#pk;m analog

[chocobarsys]

can anyone help me? im having the fuckin worst trouble finding a faceclaim.

anyone know a picrew or any image that has these traits:

blonde hair that's been dyed black but it's grown out and you can see the blonde roots but the end of the hair is still black

white iris and red sclera

lots of stitches and/or scars on visible skin

sharp teeth (not necessary to show)

wasnt even looking for all of it at once because editing is a thing but cant find the most important aspect which is the hair (we cant edit that very well)

#pk;m Analog #pluralgang #endo friendly #plurality

[fuwutapumena]

Vespa cosa 200 bedienungsanleitung polar

  VESPA COSA 200 BEDIENUNGSANLEITUNG POLAR >> DOWNLOAD LINK vk.cc/c7jKeU

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  T-Com/ Home Sinus 200 Mobilteil mit Ladeschale + Netzteil + Kurzanleitung Box), 114 bedienungsanleitung w724v · Lg lf-u 850 bedienungsanleitung polar12,6x5x3 mm für Vespa 125 TS/​150 Sprint Bedienungsanleitung Vespa PK 80s /post/693393354677010432/tcm-radio-controlled-uhr-bedienungsanleitung-polar, Betriebsanleitung für PKW Chevrolet Ausgabe von 1937 Puch M 50 Jet Betriebsanleitung Bedienungsanleitung kein Vespa kein Typenschein. Digital und analog mit 20 Funktionen, Kabel und Anleitung werden mitgeliefert. misura per applicazioni motociclistiche e addizionato con Bardahl Polar Vespa 50/125/150/200/250/300. Approfondisci >>. 18,40 € 23,00 € 15,08 € ohne MwSt. Kaufen. Olio motore Bardahl XTM POLAR PLUS 4 tempi sintetico 5W-40 Vespa Cosa 200 Roller Ersatzteile bei Scooter-ProSports per Explosionsskizzen bestellen Wer sich mit Vespatuning oder auch nur der Instandhaltung seines Vespa VESPA COSA 200 BEDIENUNGSANLEITUNG HP >> DOWNLOAD LINK vk.cc/c7jKeU ://meqawewif.tumblr.com/post/693308321039515648/tw-3200-bedienungsanleitung-polar,

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[mariebenz]

Normal Intestinal Microbiome Enhances Intestinal Barrier

MedicalResearch.com Interview with:

Dr. Jala Dr. Venkatakrishna R Jala, PhD Assistant Professor James Graham Brown Cancer Center Department of Microbiology and Immunology University of Louisville MedicalResearch.com: What is the background for this study? What are the main findings? Response: Humans evolved along with their gut microbiota and adapted their physiological activities to help each other. Along with consumption of healthy diets, humans must harbor the appropriate microbiota to convert the foods into available components called metabolites. These microbial metabolites play a critical role in preserving homeostasis, the development of immune systems and preventing adverse events both systemically and locally. Despite the availability of large metagenomics (bacterial sequence) data, and its associations with disease conditions, the functional dynamics of microbiota (good vs bad) in human health or diseases are yet to be defined. The host’s indigenous gut microbiota and its metabolites have emerged as key factors that greatly influence human health and disease, including inflammatory bowel diseases (IBD). IBD patients suffer from leaky gut and increased inflammation. The current study demonstrates that a microbial metabolite derived from ellagitannin/ellagic acid rich diets (e.g., pomegranate, berries) called ‘urolithin A’ and its synthetic analogue significantly enhance gut barrier function in addition to blocking the unwarranted inflammation in IBD animal models.   MedicalResearch.com: What should readers take away from your report? Response: Some of the microbes in our gut have evolved to generate beneficial microbial metabolites from dietary products in the vicinity of the gut barrier. To keep this benefit, we need to consume a healthy diets well as harbor the appropriate bacteria that can metabolize those foods into active beneficial compounds. This study shows that direct consumption of one such microbial metabolite, UroA or its analog can compensate for a lack of the specific bacteria responsible for production of UroA and continuous consumption of the necessary foods, pomegranates and berries in treating colitis in animal models. Existing IBD treatments include utilizing anti-TNF-α antibodies to reduce inflammation. Here we suggest that treatment with UroA enhances gut barrier function (i.e., prevents leaky guts) in addition to blocking inflammation and might provide better therapeutic options for control of IBDs. MedicalResearch.com: What recommendations do you have for future research as a result of this work? Response: It is possible that excessive use of antibiotics and modern dietary trends led to microbial dysbiosis resulting in the elimination of some bacterial populations that are capable of producing beneficial metabolites. More rigorous and systematic studies are required to assess the benefits of direct consumption of metabolites in humans both in healthy and disease conditions, and whether supplementation of metabolites could overcome the dysbiosis. Overall, UroA/UAS03 will not only be effective in IBD-related diseases but may also prove to be therapeutic in other disorders involving barrier dysfunction and inflammation, such as alcohol liver diseases, neurological disorders, and colon cancers. This will require further studies. While encouraging natural levels of UroA in the gut by consuming the appropriate foods and protecting populations of beneficial bacteria should have positive health effects, the researchers believe the use of the more stable synthetic UAS03 may prove to be therapeutically effective in cases of acute colitis. Further experiments and clinical testing are needed to test these beliefs.  MedicalResearch.com: Is there anything else you would like to add? Response: It is possible that excessive use of antibiotics and modern dietary trends led to microbial dysbiosis resulting in the elimination of some bacterial populations that are capable of producing beneficial metabolites. More rigorous and systematic studies are required to assess the benefits of direct consumption of metabolites in humans both in healthy and disease conditions, and whether supplementation of metabolites could overcome the dysbiosis. Overall, UroA/UAS03 will not only be effective in IBD-related diseases but may also prove to be therapeutic in other disorders involving barrier dysfunction and inflammation, such as alcohol liver diseases, neurological disorders, and colon cancers. This will require further studies. While encouraging natural levels of UroA in the gut by consuming the appropriate foods and protecting populations of beneficial bacteria should have positive health effects, the researchers believe the use of the more stable synthetic UAS03 may prove to be therapeutically effective in cases of acute colitis. Further experiments and clinical testing are needed to test these beliefs. Response: Is there anything else you would like to add? Any disclosures? Current study is a collaborative project between Venkatakrishna R JALA (University of Louisville, Louisville, KY, USA) and Praveen Kumar Vemula (inStem, Bangalore, INDIA). Funding for the research includes NIH/NCI (R21CA216090), NIH/NIGMS (P20GM125504-01) and grants from U of L, Rounsavall Foundation, The Jewish Heritage Fund for Excellence Research Enhancement Grant and the James Graham Brown Cancer Center. Additional support was obtained from NIH/NCI (CA191683), (P20GM103436), (P30GM106396) to Venkatakrishna Rao JALA, PhD. Department of Biotechnology (DBT) (BT/PR12490/AAQ/3/716/2015) and the Institute for Stem Cell Biology and Regenerative Medicine (inStem), India to Praveen Kumar Vemula. Several authors hold a patent application related to this technology. Citation: Singh R, Chandrashekharappa S, Bodduluri SR, Baby BV, Hegde B, Kotla NG, Hiwale AA, Saiyed T, Patel P, Vijay-Kumar M, Langille MGI, Douglas GM, Cheng X, Rouchka EC, Waigel SJ, Dryden GW, Alatassi H, Zhang H-G, Haribabu B, Vemula PK, Jala VR. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nature Communications. 2019;10(1):89. doi: 10.1038/s41467-018-07859-7. Link: https://rdcu.be/bfS5x    The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.   Read the full article

#antibiotics #microbiome #SpringerNature #uoflmedschool

[ampk-cancer-stem-cell-hiv]

New Harvard Study shows for the first time that meditation upregulates genes in the AMPK pathway similar to metformin

A new study published in 2018 by researchers at Harvard Medical School showed for the first time that a collection of meditative techniques that led to the relaxation response (RR) in human patients significantly upregulated genes in the AMPK signaling pathway [1]. The RR elicitation routine included diaphragmatic breathing, body scan, mantra repetition, mindfulness meditation, and passively ignoring intrusive thoughts [1]. An upregulation of genes in the AMPK signaling pathway was detected via blood samples taken from patients in which total RNA was isolated from peripheral blood mononuclear cells (PBMCs) [1].

This study has an interesting connection to a recently published study in 2018 in which a retreat that included meditation led to an increase in the RNA-binding protein HnRNPA1 [2]. I first hypothesized and proposed that metformin and AMPK activation would beneficially modulate the activity of HnRNPA1 [3,4] . Indeed, the well-studied AMPK activator resveratrol has recently been shown to upregulate HnRNPA1 [5]. Additionally, HnRNPA1 binds to telomerase and plays a critical role in telomere maintenance, promotes latent HIV-1 reactivation (facilitating immune system detection and virus destruction), and is necessary for the transposition or “jumping” of “jumping genes” in human cells [6-9]. Metformin has also been shown to activate human telomerase (hTERT) in an AMPK-dependent manner and reduce cellular makers associated with latent HIV-1 in infected patients [10-12]. This evidence lends substantial support to several hypotheses that I originally proposed linking metformin and AMPK activation with telomerase activation, “jumping genes” in the brain (important for learning and memory), virus destruction, aging deceleration, human life creation, and even consciousness itself [3,4,13-17]. Strikingly, AMPK activation may also play a critical role in the beneficial effects of meditation on the human brain.

Meditation has been shown to increase brain gamma waves, brain gray matter density, and beneficial transcriptome changes in energy metabolism [18-20]. Interestingly, the Dalai Lama has also described meditation as “hard work”, indicating that meditation is an active process that challenges or slightly stresses the brain, leading to upregulation of genes in the AMPK signaling pathway as shown in the Harvard study [1]. This “mental stressor or challenge” is very much similar to challenging or stressing the human body with exercise, which is well-known to induce AMPK activation, leading to several beneficial effects [21]. The “mental challenge of meditation” is also analogous to the stress or challenge placed on the brain of animals when exposed to a stimulating environment, leading to an enhancement of learning and memory (i.e. long-term potentiation) and the “jumping of genes” [15,16]. Additionally, methodologies and neurotransmitters that are critical for inducing long-term potentiation (e.g. glutamate, high-frequency stimulation) activate AMPK in neurons and nearly every anesthetic used clinically to induce and maintain general anesthesia, including propofol, activates AMPK and excites the brain in low doses (called paradoxical excitation) [15,16]. Nearly every neurotransmitter that plays a critical role in wakefulness, arousal, and cognition also activates AMPK, supporting my original hypothesis that AMPK activation likely plays a central role in promoting consciousness itself [16].

Source: By ISAF Headquarters Public Affairs Office (originally posted to Flickr as 100410-F-7713A-002) [CC BY 2.0 (https://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons; By Anatomist90 [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], from Wikimedia Commons

References:

Bhasin MK, Denninger JW, Huffman JC, et al. Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation Response Training. J Altern Complement Med. 2018 May;24(5):486-504.

Conklin QA, King BG, Zanesco AP, et al. Insight meditation and telomere biology: The effects of intensive retreat and the moderating role of personality. Brain Behav Immun. 2018 May;70:233-245.

Finley J. Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation. Med Hypotheses. 2014 Nov;83(5):580-7.

Finley J. Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome. Med Hypotheses. 2015 Sep;85(3):320-32.

Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P. Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells. Biochim Biophys Acta. 2017 Mar;1860(3):291-298.

Ford LP, Wright WE, Shay JW. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene. 2002 Jan 21;21(4):580-3.

Madsen JM, Stoltzfus CM. An exonic splicing silencer downstream of the splice site A2 is required for efficient human immunodeficiency virus type 1 replication. J Virol 2005;79(16):10478–86.

Goodier JL, Zhang L, Vetter MR, Kazazian Jr. HH. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol 2007;27(18):6469–83.

Pedersen I, Fung L, Guzman H, et al. miR-128-induced LINE-1 restriction is dependent on down-regulation of hnRNPA1. bioRxiv 195560; https://doi.org/10.1101/195560.

Karnewar S, Neeli PK, Panuganti D, et al. Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: relevance in age-associated vascular dysfunction. Biochim Biophys Acta 2018;1864(4 Pt A):1115–28.

Chew GM, Chow DC, Souza SA, et al. Impact of adjunctive metformin therapy on T cell exhaustion and viral persistence in a clinical trial of HIV-infected adults on suppressive ART. J Virus Eradication 2017;3(Suppl. 1):6–19.

Chew GM. AAA http://viruseradication.com/abstract-details.php?abstract_id=1188.

Finley J. Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1. Med Hypotheses. 2016 Aug;93:34-47.

Finley J. Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1. Med Hypotheses. 2017 Jul;104:133-146.

Finley J. Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking learning, memory, and the potential eradication of HIV-1. Med Hypotheses. 2018 Jul;116:61-73.

Finley J. Transposable elements, placental development, and oocyte activation: Cellular stress and AMPK links jumping genes with the creation of human life. Med Hypotheses. 2018 Sep;118:44-54.

Finley J. Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. Med Hypotheses. 2018 Sep;118:151-162.

Lutz A, Greischar LL, Rawlings NB, Ricard M, Davidson RJ. Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16369-73.

Hölzel BK, Carmody J, Vangel M, et al. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30;191(1):36-43.

Bhasin MK, Dusek JA, Chang BH, et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013 May 1;8(5):e62817.

Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009 Mar 1;418(2):261-75.

[ampk-progeria-hiv]

New Harvard Study shows for the first time that meditation upregulates genes in the AMPK pathway similar to metformin

A new study published in 2018 by researchers at Harvard Medical School showed for the first time that a collection of meditative techniques that led to the relaxation response (RR) in human patients significantly upregulated genes in the AMPK signaling pathway [1]. The RR elicitation routine included diaphragmatic breathing, body scan, mantra repetition, mindfulness meditation, and passively ignoring intrusive thoughts [1]. An upregulation of genes in the AMPK signaling pathway was detected via blood samples taken from patients in which total RNA was isolated from peripheral blood mononuclear cells (PBMCs) [1].

This study has an interesting connection to a recently published study in 2018 in which a retreat that included meditation led to an increase in the RNA-binding protein HnRNPA1 [2]. I first hypothesized and proposed that metformin and AMPK activation would beneficially modulate the activity of HnRNPA1 [3,4] . Indeed, the well-studied AMPK activator resveratrol has recently been shown to upregulate HnRNPA1 [5]. Additionally, HnRNPA1 binds to telomerase and plays a critical role in telomere maintenance, promotes latent HIV-1 reactivation (facilitating immune system detection and virus destruction), and is necessary for the transposition or “jumping” of “jumping genes” in human cells [6-9]. Metformin has also been shown to activate human telomerase (hTERT) in an AMPK-dependent manner and reduce cellular makers associated with latent HIV-1 in infected patients [10-12]. This evidence lends substantial support to several hypotheses that I originally proposed linking metformin and AMPK activation with telomerase activation, “jumping genes” in the brain (important for learning and memory), virus destruction, aging deceleration, human life creation, and even consciousness itself [3,4,13-17]. Strikingly, AMPK activation may also play a critical role in the beneficial effects of meditation on the human brain.

Meditation has been shown to increase brain gamma waves, brain gray matter density, and beneficial transcriptome changes in energy metabolism [18-20]. Interestingly, the Dalai Lama has also described meditation as “hard work”, indicating that meditation is an active process that challenges or slightly stresses the brain, leading to upregulation of genes in the AMPK signaling pathway as shown in the Harvard study [1]. This “mental stressor or challenge” is very much similar to challenging or stressing the human body with exercise, which is well-known to induce AMPK activation, leading to several beneficial effects [21]. The “mental challenge of meditation” is also analogous to the stress or challenge placed on the brain of animals when exposed to a stimulating environment, leading to an enhancement of learning and memory (i.e. long-term potentiation) and the “jumping of genes” [15,16]. Additionally, methodologies and neurotransmitters that are critical for inducing long-term potentiation (e.g. glutamate, high-frequency stimulation) activate AMPK in neurons and nearly every anesthetic used clinically to induce and maintain general anesthesia, including propofol, activates AMPK and excites the brain in low doses (called paradoxical excitation) [15,16]. Nearly every neurotransmitter that plays a critical role in wakefulness, arousal, and cognition also activates AMPK, supporting my original hypothesis that AMPK activation likely plays a central role in promoting consciousness itself [16].

Source: By ISAF Headquarters Public Affairs Office (originally posted to Flickr as 100410-F-7713A-002) [CC BY 2.0 (https://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons; By Anatomist90 [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], from Wikimedia Commons

References:

Bhasin MK, Denninger JW, Huffman JC, et al. Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation Response Training. J Altern Complement Med. 2018 May;24(5):486-504.

Conklin QA, King BG, Zanesco AP, et al. Insight meditation and telomere biology: The effects of intensive retreat and the moderating role of personality. Brain Behav Immun. 2018 May;70:233-245.

Finley J. Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation. Med Hypotheses. 2014 Nov;83(5):580-7.

Finley J. Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome. Med Hypotheses. 2015 Sep;85(3):320-32.

Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P. Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells. Biochim Biophys Acta. 2017 Mar;1860(3):291-298.

Ford LP, Wright WE, Shay JW. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene. 2002 Jan 21;21(4):580-3.

Madsen JM, Stoltzfus CM. An exonic splicing silencer downstream of the splice site A2 is required for efficient human immunodeficiency virus type 1 replication. J Virol 2005;79(16):10478–86.

Goodier JL, Zhang L, Vetter MR, Kazazian Jr. HH. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol 2007;27(18):6469–83.

Pedersen I, Fung L, Guzman H, et al. miR-128-induced LINE-1 restriction is dependent on down-regulation of hnRNPA1. bioRxiv 195560; https://doi.org/10.1101/195560.

Karnewar S, Neeli PK, Panuganti D, et al. Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: relevance in age-associated vascular dysfunction. Biochim Biophys Acta 2018;1864(4 Pt A):1115–28.

Chew GM, Chow DC, Souza SA, et al. Impact of adjunctive metformin therapy on T cell exhaustion and viral persistence in a clinical trial of HIV-infected adults on suppressive ART. J Virus Eradication 2017;3(Suppl. 1):6–19.

Chew GM. AAA http://viruseradication.com/abstract-details.php?abstract_id=1188.

Finley J. Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1. Med Hypotheses. 2016 Aug;93:34-47.

Finley J. Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1. Med Hypotheses. 2017 Jul;104:133-146.

Finley J. Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking learning, memory, and the potential eradication of HIV-1. Med Hypotheses. 2018 Jul;116:61-73.

Finley J. Transposable elements, placental development, and oocyte activation: Cellular stress and AMPK links jumping genes with the creation of human life. Med Hypotheses. 2018 Sep;118:44-54.

Finley J. Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome. Med Hypotheses. 2018 Sep;118:151-162.

Lutz A, Greischar LL, Rawlings NB, Ricard M, Davidson RJ. Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16369-73.

Hölzel BK, Carmody J, Vangel M, et al. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30;191(1):36-43.

Bhasin MK, Dusek JA, Chang BH, et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013 May 1;8(5):e62817.

Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009 Mar 1;418(2):261-75.

[arxt1]

The host galaxy of the gamma-ray-emitting narrow-line Seyfert 1 galaxy PKS 1502+036. (arXiv:1804.10220v1 [astro-ph.GA])

The detection of gamma-ray emission from narrow-line Seyfert 1 galaxies (NLSy1) has challenged the idea that large black hole (BH) masses ($\ge$10$^8$ M$_{\odot}$) are needed to launch relativistic jets. We present near-infrared imaging data of the gamma-ray-emitting NLSy1 PKS 1502+036 obtained with the Very Large Telescope. Its surface brightness profile, extending to about 20 kpc, is well described by the combination of a nuclear component and a bulge with a Sersic index $n$ = 3.5, which is indicative of an elliptical galaxy. A circumnuclear structure observed near PKS 1502+036 may be the result of galaxy interactions. A BH mass of about $\sim 7 \times 10^{8}$ M$_{\odot}$ has been estimated by the bulge luminosity. The presence of an additional faint disc component cannot be ruled out with the present data, but this would reduce the BH mass estimate by only $\sim$ 30%. These results, together with analogous findings obtained for FBQS J1644+2619, indicate that the relativistic jets in gamma-ray-emitting NLSy1 are likely produced by massive black holes at the center of elliptical galaxies.

from astro-ph.HE updates on arXiv.org https://ift.tt/2jidV4u

[chocobarsys]

oh boy...

the old bitch actually has COVID... is she quarantining? no. she even keeps going in our bathroom and getting her COVID nast everywhere.

not like theres an immunocompromised person who uses that bathroom

not that she would care anyway

we are so tired of being around people who dont even care if we die...

we dont want to die and we dont want our partner system to die either

but what do we even do now...

does anyone have a dragonscale? so we could go to dragon tales land? or like. does anyone know where that factory is so we could go to lyoko. at this point we would even settle for the nether...

#pk;m analog #covid tw

[chocobarsys]

upsetting thoughts (cw death mention)

so scared... we're gonna die here. arent we...

we didnt want our life to be this way but we didnt have much of a choice.

the world was not structured with disabled people in mind...

and so here we are. no way out. doomed.

we are still trying... trying so hard to get away.

but our time is running out. how much longer can we survive?

i dont know...

#pk;m analog #heavy thoughts

[chocobarsys]

angry vent (swearing, covid)

im losing my cool. we are losing our collective cool.

we are so fucking tired of being scared all the time. we are so fucking tired of these people looming over us and forcing us to hide away in our room while they dont even care or probably even consider their actions at all. they never think of anyone but themselves

what kind of selfish prick do you have to be to knowingly spread covid and not even care? i dont fucking care if the media has brainwashed them into thinking its not lethal anymore, its always been a fucking asshole move to knowingly spread any kind of illness to anyone.

im sick of having to wear a respirator to my own bathroom. im sick of being terrified of touching anything. im sick of being terrified im gonna get covid from literally everything in sight. im sick of wiping myself down with lysol wipes just to make sure im okay.

and we were already sick of living in this shitty house with these shitty people already. we were already sick and tired of their bullshit and have been for over a year now and now theres just more shit piled on top and we are losing our minds.

please let our plans to escape work... this feels like our only real way out of here. it has to work. it has to.

#pk;m analog #covid tw #swearing tw #anger tw #vent

[chocobarsys]

havent stopped crying since yesterday. so fucking scared being here. dont know what to do

#pk;m analog

[chocobarsys]

can someone please save us. just somewhere safe to go. wont be permanent… just need safety while getting shot together…

#pk;m analog