tuncaydelibasi
Prof. Tuncay Delibasi of Endocrinology Department
Tuncay Delibasi – a renowned professor from the Department of Endocrinology, Diskapi Hospital
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Leptin resistance or deficiency in the human body causes profound obesity, diabetes, infertility etc. Leptin replacement therapy is a new treatment that is successfully used to treat obesity.
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The sensitivity of insulin changes during the replacement of leptin
Leptin can also increase the sensitivity of insulin, not just through reducing lipotoxicity and adiposity as well as insulin-independent actions both peripherally and centrally. Leptin can also reduce the manufacturing of glucose which contributes to its effect of lowering the level of glucose.
In addition to engaging in exercises, getting rid of body fat will increase the sensitivity of insulin. Look for foods with more fiber and lower GI and the glycemic load, which can help increase the sensitivity to insulin. Other strategies to improve insulin sensitivity is to sleep enough, and to decrease stress levels.
What triggers increased insulin sensitivity?
Chromium, Berberine magnesium and berberine supplements can increase insulin sensitivity. Resveratrol may increase the sensitivity of insulin, especially in those with type 2 diabetes.
As insulin levels rise and the body is unable to keep on burning fats for fuel, and also encourages the storage of food items in the form of fat. This is why, so long as the diet is rich in carbohydrates and fats, the body doesn't have the chance to burn off its own fats, which makes the process of losing weight more difficult.
Two kinds, or classes of diabetes medications increase the number of cells or more sensitive to insulin. These are the biguanides and the thiazolidinediones (TZDs).
How does leptin affect insulin levels?
In addition, leptin hinders insulin secretion via PI3K-dependent stimulation of the phosphodiesterase 3B (PDE3B) and also by reduced cAMP levels, thereby hindering the protein kinase A (PKA) pathway that responsible for controlling Ca2+ channels as well as exocytosis (Marroqui and co. 2012).
Insulin is a key anabolic hormone, and it is known to promote muscle growth. The treatment of insulin in people with uncontrolled diabetes can increase muscle mass, whereas the deficiency of insulin causes the loss of muscle mass.
Source: American Journal of Physiology-Endocrinology and Metabolism
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