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#top web hosting company in nepal
rabineastlink · 24 days
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Eastlink Cloud Providing web hosting service we take words look the believable.
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himalayanhost · 7 months
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Navigating the Digital Landscape: Domain Registration and Web Hosting in Nepal
In today's digital age, establishing a strong online presence is essential for businesses, organizations, and individuals alike. To embark on this digital journey, two fundamental elements come into play: domain registration and web hosting. In Nepal, the landscape of internet services is evolving rapidly, making it easier than ever to bring your ideas and ventures online.
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Domain Registration in Nepal
Domain registration in Nepal is the initial step in creating your online identity. It serves as your web address, allowing users to find and access your website easily. In Nepal, numerous domain registrars offer the services you need to secure your unique online address.
Nepal Network Information Center (NNIC) is the official registry for .np domain extensions in Nepal. It is responsible for managing and regulating Nepal's country code top-level domain (ccTLD). Registering a .np domain is a great way to show your local presence and connect with the Nepali audience.
For those who prefer more globally recognized domain extensions like .com, .net, or .org, there are numerous domain registrars operating in Nepal. These registrars facilitate the registration of international domain extensions and offer a wide range of domain management services.
Securing the right domain name is crucial for building brand recognition and trust in the online world. When considering domain registration in Nepal, make sure to choose a reputable registrar with transparent pricing, good customer support, and domain management features.
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Web Hosting in Nepal
Once you have your domain, the next step is to find a reliable web hosting service. Web hosting providers in Nepal offer server space and the necessary infrastructure to keep your website accessible on the internet.
A few prominent web hosting companies in Nepal include Web Hosting in Nepal, eHostingServer, and AGM Web Hosting, among others. These providers offer a variety of hosting plans, including shared hosting, VPS hosting, and dedicated server hosting. The choice of hosting type depends on your website's size, traffic, and resource requirements.
Selecting the right web hosting service is critical for your website's performance and security. Look for features such as uptime guarantees, data backup, and customer support when choosing a hosting provider. It's also essential to consider server location, as this can impact the loading speed of your website for local visitors.
In the context of Nepal, local web hosting providers often offer servers located in data centers within the country. This can be advantageous for websites primarily targeting the Nepali audience, as it can lead to faster loading times and better SEO rankings in the local search results.
In conclusion, domain registration and web hosting in Nepal have become increasingly accessible and essential for anyone looking to establish an online presence. With a plethora of domain registrars and web hosting providers to choose from, individuals and businesses in Nepal have the tools they need to navigate the digital landscape successfully. To make the most of these services, it's vital to do your research, choose the right providers, and tailor your choices to your specific needs and goals.
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Best website company in nepal
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Looking for the best quality website company in Nepal Horizon  International is here. Our company is top rated so you can believe us. we have hight qualified staff for handling software developing. We provide digital marketing, Web hosting, software development, and SEO service these all are our services. For more information, you can visit our office or contact us at 9847777568, our website is https://horizonwebhost.com.
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Quarks Tech Info Soft Provides all IT solutions in PAN India.
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Our team host includes SEO experts, web designers, web developers; email marketing experts, technical support executives, PPC, SMO, SEO executives as SEO company in Nepal. They pay fanatical attention to your input and keep you on track all the time. Our goal is always to provide the best results and ROI to our clients and to follow an agile approach so that it is easy for us to personalize the solutions to adapt them to their business model and obtain more traffic.For that we are top SEO company in Nepal to give services.
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s4g2seocompany-blog · 4 years
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The Best SEO Hosting Services That Work
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emailplan5691-blog · 5 years
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The cheap web hosting NC Case Study You'll Never Forget
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How To Explain Cheap Web Hosting In Nepal To Your Grandparents
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familyvise15 · 2 years
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MLB: Blue Jays Overcome Yankees After Blowing Early Lead, Hold AL Wild Card Race Tight
Starting as the No. 6 team in AP poll, UCLA beat top-10 teams Kansas and Michigan in nonconference play, which put the stage for a great season when you look at the AAWU summit. You will find three divisions in each summit. Background: The initial Wembley Stadium hosted five European Cup finals prior to 2011. The 1968 and 1978 finals were both obtained by English sides: Manchester United overcome Benfica 4-1 in 1968 and Liverpool defeated Club Brugge 1-0 in 1978. Benfica additionally destroyed when you look at the 1963 last, beaten 2-1 by Milan, while Ajax won initial of three consecutive European Cups at Wembley in 1971, beating Panathinaikos 2-0. Into the 1992 last, Spanish club Barcelona defeated Italian part Sampdoria 1-0 into the last match played while the European Cup prior to the following season's introduction of this existing Champions League structure. Arizona, which is the owner of top road record of every staff when you look at the league at 7-0 straight up (SU), heads back to State Farm Stadium looking to improve on its 3-2 SU residence mark. Employed by football people around the world, these gloves function the back of the hand with a TurfGear surface, that is very durable and enables a great amount of airflow to the gloves. Teams ranked within the top six have plenty to try out for besides. https://bitzz.io/ and Sony Six HD to broadcast live coverage of FIFA Futsal World Cup 2021 in Asia and its particular subcontinent (Sri Lanka, Bangladesh, Bhutan, Maldives, Pakistan, and Nepal) countries; all those suits additionally live-streamed in India and its particular Subcontinent on SonyLiv (web site, App) with reasonably limited subscription - Monthly and Annually. Group A includes Pakistan, Sri Lanka, Australia, Brand New Zealand, Canada and Kenya. In the first round, Canada took care of company by going 4-0-0 against Suriname, Bermuda, Aruba, and Cayman Islands. The other two crucial transfers that took place into the Premier League during the winter market had been Sunderland's striker, English Darren Bent, to Aston Villa in return for E28 million, which put a club record. And if you are interested in the most effective football gloves 2021, you then came off to the right spot. The rise features triggered alarm when it comes to Euro 2020 baseball event taking place in numerous locations throughout European countries. As much as NFL followers love seeing backwards-leaping, one-handed captures, it's about time that followers of America’s many popular sport observe that the gloves many large receivers wear tend to be taking more out of the online game than they are contributing to it. Sports-related concussions account for 1.6 to 3.8 million accidents in the usa yearly, including about 50,000 soccer-related concussions among highschool players. Rugby World Cup 2019 award money and bonuses: simply how much will the players make? These childhood football gloves feature a high-grip plastic hand rest to really make it much easier to get the basketball. The textiles utilized in order to make these soccer gloves are top-notch material therefore the unique C-TACK information is adopted. Cutters C-Tack Revolution is another pair of Blades, plus it underscores Cutters’ superiority in neuro-scientific football gloves. Similar to the C-TACK Revolution Football Gloves, these gloves have become among the best-selling football gloves today as a result of existence of C TACK. What makes Cutters C-Tack Revolution so superior to the rest is its enhanced fit, durability, and lightweight building. It has a C-Tack hand for a secure grip. When purchasing these blades gloves, you get not just the C-TACK’s improved grip but in addition the Rev Tack Recharge purpose permits the materials become entirely renewed simply by cleaning the glove surface with a wet fabric. Increase adhesion from the palm surface and enhance gloss. This guy football glove has Under Armor Glue hold technology to ensure a firm and enduring grip in the hand of your hand. Under Armor F7 football gloves provide great toughness, exceptional ventilation and support in addition to grip. Expert baseball people will like having fun with Under Armor Boys’ F7. Under Armor has become a fundamental element of soccer, and their particular soccer gloves tend to be well-liked by both youthful and adult people. These soccer gloves feel so normal they feel like part of yours hand! These are generally very well-mannered and a component and parcel associated with the colours and craze that take this League football to a different height of destination. And in case the NFL really wants to do what’s best for football going forward, it'll have to simply take an unprecedented action into the past and make certain that getting a football is much more about skill much less about impersonating a gecko. The thing you need is one that will offer your full arms ideal comprehensive workout, not just the back of the hands. Whether you’re installing your personal staff, playing down the park, or trying to host the tiny ones before school’s back season, the products tend to be going to hone your talent in the pitch. With their second UEFA Champions League name in 36 months, put into their particular three consecutive Liga championships the players led by Joseph Guardiola have actually shown in times where email address details are much more crucial than playing great, it is perhaps not an utopia to try out showy but still find a way to win games. This has artificial panels for added assistance and durability. Every one of these merchandise offers to enhance hand durability and quickness. Durability is the additional criterion. Engaging more than simply hand and wrist muscle groups, you want to exercise from the little finger all the way through to forearm muscle tissues.
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ifactsnfigsblog · 2 years
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Top 10 Web Hosting Companies in Nepal – 2021 https://factsnfigs.com/top-10-web-hosting-companies-in-nepal/ Web Hosting Companies in Nepal: Whether you’re looking for growing your business online or powering your personal blog, discovering which hosting company to trust in Nepal for your website can be tricky. Countless companies exist to provide the hosting solutions to support roughly several thousands of websites online today – but which one best fits for you?
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nrsnepal · 4 years
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Stay Ahead Technically
Information and Technologies have become a better productive and profitable asset for an organization. With the great appreciation of technology existing as an essential part of our contemporary world, technology consulting needs constant adaptation to the latest trends.
Here we acknowledge that the rate at which technology trends evolve can be daunting for any business owner. But with a little help from dedicated consultants and close collaboration with our industrial clients, we ensure to overcome your company’s technical challenges with effective recommendations and efficient processes. Nepal Realistic Solutions has a great history of being consistent with the unique set of techniques of services and recommendations. As one of the top It consulting firms, we recommend to install, manage, monitor, enhance, and automate from small enterprises to large industrial clients and corporates.
Why shall a company go for technology consulting?
A company needs a well-crafted set of IT consulting services, outsourcing & design solutions that are centered around the organization’s needs, coupled with related knowledge and expertise being a helping hand to you for taking the lead technically in this global market.
With the help of Nepal Realistic Solutions, the technical consulting services are just fingertips away from the leverage of IT in your business environment. We make sure to cover the vital role in businesses by covering the management, implementation, deployment, and maintenance of an IT infrastructure. Likewise, NRS even takes on the role of advising and assisting companies to optimize their IT infrastructure and reach their goals and business objectives with determination.
How Nepal Realistic Solutions can assist you to stay ahead technically?
With the great honor of being an essential external IT department for your company, most of our projects which rely on technology consulting services are focused on implementation. We aim towards reassuring your company’s finances, professional services, or telecommunications teams, helping you stand up from the crowd in this emerging market.
Marking as one of the top IT Consulting Companies here in Nepal, here are some reasons that might assist you to clear up the confusion:
-Our team of experienced individuals in application and web development has been successful in providing secure and user-friendly application programs. Our approach to high-quality application drives potential customers.
-Top hosting for your business websites with a cost-friendly price is just around the corner. The service is backed with technical experts in Server Management, Datacenter, VPS hosting.
-Advancement of technology grows the possibilities for increment in new threats. Being a Managed Security Services Provider (MSSP), we understand your concern and bring you the most trusted network security service with a help of great history.
-Our team here at NRS, has been successful in the development of mobile applications for cross-platforms in order to scale up the level of business your company deserves.
-As a part of your team, NRS offers smart and reliable AI and Robotics service that helps in escalating the exponential level of success for your business.
-We undertake the challenge to hire the best talent for the job requirement of our clients. We hire, train, and deploy service to incorporate a training program that ensures to provide the most eligible candidates.
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acharya123himal · 4 years
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Top 10 Web Hosting Companies in Nepal
Top 10 Web Hosting Companies in Nepal
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Choosing the best web hosting companies to host your website is an important step for your web presence. This will help you to provide uninterrupted services to your customers. Also, the availability of support plays an important role if there is a problem with your website hosting. In addition, the types of packages available also play an important role in choosing a web host.
Here, we…
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wsmith215 · 4 years
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How scientists are using supercomputers to combat COVID-19
In March, IBM announced alongside the White House Office of Science and Technology Policy (OSTP) that it would help coordinate an effort to provide hundreds of petaflops of compute to scientists researching the coronavirus. As part of the newly launched COVID-19 High Performance Computing (HPC) Consortium, IBM pledged to assist in evaluating proposals and to provide access to resources for projects that “make the most immediate impact.”
Much work remains, but some of the Consortium’s most prominent members — among them Microsoft, Intel, and Nvidia — claim that progress is being made.
Petaflops of compute
Powerful computers allow researchers to undertake high volumes of calculations in epidemiology, bioinformatics, and molecular modeling, many of which would take months on traditional computing platforms (or years if done by hand). Moreover, because the computers are available in the cloud, they enable teams to collaborate from anywhere in the world.
Insights generated by the experiments can help advance our understanding of key aspects of COVID-19, such as viral-human interaction, viral structure and function, small molecule design, drug repurposing, and patient trajectory and outcomes. “Technology is a critical part of the COVID-19 research going on right now all over the world,” Thierry Pellegrino, VP of Dell Technologies, a member of the Consortium, told VentureBeat. “It’s crucial to the population of our planet that researchers have the tools to understand, treat, and fight this virus. Researchers around the world are true heroes doing important work under extreme and unfamiliar circumstances, and we couldn’t be prouder to support their efforts.”
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Companies and institutions matched 62 projects in the U.S., Germany, India, South Africa, Saudi Arabia, Croatia, Spain, the U.K., and other countries with supercomputers from Google Cloud, Amazon Web Services (AWS), Microsoft Azure, IBM, and dozens of academic and nonprofit research institutions for free. These are running on over 136,000 nodes containing 5 million processor cores and more than 50,000 graphics cards, which together deliver over 483 petaflops (430 trillion floating-point operations per second) of compute across hardware maintained by the Consortium’s 40 partners.
Microsoft
In addition to supercomputing infrastructure built atop its Azure cloud computing platform, Microsoft is providing researchers with networking and storage resources integrated with workload orchestration through Azure HPC. Concurrent with this is the company’s AI for Health program, which in April allocated $20 million to developments in five key areas — data and insights, treatment and diagnostics, allocation of resources, dissemination of accurate information, and scientific research — with the goal of bolstering work related to COVID-19.
As a part of its work with the Consortium, Microsoft says it’s providing teams access to its scientists spanning AI, HPC, quantum computing, and other areas of computer science at Microsoft Research and elsewhere. Much of these researchers’ work to date has entailed basic scientific discovery about COVID-19 itself and how it interacts with the human host, including the design of therapeutics, through:
Research simulations. Molecular dynamics modeling. 3D mapping of virus protein structures. Compound screening to see if existing drug molecules are able to inhibit cellular entry of the virus.
Microsoft says each organization it collaborates with receives a full Azure HPC environment, including Azure CycleCloud with the Slurm workload manager, best-fit Azure Virtual Machines, and storage. These are configured to scale on-demand and meet compute as necessary, and they’re tailored to the specific research needs of the grantee.
Nepali modeling and ventilator splitting
Through the Consortium, Microsoft’s AI for Health is supporting the nonprofit research institute Nepal Applied Mathematics and Informatics Institute for Research (NAAMII), which is employing simulation to model how COVID-19 would spread among the Nepali population, given different scenarios. These models, Microsoft says, can show patterns that might potentially save lives and livelihoods.
Duke University, another grantee, is leveraging Azure to investigate ventilator splitting, a technique that enables multiple patients to use the same ventilator. The Matlab division of MathWorks teamed up with Microsoft to optimize the researchers’ analysis for distributed computing environments.
Google
Google continues to provide compute, storage, and workload management services to Consortium grantees through Google Cloud Platform, and it recently set aside $20 million in computing credits for academic institutions and researchers studying COVID-19 treatments, therapies, and vaccines. As a part of its work with the Consortium, the company is collaborating on epidemiological modeling with Northeastern researchers and applying AI to medical imaging with the Complutense University of Madrid.
Google also partnered with the Harvard Global Health Institute to fund companies, government agencies, nonprofit organizations, and institutions working on COVID-19 research. The tech giant — along with Microsoft — also kicked off a program with Microsoft-backed cloud company Rescale to offer HPC resources at no cost to teams working to develop COVID-19 testing and vaccines. Rescale provides the platform that researchers launch experiments and record results on, while Google and Microsoft supply the backend computing resources.
Amazon
Amazon, like Google, is supplying compute and tools to researchers matched through the Consortium. Over 11 teams are currently using its infrastructure, and dedicated Amazon Web Services solution architects conference with the scientists every week.
As a part of its AWS Diagnostic Development Initiative, Amazon is also providing $20 million in computing credits to over 35 institutions and private companies that are leveraging AWS to further the development of COVID-19 point-of-care diagnostics — i.e., testing that can be done at home or at a clinic with same-day results. “This is a global health emergency that will only be resolved by governments, businesses, academia, and individuals working together to better understand this virus and ultimately find a cure,” said Teresa Carlson, VP of worldwide public sector at AWS, in a statement.
Developing protein decoys
At the MIT Media Lab, inspired by a researcher at Johns Hopkins University, a team is identifying “decoy” proteins of ACE2 receptors (the receptors coronaviruses bind to inside the human body) that might render COVID-19 inert. Using a machine learning model trained on data about the ACE2 receptor and running on AWS, the researchers are attempting to predict which variants of the decoy won’t interact with other proteins in the body and cause harmful side effects. If all goes well, tests in mice will commence soon, with clinical trials beginning toward the end of summer.
In separate efforts, AWS is empowering researchers at the Children’s National Hospital to combine hundreds of data sets to identify genes that might be targeted to treat COVID-19. A team at Iowa State University is tapping evolutionary models with public genomic data sets to suss out the relationships between strains of COVID-19 to understand how they mutate and spread. And scientists at Emory University are developing a web-based tool — tmCOVID — to extract and summarize key concepts in scientific studies on COVID-19.
Nvidia
Nvidia says that 14 of the Consortium’s projects have consumed over 3 million GPU hours on the Nvidia-powered Summit supercomputer at Oak Ridge National Laboratory. Summit is the world’s fastest supercomputer, as ranked by the Top 500 list of supercomputers. And it also offers its own 20,000-GPU infrastructure — SaturnV — which the company’s researchers are primarily using to optimize COVID-19 research applications
Nvidia has been using excess cycles on SaturnV to run Folding@home, a distributed computing project that simulates protein dynamics in an effort to help develop therapeutics for various diseases, including COVID-19. It has assisted in matching researchers to supercomputers based on each researcher’s specific requirements.
Quantum chemistry and virtual screening
In partnership with Microsoft, Nvidia is working with the University of California, Riverside on quantum chemistry solutions that benefit from GPU optimization. The number of possible COVID-19 inhibitors are immense, and carrying out experimental studies on all the candidates is both infeasible and cost-inefficient. The hope is that the project’s predictive, GPU-enabled simulations — which use up to 800,000 GPU hours on Azure — will provide guidance for efforts that narrow in on the most promising candidates.
According to Nvidia, in less than a week its experts helped project lead Bryan Wong’s package research code using HPC Container Maker, the company’s open source tool that ships with 30 containerized HPC applications. And they tapped Nvidia’s Nsight debugging tool to develop a fix for an onerous bug — making it possible to accomplish work scheduled to take 800,000 GPU-hours in 300,000 GPU-hours for a savings of $500,000.
At Carnegie Mellon University, a team led by Olexandr Isayev worked with Nvidia to apply AI approaches to the task of high-throughput virtual screening, which uses algorithms to identify bioactive molecules. Unlike traditional scientific simulations, which take a brute force approach to problems by attempting to simulate every possible combination of molecular interaction, AI makes educated guesses that reduce the number of combinations to be simulated. This leads to theoretically faster candidate drug discovery (and quicker field trials). Isayev estimates that it might be as much as a million times faster than usual mechanical calculations.
The first step in the process is using AI to analyze a library of molecules that can be purchased from chemical companies, preparing them for screening in simulation. The best candidates from the screening will then be simulated using AI-enhanced molecular dynamics, and top hits from the final screening will be tested in partner laboratories.
At the conclusion fo their work, Isayev and colleagues plan to deposit their data sets in the open source COVID-19 data lake, a centralized repository of curated data sets maintained by Amazon’s AWS division in hopes that other researchers will benefit from them.
IBM
IBM VP of technical computing Dave Turek says COVID-19 research continues with partners across the spectrum — on machines powered by its hardware and within laboratories and institutions it has relationships with. “Without any large contracts or anything of the kind, [the Consortium] came together in a way to both share resources and manage a process of expediting the scientific proposals that came into the consortia and match it to the best resources,” he said in a statement. “The teams are making rapid progress, and these supercomputing-powered projects are using novel approaches to understanding the virus.”
For example, IBM researchers at the Hartree Centre in Daresbury, England partnered with University of Oxford scientists to combine molecular simulations with AI in discovering compounds that could be repurposed as anti-COVID-19 drugs. Using Summit and the Texas Advanced Computing Center’s (TACC) Frontera, the fifth-fastest system per the Top 500, the team says they’re accomplishing months of research in a matter of hours.
Generating molecular compounds
With the help of IBM, researchers at the University of Utah tapped the National Center for Supercomputing’s Blue Waters and TACC’s Longhorn and Frontera to generate more than 2,000 molecular models of compounds relevant for COVID-19. They ranked the models based on the molecules’ force field energy estimates, which they theorized could help scientists design better peptide inhibitors of an enzyme to stop COVID-19.
The team investigated the structure of the virus’ main protease, an enzyme that breaks down proteins and peptides, in complex with a peptide inhibitor called N3. They then applied an approach developed to identify Ebola-stopping molecules that involves molecular dynamic simulations and optimization of specific structures. This enabled the COVID-19 protease to break down a series of similar, easy-to-detect probes that had already been designed, serving as the basis for assessments that test the inhibitors’ effectiveness.
The work built on a body of knowledge about how the potential energy generated by atoms can give a molecule a positively or negatively charged “force field” that attracts or repels other molecules. Using AMBER, a molecular dynamics code, the researchers observed experimental results within one hundred-millionth of a centimeter, a measure imperceptible to all but the strongest microscopes.
The University of Utah’s Schmidt lab will later transform the peptide leads into biopharmaceutical scaffolds called circular modified peptides. “Our hope is that we find a new peptide inhibitor that can be experimentally verified in the next couple of weeks. And then we will engage in further design to make the peptide cyclic to make it more stable as a potential drug,” University of Utah professor and research lead Thomas Cheatham said in a statement.
Mapping how COVID-19 spreads
It’s well understood that COVID-19 spreads via virus-laden droplets, which are transported around environments by air conditioning units, wind, and other forms of turbulence. But airborne transmission rates remain a subject of contention, and some experts say gathering useful evidence of airborne transmission could take years and cost many lives.
In a safer pursuit of clarity, scientists at Utah State University, Lawrence Livermore National Lab, and the University of Illinois intend to use the Consortium’s supercomputing resources to study person-to-person transmission of airborne respiratory infectious diseases like COVID-19. They are working from the hypothesis that aerosolized droplets from human airways contaminate rooms more quickly than initially assumed. They’ll leverage high-fidelity multiphase large-eddy simulations (LES) — mathematical models for turbulence used in computational fluid dynamics — running on IBM hardware to determine cloud paths in typical hospital settings.
The short-term aim will be to understand how long a cloud persists and where the particles settle, which could inform non-pharmacological techniques to reduce the spread. “The [goal] of this study is to fundamentally improve our understanding of person-to-person transmission of airborne respiratory infectious diseases,” wrote the researchers in a statement. “Our findings will [make] it safer for health care professionals.”
Studying genetic susceptibility
Beyond isolating COVID-19-killing compounds and mapping viral spread of the virus, researchers are attempting to define risk groups by performing genome analysis and IBM supercomputer-enhanced DNA sequencing.
A team of scientists affiliated with NASA have observed that COVID-19 appears to cause pneumonia, triggering an inflammatory response in the lungs called acute respiratory distress (ARDS). To test this, they plan to use the supercomputer at NASA’s Ames Research Center, which will sequence the genome on patients who develop ARDS and those who don’t. 
If all goes well, the team believes their study will result in practical tools for predicting which COVID-19 patients are likely to develop ARDS, and therefore which patients are likely to need intensive support prior to the emergence of severe symptoms. Such tools could help guide intensive care resource usage for the sickest patients, and enable health care workers to better manage ongoing treatment.
Intel
Intel is actively involved in the design, development, and deployment of several Consortium-affiliated supercomputers, as well as the upcoming Aurora at Argonne National Laboratory in Chicago. The company says it has a staff of engineers working on code optimizations for HPC applications that include LAMMPS (a molecular dynamics code), Gromacs (a package for protein, lipids, and nucleic acids simulation), NAMD (another molecular dynamics code), AMBER, and others. Intel is also sharing tools, architecture knowledge, and software with partners to enhance COVID-19 applications and scale their performance on Intel-based hardware.
One specific area of focus for Intel is a collaboration with NAMD to release a version of the code that provides faster simulations on Xeon processors that support AVX-512. The company says the significant performance boost will allow researchers to achieve longer timescales in the simulation of relevant molecules associated with COVID-19, by extension enabling them to better understand aspects of viral infection with “atom-level” detail. The update is expected to be made public for early use in June.
Hewlett Packard Enterprise
Some of Hewlett Packard Enterprise’s (HPE) work is done through the Consortium, while the rest is focused on a number of customers and partners. As a result of its acquisition of Cray in September 2019 for approximately $1.3 billion, HPE claims it now has more supercomputers and HPC systems in use than any leading research center.
“High-performance computing is more powerful today than it’s ever been, and its massive computing power — along with other advanced capabilities — has significantly transformed drug discovery,” said Peter Ungaro, former Cray CEO and head of HPE’s HPC and mission-critical systems group, in a statement. “Supercomputing and HPC systems unlock greater potential for AI and machine learning applications, and when applied to 3D modeling and simulations, dramatically [accelerate] time-to-insight and [increase] scientific outcomes. Our work within the consortium provides the researchers with HPC capabilities they wouldn’t normally have access to independently to help fast-track the discovery of a cure for the pandemic.”
Drug design research
In partnership with Microsoft, HPE is working with a team at the University of Alabama in Huntsville (UAH) to supply its Sentinel supercomputer through the Azure cloud. With the supercomputer, along with a team of dedicated HPE experts, it’s supporting various stages of the drug design process at UAH.
The researchers are employing a molecular docking approach, a kind of bioinformatic modeling that involves the interaction of two or more molecules to yield a stable combination. Drawing on a large, open set of natural products found in plants, animals, fungi, and the sea, Sentinel is performing calculations to determine how natural compounds interact with COVID-19’s protein. Previously, 20,000 molecular dockings could be improved against a protein target in seven or eight minutes, versus the full 24 hours it used to take. Now, the research team can perform as many as 1.2 million molecular dockings per day.
Elsewhere, HPE is supporting work at the Lawrence Livermore National Laboratory with the Theta supercomputer, which is housed at the Argonne Leadership Computing Facility. The researchers’ goal is to apply AI to accelerate the process of simulating billions of molecules from a database of drug candidates. They’ve narrowed down the number of potential candidates from 1040 to a set of 20, and they’ve tapped Catalyst — an HPE-powered HPC cluster that generates predictions like experimental and structural biology data  — to improve outcomes and speed up discovery.
HPE is also collaborating with France’s National Center for Scientific Research and GENCI to arm scientists at the Sorbonne University in Paris with GENCI’s Jean Zay supercomputer, which HPE designed. The team is using Jean Zay to optimize the Tinker-HP software, an approach to parallel computing enabled by multiple graphics cards and designed to simulate at the level of atoms for large biological molecules. Tinker-HP simultaneously performs a range of data-intensive calculations to create 3D simulations of molecular interactions faster and at high resolutions than would otherwise be possible.
Contributions from the private sector
The nature of the Consortium’s work isn’t strictly academic. Startups hope to use the group’s vast computational resources to develop treatments, molecular designs, and drugs targeting COVID-19.
Kolkata-based Novel Techsciences is identifying phytochemicals from the more than 3,000 medicinal plans and anti-viral plant extracts in India that might act as natural drugs against COVID-19. The team also plans to isolate plant-derived compounds that could help tackle multi-drug resistance that arises as the coronavirus mutates, with the goal of developing a comprehensive prophylactic treatment regime.
In London, Y Combinator-backed PostEr is overseeing the Moonshot Project, which aims to produce inhibitors based on over 60 fragment hits (i.e., molecules validated to bind to a target protein, making them a chemical starting point for drug discovery) that have been isolated in experiments to determine the molecular structure of COVID-19. By running machine learning algorithms in the background to triage suggestions and generate synthesis plans, PostEra has identified around 21 highly effective volunteer-submitted molecular designs, which will be synthesized by chemical company Enamine. The results of this project will be tested on animals in months.
If successful, PostEra’s would be one of the first drugs developed in an open source fashion. “[Machine learning] can reduce the time to determine optimal ways to make these compounds from weeks to days,” the company said in a statement. “[We believe] the worldwide scientific community [can suggest] drug candidates that might bind to, and neutralize, [COVID-19].”
Another private sector project is led by London-based AI startup Kuano. This team’s intention is to gain insights from diseases that are similar to COVID-19 — mainly other coronaviruses — to design an effective COVID-19 drug. This effort relies on a genetic algorithm that searches the chemical space surrounding existing antiviral drugs and a deep learning-based classification model built on existing binding data. The company is combining those tools with docking and molecular dynamics simulations to enhance the results and yield machine learning models that can be used to score molecular designs for synthesis as antiviral compounds.
As for AI and drug development startup Innoplexus, it’s also working with the Consortium’s supercomputers to accelerate the discovery of molecules that could lead to a drug to combat COVID-19. It expects to run permutations on five promising candidates — specifically, candidates that are potent, non-toxic, and can be manufactured.
Early days
Despite the fact that much of the work remains in the early stages, momentum around the Consortium appears to be accelerating.
Last month, IBM announced that UK Research and Innovation (UKRI) and the Swiss National Supercomputer Center (CSCS) will join the Consortium, making available machines that include the University of Edinburgh’s ARCHER; the Science and Technology Facilities Council’s DIRAC; the Biotechnology and Biological Sciences Research Council’s Earlham Institute; and Piz Daint, the sixth-ranked supercomputer in the world, according to the Top 500. The new additions have brought the total available petaflops up to 483 from 437 in May and 300 in mid-March.
“The COVID-19 HPC Consortium … is the largest public-private computing partnership ever created. What started as a series of phone calls […] five days later, more than two dozen partners came on board, many who are typically rivals,” said IBM’s Turek. “Without any large contracts or anything of the kind, this group [is coming] together in a way to both share resources and manage a process of expediting the scientific proposals that came into the consortia and match it to the best resources.”
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Web Development in Nepal | The trend of Web development in Nepal
A new era of digitalization
Nepal is starting to catch up when it comes to several technological advancements that are otherwise a part of ordinary lives in most developed countries. One of our major exports and contribution to this is in the sector of IT and Software solutions. Amongst them, Software and Web development in Nepal are the major categories.
The latest trend of startups popping around in every corner of the street providing a vast array of digital and technological solutions to businesses is not going to stop anytime soon. While it was unheard of in the last 5 years, nowadays it is very common to hear Nepali start-ups and programmers generating revenues in the millions. If you have an idea or a solution, you will find no shortages of companies and individuals willing to help you realize those ideas. 
In recent times, companies from abroad have started outsourcing their technical problems to countries like ours realizing the value of such a fresh and diversely talented market. 
In today's modern digital world, if you or your business is not available online, then you are severely missing out on various opportunities. You can use your website to connect with your clients, create awareness for your brand and overall increase the presence and reach your business can have.
If you are not yet convinced, then here are a few reasons to build a website for your business:-
To build an online presence
Digital marketing possibilities
Engage your customers and build customer relations
Reach a new range of potential customers to increase sales
Providing accessibility around the clock to customers
To build credibility.
To provide more information and guidance to customers before closing
Must consider tips to ensure a proper website design:-
Use minimal and simple design.
Ensure simple navigation between pages.
Provide helpful content and information
Ensure responsive design and mobile-first approach to website development.
Ensure faster website load times.
Make it easy for visitors to convert with a quick and simple check-out process. 
Ensure proper SEO techniques are being implemented on your website.
How to start building a website for your business?
Getting started with professional looking and responsive websites does not need to be a difficult thing. There are various free and paid options for website building services that can accommodate your requirements. Various drag and drop website building services like Squarespace and Wix are easy to use and provide affordable hosting charges. If you are someone with basic web design knowledge, you can also use WordPress, which is free to get started.
However, if you require professional web solutions and want to optimize your site for search engines, then hiring a Web development agency is the path to choose. This might require a significant investment upfront but the outcome achieved as a direct result of their understanding and experience of the digital world is well worth the price.
For one, they know the latest web development trends and can help customize your business needs to provide a positive user experience. A web development agency can also create web page content that is optimized for the search engines. 
WordPress CMS vs Laravel
We here at Top Nepal International are adept at providing website solutions in both WordPress and Laravel. Both of these can meet your requirements but how to choose one above the other?
Well, let’s explore further. WordPress is a content management system (CMS) created with the goal of building websites, whether using customizable themes or creating tailor-made solutions. Laravel, on the other hand, is a PHP framework used for creating web applications and other sorts of websites. They are both focused on the user and devoted to building websites that are easy to use and are also simple and easy to manage.
A simple difference between the two is that WordPress is a system and Laravel is a framework within PHP.
WordPress advantages include:
Search-engine friendly structure
Integrated link management
Clean permalink structure
Ability to assign multiple categories to posts
Automatic filters to format and style texts in posts
Ability to edit content both in a visual editor and an HTML-based text editor
Customizable features with the use of plugins
Easy integration of third-party services
Large supporting community worldwide
Laravel advantages include:
Developer friendly structure supported by excessive documentation
Implemented authentication system
Simple validation and authorization process for web apps
Easily manageable automated tasks
Consistency in database migrations
Fast and painless deployment of apps
Customizable features with the use of packages
Easy integration of third-party services
Large supporting community worldwide
In the end, this all boils down to the specifics of what you and your business needs. If you run a small business that requires minimal complexity and simple e-commerce features, WordPress might be the way to go. On the other hand, if your business needs a complex and robust web solution that can handle large-scale applications and processing, you should look into Laravel as the best choice for you.
If you need help designing attractive websites for your business that’s optimized for the search engines and easy to navigate, it’s time to call in the experts. Our Web development team at Top Nepal International will assess the goals of your business and create a superior product that will surely breathe life to your business and brand.
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nrsnepal · 4 years
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Technical Consulting | IT Consulting Services
Information and Technologies are the keys to a better, productive, and profitable organization. As advanced technology exists as an essential part of our contemporary world, technology consulting needs constant adaptation to the latest trends. Moreover, technology plays a more significant role in businesses; IT consulting companies in Nepal like us are operated to help businesses use technology effectively.
Here at Nepal Realistic Solutions, with a little help of dedicated consultants and close collaboration with our industrial clients, we ensure to overcome your company's technical challenges with effective recommendations and efficient processes. We have a great history of being consistent with our unique set of techniques of services and recommendations. As one of the top IT consulting firms, we recommend to install, manage, monitor, enhance, and automate from small enterprises to large industrial clients and corporate.
Why shall a company go for technology consulting?
The dedicated technical consultant team here at Nepal Realistic Solutions provides a wide range of IT services, outsourcing & design solution which are precisely crafted for your business. We are always prepared with our portfolio which is centered on the organization’s needs, coupled with related knowledge and expertise.
Here at Nepal Realistic Solutions, you not only hire IT Consulting in Nepal, but even hire experience, knowledge, and a portfolio of services which are just fingertips away from the leveraging IT in your business environment. We make sure to cover the vital role in businesses by covering the management, implementation, deployment, and maintenance of an IT infrastructure. Likewise, NRS even takes on the role of advising and assisting companies to optimize their IT infrastructure and reach their goals and business objectives with determination.
Why choose Nepal Realistic Solutions?
With the great honor of being an essential external IT department for your company, most of your projects which rely on technology consulting are focused on implementation. We make sure to bring reassurance to your company's finances, professional services, or telecommunications teams.
Marking as one of the top IT Consulting Companies here in Nepal, here are some reasons that might help you in clearing up the confusion:
- Our team of experienced individuals in application and web development has been successful in providing secure and user-friendly application programs. Our approach to high-quality application drives potential customers.
- Top hosting for your business websites with a cost-friendly price is just around the corner. The services are supported by technical experts in Server Management, Datacenter, VPS hosting.
- Advancement of technology grows the possibilities for increment in new threats. Being a Managed Security Services Provider (MSSP), we understand your concern and bring you the most trusted network security service with a great history.
- NRS team has been successful in the development of mobile applications for cross-platforms to scale up the level of business your company deserves.
- As a part of your team, NRS offers smart and reliable AI and Robotics service that helps in escalating the exponential level of success for your business.
- We undertake the challenge of hiring the best talent as per the job requirement of our clients. We hire, train, and deploy service to incorporate a training program that ensures to provide the most eligible candidates.
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