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phcoker-com · 5 days
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May Day Holiday is coming, on May 1st-5th!
Hope you have a good rest during the time~
Semaglutide
Tirzepatide
Retatrutide
CJC-1295 with DAC 5mg/vial
Sermorelin 5mg/vial
Tesamorelin 5mg/vial
AOD9604 5mg/vial
TB500 5mg/vial
BPC157 5mg/vial
TB500+BP157 5mg+5mg
Also if you have needs and quick order, please contact me~
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phcoker-com · 11 days
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Welcome to see more details about Mazdutide in Phcoker!!
About GLORY-1 (NCT05607680), this Phase 3 clinical trial is evaluating the efficacy and safety of mazdutide in Chinese adults with overweight or obesity. The trial is multi-center, randomized, double-blind, and placebo-controlled, ensuring the highest standards of research. During the 48-week double-blind treatment period, 610 participants were randomized to receive mazdutide 4 mg, 6 mg, or placebo. We are excited to see the results of this groundbreaking study!
The GLORY-1 study was a resounding success! Both mazdutide 4 mg and 6 mg outperformed the placebo in two key areas: the percentage change in body weight from baseline to week 32 and the proportion of participants with a weight loss of ≥5% at week 32. And the best part? The weight-loss efficacy continued to improve from week 32 to week 48!
Furthermore, the study achieved all key secondary endpoints with flying colors! This includes the proportion of participants who experienced significant weight loss of 10% or 15%, as well as improvements in waist circumference, systolic blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol, serum uric acid, and alanine aminotransferase (ALT). It's worth noting that mazdutide outperformed the placebo in all of these weight-loss and cardiometabolic endpoints.
During the double-blind treatment period, the safety profile of mazdutide was similar to that observed in previous clinical studies, and no new safety signals were detected. Additionally, its friendly safety profile and lack of new safety signals make it a promising candidate for future treatments. We are confident in the potential of Mazdutide and its ability to positively impact patients' lives.
Excitingly, Mazdutide has become the first GLP-1R/GCGR dual agonist to succeed in Phase 3 trials. As the first registration trial for weight management using mazdutide, the results of GLORY-1 not only confirm the efficacy and safety of mazdutide in a large population but also provide high-quality clinical evidence of long-term pharmacotherapy for weight management, specifically for the Chinese population with overweight or obesity.
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phcoker-com · 17 days
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Tadalafil Powder
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What Is Tadalafil丨Tadalafil Powder?
Tadalafil is a medicine used to treat erectile dysfunction (ED, also called impotence) and problems with urination caused by an enlarged prostate (benign prostatic hypertrophy or BPH). It is sometimes known by its generic name tadalafil, and sometimes known by its trade name, Cialis. There are also other brands of this medicine available, such as Adcirca, Alyq, Entadfi, Tadliq.
Tadalafil powder is the active ingredient of the tadalafil brand product. It is a white to off-white powder, manufacturered by chemical factories, China and India are the two major suppliers of Tadalafil powder. Tadalafil powder supplied with different purity standard, the best is 99.99% pure raw powder form. Tadalafil powder price in India is totally different than China. Researchers seeking tadalafil powder for research purpose or individual who resell tadalafil powder found that, although the tadalafil powder manufacturers claim the purity is >99%, but the testing result is totally different, some of them even no any effects. So it is challenge to find out the best supplier from so many tadalafil powder manufacturers.
How Does Tadalafil Work丨Mechanism Of Action Of Tadalafil
Tadalafil is a popular product in the market,individual can buy tadalafil with prescription from pharmacy or the doctor prescribes it for you. How is tadalafil work? What is the mechanism of action of tadalafil?  Tadalafil mainly acts in three directions, here they are:
Tadalafil for erectile dysfunction(ED): If you have erectile dysfunction also called sexual impotence, when sexually aroused, it operates by transiently boosting blood circulation to the penis. However, without physical stimulation to the penis, such as during sexual intercourse, tadalafil will not induce an erection.
Tadalafil for benign prostatic hyperplasia (BPH): Tadalafil Aids in alleviating symptoms associated with an enlarged prostate gland by relaxing the muscles in both the prostate and bladder. Individuals with BPH typically experience challenges with urination, including decreased flow and hesitancy at the onset of urination.
Tadalafil for pulmonary hypertension treatment: Men and wemen who experiencing symptoms of pulmonary arterial hypertension, where the smaller blood vessels in the lungs become more resistant to blood flow, find that the right ventricle of the heart must exert greater effort to adequately pump blood through the lungs. Tadalafil acts on the PDE5 enzyme within the lungs to relax blood vessels, thereby enhancing blood supply to the lungs and alleviating the heart’s workload.
It is precisely because Tadalafil works through the above 3 ways and brings great convenience to people’s lives that more and more people are buying Tadalafil for different purposes. Tadalafil related  drug sold under different brand name for different purpose, like tadalafil 5mg, tadalafil 20mg tablet for oral, people can choose to buy the form of Tadalafil that suits them according to their needs. But tadalafil price is different from place to place, be sure buy it from the best tadalafil suppliers!
What Are The Benefits You Can Get From Tadalafil丨Tadalafil Benefits
One of the most well-known benefits of tadalafil is as a treatment for male erectile dysfunction(ED). While this is the common benefits of tadalafil, tadalafil have some other good benefits for men and wemen, here are the primary 8 benefits of tadalafil in 2024:
Tadalafil for Erectile Dysfunction(ED): Tadalafil is popular sell for sexual function problem treatment, in combination with sexual stimulation, tadalafil works by increasing blood flow to the penis to help a man get and keep an erection. This type of Tadalafil drug is usually available on the market in different dosage strengths, from small dosage 2.5mg to large dosage 20mg.
Tadalafil for enlarged prostate: Research show that tadalafil helps to treat and prevent enlargement of the prostate, although tadalafil is not the first line treatment for prostate conditions, but it helps to relieve symptoms of BPH.
Tadalafil for heart performance improvement: Among the remarkable health advantages associated with tadalafil is its capacity to enhance heart function. Research indicates that use tadalafil can alleviate symptoms of pulmonary arterial hypertension and enhance physical endurance in individuals suffering from chronic heart failure. Notably, a study revealed that individuals who took 20mg doses of tadalafil for six months experienced enhanced blood circulation and increased oxygen delivery to their hearts.
Tadalafil for blood pressure control: Another benefits of tadalafil use is it helps reduce blood pressure. Studies show that a lot of patients have reported tadalafil can reduce systolic blood pressure by 4-5 mmHg over a 24-hour period.
Tadalafil is safe to use: as a prescription drug, tadalafil has quite mild side effects. Research datas show that taking daily dosage of tadalafil 2.5mg or 5mg means having a constant working concentraton in your body, instead of the peaks and troughs you get with occasional dosing, this help to reduces the irritating side effects of tadalafil.
Tadalafil for longevity: Studies in 2020 found another useful benefits of tadalafil. The study showed that Tadalafil has a positive effect on vascular endothelial cell regeneration by increasing the amount of endothelial progenitor cells and CXCR4 expression which is linked to the cGMP cellular messenger system resulting in improved repair of vascular damage. So it mean tadalafil can help to improve the repair and recovery of the lining of blood vessel walls thus improving cardiovascular health and longevity.
Tadalafil for antidepressant use: One of the most exciting health benefits of tadalafil is its potential for fight depression. There are research results indicate that tadalafil is effective in treating depression in men by boosting serotonin levels in the brain, which helps lift mood and fight off feelings of sadness and despair.
Tadalafil for self-confidence building: Erectile dysfunction is a problem faced by more and more men, and their self-confidence is severely affected by this problem.Tadalafil is a medication which comes under the class of selective PDE 5 inhibitors, it works quickly and effectively to help men with ED get and maintain an erection.Thereby helping men increase their self-confidence and improve their happiness in life.
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phcoker-com · 25 days
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CONGRATULATION!! Production New Stock in Phcoker~
Tirzepatide 15mg/vial Semaglutide 10mg/vial CJC-1295 with DAC 5mg/vial Sermorelin 5mg/vial Tesamorelin 5mg/vial AOD9604 5mg/vial TB500 5mg/vial BPC157 5mg/vial Ipamorelin 10mg/vial
Tirzepatide peptide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) dual receptor agonist. The drug is currently approved by the FDA under the brand name of Mounjaro for the treatment of type 2 diabetes. According Tirzepatide research result, the current clinical trial results show that the participants in the experiment showed a substantial weight loss. Participants who used the highest dose of 15mg lost an average of 15.7% of their weight, which is a major milestone in the history of weight loss drugs.
Qingming Festival is coming~
One of the traditional Chinese festivals, usually on April 4 or 5 every year. It is a day for worshiping ancestors and sweeping tombs. It is also one of the traditional Chinese solar terms.
Hope everything is well!
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phcoker-com · 1 month
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CJC-1295 & Ipamorelin
CJC-1295/Ipamorelin is a unique peptide combination that works synergistically to potentially enhance overall vitality, promote lean muscle growth, and support an optimal sleep cycle. CJC-1295, a growth hormone releasing hormone (GHRH) analog, works in harmony with IPAMORELIN, a selective growth hormone secretagogue, to stimulate the body’s natural production of growth hormone. The combination of these two peptides can lead to a cascade of positive effects, including an improved metabolic rate, increased lean muscle mass, enhanced recovery, and better sleep patterns.
What about Ipamorelin?
Ipamorelin is a peptide hormone utilized to manage various medical conditions. It is a growth hormone-releasing peptide that spurs the body’s natural production of growth hormones. It’s frequently employed to address adult growth hormone deficiencies and aid in weight loss, energy boosting, muscle building, and overall well-being. Ipamorelin also treats conditions such as chronic fatigue syndrome, fibromyalgia, and osteoporosis. It can be administered orally or via injection and is generally well-accepted by patients.
The Synergy between CJC 1295 and Ipamorelin
When Ipamorelin and CJC-1295 are expertly combined, your body produces a stronger and more steady release of HGH. Ipamorelin releases the pulse of HGH, and the CJC-1295 releases and amplifies this pulse.
CJC 1295 and Ipamorelin function together to enhance the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). CJC 1295 promotes GH release, while Ipamorelin provokes the body to release additional GH in response to elevated GH levels in the bloodstream. Together, these two peptides can aid in promoting lean muscle mass and reducing body fat. They can also enhance skin elasticity, bone density, and sleep quality.
CJC-1295 and Ipamorelin are typically combined in therapy because they are known to work well together. CJC-1295 takes anywhere from 1-4 hours to reach peak serum in the blood, while Ipamorelin works much quicker. Ipamorelin is cleared from the body more rapidly as its half-life is about 2 hours. The combination of both peptides ensures a rapid onset with Ipamorelin and lasting effects with CJC-1295.In fact, this is the most used combination of therapeutic peptides prescribed for anti-aging.
So who is a good candidate for CJC 1295 / Ipamorelin? CJC-1295 can help individuals over the age of 30 to have more energy, a faster metabolism, and stay in better shape as you age. It’s not a hormone itself, so it is a relatively safe and low-risk option when all things are considered. However, it requires a prescription and is delivered via an injection, so there are some important points to cover regarding the CJC-1295 benefits and side effects trade-offs.
What are the benefits of CJC 1295 IPAMORELI?
Benefits of CJC 1295 & Ipamorelin include but are not limited to:
Increased Bone Density
As we get older, our bones get brittle, that is why injuries are more common.
Strengthens the cardiovascular system
Increase in muscle mass
More muscle mass = higher metabalism = less body fat
The ability to burn fat
As we mentioned, with an increase in muscle mass allows the body’s resting metabolic rate is boosted leading to more calories burned throughout the day.
Increased Sex drive
Guys (proverbial guys, that means girls too). Sex his huge. I don’t care what anybody says, it’s a vital part of our health, our mood, everything. Not being able to function properly sexually can really take a tole on your mental well-being
Improved Recovery and Repair from Injuries
Being on a proper bio-identical hormone replacement therapy program leads to an overall improved state of well-being. This adheres to recovery time (soreness) and acute musculoskeletal injuries.
Strengthens Immune System
Personally, what I can notice and I can attest to being on hormone replacement therapy, being on the CJC 1295 Ipamorelin.. I don’t get sick. It is a tremendous benefit when you are trying to attain optimal health and that is achieved by having a strong immune system
Improves cognition and memory function
It is an improved overall benefit to the body, this includes focus and feeling mental clarity and sharpness throughout the day.
Improves Insulin Sensitivity
CJC 1295 and Ipamorelin improves insulin sensitivity thus reducing the body’s triglycerides. High blood sugars are reduced which helps burning more body fat.
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phcoker-com · 1 month
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HGH Fragment 176-191 is getting more attention as a solution for losing weight. The synthetic peptide is specifically designed to promote weight loss and improve metabolism. Even better, Fragment 176-191 does so without introducing the body to harmful and dangerous compounds or side effects.
Interested? Discover more about Fragment 176-191 in the review of the peptide below:
What HGH Fragment 176-191 can be used for?
HGH Frag 176-191, also known as Fragment 176-191 or HGH Fragment, is a synthetic peptide derived from amino acids 176-191 of the human growth hormone (HGH). It's recognized for its potential in weight loss and anti-aging effects. Here's a summary of its key aspects:
Weight Loss Benefits
HGH Fragment 176-191 is designed to aid in weight loss by stimulating the production of growth hormone and regulating fat metabolism. It targets fat cells specifically, promoting fat burning while sparing muscle tissue.
Improved Metabolism
By focusing on fat metabolism, HGH Fragment 176-191 helps individuals overcome the challenges of weight loss, especially when traditional methods like exercise and dieting yield minimal results.
Muscle Growth
Alongside its fat-burning properties, HGH Fragment 176-191 also supports muscle growth and repair. This makes it a valuable supplement for individuals looking to achieve a leaner physique.
Appetite Control
The peptide has been reported to help manage appetite and reduce late-night hunger cravings, aiding in adherence to dietary goals.
Anti-Aging Properties
HGH Fragment 176-191 exhibits anti-aging properties, contributing to a youthful appearance and improved overall well-being. It may help individuals combat the signs of aging and maintain a more youthful appearance.
Safety Profile
Compared to synthetic HGH injections, HGH Fragment 176-191 is considered safer and more reliable. It offers similar benefits without some of the potential adverse effects associated with exogenous HGH therapy.
Ongoing Research
While HGH Fragment 176-191 shows promising results, further clinical studies are needed to confirm its efficacy and safety across diverse populations. Ongoing research aims to deepen understanding of its mechanisms of action and potential applications.
In summary, HGH Fragment 176-191 represents a novel approach to weight loss and anti-aging, offering targeted effects on fat metabolism and growth hormone production. Its potential benefits make it an area of active interest in scientific research and development.
HGH Fragment 176-191 Weight Stacks (Cutting & Bulking Up)
Combining Fragment 176-191 with other peptides and compounds in a weight stack can enhance its effects on weight loss by burning fat. By incorporating these peptides below, individuals can experience even greater results in their weight loss journey.
GHRP-2 and GHRP-6: These growth hormone-releasing peptides (GHRPs) work synergistically with Fragment 176-191 to stimulate the release of growth hormone, which aids in fat loss and muscle preservation during a cutting phase.
Melanotan 2: While primarily known for its tanning effects, Melanotan 2 also has appetite-suppressing properties, which can complement the weight loss efforts of Fragment 176-191 by helping to control calorie intake.
Liquid Growth Hormone: Supplementing with liquid growth hormone can further amplify the effects of Fragment 176-191 on fat metabolism and muscle preservation, potentially leading to more pronounced weight loss results.
BPC-157: This peptide is known for its healing properties, which can be beneficial during intense workouts or in case of injuries, allowing individuals to maintain their training intensity and consistency while on a cutting regimen.
TB-500: Similar to BPC-157, TB-500 promotes tissue repair and recovery, potentially reducing the risk of overuse injuries and aiding in the maintenance of muscle mass during calorie restriction.
CJC 1295 Ipamorelin: This combination stimulates the release of growth hormone and has been shown to promote fat loss and muscle gain, making it an effective addition to a weight stack focused on cutting.
Overall, combining peptides and compounds, it's important to follow proper dosage guidelines and consult with a healthcare professional to ensure both safety and effectiveness. With the right approach, you can achieve your desired results safely and efficiently!
When it comes to sourcing peptides, it's important to work with a reputable supplier to ensure both purity and potency. That's why I highly recommend Phcoker (Polypeptide), a professional GMP manufacturer that specializes in HGH Frag 176-191. By combining Fragment 176-191 with other peptides in a weight stack, you can maximize its benefits and accelerate your progress towards your weight loss goals!
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phcoker-com · 2 months
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Good News!!
Phcoker has completed some production, such as:
Ipamorelin 10mg * 500vials
CJC-1295 without DAC 5mg * 500vials
TB500 5mg * 500vials
Selank 5mg * 500vials
Ipamorelin peptide was originally developed by Novo Nordisk and was initially used to treat postoperative intestinal obstruction. As a pentapeptide, it is also a ghrelin/ghrelin receptor agonist. As a ghrelin, it can not only promote weight loss, increase muscle mass and improve sleep, but also maintain bone health and reduce the impact of glucocorticoids.
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phcoker-com · 2 months
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CJC-1295, whether with or without DAC (Drug Affinity Complex), has demonstrated effectiveness in stimulating the release of growth hormone in the body. The main difference between the two is Half-life:
CJC-1295 without DAC: This variant has a relatively short half-life, lasting approximately 30 minutes. Its half-life closely resembles that of endogenous growth hormone-releasing hormone (GHRH) found naturally in the body.
CJC-1295 with DAC: With the addition of DAC (Drug Affinity Complex), the half-life of CJC-1295 is significantly extended. It can last approximately 6-8 days due to the binding of DAC to serum albumin. This binding protects the peptide from degradation, allowing it to remain active in the body for a much longer duration compared to CJC-1295 without DAC.
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phcoker-com · 2 months
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Peptide products can be customized and produced by mixing multiple ingredients for customers' different inquiry. 🤩 For example: TB500 5mg+bpc157 5mg TB500 5mg+bpc157 5mg+1295 5mg
👉👉Also, new batches of products have been scheduled for production!! Ipamorelin 10mg CJC-1295 with DAC 5mg CJC-1295 without DAC 5mg TB500 5mg Sermorelin 5mg Tesamorelin 5mg Selank 5mg AOD9604 5mg
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phcoker-com · 2 months
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New batches of products have been scheduled for production in Phcoker, here are the products.
If you have any products interested, please feel free to contact us!
Ipamorelin 10mg
CJC-1295 with DAC 5mg
CJC-1295 without DAC 5mg
TB500 5mg
Sermorelin 5mg
Tesamorelin 5mg
Selank 5mg
AOD9604 5mg
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phcoker-com · 2 months
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Good day.
We are back from the Chinese holiday, hope everything is well.
Now we normally work, please feel free to contact for what products you are interested in.
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phcoker-com · 3 months
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Phcoker is a high-tech enterprise specializing in active pharmaceutical intermediates (APIs).
To control the quality during production, a large number of experienced professionals, a first-class production equipment and laboratories are the key points. Under the regulations of ISO 9001: 2015 quality system and strictly management, the high-quality products makes helps our market expand to the United States, Europe, Japan and other countries, for the local research institutions and pharmaceutical companies, and we are constantly exploring more chance to service more clients.
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phcoker-com · 3 months
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Why we can’t visit "Polypeptide.ltd" website?
In order to provide customers with a better one-stop shopping experience, "Polypeptide.ltd" has been changed to "Phcoker" officially.
Phcoker.com are currently upgrading the website, which will be completed soon.
You’re welcome to visit our upgrade website "https://www.phcoker.com/ at any time or follow the news on our official channel. We will update company and product news regularly.
#polypeptideltd#phcoker#phcokercom#website#peptide#onestepshopping#GMPmaanufacturer
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phcoker-com · 3 months
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Why "Polypeptide.ltd" has been changed to "Phcoker"?
We are a manufacturer specializing in contract customized production of peptides. But due peptide products are also related to other markets, such as nootropics, anti-aging, etc., many customers need us to provide these related products at the same time. So in order to provide customers with a better one-stop shopping experience, we acquired Phcoker.com and are currently upgrading the website, which will be completed soon. You’re welcome to visit our new website at any time or follow the news on our official channel. We will update company and product news regularly.
To provide one-stop shopping experience, "Polypeptide.ltd" has been changed to "Phcoker" officially. More information, please visit upgrade website "https://www.phcoker.com/ and pay attention to the news of the official social platforms.
Polypeptide.ltd (Phcoker.com) is the GMP Manufacturers of Custom Synthesis Peptide. Email: [email protected]
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phcoker-com · 3 months
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To provide one-stop shopping experience, "Polypeptide.ltd" has been changed to "Phcoker" officially. More information, please visit upgrade website "https://www.phcoker.com/ and pay attention to the news of the official social platforms.
Polypeptide.ltd (Phcoker.com) is the GMP Manufacturers of Custom Synthesis Peptide. Email: [email protected]
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phcoker-com · 3 months
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Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist.
It is injected once weekly and is being tested in type 2 diabetes and obesity. Preliminary trial results found a greater weight loss compared to either medication alone. HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone.
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phcoker-com · 3 months
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Cagrilintide peptide is a long-acting amylin analog used to treat obesity. Acts as a non-selective amylin receptor (AMYR) and alcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide can significantly reduce food intake, resulting in weight loss. Cagrilintide has shown strong potential in studying obesity. Studies have shown that the combination of Cagrilintide and Semaglutide has a more powerful therapeutic effect. The combination of Cagrilintide and Semaglutide is commonly sold under the brand name CagriSema.
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