse mother for T: The New York Times Style Magazine’s “Tell T a Joke” feature.

Smarter Living: Sound homework routines set children up for success in school. The bedrock is organized work spaces and backpacks, so important assignments don’t get lost in clutter. Nightly to-do checklists help them prioritize and plan ahead. And you can help your child deal with three main challenges in studying: procrastinating, feeling overwhelmed and struggling to retain information.

And this week’s Social Q’s column offers advice on the etiquette of refusing a secret bribe from a friend’s mother.

And now for the Back Story on …

Sunscreen

The Egyptians used rice, jasmine and lupine; the ancient Greeks used olive oil; and some Native American tribes used a type of pine needle.

Preventing sun damage has been around for millenniums, but the modern concept of sunscreen began on a mountaintop in Switzerland.

After developing a sunburn while climbing Mount Piz Buin in 1938, a Swiss chemistry student set out to invent an effective sunscreen. Eight years later, Gletscher Crème (Glacier Cream) came to market, with what is thought to have been a Sun Protection Factor (SPF) of only two.

A World War II airman mixed an early, heavy form of petroleum jelly with cocoa butter and coconut oil into a product that would eventually become Coppertone.

Don’t leave home without it? The American Academy of Dermatology’s official position is that everyone should wear sunscreen to forestall skin cancer, but, as our reporter Kendra Pierre-Louis recently wrote, dark-skinned people may have enough protection from their own melanin.

That’s it for this briefing. See you next time.

— Melina

Thank you To Mark Josephson and Eleanor Stanford for the break from the news. Remy Tumin, on the briefings team, wrote today’s Back Story. You can reach the team at [email protected].

P.S. • We’re listening to “The Daily.” Our latest episode is about an early accusation of sexual assault against Jeffrey Epstein. • Here’s today’s Mini Crossword puzzle, and a clue: Back talk (four letters). You can find all our puzzles here. • A.G. Sulzberger, the publisher of The New York Times, wrote a cautionary note to the staff, calling attention to a Times article about a campaign led by President Trump’s allies intended to harass and embarrass people affiliated with several leading news organizations.

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airoasis · 5 years

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University Interview

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University Interview

Ah, Harry Sorry i am late No, thanks for coming. You must meet you. You too So, to begin with, can you inform me about your self please? Well, my title’s Harry, 18 years historic. Presently doing my A levels at the moment, i am doing lovely well virtually. And yeah i might wish to be a surgeon after I’m older. First impressions certainly rely 100%. Interviewers can many times make their determination and intellect up on the man or woman that they may be interviewing inside the first few minutes.So even though you’re fearful or now not feeling so optimistic, be certain that your first affect does really depend. Have a organization handshake, good eye contact, and smile. Initially, can you inform us slightly bit about yourself please? Definite, my title’s Harry, i am 18 years historical and i am currently learning Biology, Chemistry, and Maths at institution. As you are aware, i am hoping to pursue a profession in medication. Anybody who’s called for an interview has without doubt acquired to plan their journey, mainly if they may be coming from the Channel Islands, to make special that they are going to be there in time. So if it is in the morning, that they waft over the night time earlier than, so they arrive on time, they’ve time to calm down, be all set, they gown thoroughly. That certainly for one of the most official guides, which is the majority of our publications that interview, an individual simplest has to stroll in carrying thoroughly the incorrect clothing and they’ll have made the worst affect. So why do you need to be a healthcare professional, and what would you wish to acquire in medication? Ah good all people in my loved ones is a health practitioner, so I think it just follows on effectively that i’m too quite.I suppose i’d be a satisfactory general practitioner to be sincere. I’ve received quality persons talents. Be confident but try not to encounter as if you’re smug and a comprehend-it-all. It is a best steadiness given that you have got acquired to sell your self however you want to exhibit that you are a team participant, and that you’re going to fit in good, and that you are teachable. Yeah i’d also prefer to be a Director, have a satisfactory big revenue for myself. Ok, thanks. Men and women that are interviewing you need to look that you are committed to the area, that you’ve bought a passion for the field, and that’s the reason why you are trying to commit your self to this interval of expanded study. They wouldn’t need to situation any one who’s doing it in simple terms for money. And why do you need to be a surgeon, and what do you hope to acquire in medication? Well I’ve accomplished a number of work experience in many exceptional areas, for instance the nearby health center radio, I’ve accomplished some volunteering on the wards there, and likewise at the Jersey Hospice and the Cheshire houses, and the whole lot I did there, I saw patients of their environment and doctors working alongside them in the multidisciplinary group that they have.It was once obviously interesting and everything I did there simply relatively made me need to continue my study and be triumphant in getting a place at clinical school. After we see a CV if a person has work experience, even though it can be volunteering or is free, then it can be certainly goes some distance for us seem on the CV somewhat bit harder. We’re rather looking for a scholar who has undertaken work expertise, no longer simply so they’re just ticking a box to show us they’ve carried out it. But they can fairly show to us what they’ve learnt, what they’ve won, how they’ve reflected on their experiences and it is given them an insight into that profession.So aside from treating sufferers Harry, what do you feel being a healthcare professional is going to entail? Good, it’s numerous bureaucracy surely, not fairly looking forward to that at all to be honest, I suppose it is a bit of a faff. However, yeah there’s a bedside method phase as well I feel, yeah. The worst thing that we have obvious at an interview is poor language. The right perspective is vital, we’re watching for an individual who’s enthusiastic, who’s optimistic, who’s willing to be trained, who can prove they’ve acquired the great organisational advantage, the great communique capabilities. Well without doubt the remedy is an extraordinarily foremost section, but alongside that you additionally must be very academic and very studious to maintain up to date with the continuously altering and evolving subject that you are in. You also have to be an nice communicator along with your workforce and in addition with the patients. If a pupils very intelligent when they’re honestly writing their personal declaration, they could be scripting their own interview.Most of the questions they’ll be requested, primarily in the beginning, are going to be headquartered around understanding they put in that statement. So if someone is unable to definitely broaden on questions, there may be going to be real concerns that did they relatively undertake that have? What steps have you ever taken to fairly discover that you want to be a health care professional? I’ve executed a lot of work expertise and volunteer work, yeah. Vague answers are the equal as no reply particularly. You are now not giving whatever. The interviewer is spending time to comprehend you, you are motivations. They need to get to understand you better and thus see what your knowledge is. For those who simply provide a indistinct reply, it is very intricate for them to make that judgement.It’s relatively main to develop on your answers. The interview is the time to promote yourself fairly. Adequate Harry, moving on to more of an ethical question. Do you believe NHS medical professionals and employees should be looking after private sufferers? Uhh… Umm… I’m not rather sure actually. Umm I dunno, possibly yeah. It can be relatively fundamental to realize what’s going on on the planet on the grounds that it impacts how each agency is doing. It is sincerely a question that I peculiarly ask at the end of every interview is set what a candidate has just lately learn that is interested them about fiscal offerings. So it is really most important, although it’s from whatever you may have read in a trend journal or that you have obvious on a website, it’s rather primary to grasp what’s going on in the market. I might expect anybody to be conscious of their environment, to fully grasp and be aware of what is going on on. I wouldn’t necessarily ask for a political persuasion or some thing like that, but a general working out of what is going on on inside the group within their atmosphere, I suppose that is most important.Do you consider NHS medical professionals and employees should be treating private sufferers? Well it’s an awfully hotly debated matter. Is it proper for private sufferers to have priority over the NHS sufferers who are usually not paying? That’s anything which desires to be suggestion about somewhat bit. At current it sounds as if the overall consensus is that sure, they’re allowed to have precedence over the non-paying sufferers. But nevertheless the NHS will advantage from this as they are going to acquire the additional costs that the private sufferers must opt for up then.We’re continuously looking for whole humans. We don’t determine the solutions that we’re getting on more basic questions, nevertheless it’s main for persons to show that they are , that they have got received a common degree of cognizance to what’s happening on this planet. Can you might be inform me about some large advances you could have examine in science or in remedy? Well there’s been rather a lot particularly hasn’t there, umm lots of stuff, learn daily within the papers. It enables us to get a flavour of them as a individual. So what is it that makes them tick, what are they relatively inquisitive about. I recently have read a gain knowledge of on a melanoma drug named ‘cetuximab’ which is really a particularly interesting factor, simply the motion of it on the physique. Nevertheless, it has been discovered that tumours honestly turn out to be resistant closer to cetuximab and that may be a very interesting discipline of study in oncology which has relatively me not too long ago. Are you able to supply an instance of a quandary the place you have supported a buddy in complex instances, and what quandary they confronted and the way you helped them? Sorry, might you repeat the query? If you happen to do not comprehend the query that a person has requested you, it is quite foolish to try and answer it no longer figuring out what they’re watching for.It is a lot better to ask them to rephrase or to ask the question once more in another way. In a similar way if anyone asks you a relatively complicated question, they would no longer expect an instantaneous reply, so do take a second to consider about it and construct your reply. It’s going to make you a way more confident and robust candidate. Good enough Harry, have you got any questions for us? Umm, nope, no i don’t suppose so no. For me that shows a stage of disinterest. When you are getting ready for the interview you might opt for questions at that factor, but in addition there’s normal questions that you could ask at the end of any interview, and a really excellent one who I consistently consider is ‘do you have got any reservations about me at this factor?’, considering it gives you the opportunity to answer anything that they is also thinking.It is predominant to ask questions, this quite is your final hazard to provoke and it shows you could have prepared in your interview. Even if it’s only one question. I was once just wondering, do you motivate scholars to take rotations abroad? The biggest factor to stand out for the group is to be your self given that everybody is unique so for those who go in and show your possess personality and simply calm down into an interview then that’s how you’ll stand out. If you are all set that you may count on probably the most questions that may be requested, and you can show confidence to your answers and provides a breadth of expertise, then it will not be a fairly daunting experience, however it’s all concerning the preparation. .

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batterymonster2021 · 5 years

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University Interview

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University Interview

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gethealthy18-blog · 5 years

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Top 14 Gluten-Free Flours

New Post has been published on http://healingawerness.com/getting-healthy/getting-healthy-women/top-14-gluten-free-flours/

Top 14 Gluten-Free Flours

Ravi Teja Tadimalla March 25, 2019

Flour is a common ingredient in most everyday foods. It is used in desserts and breads and noodles. Most often, we use white or wheat flour, which contains gluten that affects your digestion and has many other side effects. If you have Celiac disease or are gluten sensitive, here’s good news for you!

Gluten-free flour is the rage right now. In this post, we will discuss the top gluten-free flours and how most of them can benefit you. Keep reading!

Why Gluten-Free Flour? What Is It Made Of?

If you are gluten intolerant, you might have a hard time eating most foods made of flour (as most of them tend to contain gluten). But with gluten-free flour, this need not be the case.

Over 2.5 million Americans are known to have Celiac disease (1). For them, avoiding gluten is the only option to maintain good health. Many others face issues with gluten – and for them, going gluten-free is one way to ensure they don’t fall sick. This is where the importance of gluten-free flours comes into the picture.

Gluten-free flours are typically made of nuts and seeds. Apart from not having gluten (which can be beneficial for some), they can also help you in other ways. What are these flours?

What Are The Gluten-Free Flours You Can Look At?

1. Almond Flour

Almond flour is made from ground and blanched (and with the skin removed) almonds. This flour has a nutty flavor – and one cup typically contains over 90 almonds.

It is commonly used in baked foods as an alternative to wheat flour that contains gluten.

Almond flour has some benefits too. Almonds have been found to lower bad cholesterol levels, which increase the risk of cardiovascular disease. Intake of almonds may also elevate the levels of good cholesterol (2).

But be wary of the calories as one cup of almond flour has 640 calories, which is 200 calories more than wheat flour.

2. Amaranth Flour

Amaranth was once a staple in the Maya and Aztec civilizations. It has an earthy and nutty flavor. When baking, it is important you combine this with other gluten-free flours. You can use it to make tortillas, bread, and pie crusts.

Amaranth contains phytochemicals that offer excellent antioxidant benefits (3). It also contains quality protein and other unsaturated fatty acids (4).

3. Teff Flour

Teff is the world’s smallest grain, but it is quite nutritious. It is popularly used in cereals, pancakes, breads, and other snacks. The flour is rich in protein and helps curb cravings, which can help individuals wanting to lose weight.

Teff also contains the most calcium than any other grain (5). It is also rich in dietary fiber, which boosts the digestive system. The grain also contains other important polyphenols and minerals – making it an ideal addition to gluten-free food preparations (6).

Teff flour can also improve glucose metabolism, thereby helping people with diabetes (7).

4. Buckwheat Flour

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This flour has a rich, earthy flavor and works wonderfully well for baking quick breads. Though it has ‘wheat’ in its name, it is not a wheat grain and doesn’t contain gluten.

Buckwheat flour is particularly rich in rutin, a flavonoid that helps in the treatment of insulin-resistant diseases (8).

The flour also possesses prebiotic and antioxidant properties. Its other benefits include cholesterol reduction, neuroprotection, and anticancer and anti-inflammatory effects (9).

The rutin in buckwheat flour was also found to have potential beneficial effects in treating Alzheimer’s disease (10).

5. Chickpea Flour

Chickpea flour is also known as garbanzo flour, gram flour, or besan. The flour has a nutty taste and a grainy texture – and is an excellent source of fiber and plant-based protein.

In combination with other pulses and cereals, this flour can have beneficial effects on cardiovascular disease, type 2 diabetes, and even some forms of cancer (11).

6. Tapioca Flour

This flour is made from the starchy liquid extracted from the cassava root. It is often added as a thickener in soups and sauces and pies and is also used in bread recipes.

The resistant starch in the flour functions like fiber and boosts digestive health (12).

7. Cassava Flour

Cassava flour is made by grating and drying the entire cassava root. It is most similar to white flour (though it doesn’t contain gluten) and can be used in recipes that need all-purpose flour.

Similar to tapioca flour, this flour variety also contains resistant starch that promotes digestive health.

8. Brown Rice Flour

As the name suggests, this flour is made from ground brown rice. This is a whole-grain flour as it contains the bran, the germ, and the endosperm.

This flour is used to make noodles, breads, cakes, and cookies.

Brown rice flour is far superior to refined flour as it contains essential amino acids, dietary fibers, vitamins, and minerals. Studies also show that this flour can help treat hypertension and diabetes and may even prevent cancer and cardiovascular disease (13).

9. Oat Flour

This is made from whole-grain oats. It contains a soluble fiber called beta-glucan, which has several health benefits. Studies show how this fiber can reduce bad cholesterol levels (14).

Oat flour also contains nutrients like protein, B-vitamins, phosphorus, and other essential antioxidants.

10. Coconut Flour

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Coconut flour is made from dried coconut meat. It can be used like regular flour to make desserts and breads.

The flour is high in lauric acid, a medium-chain triglyceride that is known to lower bad cholesterol levels (15).

11. Tigernut Flour

Tigernut flour is made from small root vegetables (tigernuts). It has a nutty and sweet flavor. The flour can be used for preparing baked goods. Thanks to its sweet flavor, it may easily help you cut added sugar in your food preparations.

Tigernut flour is a powerful source of essential antioxidants (16). The flour also contains several essential amino acids important for human consumption (17).

12. Arrowroot Flour

This flour can be mixed with other flours (like that of coconut, almond, or tapioca) to make breads and desserts.

Arrowroot flour is made from a starchy substance extracted from a tropical plant named Maranta arundinacea. It contains potassium, phosphorus, magnesium, iron, and calcium (18).

Arrowroot was also found to have immunostimulatory effects (19).

13. Sorghum Flour

Sorghum flour has a light color and texture and a mildly sweet flavor. It is a dense flour – and is often used in recipes requiring just a small amount of flour.

Studies show that sorghum can reduce glucose responses – making it an ideal ingredient for managing glucose levels in healthy individuals (20). Sorghum flour also contains phytochemicals that can promote cardiovascular health (21).

14. Corn Flour

Corn flour is commonly used as a thickener for liquids. It can also be used to make tortillas and breads. It can also be combined with other gluten-free flours to make pizza crust at home.

The flour is a rich source of lutein and zeaxanthin, antioxidants that boost eye health (22). Corn flour is also rich in other nutrients like thiamine, vitamin B6, magnesium, and selenium.

Being on a gluten-free diet has never been easier! You can go ahead and make your favorite dishes with any of the flours mentioned above. They will not cause issues – unlike other flours that contain gluten. More importantly, these flours also offer other health benefits.

Talking about that, is going gluten-free worth it? Does it have any benefits?

What Are The Possible Benefits Of Going Gluten-Free?

Individuals with gluten sensitivity or Celiac disease can benefit the most from a gluten-free diet. It can prevent the symptoms of irritable bowel syndrome.

A gluten-free diet may also improve certain symptoms of autism. Some sources suggest that a gluten-free diet can improve behavior and social skills in children with autism. However, we need more research before we can arrive at a conclusion.

That said, gluten-free diets shouldn’t become a fad. Many people on gluten-free diets don’t have the actual need to be on these diets. The biggest risk they potentially have is that they miss on a healthy, well-balanced diet. This is because most gluten-free foods that you find on supermarket shelves are actually processed to remove gluten from them. These pose a bigger risk.

Gluten can be bad for some people – but not for all. If gluten is bad for you, you may also want to avoid wheat flour, rye flour, and barley flour. These flours contain high amounts of gluten.

Conclusion

Gluten-free flours serve as a wonderful alternative for people with Celiac disease or gluten sensitivity. Make sure you look into the nutrients, flavor, and recipe before you choose a flour. However, if you have no issues with gluten, you don’t have to switch to gluten-free flours.

Are you sensitive to gluten? Have you tried any of these gluten-free flours? Do let us know by leaving a comment in the box below.

Expert’s Answers For Readers’ Questions

Can you store gluten-free flour in the freezer?

Yes, you can store most gluten-free flours in the freezer for up to a year. All nut flours, like that of almonds or coconut, must be refrigerated or frozen.

References

“What is Celiac Disease?” Celiac Disease Foundation.

“Almonds and cardiovascular health…” Nutrients, US National Library of Medicine.

“Phytochemicals in quinoa and amaranth grains…” Molecular Nutrition & Food Research, US National Library of Medicine.

“The revival of amaranth as a third-millennium food” Neuro Endocrinology Letters, US National Library of Medicine.

“Teff as a raw material for malting…” Journal of Food Science and Technology, US National Library of Medicine.

“Chemical composition and food uses of…” Food Chemistry, US National Library of Medicine.

“Improved glucose metabolism by…” PloS One, US National Library of Medicine.

“Application of near-infrared reflectance…” Journal of Agricultural and Food Chemistry, US National Library of Medicine.

“Buckwheat as a functional food and its effects…” Journal of Agricultural and Food Chemistry, US National Library of Medicine.

“Buckwheat phenolic metabolites in health…” Nutrition Research Reviews, US National Library of Medicine.

“Nutritional quality and health benefits of…” The British Journal of Nutrition, US National Library of Medicine.

“Health properties of resistant starch” Wiley Online Library.

“Germinated brown rice and its role in…” Critical Reviews in Food Science and Nutrition, US National Library of Medicine.

“Cholesterol-lowering effects of oat…” The American Journal of Clinical Nutrition, US National Library of Medicine.

“Coconut fats” The Ceylon Medical Journal, US National Library of Medicine.

“Processing effects on the antioxidant…” Preventive Nutrition and Food Science, US National Library of Medicine.

“Tiger nut: as a plant, its derivatives and benefits” African Journal of Food, Agriculture, Nutrition and Development.

“Chemical composition, mineral profile, and functional…” Plant Foods for Human Nutrition, US National Library of Medicine.

“Evaluation of immunostimulatory effect of…” Cytotechnology, US National Library of Medicine.

“Grain sorghum muffin reduces…” Food & Function, US National Library of Medicine.

“Sorghum phytochemicals and their…” ScienceDirect.

“Dietary sources of lutein and zeaxanthin…” Nutrients, US National Library of Medicine.

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reomanet · 5 years

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Dissecting the Bloodthirsty Bliss of Death Metal

Dissecting the Bloodthirsty Bliss of Death Metal By David Noonan, Scientific American Contributor | October 31, 2018 08:22am ET MORE Death metal band Cannibal Corpse. Credit: Steve Brown/Photoshot/Getty Images Brutality now becomes my appetite Violence is now a way of life The sledge my tool to torture As it pounds down on your forehead Shakespeare it’s not. Those lyrics, from “Hammer Smashed Face” by the band Cannibal Corpse, are typical of death metal — a subgenre of heavy metal music that features images of extreme violence and the sonic equivalent of, well, a sledgehammer to the forehead. The appeal of this marginal musical form, which clearly seems bent on assaulting the senses and violating even the lowest standards of taste, is mystifying to non-fans — which is one reason music psychologist William Forde Thompson was drawn to it. Thompson and his colleagues have published three papers about death metal and its fans this year, and several more are in the works. “It’s the paradox of enjoying a negative emotion that I was interested in,” says Thompson, a professor at Macquarie University in Sydney, Australia. “Why are people interested in music that seems to induce a negative emotion, when in everyday life we tend to avoid situations that will induce a negative emotion?” A number of studies have explored the emotional appeal of sad music, Thompson notes. But relatively little research has examined the emotional effects of listening to music that is downright violent. Thompson’s work has produced some intriguing insights. The biggest surprise? “The ubiquitous stereotype of death metal fans — fans of music that contains violent themes and explicitly violent lyrics — [is] that they are angry people with violent tendencies,” Thompson says. “What we are finding is that they are not angry people. They’re not enjoying anger when they listen to the music, but they are in fact experiencing a range of positive emotions.” Those positive emotions, as reported by death metal fans in an online survey that Thompson and his team conducted, include feelings of empowerment, joy, peace and transcendence. So far, almost all of the anger and tension Thompson has documented in his death metal studies has been expressed by non-fans after listening to samples of the music. In a paper titled ” Who enjoys listening to violent music and why? ,” published earlier this year in Psychology of Popular Media Culture, Thompson and colleagues sought to identify specific personality traits that distinguished death metal fans from non-fans. In the study, which involved 48 self-described death metal fans and 97 non-fans (all in their 20s), he deployed an arsenal of established psychological tools and measures. These included the Big Five Inventory (BFI) of personality — which assesses openness to experience, conscientiousness, agreeableness and neuroticism — as well as the Interpersonal Reactivity Index (IRI), a 28-item measure of empathy. Notably, on measures of conscientiousness and agreeableness, the scores of death metal fans were subtly but reliably lower than those of non-fans. One possible explanation for this finding, the authors write, “is that long-term, persistent exposure to violent media may lead to subtle changes in one’s personality, desensitizing fans to violence and reinforcing negative social attitudes.” But Thompson emphasizes that we just don’t know. It is also possible that people with these personality traits are more likely to gravitate to death metal. Results from the IRI showed the fan group and non-fan group with similar scores on the four dimensions of empathy that the index measures. When listening to death metal, however, study participants with lower empathy scores were more likely to experience higher levels of power and joy than those with greater empathic concern. That was true as well, Thompson found, for people whose personality assessment showed them to be more open to experience and less neurotic. In the study, each participant listened to four out of eight 60-second samples of popular death metal songs (selected by the researchers from multiple online lists) and answered questions about the feelings the music evoked. The songs included “Slowly We Rot,” by Obituary and “Waiting for the Screams,” by Autopsy, as well as “Hammer Smashed Face.” In one set of responses, the subjects rated (on a scale of 1 to 7) the emotional effects of the music, using pre-selected terms such as “fear” and “wonder.” In a second step, they described in their own words how death metal made them feel. “With its repetitive, fast-paced tempo, down-tuned instruments and blast beats, it is virtually impossible not to be excited!” one fan wrote. “It sounds like messed-up teenagers making throaty, irritating noises about how bad their lives are,” wrote a non-fan. “It’s annoying.” The fact that the study relies on self-reporting by the subjects is a red flag for Craig Anderson, a psychology professor at Iowa State University who has spent his career researching the links between media violence and aggression, and who was not involved in Thompson’s study. Self-reporting “may or may not reflect reality,” Anderson says. “People may be lying to you, or, more likely, people don’t have direct access to many of the kinds of effects that media have on them. They can construct an idea or hypothesis, and self-reports are essentially that kind of data. People may report that ‘Oh yeah, this makes me feel this way,’ without recognizing whether that’s really true.” The paper acknowledges the limitations of self-reporting. But the researchers add that “the convergence of evidence” from the personality assessments and other measures, along with the fans’ enthusiastic embrace of death metal, “suggest that the dramatic differences in emotional and aesthetic responses between fans and non-fans are genuine. Chris Pervelis, a founding member and guitarist of the band Internal Bleeding (whose songs include Gutted Human Sacrifice and em>The Pageantry of Savagery), is confident that the positive emotions he experiences when he plays and listens to Death Metal are the real thing. “When I’m locked into it, it’s like there’s electricity flowing through me,” says the 50-year-old, who runs his own graphic design business. “I feel really alive, like hyper-alive. And the people I know in Death Metal are smart, creative and generally good-hearted souls.” In an essay published in August in Physics of Life Reviews , Thompson and his co-author Kirk Olsen considered the possible role of brain chemistry in the response to violence and aggression in music. The high amplitude, fast tempo and other discordant traits of death metal, they write, may elicit the release of neurochemicals such as epinephrine — which “may underpin feelings of positive energy and power reported by fans, and tension, fear and anger reported by non-fans.” As for the central riddle of death metal — how explicitly violent music might trigger positive emotions in some people — Thompson cites a 2017 paper on the enjoyment of negative emotions in art reception, published in Behavioral and Brain Sciences . The paper, from the Max Planck Institute for Empirical Aesthetics, suggests a mental process that combines “psychological distancing” and “psychological embracing.” In other words, a lack of real-world consequences — it’s just a song! — may provide the distance necessary for fans to appreciate the music as an art form and embrace it. A large body of research, by Anderson and others, has established a clear link between aggression and multiple types of media violence including video games, film, television and music with violent images and themes. “But no one is saying that a normal, well-adjusted person — who has almost no other risk factors for violent behavior — is going to become a violent criminal offender simply because of their media habits,” says Anderson, whose research includes a 2003 study of the effect of songs with violent lyrics. “That never happens with just one risk factor, and we know of dozens of common risk factors. Media violence happens to be one.” One finding from Thompson’s research — that many death metal fans say they listen to the music as a catharsis, a way to release negative emotions and focus on something that they enjoy — is also familiar to Pervelis. “I call it the garbage can,” he says of the music he’s been involved with for decades, “because it’s where I can dump all my bad, emotional baggage. I put it into writing riffs and letting it all out on stage, and it keeps me level and completely sane.” In his ongoing study of violent and aggressive music, which includes a June paper in the journal Music Perception about the intelligibility of death metal lyrics (forget about it, non-fans), Thompson has found that the limited appeal of the form may be one its key features for fans—one at least as old as rock itself. He cites a 2006 paper by the late Karen Bettez Halnon, who found that fans of heavy metal (as has certainly been the case with many other genres and sub-genres over the decades) view the music as an alternative to the “impersonal, conformist, superficial and numbing realities of commercialism.” In that vein, one possible function of the gruesome lyrics that are the hallmark of death metal, says Thompson, may be to “sharpen the boundary” between fans and everybody else. Pervelis, who compares the violent imagery to the “over-the-top, schlock horror films of the 70s,” says feeling like an outsider and an insider at the same time is at the core of the death metal experience. “This music is so extreme and so on the fringe of the mainstream that people who listen to it and people who play in death metal bands belong to an elite club. It’s like we’ve got a little secret, and I think that’s what binds it all. It’s a badge of honor.” This article was first published on Scientific American . © 2012 ScientificAmerican.com. All rights reserved. Follow Scientific American on Twitter @SciAm and @SciamBlogs . Visit ScientificAmerican.com for the latest in science, health and technology news. Editor’s Recommendations

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optometrist0 · 6 years

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Where To Study Optometry

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College mathematics through calculus

And institutions and were recently named

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To be an optometrist, one must earn the Doctor of Optometry professional degree . A Bachelor's … order to practice. Optometrists prescribe glasses, contact lenses and visual therapy, and offer non-surgical treatment of eye diseases and the rehabilitation of patients with visual disabilities. … Interested in this program of study?

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sublimotion · 6 years

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The Most Damaging Food Lie We Have Ever Been Told

http://drhyman.com/wp-content/uploads/2017/12/mark-hyman-hd-headshot.jpg?v=1.1

Other than the lie that fat makes you fat and causes heart disease (which has been thoroughly debunked by myself in Eat Fat Get Thin, in Harvard doctor David Ludwig’s book Always Hungry, and even in our new 2015 US Dietary Guidelines), the biggest lie that has caused endless suffering for tens of millions of people is that to lose weight you need to eat less and exercise more.

This lie goes something like this: All calories are the same. Weight loss is about math—calories in/calories out. If you eat more than you burn you will gain weight. If you eat less than you burn you will lose weight. This is called the Energy Balance Hypothesis. This seems logical, except it is scientifically wrong. It is the message that our government tells us, the message that almost every doctor, nutritionist, and weight loss program tell us. And, it’s even what our public health and professional organizations tell us, including the American Nutrition and Dietetic Association, the American Heart Association, and the American Diabetes Association (which, by the way, all get huge amounts of funding from the food industry).

The food industry, of course, tells us the same thing. That fact alone should make us suspicious. Weight loss is an energy balance problem. Just eat less and exercise more. It’s just about moderation. Any food is fine as long as you don’t eat too much. The 100 calories snack packs of Oreos are the same at 100 calories of blueberries or nuts. Two hundred calories of soda are the same as 200 calories of an avocado. Nonsense.

In fact, on one major morning show I did a segment about why they weren’t the same and snuck it under the radar working closely with one producer. After that, they wouldn’t let me back on the show. Why? Because the food companies are a major source of advertising revenue. Our news is driven my money, not science or facts.

What is so bad about this message is that it blames the person who is overweight. The implication is that you are a lazy glutton who eats too much and won’t exercise. This is, in my view, harmful, cruel, and even criminal because it flies in the face of science and perpetuates a harmful myth that literally kills millions from chronic disease.

This implies that a diet of 1,800 calories of soda is the same as 1,800 calories of broccoli or almonds. Even a 5-year-old would understand that this just doesn’t make sense. Yet it is the foundation of almost every weight loss program.

This is not just my opinion, but from an increasingly growing body of literature that proves that all calories are not the same. That quality matters more than quantity. That food is not just energy but information or instructions or code that literally controls almost every function of your body—including your hormones, appetite, brain chemistry, immune system, gene expression, and even your microbiome with every single bite. And that the quality of the information matters more than the quantity. The composition of the food you eat is what matters.

The Science of Why Exercising More and Eating Less is the Worst Idea for Weight Loss

Let’s just look at a few studies (and if you want more you can read my books Eat Fat Get Thin and The 10 Day Detox Diet.

A review of 53 randomized trials (the highest quality evidence possible) of low-fat vs. high-fat diets published in Lancet Obesity found that the high-fat diets won out every time and the bigger the difference—meaning the highest fat/lowest carb vs. the highest carb /lowest fat diets—the more the weight loss.

A recent year long randomized controlled trial in the prestigious journal Nature found that an unrestricted high-fat diet (meaning low carb, high fat, eat as much as you want) compared to a calorie restricted (not so much fun), low fat diet did much better. In fact, the high-fat diet group lost more weight, had better control of blood sugar, and lower triglycerides and better HDL or good cholesterol). And the high fat group got off diabetic medications too!

Even more research is pouring in about the extraordinary benefits of ketogenic diets (super high fat—70%—and very low-carb diets with no grains, beans, sugar, starch) for weight loss and reversing type 2 diabetes as was recently reviewed in this JAMA article.

A new online company, Virta Health, uses a ketogenic diet to treat type 2 diabetes with more success than any other approach. 87% of patients eliminated or reduced insulin, 56% of patients completely normalized their blood sugar and reversed type 2 diabetes, and the average weight loss at 6 months was 12% of their body weight. All without restricting calories. That is unheard of in traditional calorie restricted low-fat programs.

Food is Information and Quality Matters More than Quantity

And I could go on and on. But the take home message is this: Food is information. Quality matters more than quantity. Weight loss and health depend far more on the type and quality of the food you eat than the calories or amount. In my new book, Food: What the Heck Should I Eat?, I go over exactly what food in each category is the best to eat. Which meat, what dairy, which veggies, what grains, etc. Taking the guesswork out of how to eat food that is good for you, good for the planet and environment, and even good for human rights!

Non-food or food like substances (which is about 60% of American’s diet) is out. This is where I agree with Nancy Reagan. Just say no! It will unhook your brain and palate from highly addictive, health destroying food. And we are being inundated with ads and marketing for the worst possible food under the guise that it is healthy—low fat, high fiber, whole grains, low sugar, etc. It’s all bad.

The Corrupt and Dangerous Behavior of Big Food, Scientists, and Governments

Take for example the massive effort by Big Food to ply their junk across the globe through what I think are criminal activities. Nestlé’s developing world product, a drink called Milo, is a combination of flour and sugar and chocolate with the same glycemic index as Coca Cola. Pure junk promoted as a health food.

Milo is huge in Malaysia. Nestlé hired rock stars for a commercial to promote the drink for performance enhancement in school and sports, plus they made up this scientifically fabricated concept called an “energy gap”, which they claim affects 4 out of 5 kids. Which is why they need Milo. Watch this ad and cringe. It has as of this writing 18 million views! The New York Times published an investigative report about how Nestlé funds corrupt science, pays off nutritionists, and lobbies and funds government policies in Malaysia, making it the fattest country in Asia. If the International Criminal Court focused on Big Food, they would be in Big Trouble.

In my book out February 27, 2018, Food: What the Heck Should I Eat? I uncover the truth about the food we actually eat—what is healthy and not in each group of foods we eat—meat, poultry and eggs, dairy, beans, grains, veggies, fruit, nuts and seeds, beverages, and more, and guide to you to a science based, sensible way of eating for life that keeps you, our planet, and our society healthy. I also address the environmental and social impact of the food we eat.

And I take the guesswork out of how to eat food that has the best information, the best quality to make you feel good now and prevent and even reverse illness.

If you have ever woken up wondering what the heck you should eat, this book is for you. Check out the trailer and order it at Amazon, Barnes and Nobles, or get one at your local bookstore. And get a free video of the 4 biggest food lies out there!

Wishing you health and happiness,

Mark Hyman, MD

[Read More ...] http://drhyman.com/blog/2018/02/07/damaging-food-lie-ever-told/

#infrared sauna #health

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abdallahalhakim · 6 years

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The Most Damaging Food Lie We Have Ever Been Told

The Science of Why Exercising More and Eating Less is the Worst Idea for Weight Loss

Let’s just look at a few studies (and if you want more you can read my books Eat Fat Get Thin and The 10 Day Detox Diet.

Food is Information and Quality Matters More than Quantity

The Corrupt and Dangerous Behavior of Big Food, Scientists, and Governments

And I take the guesswork out of how to eat food that has the best information, the best quality to make you feel good now and prevent and even reverse illness.

Wishing you health and happiness,

Mark Hyman, MD

[Read More ...] http://drhyman.com/blog/2018/02/07/damaging-food-lie-ever-told/

#Health #Medical

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humofun-blog · 6 years

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13 of the best business books of 2017

Looking to get a promotion at work, become an entrepreneur or just have smart topics of conversation at your fingertips for cocktail parties in 2018? Hit the business section of your local bookstore.

There are so many business books published each year, it can be overwhelming to sort through them all. So here are 13 business books from 2017 that received glowing commendations.

"The One Device: The Secret History of the iPhone" by Brian Merchant

This examination of the iPhone includes analysis of both the enormous cultural impact of the device and a history of its manufacturing process. It was on the shortlist of finalists for the Financial Times and McKinsey Business Book of the Year.

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Brian Merchant

✔@bcmerchant

Welp, this just got real.

8:54 PM - Jun 7, 2017

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"'The One Device' is a road map for design and engineering genius, an anthropology of the modern age and an unprecedented view into one of the most secretive companies in history. This is the untold account, ten years in the making, of the device that changed everything," the Financial Times says.

"The Captain Class: The Hidden Force That Creates the World's Greatest Teams" by Sam Walker

The deputy editor for enterprise at the Wall Street Journal and a former sports columnist, Walker identified the pre-eminent sports teams throughout history and determined they all had an influential captain at the time they reigned supreme. He then analyzes the seven commonalities of those captains.

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strategy+business@stratandbiz

The 3 best business books of 2017 on leadership: The Captain Class, One Mission, & Emotional Agility. http://http://ift.tt/2BMWMrd

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Walker's book was selected as the best book in the "leadership" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

"This wonderfully written and wildly entertaining study of the most winning sports teams in history has more to say about leadership, engagement, and the chemistry that sparks and sustains extraordinary achievement than a decade's worth of leadership books," says Strategy + Business reviewer Sally Helgesen.

"Reset: My Fight for Inclusion and Lasting Change" by Ellen Pao

This is Pao's story of suing the esteemed venture capital firm Kleiner Perkins Caufield & Byers for discrimination. She lost the suit, but the litigation brought attention to the overwhelmingly white, male culture of Silicon Valley.

It was a finalist for the Financial Times and McKinsey Business Book of the Year. "Ellen K. Pao's Reset is a rallying cry — the story of a whistleblower who aims to empower everyone struggling to be heard, in Silicon Valley and beyond," the Financial Times says of its selection.

"Principles: Life and Work" by Ray Dalio

Business and life coach Tony Robbins preaches the importance of constantly educating yourself. Robbins tells CNBC Make It that Dalio's book is one of the most inspirational he's read recently. The book is Dalio's explanation of the highly unique leadership strategy he employs at his wildly successful hedge fund, Bridgewater Associates.

Ray Dalio

✔@RayDalio

The key to success at Bridgewater has been an idea meritocracy.

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Dalio "has returned more money as a hedge fund manager to investors than anybody in history," Robbins, author of "Unshakeable: Your Financial Freedom Playbook,"tells CNBC Make It. "If you're not familiar with hedge funds, you know wealthy people give their money to hedge funds, and a big hedge fund might be $20 billion — he's $160 billion. ... He's made money 23 of the last 26 years. He's a total genius, and he gives you his story of how he figured it out, and he gives you his principles for life, his principles for business."

"Machine, Platform, Crowd: Harnessing Our Digital Future" by Andrew McAfee and Erik Brynjolfsson

The authors, from MIT's Sloan School of Management, explain how businesses can best use artificial intelligence and crowd wisdom and how leaders should manage amid these massive technological changes.

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strategy+business@stratandbiz

The 3 best books of 2017 on innovation: Machine, Platform, Crowd; Competing Against Luck; & The Inevitable. http://http://ift.tt/2BNgKCe

1:38 PM - Nov 7, 2017

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It was selected as the best book in the "innovation" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

"Beneath all the concrete problems it raises, an intriguing question lies at the heart of the book: Given the rise of algorithmic decision making, the ability to outsource tasks to the crowd, and such technologies as blockchain, will the corporation as we know it become obsolete?" writes Strategy + Business reviewer James Surowiecki.

"The Spider Network" by David Enrich

This is the story behind the Libor scandal, the deliberate manipulation of the key banking interest rates. It was one of the finalists for the Financial Times and McKinsey Business Book of the Year.

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David Enrich

✔@davidenrich

Coming in March 2018: The Spider Network in paperback! https://www.http://ift.tt/2CfFZk02991/ref=tmm_pap_title_0?ie=UTF8&qid=&sr= …

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"'The Spider Network' is the almost-unbelievable and darkly entertaining inside account of the Libor scandal – one of history's biggest, farthest-reaching scams to hit Wall Street since the global financial crisis, written by the only journalist with access to Tom Hayes before he was imprisoned for 14 years," the Financial Times says.

"If You're in a Dogfight, Become a Cat: Strategies for Long-Term Growth" by Leonard Sherman

The Columbia Business School professor and consultant analyzes the formidable growth of companies including JetBlue, Southwest Airlines, IKEA and Apple. It was selected as the best book in the "strategy" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

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strategy+business@stratandbiz

2017's top strategy books: If You're in a Dogfight, Become a Cat; The Net and the Butterfly; & Smart Collaboration. http://http://ift.tt/2CeObRL

1:28 PM - Nov 7, 2017

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"Like a skilled arborist, Sherman prunes back the ungainly, overgrown tree that strategy has become since it entered the corporate mainstream in the middle of the last century. He saws off a number of dead branches, including the many prescriptions that emerged from the countless searches for excellence, greatness, and the secrets of success," writes the Strategy + Business reviewer Ken Favaro.

"What's left behind is an expertly trimmed tree of knowledge that brilliantly summarizes and integrates what's been learned about strategy over the last 60 years."

"The Great Leveler: Violence and the History of Inequality from the Stone Age to the Twenty-First Century" by Walter Scheidel

The professor of history at Stanford University examines inequality across history. The book was on the list of finalists for the Financial Times and McKinsey Business Book of the Year, as well as being the best book in the "economics" category on the 17th annual best business books of the year list from Strategy + Business.

"Inequality declines when carnage and disaster strike and increases when peace and stability return. The Great Leveler is the first book to chart the crucial role of violent shocks in reducing inequality over the full sweep of human history around the world," the Financial Times says.

"Janesville: An American Story" by Amy Goldstein

The Pulitzer Prize-winning reporter studied Janesville, Wisconsin, after General Motors shuttered its assembly plant there during the Great Recession. It won the award for the Financial Times and McKinseyBusiness Book of the Year and the accompanying £30,000 ($39,339) prize.

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Financial Times

✔@FT

'Janesville', a story about the impact of factory closure on a US community, is FT & McKinsey Business Book of 2017 http://on.ft.com/2yC1ef2

4:08 AM - Nov 7, 2017

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"This is the story of what happens to an industrial town in the American heartland when its factory stills — but it's not the familiar tale. Most observers record the immediate shock of vanished jobs, but few stay around long enough to notice what happens next when a community with a can-do spirit tries to pick itself up," the Financial Times says of its 2017 winner, announced Monday. "This is not just a Janesville story or a midwestern story. It's an American story."

"Stealing Fire: How Silicon Valley, the Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work" by Steven Kotler and Jamie Wheal

This is a study of how to achieve peak performance by getting to aflow state of being exceptionally present. It was selected as the best book in the "management" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

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strategy+business@stratandbiz

3 best business books of 2017 on management: Stealing Fire, The Leading Brain, and Insight. http://http://ift.tt/2i5fuSF

1:14 PM - Nov 7, 2017

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"Most books that focus on using neuroscience in order to work better concentrate on improving our understanding and control of our own brains. But 'Stealing Fire' shows us how to find peak performance through release rather than effort: We get in the peak performance zone not by finding ourselves but by allowing our sense of self to vanish. The goal is to enter 'an elongated present,' which researchers also describe as 'the deep now,'" writes the Strategy + Business reviewer Duff McDonald.

"Adaptive Markets" by Andrew Lo

This is an analysis on the effectiveness of economic markets. It was on the shortlist of finalists for the Financial Times and McKinsey Business Book of the Year.

Andrew W. Lo@AndrewWLo

My book #AdaptiveMarkets is finally out https://www.http://ift.tt/2BNS7p9ts-Financial-Evolution-Thought/dp/0691135142/ref=sr_1_1?ie=UTF8&qid=1493773721&sr=8-1&keywords=adaptive+markets … Thanks to @PrincetonUPress for publishing it and I hope you all like it!

2:26 AM - May 3, 2017

Adaptive Markets: Financial Evolution at the Speed of Thought

A new, evolutionary explanation of markets and investor behaviorHalf of all Americans have money in the stock market, yet economists can't agree on whether investors and markets are rational and...

amazon.com

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"Drawing on psychology, evolutionary biology, neuroscience, artificial intelligence, and other fields, Adaptive Markets shows that the theory of market efficiency isn't wrong but merely incomplete. When markets are unstable, investors react instinctively, creating inefficiencies for others to exploit," the Financial Times writes.

"Once Upon a Time in Shaolin: The Untold Story of Wu-Tang Clan's Million-Dollar Secret Album, the Devaluation of Music, and America's New Public Enemy No. 1" by Cyrus Bozorgmehr

This is the story of Wu-Tang Clan's effort to create an album and sell it to only one buyer. The rap group sold their album to Martin Shkreli, the "pharma bro" businessman turned convicted felon. At the time Wu-Tang sold the album to Shkreli, the rap group had no idea about his nefarious doings.

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strategy+business@stratandbiz

3 best narratives of 2017: Once Upon a Time in Shaolin, Why They Do It, & Move Fast and Break Things. http://http://ift.tt/2Ce6AxT

1:20 PM - Nov 7, 2017

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Bozorgmehr's book was selected as the best book in the "narratives" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

"Bozorgmehr ultimately decides that because what Wu-Tang wanted to do was foster a debate, it's actually good that the album ended up in Shkreli's hands," writes the Strategy + Business reviewer Bethany McLean.

"Superconsumers: A Simple, Speedy, and Sustainable Path to Superior Growth" by Eddie Yoon

This is a delve into what makes a consumer obsessed with a product. It was selected as the best book in the "marketing" category on the 17th annual best business books of the year list by the book reviewers at the management publisher Strategy + Business.

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strategy+business@stratandbiz

The 3 best marketing books of 2017: Superconsumers, The Aisles Have Eyes, & Woo, Wow, and Win. http://http://ift.tt/2Cgq2KD

1:25 PM - Nov 7, 2017

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"For many marketers, Superconsumers will prove illuminating because it emphasizes that you don't have to be a maker of cutting-edge basketball shoes or fast cars to inspire passion. The key, says Yoon, is to uncover the larger reason that superconsumers are hiring your product, and use those insights to expand your market," writes the Strategy + Business reviewer Catharine P. Taylor.

December 27, 2017 at 07:17PM http://ift.tt/2E6XNME

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somekindamushroom · 7 years

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AMANITA DERIVATIVES: A NEW TREATMENT FOR DEMENTIA? - PART II

If Carlsberg is 'probably the best lager in the world', then the multi award-winning University of Copenhagen professor Povl Krugsgaard-Larsen is probably the best medicinal chemist in the world. Unless you drink Carlsberg, and even then, you've probably never heard of him. He is a member of various academies and has honorary doctor degrees from Strasbourg, Uppsala, and Milan universities. He wrote the 'Textbook of Drug Design and Development' and was European editor of the Journal of Medicinal Chemistry from 1998 to 2013. He has authored or co-authored some 450 scientific papers. In 2002, he founded the Drug Research Academy for industry. He was chairman of Carlsberg and The Carlsberg Foundation until 2012 and is currently chairman of The Lundbeck Foundation and the The Grete Lundbeck European Brain Prize Foundation (The Brain Prize) which gives an annual award of one million Euros for outstanding contributions in nueroscience, the biggest award of its kind.

In 1970, Krugsgaard-Larsen achieved his PhD in natural product chemistry before launching a research programme to find new drugs from naturally occurring psychoactive substances. The key structures of his programme were the Amanita muscaria constituents, muscimol and ibotenic acid (which interact nonselectively with GABA and glutamate receptors, respectively) along with the Areca nut's nicotinic acid-based alkaloid, arecoline (which interacts nonselectively with the brain's muscarinic receptors). Muscimol is a natural analogue of gamma-Aminobutyric acid or GABA for short, the neurotransmitter that stops our nerves from getting overexcited and is responsible for muscle tone. A number of different routes for the chemical synthesis of muscimol were published in 1965, 1966, 1968 and 1971 before Povl Krugsgaard-Larsen and Søren Brøgger Christensen submitted a much-simplified method in December 1975 (Christensen himself is a fine biochemist with over 200 papers to his name and has recently done great work with the muscle calcium inhibitor thapsigargin).

Once a relatively easy though tedious synthesis was established, Krugsgaard-Larsen spent the next few years 'redesigning' muscimol to produce a number of intriguing compounds that were either specific GABA agonists (such as gaboxadol and isoguvacine) or antagonists (such as nipecotic acid and guvacine); but the one that seemed most promising was gaboxadol, also known as THIP. Like Albert Hofmann and many other great scientists before him, Krugsgaard-Larsen decided to test the drug initially on himself: beginning with a microdose and working his way up while a colleague took intravenous blood samples. At a 10 milligram dose he didn't feel any pain from the needle and described the feeling “as if I had taken two or three beers. It was a very comfortable feeling.” Gaboxadol was less toxic than its parent muscimol. Moreover, unlike other GABAergic drugs such as alcohol, barbiturates, valium and sleeping pills, all of which influence endogenous GABA already circulating in the brain, both muscimol and gaboxadol work a different way by actually replacing GABA on the neuron. Krugsgaard-Larsen was struck by this unique property and it convinced him of gaboxadol's potential to treat brain disorders such as Huntington's Disease. He quickly patented the drug before passing it to the Danish pharmaceutical company Lundbeck along with his recommendations.

However, whereas nipecotic acid would eventually go on to yield the approved anti-epileptic drug tiagabine, gaboxadol suffered a series of setbacks in both human and non-human trials under a bewildering array of depositor/developmental code names including, but not limited to, MK-0928, AC1LIFYK, Spectrum-001484, LU 2030, UNII-K1M5RVL18S, Lopac-T101, Tocris-0807, Prestwick-13B03, EINECS 264-963-0, and 64603-91-4.

As is common practice in the industry, the first human testing was done on the mentally ill, people like schizophrenics who had developed an involuntary, jerky, repetitive body movement syndrome called tardive dyskinesia (TD) due to the antipsychotic drugs they were prescribed. They were given awfully high doses of gaboxadol, up to 120 milligrams a day, and seen as the drug is derived from a potent entheogenic mushroom, the side-effects should not have been surprising. Gaboxadol failed the TD test and was suggested as a possible anxiety inhibitor.

The next human test involved intramuscular injections on the terminally ill, in this case cancer patients with a few months to live. Gaboxadol succeeded in reducing cancer pain, making the drug a possible substitute for morphine which sometimes results in cancer patient fatalities, but it failed on side-effects. Similar failures would result in later tests on people with mixed anxiety disorders, Huntington's Disease, epilepsy, spasticity, and other neurological afflictions. A final test in the mid-80s was done on Alzheimer's patients who were given an exceedingly high dose of 160 milligrams a day. By then, a cluster of particularly common side-effects had crystallized, and I can put them in descending order: euphoria (a“very comfortable feeling”), confusion, dizziness, sedation, and loss of consciousness altogether. At the higher doses there was reports of colour distortion, the odd hallucination, or of feeling detached from reality in some way (one patient reported “dream-like illusions”) and this may be expected since the Fly Agaric is an hallucinogenic-of-sorts; but the most striking thing to come out of all of this early research was that gaboxadol makes people fall into a deep, deep sleep.

So what exactly has Povl Krugsgaard-Larsen extracted from muscimol? It looks to me like he simply isolated a certain substance found in the chemical make-up of the Fly Agaric mushroom which is responsible for one of its most common and notorious effects, an effect that has been reported for 1000's of years - it makes you pass out. There is certainly something in muscimol that causes the “death-like” sleep state commonly associated with Fly Agaric intoxication. As Clark Heinrich in his book 'Strange Fruit' points out, this state is 'not at all voluntary. This unconscious state can mimic death to the extent that people have been thought dead when discovered by others.' Even breathing slows to a virtual standstill, though this is only a precursor for a different, conscious state. Heinrich calls it a 'dying-that-is-not-dying' and likens the sequel to the meditative trance-like state of Samadhi which yoga practitioners and Buddhists may spend decades trying to harness without success. The Fly Agaric can induce a Samadhi-like state as a matter of course, but depending on your mental state the experience may be terrifying.

As for the detachment and hallucinatory-type effects described above, they were generally at high doses and show that the molecule Krugsgaard-Larsen 'designed' and patented, gaboxadol, still carries traits inherited from its parent, muscimol. Muscimol is a complex conglomeration of molecules designed by natural synthesis (biosynthesis). Chemical synthesis (semisynthesis) of organic molecules in the laboratory is clearly not an exact science.

Nevertheless, gaboxadol was too good a find to throw away. After the Alzheimer's study, the drug sat on Lundbeck's shelves of failed substances for over a decade, except for occasional requests for samples used in experiments with rodents and monkeys. Then, on 1 March 1996, a young somnologist named Marike Lancel who was working in Munich, filed a U.S. patent for a 'Method for treating sleep disorders' (USPTO patent no. 5929065: 'The invention relates to a method of treating sleep disorders in a patient in need thereof comprising the administration of a hypnotically effective amount of a non-allosteric GABA sub.A agonist'). Lancel had been on the lookout for a new sleep drug and realized that although gaboxadol's success in treating the target disorders in human trials was modest at best, it remained a powerful hypnotic. An experiment on rats convinced her of gaboxadol's efficacy as an effective sleep inducer. She was granted her patent on 27 July 1999.

Whatever else gaboxadol may turn out to be (a new treatment for dementia?), it remains a sleep drug/hypnotic par-excellence and should have gone to market. As Marike Lancel et. al. showed in a paper published in the September 2001 edition of the journal Psychopharmacology, gaboxadol 'tended to shorten sleep latency, significantly decreased intermittent wakefulness, increased total sleep time and SWS and enhanced delta and theta activity in the non-REM EEG. Furthermore, gaboxadol increased subjective sleep quality [and] in addition to promoting deep sleep and sleep maintenance, gaboxadol is able to facilitate sleep initiation'. In other words, whereas traditional GABAergic benzodiazepine blockbusters like the much-abused Valium (diazepam) and Xanax (alprazolam), as well as the insomnia drug Ambien (zolpidem), all suppress REM sleep and slow-wave sleep (SWS), gaboxadol actually preserves sleep's 'natural architecture'. It facilitates REM sleep and lengthens the duration of all-important slow-wave sleep, that deep, dreamless state of sleep which is linked to memory consolidation and most of us don't get enough of, especially the elderly.

Good sleep and a healthy brain go hand-in-hand. Slow-wave sleep is the time when our busy neurotransmitters take a nap and the brain clears out the molecular trash accumulated over the course of a hectic day. Since the length of slow-wave sleep gradually shortens as we get older, and since slow-wave sleep is considered essential for memory consolidation and normal cognitive function in general, it seems reasonable to assume that any substance which lengthens the duration of slow-wave sleep in the elderly might have an application in the treatment of dementia. With this in mind, I came across a research paper by neurologist Prof. David M. Holtzman et al. published in the August 2017 edition of the journal 'Brain' entitled 'Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels'. This is the calcium-linked, beta-amyloid plaque build-up spoken of earlier (see part one) which causes atrophy and the degeneration of brain cells. By analysis of cerebrospinal fluid following spinal tap, Holtzman and his team found that disrupting just one night of slow-wave sleep in healthy, middle-aged adults caused a 10% increase in beta-amyloid production. Moreover, six consecutive nights of sleep deprivation increased the level of tau, another brain protein linked to the brain damage (inflammation) found in Alzheimer's and dementia patients as well as various other nuerological disorders.

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greenlifestylemarket · 7 years

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Chemotherapy found to SPREAD cancer throughout the body

(Natural News) Though conventional medicine claims to be winning the war against cancer, along with the holistic health community, we at Natural News have consistently been trying to expose one of the biggest frauds known in human history: CHEMOTHERAPY.

Brainwashed by doctors, oncologists, and the mainstream media, most cancer patients think their only hope for survival is chemotherapy. In America, treating cancer is BIG business. Since the cancer industry makes billions of dollars each year, a cure is not what they are after.

Did you know that the number one side effect of chemotherapy is cancer? Conventional cancer treatments not only fail miserably, they are also designed to make cancer patients sicker. Though chemotherapy may shrink the initial tumor(s), what is happening in the background is far more important. It is the one dark and criminal truth nobody seems to knows about.

Related: How to Detoxify From Chemotherapy and Repair the Body

A new study published in the journal Science Translational Medicine earlier this month proved what we have been saying for decades; conventional cancer treatments cause more cancer. A team of scientists at New York’s Albert Einstein College of Medicine has found compelling evidence that chemotherapy is only a short-term solution.

Eventually, the drugs will make you sick again, pushing patients towards a second round of expensive treatments. Clever money generating trick: Instead of helping patients to get rid of the disease, they temporarily put it on hold so they can take the dollars twice.

Chemotherapy kills more patients than cancer itself

In 2017, an estimated 1,688,780 new cancer cases are expected to be diagnosed and about 600,920 people will die from the disease in the United States, according to the annual report by the American Cancer Society.

The New York scientists explained that while shrinking the tumors, chemotherapy simultaneously opens new doorways for tumors to spread into the blood system, triggering more aggressive tumors which often result in death.

The researchers believe toxic chemo drugs switch on repair mechanisms in the body that allow tumors to grow back faster. Furthermore, Dr. George Karagiannis, lead author of the study, and his team found that two common chemo drugs increased the number of “doorways” on blood vessels which allowed cancer cells to spread to other parts of the body. The team also discovered that chemotherapy increased the number of cancer cells circulating the body and lungs of mice.

Related: Chemotherapy vs Placebo

Though this study only investigated the effects of chemotherapy on breast cancer, the researchers are currently experimenting with other types of cancer to see if similar effects occur, reported The Telegraph.

Dr. Karagiannis noted that women receiving preoperative chemotherapy to treat breast cancer should be monitored to check if the cancer isn’t circulating or creating more possibilities to spread. He recommends taking a small amount of tumor tissue after a few doses of preoperative chemotherapy. If the markers are increased, the therapy should be terminated immediately.

This study is not the first to demonstrate the ways in which chemotherapy can trigger secondary or metastatic cancers. In 2010, researchers at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB Department of Chemistry were awarded a $805,000 grant from the U.S. Department of Defense Breast Cancer Research Program to investigate the question whether chemo encourages cancer to spread throughout the body.

Many studies later, we can no longer ignore the answer to that question. YES, patients are dying from chemotherapy, not cancer itself. It has been shown to not only cause secondary cancers but also accelerates tumor growth and causes cancer cells to become resistant to treatment.

Seventy-five percent of physicians and scientists would refuse chemotherapy for themselves or their family

What does this number say about the effectiveness and risks of therapy? Do these people know more? And what is the mainstream media hiding from us?

Due to the devastating effects on the entire body and the immune system, and an extremely low success rate, three of every four doctors and scientists would refuse chemotherapy, according to polls taken by the McGill Cancer Center. Additionally, an estimated 97 percent of cancers don’t respond to chemotherapy, yet it remains the go-to treatment for nearly every cancer type.

Think about it. When your body is fighting cancer, the last thing it needs is more cancer-inducing, immune suppressing chemicals, right? Though all scientists and doctors know that chemotherapy is pure poison and can make things worse, the U.S. Food and Drug Administration (FDA) outlaws doctors from choosing non-chemical routes, such as vitamins, supplements, herbs, superfoods, and other natural cancer solutions, for their patients.

Over the past few years, one study after another has been coming out, linking chemotherapy to cancer. Yet authorities fail to make the healthy call. How much more proof do they need before they start to acknowledge that there are far better, less expensive real cures out there?

Detox Cheap and Easy Without Fasting – Recipes Included

How to Detoxify and Heal the Lymphatic System

Holistic Guide to Healing the Endocrine System and Balancing Our Hormones

Candida, Gut Flora, Allergies, and Disease

Sources:

Telegraph.co.uk

STM.ScienceMag.org

Cancer.org

NaturalNews.com

Collective-Evolution.com

#Cancer #Chemotherapy

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