#E. Frouin

[hippography]

URUS, petit Trait breton, bai, 1 m. 52, 4 ans en 1924, par Chiny, Trait ardennais aux Haras, à M. Kermen, de Callac. Région de Cornouailles (Côtes-du-Nord)  Acheté pour les Haras Nationaux en 1924 

Cliché E. Frouin 

Stud Book No 6321 

E. Frouin, 1927, Le Cheval Breton. 

#Petit Trait breton #Breton #cheval de trait #étalon #Urus #stallion #draft horse #draught horse #E. Frouin #1927 #Le Cheval Breton

[atintintintin]

Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project.

Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project.

Mol Autism. 2020 Feb 22;11(1):17

Authors: Moessnang C, Baumeister S, Tillmann J, Goyard D, Charman T, Ambrosino S, Baron-Cohen S, Beckmann C, Bölte S, Bours C, Crawley D, Dell'Acqua F, Durston S, Ecker C, Frouin V, Hayward H, Holt R, Johnson M, Jones E, Lai MC, Lombardo MV, Mason L, Oldenhinkel M, Persico A, Cáceres ASJ, Spooren W, Loth E, Murphy DGM, Buitelaar JK, Banaschewski T, Brandeis D, Tost H, Meyer-Lindenberg A, EU-AIMS LEAP group

Abstract BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the "social brain," a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizing in ASD. METHODS: As part of the Longitudinal European Autism Project, we performed functional magnetic resonance imaging at six European sites in a large, well-powered, and deeply phenotyped sample of individuals with ASD (N = 205) and typically developing (TD) individuals (N = 189) aged 6 to 30 years. We presented an animated shapes task to assess and comprehensively characterize social brain activation during mentalizing. We tested for effects of age, diagnosis, and their association with symptom measures, including a continuous measure of autistic traits. RESULTS: We observed robust effects of task. Within the ASD sample, autistic traits were moderately associated with functional activation in one of the key regions of the social brain, the dorsomedial prefrontal cortex. However, there were no significant effects of diagnosis on task performance and no effects of age and diagnosis on social brain responses. Besides a lack of mean group differences, our data provide no evidence for meaningful differences in the distribution of brain response measures. Extensive control analyses suggest that the lack of case-control differences was not due to a variety of potential confounders. CONCLUSIONS: Contrary to prior reports, this large-scale study does not support the assumption that altered social brain activation during mentalizing forms a common neural marker of ASD, at least with the paradigm we employed. Yet, autistic individuals show socio-behavioral deficits. Our work therefore highlights the need to interrogate social brain function with other brain measures, such as connectivity and network-based approaches, using other paradigms, or applying complementary analysis approaches to assess individual differences in this heterogeneous condition.

PMID: 32087753 [PubMed - as supplied by publisher]

via pubmed: autism https://ift.tt/37TJlFl

#IFTTT #pubmed: autism

[neurogenpapers]

A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease.

PubMed: Related Articles A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease. J Alzheimers Dis. 2017;56(3):1159-1174 Authors: Khan W, Giampietro V, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A, Gallinat J, Vellas B, Soininen H, Kloszewska I, Tsolaki M, Mecocci P, Spenger C, Villemagne VL, Masters CL, Muehlboeck JS, Bäckman L, Fratiglioni L, Kalpouzos G, Wahlund LO, Schumann G, Lovestone S, Williams SC, Westman E, Simmons A, Alzheimer–s Disease Neuroimaging Initiative, AddNeuroMed Consortium, Australian, Imaging, Biomarkers, and Lifestyle Study Research Group, IMAGEN consortium Abstract The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the effect of APOE and amyloid-β (Aβ) on baseline hippocampal volumes in AD patients, mild cognitive impairment (MCI) subjects, and healthy controls. A large sample of healthy adolescents (n = 1,387) was also used to compared hippocampal volumes between APOE groups. Subjects had undergone a magnetic resonance imaging (MRI) scan and APOE genotyping. Hippocampal volumes were processed using FreeSurfer. In the AD and normal aging dataset, hippocampal comparisons were performed in each APOE group and in ɛ4 carriers with positron emission tomography Aβ who were dichotomized (Aβ+/Aβ-) using previous cut-offs. We found a linear reduction in hippocampal volumes with ɛ4 carriers possessing the smallest volumes, ɛ3 carriers possessing intermediate volumes, and ɛ2 carriers possessing the largest volumes. Moreover, AD and MCI ɛ4 carriers possessed the smallest hippocampal volumes and control ɛ2 carriers possessed the largest hippocampal volumes. Subjects with both APOE ɛ4 and Aβ+ had the lowest hippocampal volumes when compared to Aβ- ɛ4 carriers, suggesting a synergistic relationship between APOE ɛ4 and Aβ. However, we found no hippocampal volume differences between APOE groups in healthy 14-year-old adolescents. Our findings suggest that the strongest neuroanatomic effect of APOE ɛ4 on the hippocampus is observed in AD and groups most at risk of developing the disease, whereas hippocampi of old and young healthy individuals remain unaffected. PMID: 28157104 [PubMed - in process] http://dlvr.it/NJcKW6

[hippography]

VERMEILLE III, Pouliche de 3 ans en 1924, baie, 1 m. 54, par Bon, pur sang anglais, et Pedlar, pur sang anglais, Soliman d. s. a. n., Quatremère de Quincy d. s. a. n., trot., et Corlay, trot. a. br., à M. J. Dagorne, de Corlay (C.-du-N.) — Poids moyen 

Cliché E. Frouin 

E. Frouin, 1927, Le Cheval Breton.

#pouliche #cheval #Vermeille III #filly #E. Frouin #1927 #Le Cheval Breton

[hippography]

CONCOURS-ÉPREUVE à St-NICOLAS-du-PÉLEM (Côtes-du-Nord)  Épreuves de traction à la déchameuse — Pouliches de 2 ans — “Bonne Note” 

Cliché E. Frouin 

E. Frouin, 1927, Le Cheval Breton.

#pouliche #cheval #cheval de trait #Breton #1927 #Le Cheval Breton #E. Frouin

[hippography]

BIJOU, Pouliche 3 ans en 1925, 1 m. 56, à M. Herviou F., de Saint-Clet, Région de Pontrieux (Côtes-du-Nord) 

Cliché E. Frouin 

Stud Book No 6510

E. Frouin, 1927, Le Cheval Breton. 

#Breton #Trait breton #pouliche #cheval de trait #Bijou #draft horse #draught horse #filly #E. Frouin #Le Cheval Breton #1927

[hippography]

VALANDALLE II, Pouliche, 3 ans en 1924, baie, 1 m. 60  par Rendez-Vous, pur sang anglais ou Bon, pur sang anglais et Pedlar, pur sang anglais  à M. F. Pérennés, de Corlay (Côtes-du-Nord) — Poids lourd 

Cliché E. Frouin 

Phototypue des imprimeries Réunies de Nancy

E. Frouin, 1927, Le Cheval Breton.

#pouliche #cheval #Valandalle II #E. Frouin #1927 #Le Cheval Breton

[hippography]

CONCOURS-EPREUVE. — Le Saut 

VIRGULE (No 62), Jument précédente montée par son propriétaire, M. Le Coz, sautant l’obstacle au Concours de «Trait Léger» à Gouarec (Côtes-du-Nord). 

Cliché E. Frouin 

E. Frouin, 1927, Le Cheval Breton.

#Virgule #jument #Breton #mare #cheval de trait #draught horse #draft horse #jumping #Gouarec #France #1927 #E. Frouin #Le Cheval Breton

[hippography]

ÉLEVAGE DE SANG DE CORLAY 

VANUPIED, Hongre, 3 ans en 1924, bai, 1 m. 58, par Rendez-Vous, pur sang anglais et Javeleuse, par Soliman, 1/2 sang anglais N. et Marrubia, pur sang, par Boudoir et Mothoa  à M. Le Breton E., du Haut-Corlay (Côtes-du-Nord) — Poids lourd — Vendu 25.000 fr. en 1925 

Cliché E. Frouin

E. Frouin, 1927, Le Cheval Breton.

#hongre #cheval #Vanupied #E. Frouin #1927 #Le Cheval Breton

[hippography]

ÉLEVAGE DE SANG DE CORLAY

VENISE XII, Pouliche, 3 ans en 1924, baie, 1 m. 57, par Rendez-Vous, pur sang anglais et Vertumne, pur sang, Brullemail, trotteur anglais N., Utle, trotteur anglais N., Shériff, pur sang, à M. Harmoy J.-F, du Haut-Corlay (Côtes-du-Nord) — Poids moyen 

Cliché E. Frouin 

E. Frouin, 1927, Le Cheval Breton.

#pouliche #Venise XII #filly #E. Frouin #1927 #Le Cheval Breton

[hippography]

PETIT TRAIT BRETON - Centre Montagne

BADRIGE, Pouliche, 3 ans en 1926, alezane, 1 m. 53, par Tonnerre, Trait breton aux Haras, et Cadrige, petit Trait breton (5399), à MM. Le Coz, de Gouarec, Région de Cornouailles (Côtes-du-Nord) — Issue de Codrige, No 36 

Cliché E. Frouin 

E. Frouin, 1927, Le Cheval Breton.

#pouliche #cheval de trait #Petit Trait breton #Breton #Badrige #draught horse #draft horse #filly #E. Frouin #1927 #Le Cheval Breton

[hippography]

NOUVEL ÉLEVAGE DE CORLAY 

ATTIRA, Pouliche, 3 ans en 1925, 1 m. 50, par Petiot, Trait postier aux Haras et Reis, Trait breton, Haras, à M. Le Bohec, de Plussulien, près Corlay (Côtes-du-Nord)  Type du Novel Élevage de la Région de Corlay 

Cliché E. Frouin 

Stud Book No 6545

E. Frouin, 1927, Le Cheval Breton.

#cheval #pouliche #Attira #E. Frouin #1927 #Le Cheval Breton

[hippography]

RENDEZ-VOUS, Pur sang anglais, par Saint-Bris et Rosen-Dhu, par Sorcerer et fille de Bend-Or  Dépôt d’Étalons Nationaux de Lamballe — Station de Monte de Corlay (Côtes-du-Nord)  Père de presque tous les demi-sang galopeurs bretons actuels 

Cliché E. Frouin - 1925

E. Frouin, 1927, Le Cheval Breton.

#pur sang #étalon #cheval de course #Rendez Vous #Thoroughbred #racehorse #stallion #E. Frouin #1925 #Le Cheval Breton #1927

[hippography]

AMÉRICAINE, Pouliche, 3 ans en 1925, baie, 1 m. 56, par Rendez-Vous, pur sang anglais et Roncal, pur sang anglais, Voiron, 1/2 sang, et Chassenon, pur san anglais  Élevage de Corlay, à M. de Gonneville, Lamballe Poids moyen 

Cliché E. Frouin

E. Frouin, 1927, Le Cheval Breton.

#pouliche #Américaine #cheval #filly #horse #E. Frouin #1927 #Le Cheval Breton

[hippography]

LISETTE, Pouliche de 3 ans en 1925, 1 m. 52, par Porlo, Trait postier aux Haras et Jument de Trait, à M. Robin V., de Haut-Corlay (Côtes-du-Nord)  Nouvel Élevage de la Region de Corlay 

Cliché E. Frouin 

Stud Book No 6544

Phototypie des Imprimeries Réunies de Nancy

E. Frouin, 1927, Le Cheval Breton.

#pouliche #cheval #Lisette #E. Frouin #1927 #Le Cheval Breton

[hippography]

CONCOURS-ÉPREUVE à St.-NICOLAS-du-PÉLEM (Côtes-du-Nord)  Jeunes Mâles de 2 ans — Épreuve de traction à la déchaumeuse 

Cliché E. Frouin

E. Frouin, 1927, Le Cheval Breton.

#cheval de trait #draught horse #draft horse #St.-Nicolas-du-Pélem #E. Frouin #1927 #Le Cheval Breton