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Syphilis (treponema pallidum)

1. Sexually transmitted (acquired) Primary – Chancre (chronic ulcer) Picture Secondary Oral mucosal patches Condyloma latum Maculopapular rash Organopathy Tertiary Gumma (non cancerous growth) Picture Destructive ulcers CNS disease – Neurosyphilis: Meningovascular lesions Tabes dorsalis General paresis CVS disease – Aortitis: Aneurysms Aortic regurgitation and gumma NB: Can go…

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Journals on Emergency Medicine - BJSTR Journal

Darbepoetin Alpha For the Treatment of Anemia in Systemic Mastocytosis by  Pier Paolo Piccaluga* in Biomedical Journal of Scientific & Technical Research https://biomedres.us/fulltexts/BJSTR.MS.ID.002462.php#/ Human systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cells accumulation in various tissues. The most aggressive forms have a rapid course and required treatments to reduce the neoplastic burden and to slacken the progression. Unfortunately, no therapy has been demonstrated efficacy, mostly in the treatment of aggressive systemic mastocytosis (ASM). Supportive treatments include growth factors, transfusions, steroids and anti-histaminic. No data have been reported so far concerning the use of darbepoetin alpha in this setting. Here, we describe a patient affected by ASM who experienced significant improvement of the hemoglobin level with darbepoetin (from 7.8 g/dl to 14.7 g/dl). Of note, a previous attempt with erythropoietin alpha did exert a transient response, which was lost before starting darbepoetin. We conclude that darbepoetin alpha might be considered for prospective evaluation within clinical trials in ASM patients with severe anemia. The Systemic mastocytosis (SM) is a rare disease that is characterized by over-proliferation and accumulation in organs and tissues of clonal mast cells (MCs). It usually occurs in adults involving skin, bone marrow, spleen, skeletal system, liver, or lymph nodes. The World Health Organization (WHO) classification divides the disease into cutaneous mastocytosis, systemic mastocytosis, and localized mast cell tumors. On the basis of histomorphologic criteria, clinical parameters, and organ involvement, systemic mastocytosis is further divided into indolent systemic mastocytosis and advanced systemic mastocytosis variants, including aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) [1,2]. Constitutional symptoms may be present, their intensity being quite variable, and directly related to tissue infiltration and to chemical mediators release by MCs [3,4]. Patients with ASM are marked by the presence of symptoms due to significant organopathy produced by MCs infiltration [1,2,5]. For more articles Journals on Emergency Medicine please click here bjstr Follow on Twitter : https://twitter.com/Biomedres01 Follow on Blogger : https://biomedres01.blogspot.com/ Like Our Pins On : https://www.pinterest.com/biomedres/

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