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alizardbro · 5 months

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I trust medical science, I believe in treating disease and that vaccines work, but I do not trust doctors. When I was 15 I started experiencing chronic pain in my left foot, shortly after I had a plantar wart removed from that foot. I went to my pediatrician and he said that it was normal to have a little pain after surgery, and he dismissed me when I told him it was more than "a little pain".

Months went by and the pain only kept getting worse, and now it had spread to my right foot. I went back to my pediatrician and told him that it felt like my feet were on fire and that I was having pins and needles almost all the time. He told me that it was plantar fasciitis, and that if I do some stretching it will get better.

More months went by and now I was 16, the pain had spread up both my legs and was only getting worse. Again I went to my pediatrician and begged him to help me, but he told me that I was just overweight, and that if I lost 20 lbs I'd feel a lot better.

Another 6 months went by, the pain had spread to my hips and lower back. It was a burning agonizing pain that was constant, I could barely walk most days and never without a cane. I asked my parents to go to the doctor again, but they pointed out that the doctor said that I just needed to lose weight. I told them that the pain was unbearable, that I needed more than weight loss, but they said that I had a tendency to be over dramatic about illness.

More time passed and now I was 17. The pain was so bad that I couldn't sleep through the night anymore, even with my psych meds I was on to help me sleep. I as passing out and throwing up from the pain now, and it had spread to just below my chest. It was horrifying to feel the pain slowly crawl up my body. I finally convinced my parents to take me to the doctor again, and the doctor told me that he would have me tested for a few autoimmune disorders. I went in for bloodwork, and a week later it all came back normal. My parents and pediatrician were very confused when I got upset at this news, because this meant that I was healthy and that their suspicions of me being dramatic were confirmed.

3 months went by before I told my parents that I couldn't take it anymore, and demanded to see my doctor again. My pediatrician was about to write me off again as just fat, but I told him that I needed a referral or else I would take action. Magically I had a referral to a rheumatologist.

I went and saw the pediatric rheumatologist a few weeks later. He looked me over and did some mobility tests, and diagnosed me with AMPS or Amplified Musculoskeletal Pain Syndrome. I was told to do physical therapy and that if I stick to a routine of physical therapy and desensitization therapy, I should recover completely or almost completely. My dad was very pleased to hear this, a cure for my condition was all my parents wanted, my pain had been inconveniencing and embarrassing them for long enough.

I went to physical therapy multiple times a week, I did the desensitization therapy multiple times daily, no matter how agonizing it was. Eventually I was "done" with physical therapy, my balance had improved a lot, but my pain hadn't. My pain had only continued to get worse. I told my parents this, but it was clearly only because I wasn't working hard enough. "Are you doing your home physical therapy?" "Are you doing your stretching in the morning?" "You just need to push through it"

After I turned 18 I started doing research on my condition, and apart from the pain, none of my symptoms matched AMPS. I told my parents this and pediatrician this, ut again they were very dismissive. After doing a lot of research I've come to the conclusion that I have CRPS or Complex Regional Pain Syndrome. I will never get better, I will never not be in pain, and I knew that, I always knew that.

A lot of pediatric doctors put their head in the sand when I young person (especially a female presenting young person) tells them they're in pain. They tell the parents what they want to hear and don't actually try to help you. As soon as I'm able to, I'm going to find someone who will help me. Hopefully once I get an official diagnosis things will finally get better.

#actually disabled #disability #crps #medical gaslighting #chronic illness #chronic pain

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yennasun · 2 years

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TW: Dissociation, panic attacks, mentions of addiction and paranoia

January 16th, 2013: aches and pains.

The next year and a half was comprised of MT finding work wherever he could.

He worked all manner of odd jobs just to get by, but it wasn't enough.

He'd busted his ass working construction, maintenance, painting and cleaning buildings, repairs and many other back-breaking tasks. Working 70 hour weeks for measly paychecks.

It was miserable.

Pair that with the fact there was currently a housing crisis, so he couldn't even afford a small apartment. He was stuck sleeping in back alleys or park benches, in December when it was especially cold. He was homeless

It got so bad that he had to resort to setting fire to old barrels and dumpsters to keep warm, and when they weren't available he'd just activate his powers. It wasn't much better but he was at least used to it.

However it began to hurt much more than usual.

On that note, he learned the hard way that not all sticks had powers and that any that did had to register and were legally required to wear an identification card stating their powers, danger level and in the case of former slaves; their date of creation, date of relinquishment, registration signature and big bold letters announcing their status for everyone to see...

"I hope I get 3 minutes alone with the prick that made that a law" he grumbled to himself

He also learned that most sticks DIDNT have powers and they tended to look down on those that did, it was even worse if they were a freed (escaped) slave or "bondie" and he'd been called many times.

Being one or the other was bad enough, but being both all but beckoned ridicule and discrimination.

Thankfully, the guy at the registry threw him a bone, most likely because he was an escaped slave himself. He wasn't turned in, but had to register as an "amp" and a freed slave.

He had to wear what was essentially a badge of shame at all times when he was out in public or else he'd face fines which he just couldn't pay, and if he couldn't pay the ridiculous fines he'd definitely do time.

But it wasn't all bad, it actually helped him find work. And many illicit businesses had work for a level 5, or "catastrophic" level amp.

He worked jobs for the local gangs on the side, helping push drugs and intimidating any competition. But really he wasn't affiliated the gangs, he was affiliated with the money they payed him.

In that line of work, he'd witnessed and been caught in so many gunfights that he was almost used to it. At least the shots weren't as loud...

His back and shoulders ached once again, reminding him of all the terrible conditions he'd worked in; not just with the street gangs.

He'd worked in disease infested sewers, on massive skyscrapers when his contractor got him a work passport to stickcity, he'd repaired pipes in a half-flooded pump station, the list goes on.

But today, at long last he had enough to lease out a small apartment.

But in the process he'd lost many of his morals; he'd hurt people, he'd hurt them bad and he helped push drugs that fueled someone else's addiction...

Worse then, his paranoia was beginning to get out of hand.

He remembered when he was working repairs and he saw a pedestrian that he thought was staring a bit too intently at him. He'd been on edge the rest of the week over it.

Why is he there, why does he keep staring at me? Is he a commission rat? Does he want to rob me?!

That wasn't even close to the only instance, it was just the most recent and the most tame.

His mind seemed to take joy in playing all sorts of tricks on him and frankly, he was getting sick of it.

Many days he didn't even feel like himself, he'd felt like someone else was in control and he only had partial control. It was sublime.

It was as if someone else had assumed control of his body, but he controlled their thoughts, if that makes any sense.

But he wouldn't worry about that now, he had to get to shelter.

He walked in the building, cash in hand, more than confident that he'd finally be able to sleep on something soft.

He wasn't expecting much, but then again literally anything was better than what he had now.

He approached the lady at the front desk.

"You're back!" She began

Oh yeah, I've been here before...

"I'm really sorry sir, but due to the recent housing crisis our leasing prices went up and this ain't enough"

The embarrassment and hopelessness still stung at him and his shoulder tensed.

"Want to lease out an apartment?" He responded with a small nod.

"$4,500 for a 2 year lease, after that it's $600 a month rent."

He would've gawked at the huge prices if he hadn't already heard them before.

First time he heard them he nearly choked, earning a sympathetic look from the clerk.

But this time he came prepared, he had saved enough for the lease and 3 months rent. He was certain 3 months was more than enough time to scrape up enough money to continue paying rent.

"Great! I'll show you to your room." He followed her up 2 flights of stairs and went about halfway down the hall on the third floor.

"Here is your room, enjoy your stay!" She handed him his key with a smile that he honestly found welcoming.

Too many people down here are down and have constant frowns plastered on their faces, it was refreshing to see a smile after so long, Even if it wasn't entirely genuine.

He entered his room and took a second to get familiar with the place.

Taking a few steps from the door, to his right was a door leading to a bathroom where he could shower, brush his teeth, etc.

Continuing forward, he saw a living room attached to a kitchen.

In the living room was a simple sofa, coffee table, TV stand and small TV. There was also a large window to the right of the sofa.

In the kitchen was all the basics, counter, sink, cabinets both under the counter and above, a fridge and an oven with a stove top.

But best of all, it had heating.

He finally felt safe enough to let his shoulders fall, he dropped his bags containing his groceries and all but limped over to the couch, flopping on to it.

He grabbed the remote and turned the TV on, since he never used a remote before he had to experiment, seeing what buttons do what.

Before long, he found himself on the sports channel which played a re run of his first ever fight at cruiserweight which, since he was already a big shot, was against the #10 contender.

He remembered how much of a statement he made during the fight, bombing him out in 2 rounds.

He spent the first round finding range with his jab, and in the second round he landed the bomb.

He jabbed his body to set bait him into parrying downwards, opening his chin to a huge right hand. He dug his weight down and threw it with full leverage, even chopping it downwards to add even more kinetic energy to it.

The guys body froze up and he fell, after a 4 count the ref waved it off. It was a brutal knockout.

He would've very much loved reminiscing on these supposedly good memories, but what happened afterwards left a terrible taste in his mouth.

It wasn't even the first time it's happened, far from it. But this should've been a monumental achievement, deserving of celebration and praise.

Their sick smiles, almost couldn't see them because of the blood...

His blood ran cold at the memory...

Switching to the news channel, he was told the weather and finally learned what day and year it was.

"Has it really been that long?" He muttered

But he really started paying attention at the mention of his old pseudonym.

"-and there is still an ongoing investigation into the disappearance of former multi-weight class world champion "Marvelous" Michael tarvor. He was reported missing for almost 3 years now, his owner had reported that he'd practically vanished overnight for no apparent reason."

Oh he knows the reason...

"The commission had oversaw his training with his owner following his jump to the cruiserweight division, and they released a statement early last year stating the following: "we at the USFC are distraught and heartbroken to report our golden prospect, Michael tarvor as missing. We helped him accomplish so much and we've done alot for eachother, but he has vanished into seemingly thin air. He was so happy and full of life, he couldn't have left of his own accord. We just hope that wherever he is, he's okay. We want to get him home safely."

Even with his exhaustion, his blood boiled. He almost felt insulted, after everything they did to him they act like he's their golden boy in the face of the public eye.

"Slimy fuckers...those lit-little f-fuckin rats!" He nearly yelled through his rage induced stutters.

After another few hours, his anger have way to...nothing.

His emotions felt dull, the only ones that had any feeling to them was anger and sadness. But it felt as though the sadness had evolved into a perpetual mindset, it was a vicious cycle.

Over the next few weeks, he kept working bone breaking labor, he kept working with the organized street gangs.

It was awful, it felt like he didn't really get anywhere, he just had a place to stay afterwards.

His bones ached to so bad...and every day it got worse.

Eventually one of his coworkers noticed this and handed him a small pill.

"You look sore man, take that. It'll help for now, if you need more you can usually find painkillers at pharmacy stores. A little liquor will help even more" he took the pill, having a hard time swallowing it since not only did he not have water to help, but his mouth was also completely dry.

But after a few minutes it worked, it fucking worked!

The pains were dulled to neigh-invisibility.

He took that information with him to the pharmacy store a few blocks away from his apartment, buying 3 bottles of over-the-counter painkillers.

He then took that same information to the liquor store down the road, getting some cheap bourbon to see if it really helped.

As he walked home, he noticed someone walking behind him and paranoia took over.

He sped his pace up and turned a corner, looking over his shoulder every couple seconds only to see him turn the same corner.

He turned another corner, and made eye contact with the man as he turned the corner after him.

If he really was following him, he now knew that MT knew.

It didn't help his nerves, in fact his mind was going wild.

Shitshitshitshitshit he's still following! He's still following, run. Run now before he catches up!

After he turned another corner MT complied, running as fast as his pained legs would let him go.

He finally came up to his building and sped through the lobby, visibly shaken and out of breath.

The clerk noticed this.

"Is something wrong? Are you ok-"

"Yea-Yeah I'm...I'm alright." He went up the stairs, his mind running even more wild.

Why would you go back to the building you live in?! They know where you live now! Are you fucking stupid?! They're gonna get you now, they're gonna get you they're gonna get you they're gonna get you-

He ran up to his room and slammed the door behind him, locking it behind him.

His mind was racing and his heart was pounding out of his chest.

It felt so hard to breath, he felt like he was suffocating and that the walls were closing in on him.

They know where I am now...oh God they're gonna get me! They'll skin me alive when they get me, it's gonna be so much worse than before!

As it would turn out, the guy was just walking home from work and happened to live near his building. But he didn't know that.

He keeled over, on the verge of passing out from hyperventilation, before slumping up against a wall.

He reached into his bag and pulled 2 bottles out, the burbon and painkillers.

He shakily put 3 pills in the palm of his hand and washed it down with the burbon.

While he waited for both to kick in, he took deep breaths to try and calm himself down as well as using many other tricks that had worked for him in the past.

But none of them began to work until they kicked in.

It hit his body first, he got up and went to the couch with the TV still on and sat down, as the aches dulled to almost nothing he started calming down.

"They really do work..." he strung out montonously

But before he knew it, he began to feel disconnected from his thoughts and actions once again.

It was always a sublime experience, but it was never before as strong as this. It even begun to affect his memory.

He felt like a passenger, and the pilot was someone completely different. Carrying out his housework stoicly and unblinkingly.

It almost felt like watching a very dull, mildly entertaining movie but not one where he was a character, but one where he was just a spectator.

All of his thoughts blended together, a cacophony of sights, sounds and experiences that just didn't connect or makes sense at all.

Like it was someone else's thoughts.

After it finished the housework, it went over to the sofa and slowly layed down before falling asleep.

This experience only cemented a budding relationship between him, alcohol and pain pills.

And it would nearly cost him his life.

---------------------------------------------------

I know I've been out awhile but i promise I have a good reason.

On top of alot going on in my life, I had to research on how to write dissociation (as grim as it is) and I don't really have it down, which is why I kept it vague.

I will probably continue to keep it vague until I research it more and get a better understanding of it as I'm not a psychologist.

I also want to reiterate that I'm not romanticism not demonizing Dissociative identity disorder or dissociation as a whole, in this story it serves only as a character trait to further the plot. If I rubbed anyone the wrong way with it, then I apologize l.

If not, then I hope you like it :D

#alan becker #animation vs minecraft #avm #avm king orange #avm mt #animator vs animation #avm mango #au #ava #usfc

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amplified-pain-culture-is · 2 years

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About this blog

- Submission-based blog

- Please start submissions with "[AMPS/CRPS/RSD/amplified pain/etc] culture is..."

- Mod is an adult and uses they/them pronouns

- As much as I'd love to answer questions and you are free to send some, amplified pain syndromes are confusing conditions with conflicting information out about them, so I may not always be able to answer it.

- That being said, I am not a doctor. I cannot give out medical advice.

Inspired by blogs such as @chronic-illness-culture-is

More information about AMPS/CRPS under the cut

What is AMPS/CRPS?

Amplified Musculoskeletal Pain Syndrome (AMPS) and Complex Regional Pain Syndrome (CRPS) are also known as juvenile fibromyalgia, Reflex Sympathetic Dystrophy (RSD), or causalgia. They're chronic conditions that, though not always synonymous with each other, fall under the same category of amplified pain syndromes. They're also rare (with under 200,000 cases currently known) and frequently misdiagnosed and misunderstood.

AMPS and CRPS both cause extreme muskuloskeletal pain as well as a heightened sense of pain. Though its existence has been documented back to the 1850s in America, its been labeled as "hysteria" by some because of the lack of understanding, and has been labeled the "suicide disease" by nonprofit Ferocious Fighters.

Resources for AMPS/CRPS patients:

Ferocious Fighters - non-profit for patients ages 0-21. They provide resources, care packages, support groups, as well as a list of more organizations here

RSDSA - non-profit for all ages, funding research into CRPS/RSD. This website also provides tons of literature and papers you can read up on or give to your doctors as an AMPS/CRPS patient. Theres also more resources here

An overview on AMPS

#amps #amplified musculoskeletal pain syndrome #crps #crps awareness #crps/rsd #complex regional pain syndrome #pinned post #info #reflex sympathetic dystrophy #disabled #disability

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mcatmemoranda · 2 years

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The most effective medication for intermittent claudication in patients with peripheral artery disease (PAD) is cilostazol, a phosphodiesterase 3 inhibitor. This leads to inhibition of platelet aggregation and vasodilation through increased cyclic AMP.

Rest pain is concerning for critical limb ischemia. Common co-morbid conditions include diabetes, hypertension, and hyperlipidemia. Common examination findings are indicative of poor arterial circulation to the extremities, including pallor, loss of hair, and diminished pulses. First-line medical treatment for intermittent claudication caused by PAD is cilostazol, a medication that inhibits phosphodiesterase 3, leading to relaxation of vascular smooth muscles.

First-line treatment without pharmacotherapy for intermittent claudication includes multiple lifestyle modifications. Measures for prevention may include smoking cessation, blood pressure control, anti-lipid therapy, weight loss, and the initiation of an exercise program. If an exercise program fails or causes additional pain, pharmacotherapy may be indicated. If pharmacotherapy fails, patients may be a candidate for more invasive interventions by a vascular surgeon depending on the degree and location of obstructed flow.

#PAD #cilostazol #claudication

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highonsprite · 16 days

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Diagnosis for AMPS

Diagnosing AMPS can be challenging due to its heterogeneous presentation and overlap with other pain disorders. Healthcare providers typically rely on a comprehensive evaluation, including:

Thorough medical history and physical examination to assess for musculoskeletal symptoms and associated features.

Diagnostic criteria, such as those outlined by the American College of Rheumatology (ACR), which include widespread pain and tender points.

Laboratory tests to rule out other medical conditions and assess for markers of inflammation or autoimmune diseases.

Psychological assessment to evaluate for mood disturbances, coping strategies, and psychosocial stressors.

Visit FirstChoice Rheumatology for more

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automatismoateo · 23 days

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Why are disabled & chronically ill people Christians ? via /r/atheism

Why are disabled & chronically ill people Christians ? As a person with multiple disabilities / disorders (some I'm born with such as autism and HSD), it baffles me If God exists, it means he's responsable for disabilities/illnesses. Especially medical conditions you're born with. Or acquired conditions caused by factors outside your control. Some believers say it's "trials of faith", but even if it was true, it would still mean their God inflicts physical pain, distress and impairment on us. And also blackmails us into meekly accepting this life (of medical suffering caused by Him) and being "grateful" for it, because otherwise we'll be punished after death. Others say "God only gives you what you what you can handle". Well, for disability and illness it's CLEARLY false. Otherwise, no disabled or chronically ill would be suicidal, or forced to use very unhealthy coping mechanisms. Also, in the case of mental health disorders, many sufferers go on developing lethal PHYSICAL diseases (such as heart diseases) because of the stress caused by mental illness. Then clearly their body CANNOT handle it. The very concept of a loving and good God that created us, wants the best for us, and deserves our faith, is simply incompatible with the (ugly and messy) reality of disability and chronic illness. And the idea that disabled & chronically ill should be grateful for being given a life of medical suffering (deliberately by their creator), and revere this creator, is incredibly ableist. Submitted May 06, 2024 at 11:46AM by Archonate_of_Archona (From Reddit https://ift.tt/8RjsWBg)

#reddit

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banarjeenikita · 1 month

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Xanthine Derivatives as Emerging Neuroprotective Agents

In recent years, xanthine derivatives have garnered significant interest in the field of neurology, primarily due to their potential as neuroprotective agents. Historically recognized for their role in respiratory conditions as bronchodilators, these compounds are now being explored for their capacity to guard against neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and multiple sclerosis. This shift toward neurological applications highlights a promising area of pharmacological research, where the multifunctional nature of xanthine derivatives could offer new avenues for treatment strategies.

Understanding Xanthine Derivatives

Xanthine derivatives, which include well-known compounds such as caffeine, theobromine, and theophylline, are purine bases found naturally in plants and animals. They have various systemic effects, most notably as stimulants of the central nervous system (CNS). Their mechanisms of action typically involve phosphodiesterase inhibition, adenosine receptor antagonism, and modulation of intracellular calcium levels—all of which contribute to their psychoactive and physiological effects.

Mechanisms of Neuroprotection

The potential neuroprotective mechanisms of xanthine derivatives are multifaceted. One key aspect is their ability to modulate neurotransmitter systems, particularly adenosine receptors in the brain. Adenosine acts as a CNS depressant and plays a role in promoting sleep and suppressing arousal. By blocking adenosine receptors, xanthine derivatives can enhance neuronal firing and increase dopamine and glutamate release, which are crucial for cognitive function and overall brain health.

Moreover, xanthine derivatives have been shown to exhibit antioxidant properties. Neurodegenerative diseases often involve oxidative stress, where harmful free radicals cause cellular damage. Xanthines can mitigate this by neutralizing free radicals and reducing oxidative stress, thereby protecting neuronal integrity and function.

Research and Evidence

Extensive research has been conducted to evaluate the neuroprotective potential of these compounds. For instance, studies have suggested that caffeine, the most widely consumed xanthine, may reduce the risk of developing Parkinson’s disease. Research indicates that caffeine may help in maintaining dopamine levels in the brain, which are critically depleted in Parkinson’s patients. Similarly, epidemiological studies have found a correlation between caffeine consumption and a reduced risk of Alzheimer’s disease, hypothesizing that caffeine’s ability to inhibit amyloid-beta production—a key factor in Alzheimer’s pathology—may play a role.

In experimental models, theophylline has shown promise in reducing neuronal damage in models of ischemic stroke. By inhibiting phosphodiesterase, theophylline helps in elevating cyclic AMP levels, which can have protective effects against cell death in acute neurodegenerative conditions.

Clinical Implications and Future Directions

The translation of these findings into clinical practice could revolutionize the management of neurodegenerative disorders. Currently, most neuroprotective strategies focus on managing symptoms rather than halting disease progression. Xanthine derivatives could potentially fill this gap, offering not only symptomatic relief but also a means to protect against neuronal degradation over time.

However, more clinical trials are needed to substantiate these effects in human populations and to understand the optimal dosages and potential side effects. The challenge lies in balancing efficacy with safety, particularly because excessive consumption of xanthine derivatives can lead to side effects like insomnia, nervousness, and in some cases, cardiovascular issues.

Conclusion

As research progresses, xanthine derivatives continue to be a focal point of interest for their neuroprotective properties. Their widespread availability and relatively low cost also make them attractive candidates for large-scale use if their efficacy and safety are clinically confirmed. Moving forward, it will be crucial to conduct detailed studies to elucidate the mechanisms through which these agents exert their effects and to establish clinical guidelines for their use in neurology. Harnessing the power of xanthine derivatives could indeed pave the way for novel therapies in combating the complex challenge of neurodegenerative diseases, potentially improving quality of life for millions of affected individuals worldwide.

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gauricmi · 1 month

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Medical Second Opinion Market is Estimated to Witness High Growth Owing to Rising Awareness About Advanced Treatment Options

The medical second opinion market involve seeking additional medical advice or medical consultation from a specialist to confirm or refute an initial diagnosis or recommendation for treatment of a health condition. It helps reduce medical errors, avoids unnecessary treatments or surgeries, and provide alternative treatment options if required. Due to the complexity of diseases, patients often require specialized examination and diagnostic procedures to thoroughly understand the condition. Medical second opinions provide assurance to patients and improve clinical decision making.

The Global Medical Second Opinion Market is estimated to be valued at US$ 7.12 Bn in 2024 and is expected to exhibit a CAGR of 16% over the forecast period 2024 To 2031. Key Takeaways Key players operating in the Medical Second Opinion Market Growth are M | O | C Cancer Care & Research Centre, Yashoda Hospitals, Mayo Clinic, Cedars-Sinai Medical Center, Cleveland Clinic, Johns Hopkins Hospital, UCLA Medical Center, Cromwell Hospital, St Thomas' Hospital, The Wellington Hospital, Birmingham City Hospital, The University of Tokyo Hospital, St. Luke's International Hospital, Kameda Medical Center, Apollo Hospitals, Fortis Hospitals Group, Wockhardt Hospital, Medanta Hospital, Charité University Hospital Berlin, and University Hospital Tuebingen. The key opportunities in the market include increasing adoption of telemedicine and virtual consultations for medical second opinions due to pandemic. Virtual consultations provide convenience, are more cost effective and help patients receive advice from leading specialists sitting anywhere. Technological advancements like AI assisted medical imaging analysis and remote monitoring devices are helping specialists provide more accurate second opinions. AI powered tools can analyze huge imaging data within seconds and detect subtle abnormalities missed on initial examination. This is improving disease diagnosis and management. Market Drivers Rising incidence of critical illnesses like cancer and heart diseases drive the need for medical second opinions. Complex cases often require review by multi-disciplinary medical teams to determine the best course of treatment. Increasing health insurance coverage and awareness about treatment alternatives also boost the market growth. Shorter waiting times and convenience of online consultations with top doctors will further support the medical second opinion market expansion.

Current challenges in Medical Second Opinion Market The medical second opinion market is plagued by several challenges. Some of the key ones include high costs associated with second opinions, lack of awareness about the benefits of second opinions, shortage of medical experts who can provide second opinions, and reluctance of doctors to recommend second opinions due to perceived damage to their reputation. There is also a lack of standardization and regulation in this market that has led to variation in quality of services being offered by different providers.

Get More Insights On This Topic: Medical Second Opinion Market

Explore More Related Topic: Medical Second Opinion Market

#Medical Second Opinion Market #Medical Second Opinion Market Size #Medical Second Opinion Market Share #Medical Second Opinion Market Trends #Medical Second Opinion Market Analysis #Medical Second Opinion #Healthcare #Medical Devices

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twiainsurancegroup · 1 month

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swissforextrading · 2 months

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The proteins that shield the body against its own immune attacks

26.03.24 - Researchers at EPFL reveal how Drosophila's Turandot proteins protect against immune self-harm. The study is the first to identify some proteins that protect against antimicrobial peptides offering insights into cellular resilience mechanisms with potential therapeutic applications. In the constant battle between organisms and pathogens, our immune system plays the role of a vigilant guardian. Yet, this defense can sometimes turn into a double-edged sword, harming the very tissues it's meant to protect. Now, a study from the group of Bruno Lemaitre at EPFL sheds light on a novel aspect of this balance, focusing on the fruit fly, Drosophila melanogaster, and a family of proteins called Turandot (like Puccini’s opera), known for being expressed during stress and immune responses but with unclear functions. The study, published in Current Biology, shows how the Turandots protect against damage from the fruit fly’s own immune system. Drosophila, a model organism used widely in biological research, employs antimicrobial peptides (AMPs), which can destroy pathogens by disrupting their cell membranes. However, this can inadvertently damage the host's own cells, particularly when AMPs are produced in large quantities. The EPFL study reveals the Turandot proteins bind to the membranes of host cells, particularly those in the respiratory epithelium, and shield them from the deleterious effects of AMPs. This protective mechanism is crucial for maintaining tissue integrity and ensuring the organism's survival under stress. The researchers employed a range of sophisticated techniques including electrophysiology, lipid binding assays, and molecular dynamics simulations. These methods allowed them to observe the interactions between Turandot and cell membranes, highlighting how it preferentially binds to phosphatidylserine, a phospholipid that becomes exposed on cell surfaces under stress conditions. Turandot sequesters phosphatidylserine, thus preventing AMPs from attacking the host’s cells. The study not only advances our understanding of the immune system's intricacies but also highlights the evolutionary strategies organisms have developed to minimize self-inflicted harm during immune responses. The authors write: “To our knowledge, our study is the first to identify a class of molecules protecting animal cell from the action of antimicrobial peptides”. The findings could have broader implications, suggesting that similar protective mechanisms might exist in other organisms, including humans. This opens up potential therapeutic avenues, particularly in conditions where immune system overactivity can cause damage, such as in certain neurodegenerative diseases. Other contributors * EPFL Institute of Bioengineering * Queen Mary University of London * Tokyo University of Science * Imperial College London * University of Geneva Nik Papageorgiou http://actu.epfl.ch/news/the-proteins-that-shield-the-body-against-its-own- (Source of the original content)

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nutrameltz · 5 months

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New standards on nutritional demands

Here is a reworked rendition of the text about new principles in sustenance:

Past the plate: Moving ideal models by they way we approach food and health

The one-size-fits-all way to deal with sustenance is blurring. Instead, "a vibrant tapestry of new standards is emerging," which acknowledge the distinct requirements of each person and the intricate web of factors that affect our well-being. Ten major trends are encompassed by this shift:

From cutout plans to custom tailored blueprints: The fact that our genes, lifestyles, and health journeys are as diverse as our fingerprints is acknowledged by personalized nutrition. By considering in these subtleties, we can make really powerful dietary plans.

Past calories, towards all encompassing harmony: Sustenance is at this point not exclusively about fuel; It's about taking care of ourselves in every way. The stomach mind hub, psychological well-being, and generally speaking health are currently essential pieces of the dietary condition.

Providing for people and the planet: Manageability becomes the overwhelming focus, directing us towards food decisions that focus on ecological wellbeing and moral obtaining.

Demystifying the meal: Straightforwardness rules. Clear, precise data about food content and beginning enables us to pursue informed decisions that line up with our qualities.

Embracing dietary diversity: Plant-based ways of life, social contrasts, and individual inclinations are praised. The new standards are inclusive, ensuring that everyone is seen and heard.

Tech-controlled health: Wearables and shrewd applications become our nourishing partners, giving continuous bits of knowledge and customized input to upgrade our dietary process.

Avoidance is the key: Preventing disease takes precedence over treating it. Understanding what food decisions mean for long haul wellbeing engages us to settle on proactive choices.

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alldaypillsus · 5 months

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animalecbd-au · 6 months

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