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bcqins7ag · 1 year
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tinymaru-archived · 2 years
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ME??? Baybeeee why, I am a worm
Well that answers the question if I’d still love you if you were a worm, right?
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jcrmhscasereports · 1 year
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Coinfections and pulmonary embolism in a patient with onset of Leukemia concomitantly with COVID19- Case report by Evgenia Papakonstantinou in Journal of Clinical Case Reports Medical Images and Health Sciences
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ABSTRACT
The pandemic of COVID19 is ongoing, with the treatment of neoplastic diseases to be challenging. Patients with acute leukemia are vulnerable to many pathogens due to impaired immunity coming from their disease and simultaneous chemotherapy. Although the COVID19 disease evolves milder in children, concomitant treatment for leukemia may be fatal. We present a girl with COVID19 and Escherichia Hermannii infection at diagnosis for Acute Lymphoblastic Leukemia (ALL). This child suffered bilateral pulmonary embolism after initiation of treatment. We discuss the therapeutic challenges about the initiation of chemotherapy in the context of coinfections as well as the role of COVID19 and other predisposing factors to pulmonary embolism. We found that the slight delay in the antineoplastic treatment contributed to the remission of the acute infection and did not negatively impact the initial response to the leukemia treatment. Nevertheless, the resumption of the oncological treatment should remain among our priorities.
KEYWORDS
Acute leukemia, COVID19, Escherichia Hermannii, pulmonary embolism
INTRODUCTION
Given the immunodeficiency due to their disease and chemotherapy, patients with cancer are vulnerable to infections and COVID19 infection is really threatening. We describe a successful management of a girl diagnosed with acute lymphoblastic leukemia (ALL) and COVID19 infection concomitantly with Escherichia Hermannii sepsis. The initiation of chemotherapy was slightly postponed, due to the danger of these severe infections until blood cultures were negative for E. Hermanii. Pulmonary thrombosis was added, as COVID-19 infection predisposes for developing cardiovascular complications, while our patient was under existing predisposing factors for thrombophilia, but with appropriate management had successful outcome.
CASE HISTORY
A three-year-old girl who presented with a four-day fever, rhinitis, and cough, found positive for COVID19 infection without mutation, as all her family members. She had anemia (Hb: 2.9 g/dL), neutropenia (N: 371/μL), thrombopenia (PLT: 24 K/μL) while tachypnea (RR=31/min), tachycardia (HR=146/min), fever 38.6°C, air oxygen saturation 97%, were found on examination. Empirical antimicrobial treatment with Tazobactam-Piperacillin, Amikacin, Teicoplanin, and Micafungin were given for febrile neutropenia, transfusions (blood, platelets) for myelosuppression, Remdesivir (5 mg/kg) for COVID19. Blood culture yielded Escherichia Hermannii sensitive to receiving antibiotics, but therapy was upscaled to Meropenem due to elevated CRP (109mg/l) and persistent fever 40.6°C. The antibiotic treatment lasting 14-days ceased after two negative cultures. Baseline chest computed tomography (CT) scan showed small cloudy glass spots, areas of pulmonary thickening, atelectasis. Bone marrow aspiration, with 61% blasts, set the diagnosis of pre-B acute lymphoblastic leukemia (ALL) hyperdiploid, Central Nervous System (CNS) negative. Abdominal ultrasound showed hepatomegaly and splenomegaly. Examinations for thrombophilia revealed heterozygosity for factor V Leiden. Chemotherapy started while positive for COVID according to ALLIC 2009 protocol, standard risk arm, 15 days post diagnosis. Remained in COVID clinic until two negative PCR tests. The ALL re-examination showed good prednisolone response on Day 8, complete remission on Days 15, 33. On Day 40 from the initiation of chemotherapy, she had tachypnea with a value of D-dimer elevated at 2.145 ng/mL. Chest CT revealed subsegmental pulmonary embolism on both lower lobes of the lungs. She had not high oxygen requirements, hemodynamic instability requiring intubation, and was treated with low molecular weight heparin for 3 months. She continued chemotherapy without delays, with regular weekly tests for COVID19 and without reactivations, despite the use of corticosteroids and immunosuppressive therapy.
For more information: https://jmedcasereportsimages.org/about-us/
For more submission: https://jmedcasereportsimages.org/
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mindblowingscience · 5 months
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Certain types of bacteria can mutate to reproduce more quickly when exposed to microgravity, and that's not great news for our space tourist dreams, seeing as we humans are teeming with bacteria. It's not clear why these bacteria respond so positively to microgravity, but researchers are figuring out ways to protect astronauts out in space, as well as mitigating the damage should a space-modified colony ever find its way back to Earth. In a study published in 2017, researchers from the University of Houston monitored Escherichia coli cells through 1,000 generations of growth in simulated microgravity conditions, finding that it spread significantly faster than a control sample of unaltered bacteria. The E. coli cells also picked up at least 16 different genetic mutations along the way, though it's not clear how these mutations affect growth rates, either individually or as a group. "This study is broader in scope than previous ones on two counts," one of the team, Jason Rosenzweig, told Leah Crane at New Scientist at the time.
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segretecose · 3 months
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100% natural organically grown escherichia coli 🌱💫
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phoenixonwheels · 3 months
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[ID: Tweet by Dr. Raven @DrRavebSciMaven 1/19/24 “So the virus that causes COVID has the ability to hide from your immune system and mutate in different parts of your body. Places like your nervous system, gut, and more. So you'll have a negative PCR test and everything but your body is actually still being EFFED UP, BAD 😭😭”
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“I'm reading these papers and WHEW, this virus is absolutely disrespectful. Like, a complete violation. PLEASE 😫😫😫 pubmed.ncbi.nlm.nih.gov/34248921/ “]
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[ID: A page from a medical journal with phrases highlighted “They identified SARS-CoV-2 RNA in 7 of the 14 biopsy samples obtained from asymptomatic COVID-19 patients with negative nasal-swab PCR at an average of 4 months after acute infection. Another team found SARS-CoV-2 RNA in olfactory mucosa samples collected from 4 patients with negative nasopharyngeal swab SARS-CoV-2 RNA tests but ongoing loss of smell after acute COVID 19 disease (samples were collected 110-196 days after COVID 19 onset)”]
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booksbeansandcandles · 8 months
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With cold and flu season fast approaching, I want to post herbal recipes I am finding. These are not mine, and not medical advice!!!
Plant Origins of Thieves Oil
Clove: clove buds originate from the evergreen tree Syzygium aromaticum or Eugenia caryophyllata. These flower buds contain up to 20 percent essential oil, and are incredibly pungent, thanks to the major active chemical component called eugenol.
Rosemary: rosemary is a popular herb that comes from a small evergreen plant that belong to the mint family. It is native to the Mediterranean region, and possesses strong anti-inflammatory properties .
Eucalyptus: eucalyptus trees are native to Australia, Tasmania, and nearby islands. They’re the popular plant exclusively enjoyed by koala bears, and come in many different species. The oil is derived from the leaf of the eucalyptus tree, and is commonly used in cold remedies.
Cinnamon: cinnamon oil and the dried spice cinnamon both come from the bark of the true cinnamon tree (Cinnamomum zeylanicum). Essential oils that come from the leaf, bark and root of the cinnamon tree are much different, but the most common used version in Thieves oil is the cinnamon leaf. The active component in cinnamon bark essential oil is cinnamaldehyde.
Lemon: lemons come from a small tree in the Rutacea family. Lemon essential oil is derived by cold-pressing the peel of the lemon fruit, which is rich in different phytonutrients and beneficial compounds.
Thieves Oil Recipe
As long as you have all of the necessary essential oils on hand, you can easily make your own version of Thieves oil at home.
Ingredients: Master Blend
80 drops of clove essential oil
70 drops of lemon essential oil
40 drops of cinnamon essential oil
30 drops of eucalyptus essential oil
20 drops of rosemary essential oil
Method:
Combine all of the above essential oils in a dark amber coloured 15 milliliter (0.5 fluid ounce) glass bottle. Make sure you store it a cool, dry place, away from heat and light.
Benefits and Uses of Thieves Oil
This thieves oil recipe can be used to address certain health ailments, check out the benefits and uses below! Not medical advice
1. Relief from Aches and Pains
This Thieves oil recipe is loaded with plenty of anti-inflammatories to ease muscular and joint aches and pains. Rosemary and eucalyptus oil have actually been found to relieve rheumatoid arthritis, as well as muscle and joint aches and pains. You can dilute Thieves oil in a carrier oil (like jojoba oil, almond oil or grapeseed oil) to be used topically on the ache or pain. Typically the ratio is 1 drop essential oil to 4 drops carrier oil.
2. Immune System Support
Thieves oil was used to protect the “thieves” from the Black Plague, so you can be rest-assured that this oil provides some hefty immune support. Clove and rosemary essential oils are powerful antibacterials and anti-fungals. They’ve both been shown to have significant anti-microbial effects against dangerous bacteria like Staphylococcus epidermidis, Escherichia coli, and Candida albicans.
Massage the blend on your feet, lower back, neck and behind your ears for daily immune support. You can also diffuse Thieves oil to allow the essential oil molecules to enter your blood stream after they’ve entered your lungs! To get Thieves oil into your lungs is to diffuse the oil in a diffuser. Diffuse 15-20 drops of Thieves oil for 15 minutes, 3-4 times a day.
By live life fruit.
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kon-igi · 3 months
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COME SIAMO RIDOTTI
Ieri stavo facendo un importante lavoro di riparazione all'impianto idraulico di casa mia che, premetto, si trova posizionata in zona carsica argillosa e per questo è stata eretta in cima a una collina su un sistema di pali in cemento armato che la forano per andarsi ad ancorare alla roccia a 15-20 metri di profondità.
Questo, oltre ad aver fulminato una parte cospicua del budget di costruzione, implica che sì, la nostra casa è meravigliosamente antisismica ma che ogni qual volta un evento atmosferico cambia la composizione di suolo, atmosfera, campo elettromagnetico terrestre etc essa si comporta come il Castello Errante di Howl o, visto l'umore condiviso, la capanna della famigerata Strega Baba Yaga
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In parole povere, qualsiasi tubo, condotto, filo o corrugato che non abbia sufficiente capacità dilatativo-estensoria SI STACCA DALLA CASA, con ben immaginabili fastidiose conseguenze sul benessere psico-fisico degli abitanti.
Ieri stavo perciò posizionando una riduzione a un tubo di gomma estensibile affinché si evitasse che il mio bel giardino si trasformasse in una fossa settica a cielo aperto, quando nel cercare di incastrarne una sul tubo, perdo l'equilibrio e per non farmi troppo male appoggio la mano su un tondino di ferro sporgente, facendomi molto male
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Mentre scateno un supercalifragilistichespiralidoso di apprezzamenti sulla madonna, in contemporaanea compilo in multitasking una lista mentale di tutte le potenziali conseguenze della lesione, arrivando alla conclusione che potrei essere il primo caso di decesso da infezione tetanica, escherichia coli, leptospirosi, clostridium perfrigens ed emorragia cerebrale da brusca ipertensione su base psichiatrica ma poi una buona detersione della ferita seguita da adeguata medicazione (nonché respiri profondi) mi permettono di riportare tutto alla quasi normalità.
E allora ripenso con calma all'incipit con cui ho dato il via alla sequenza di bestemmie...
Ho urlato
MALEDETTE RIDUZIONI!
E poi, non so perché, mi viene in mente quella figura retorica chiamata REDUCTIO AD HITLERUM e il suo successivo adattamento alle discussioni in ambito digitale che recita
A mano a mano che una discussione online si allunga, la probabilità di un paragone riguardante i nazisti o Hitler tende ad 1, ovvero, se una discussione online (a prescindere dall'argomento o dallo scopo) va avanti abbastanza, prima o poi qualcuno paragonerà qualcuno o qualcosa a Hitler.
E mentre la mano mi pulsa e la frequenza cardiaca scende, immagino che questo tipo di ragionamento può applicarsi ad altri tipi di riduzioni
REDUCTIO AD FERAS -> gli animali sono meglio degli esseri umani!
REDUCTIO AD RAPTORES -> alla fine i politici rubano tutti alla stessa maniera!
REDUCTIO AD VENENUM -> chissà cosa c'è dentro che non ti dicono!
REDUCTIO AD PUEROS -> sì però qualcuno pensi ai bambini!
REDUCTIO AD TEMPUS IENTEM -> ai miei tempi c'era X/non c'era X!
REDUCTIO AD LICTORIUM -> ci vorrebbe la disciplina del servizio militare!
La lista, poi, sarebbe lunghissima e da aggiornare in maniera pressoché costante ma se vi state chiedendo il senso di questo lungo post ai limiti del delirante, nulla... serviva solo a lamentarmi dei tubi di merda e del male alla mano.
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