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#also being on my period does not help
mihrsuri · 4 months
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I need to make a list of reasons to continue to be here on this earth and forgive me, I’m doing this on tumblr because it seems to help (feel free to skip)
[redacted private Jewish Thing]
more swimming to do
rings of power season two
need to leave flowers for Anne Boleyn in England
have to get some more pretty dresses
might make people sad
listen someone has to have a bisexual crisis over Natalie Dormer and James Frain Lil
promised yourself chocolate chip cookies
taylor swift album
the cup of tea you are going to make
????
writing your fanfiction
promised
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clownsuu · 1 year
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I guess you could say Wally has the eye of the tiger- (sorrynotsorry)
So uh, It is done! I wanted to thank you and other Welcome Home fan artists to be frank. It made me want to create fanart as well but I just recently came out of a 4 year art block and the only thing that really stuck was abstract drawing, which I still love, but it doesn't help anatomy-wise. So thank you, A LOT (and other artists) for getting me into drawing anatomy again!
FUCKIN
K I B B Y
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lateseptemberdawn · 8 days
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No but like. Men could be the lowest of the low, not be knowing the most basic shit, inept at wit or anything else pertaining to the brain or mind or conscious, and yet the audacity be there. Like. How.
#legit listening to my brother tall of how many qualities he has which mainly just includes having a nice face and using his voice#like this is the dude who is in his last year of high school and absolutely refuses to look at a book for more than half an hour a day#you can imagine the amount of basic knowledgeable he would have with that time period dedicated to studies (not even dedicated hes forcedto)#he knows nothing of the most basic thing needed in class#knows nothing of even the language subjects#and yet thinks just because he can talk he can land a job#theres delusional and then theres this piece of shit#like this family is on the verge of struggling financially and this dude decides to use the lakhs of the rupees worth of tution to eat out#with friends and learn NOTHING#like#im legit so. like i wish he would succeed in life by the sheer power of luck and wishes bc god knows hes a degenerate#yet we care enough to not have him roam around like how it looks like he might bc lets be real if not that he'll end up being a worse pain#but seriously tho how does one be SO behind the very fundamental of human experience and still think their gaming skills and music taste#can save them in this world?#this dude is more or less addicted to his phone and literally like im not exaggerating hes so dumb you have one conversation with him and it#becomes glaringly obvious bc hes so delusional about it that he talks with full confidence but you realise hes not really talking hes just#spitting bs that hes heard on youtube 😭#not to drag him or anything but im seriously so sympathetic. how much of an idiot do you have to be?#to think HIGH SCHOOL education is worthless? hIGH SCHOOL. Tgats like. the very bottom of it.#worst part is he refuses to acknowledge he should get better 🗿#so theres no point in helping bc its one steo forward ten steps back with him#and also feels shitty as fuck to be guiding a fucking 18 yo thru SCHOOL#its fucking SCHOOL FOR CRYING OUT LOUD
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poisonouspastels · 9 months
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@beegswaz genuinely i think my favorite tags on any of my work ever. i fucking love when people talk abt my characters like this
#its like blorbo from my show but with fucking minecraft and i love it deeply#for the record both Groda and White Eyes get socialized in the modern world like feral cats#both by the main players but it does happen at different times bc they all encountered Groda first when she held Rana hostage for bait#she'd kinda gone crazy after all those years of isolation lol#did that bc she thought Herobrine was the knight who betrayed her during the time period where people were wanting to overthrow her#(the knight worked for the royal family and was one of Groda's childhood friends. that did not last needless to say)#thankfully at the end of the day all 4 of the main players managed to get out alive though not unharmed with Groda in tow#when there's something trying to kill you every other day in this universe though they honestly cant be too mad about it#it doesnt help that Groda is just Really Stupid sometimes (all the time)#she's literally Peridot from SU in that she seems really intimidating but in hindsight is a massive dork#and also the fact that is the voice i imagine her having its so good#once her ability to use magic is taken away she's literally just like a scared feral street cat. does not know what the FUCK is going on#also rendering her communication with 3/4ths of the players useless since she only knows Galactic and no one alive knows that but Herobrine#(not helping the coincidental similarities to the knight but thats not him) she'll learn commonspeak later tho#ironically later down the line when Groda is spotted by the cult getting her magic back will be a key part in taking down White Eyes#she really does want to change for the better but she needed a LOT of shit kicked into her in order to start actually making the change#that being said when White Eyes eventually gets integrated it IS On Sight#she has had to been quite literally pried of Groda AT LEAST once by the others in order to keep from killing her#but other than that she'll be okay :) she picks up painting eventually#her open wounds are finally able to heal over once released from the influence of the Wither but she's still scarred unfortunately#mentally and physically!#but its only up from here... right?#actually since I talked abt the players first encounter with Groda im gonna reblog that aftermath comic again it still fucks#minecraft au mastertag
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exopelagic · 1 day
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i said i wouldn’t do it this time but it’s 3am and mods asleep. boy
#welcome to another episode of Luke is insane abt hockey boy!#this time featuring a guy who is actually this time almost (ALMOST) confirmed to be queer#the almost is partly me being insane because I don’t trust anything anymore#but like. there are only so many reasons you wear pride converse. that is not ally behaviour#it just threw me this time I think bc I’d been like no. heterosexual. bc I think I became aware of him when he joined the real hockey team#because the OTHER problem is that the whole time I’d been thinking he was cute as hell (bc he is) and simultaneously being like no. bad.#anyway this meant that I have actually talked to him a bunch without overthinking it this term which honestly has been very cool#not like a whole lot but we’ve played together a decent amount and hopefully will keep doing that#and yesterday discovered hes recommending other people talk to me abt goalieing which is insane to me bc I am truly not that good#but apparently I made an impression!#anyway it does not help that this guy has gotten incredibly good at hockey in the past few months#idk man I make bad decisions (I say as if this was a decision) bc it is now the end of term once again <3#which means absolutely nothing can or will happen until after summer. which isn’t an issue#I’m just frustrated by my tendency to realise these things right before I’m about to not see the guy for X period of time#I also desperately need to stop crushing on hockey boys I swear but in my defence that is the main way I meet people#I think I’m cursed actually. that would explain many things#anyway he also has exams until next Tuesday which means he’ll be at hockey next week but idk abt this week which is devastating#i just wanna have talk to the guy more honestly to see how that goes bc we’ve not rlly talked individually for an extended time yknow.#in other words we have not had A Conversation it’s been groups or like quicker exchanges#he’s kinda quiet but i can’t quite tell which way yknow. I know he’s Watching basically all the time. and he is slightly awkward#which is also kinda cute. he gets a lil rambly when he talks abt hockey and I wanna push that button more#i. topsy if you’re reading this you’re gonna laugh so hard I just realised. he’s captain of the team now.#which sidenote is INSANE bc he started playing with them THIS YEAR#but oh my god. okay.#anyway. I need to start complimenting guys more for multiple reasons but also#1. he dresses very cool 2. he caught me looking at his shirt last week without saying anything (BEFORE I caught the rainbow converse)#i compliment women on their clothes and jewellery and hair and shit all the time but I do not with men bc. I mean do I need to explain.#but ​this is so unfair I am haunted by existence of boy and here we are once again. posting on tumblr with the possibility of seeing him lik#two more times before summer. might be three or four depending on what he comes to#luke.txt
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bunnyhysteria · 1 month
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so i finally read the extra I see a lot of ppl mad pressed about and go "this is why shen qingqiu is absolutely an abuse victim and binghe raped him!!"
throwin away the main story sex which is it's own can of worms and argument, it's not the one where he literally drugs him, no it's... shizun said be gentler and then just binghe didn't. that's what constitutes rape in fiction now??? honestly it's dubcon if you want to slap a problematic label on it. and I'm not sayin bingqiu isnt toxic, definitely not at a healthy point even when the story ends but. I just feel like people are graspin for straws to paint binghe as big bad evil man because shouldn't he know our very explicit means of consent in modern culture?! I'm not as caring on the antis who take their stance on shen qingqiu's nonsense because usually they make far more sense because the thing that gets me is I literally saw an exchange like "man I love it up until that point but I don't wanna throw it all away for one extra" and I'm just like. that's your tipping point? buddy it's literally just the same shit you were fed the whole time. I don't get it. why is everything else okay, but this isn't? throw the whole bag away or don't; don't eat half of it enjoying it then eat some more suddenly declaring you hate it.
but the real thing is that their dynamic strongly comes off as "if dear shizun actually wanted it to stop, it would stop". he's whiny and annoyed at best in the extra. he's not even really fightin back. "oh but the outside pressures and binghe always guilt trips him-" no, we are explicitly shown in another extra that shen qingqiu can turn him away, even if he starts wailing, even if it's sex. and you would think if he hates sex so badly with binghe, why would he in another extra again purposely initiate and say that he would gladly endure it??
as for the blood ppl are pressed about, yea it's kind of gross, but also injuries are basically nothing in this world. they're like a paper cut that just stings really badly and then heals within a day or even hour. people spew countless liters of blood and they're still around kicking next scene. in our world would anal bleeding be a very big problem? yes, yes it would. is it a problem for an immortal who can ask his friends to hit him up with spiritual juice and heal instantly? no, not at all. and I only ever recall blood twice, that being the main story scene and the wedding extra. I genuinely think the blood in this case is nothing to do with the actual story and just narrative device to play on the wedding night fetish.
and just... not only is shen qingqiu an unreliable narrator with severely tsundere tendencies, this is ultimately sung in a comedic tune. none of it is face value nor is all of it supposed to be a serious part of the story. not only is this me going "chill" but I also believe this is part of the reason why people feel justified in trying to pretzel shizun into a rape victim. because shen qingqiu is never actually giving the full picture on what's actually going on or even his on true feelings, we're left to guess to fill some parts in, and so with their own growing discomfort of the yandere binghe they signed up for, they latch onto the smallest bit of shen qingqiu rejecting him. they're obsessed specifically with the wedding extra because it's where it ends. forget how the previous shit is arguably far worse, this is where it ends. and it's not their picture perfect healthy relationship. and it bothers them so badly that they still like bingqiu. so they proclaim themselves critical, write a few essays on how it's so awful to distance themselves from the nasty bingqiu enjoyers who openly like problematic stuff and wouldn't actually care if it was rape, and then circle back around to enjoying it because they've done their moral obligation so they're now enjoying the ship in a pure and holy way.
and maybe I have a personal bone to pick because I see me and my hubby in bingqiu so much, including how everyone wants to paint him as an evil abuser despite never even meeting the man, just because we have a colourful past I'm not ashamed of. how because I'm a small and weak feminine person and because he's a large and strong masculine person. despite the fact I'm also upfront about the shit I did. like don't think heteronormativity and misogynistic ideals aren't playing a role in how binghe is always the abuser and shen qingqiu is always the victim. there's hardly ever any room for shen qingqiu is the abuser or how about they're both just two toxic clusterfucks made in heaven and hell for each other. and people just love to down play emotional control when it's shen qingqiu dishing it out, but as soon as it's binghe, the world is ending someone save shizun.
in my hot take, shen qingqiu has far more control over binghe than binghe could even dream of having over his shizun.
do I even wanna drag out the corpse of bl culture, misogyny towards women writing gay shit, or the general homophobia of how we hold gay shit to a way higher moral standard because it's already impure and immoral so there's no room for it to be down and dirty? and why are we pressed about this being our reason to throw out book 4 and not the literal slur printed on the page that was also written in the original. like the guy who says slurs is the one we're putting into the uwu baby box??? okay.
#text#mine#not tagging this anything so if it shows up in tags it does and if it doesn't it doesn't#I wish I could find that one blog I strolled that just had whiplash back snd forth between bingqiu is the worst thing ever to fanfic ideas#but also because I want to reread the posts now that I actually know what they were talkin about#like the high points of it all was just binghe has manipulated and gaslighted him into fawning all the time or smth#honestly binghe or at least bingmei is not a mastermind manipulater. he's a broken and abused child who was then tossed after being shown#his only scraps of kindness then constantly blamed and treated like a monster and chronically has his fear of abandonment triggered by guess#what. abandonment. and then of course the whole dating culture in the loose time period it's set in and how he's led to believe this is how#you treat your wife which is honestly like property. which is not helped by his shizun sharing those same ideals onto him. then you mix in#binghe has no concept of straight verses gay and literally calls shizun his wife because one is the husband and one is the wife in his mind#honestly I don't even know if binghe knows what gender is other than he's just told he's a man all his life#like yes he's fucked up and going to do fucked up shit. and you wonder why it's almost like shen qingqiu kept mentally fucking him up#like all these things I listed here are of direct consequence from how his shizun treats him and acts#give me a break on binghe is the abuser here. shen qingqiu is just getting what he's dished out. and he's fully fucking aware it.#if it's not clear I'm not arguing bingqiu is healthy. I'm arguing bingqiu is mutually toxic if not shen qingqiu holding the power.#thank you for coming to my ted talk
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geoffrey · 2 months
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No your take on gay bars is wrong. Also gay men have a hook up culture whereas lesbians dont and require emotional connection.
lol.................... just walk away from me
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studiousbotanist · 10 months
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#does a bear blog in the woods#just phantom period stuff fuckingbw my brain chem i think is whats going on this week !#i knew the new tfb would rip emotions outta me but im messed uppppp .#ive been single the longest ive been in a Long Time now ...#theres good and bad . theres so much cooking in my head from these few months#dealint with grief . bad job . good job now#and still working on getting my life and health togethwr#and im really trying to craft and make shit again . its So necessary for your soul and ive been neglecting#tabletop has helped so much and roleplay will too qhen i get into it#in the mean time though . im LONELY !! im in a mood where being by myself is Torrrtureeee . butnive also been overstimmed !#i was very somber earlier cuz i jusf did Not have rhe energy to be up and do shit ..wjich is why i called out#but was just thinking the thing i miss most abt a relationship is always having some1 to hang out w or be around#especially physical side cause i am very physically affectionate !!! and tryin to get back to it .#its been hard cus of well ...trauma and also the pandemic . overthinking . itd help if i cried i think#i coulsve put this all ina read more ..too late now LOL !#i just want to word vomit . been stuck in a bad nasty rude to myself feedback loop abt NOT venting and NEEDING to reach out directly#but good gd its difficult when we are All exhausted . and when i judt Need the vocal speak vs typing#if u read all this mess thank you LOL . ill be okay . ive got to let myself feel this
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la-cocotte-de-paris · 4 months
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I've only just realised you're literally Never Okay as a woman and you just have to act like it's all fine all the time
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fantabulisticity · 2 years
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Posted July 19, 2022
By Christopher Lane, Ph.D; reviewed by Vanessa Lancaster
Key points
Surveys indicate that 85-90 percent of the public believes low serotonin or a chemical imbalance causes depression.
Among 237 psychology students interviewed, 46 percent had heard the chemical imbalance explanation from a physician.
The serotonin hypothesis has been challenged repeatedly and found wanting, even as it remains popular and influential.
A comprehensive, well-powered, high-quality umbrella review now determines that the theory is “not empirically substantiated.”
Almost as soon as it was floated in 1965 by Harvard psychiatrist Joseph Schildkraut, the serotonin hypothesis of depression—reduced and simplified by pharma marketing to the “chemical imbalance” theory of depression and anxiety—has been subject to critical research and found wanting.
The poor standing of the hypothesis in the scientific literature, however, barely dented its afterlife in textbooks, across clinical and treatment settings, and on mental health apps and websites. Nor has it dispelled the continued use of the phrase as “shorthand” between doctors and patients and in everyday settings, including for quite different mental states and conditions.
The “Chemical Imbalance” Metaphor Takes Root
Revisiting the history of this controversy raises several still-relevant details. In December 2005, as advertising for SSRI antidepressants flooded American magazines, talk shows, and network TV, the result of multibillion-dollar campaigns pitched in this case directly to consumers, Florida-based professors and researchers Jeffrey Lacasse and Jonathan Leo asked pointedly in PLoS Medicine, “Are the claims made in SSRI advertising congruent with the scientific evidence?”
The answer in “Serotonin and Depression: A Disconnect Between the Advertisements and the Scientific Literature,” their well-researched article, was a resounding no. The resulting “incongruence,” they determined, was “remarkable and possibly unparalleled.”
Lacasse and Leo found repeated evidence that the U.S. Food and Drug Administration had approved the marketing of SSRIs with two phrases still heavily in the subjunctive—that depression “may be due to a serotonin deficiency” and that SSRI efficacy, “modestly” outcompeting placebo, was “presumed to be linked to potentiation of serotonergic activity.” However, the research itself could not identify the precise mechanism.
The FDA had accepted aspirational language that the drugs “help to restore the brain’s chemical balance” and “bring serotonin levels closer to normal,” even though both claims were, and remain, scientifically meaningless.
“There is no such thing as a scientifically established correct ‘balance’ of serotonin,” Lacasse and Leo cautioned more than a decade ago, joining numerous other experts then and now. Additionally, both aspirational claims rest on a hypothesis that follow-up studies would end up contradicting repeatedly. In short, both the hypothesis and the expensive marketing that pushed it into American living rooms rested on a hedge: “Scientists believe that it could be linked with an imbalance of a chemical in the brain called serotonin.”
A Multibillion-Dollar Error
The hedge proved highly effective, even though, as David Healy explained in 2015 in “Serotonin and Depression,” in the BMJ, in practice, it entailed embracing or tacitly accepting “the marketing of a myth.” Through further oversimplification, a revised metaphor of a “chemical imbalance” took root as folk wisdom for multiple, dissimilar conditions listed in the DSM.
Returning to the controversy in “Antidepressants and the Chemical Imbalance Theory of Depression” (2015), Lacasse and Leo found that while the marketing had shifted emphasis from “correcting imbalances” to “‘adjusting’ or ‘affecting’ neurotransmitter levels,” leading psychiatrists were if anything, more wedded to the “chemical imbalance” metaphor than before.
Some had taken to the airwaves to say that it simplified communication with their patients. Daniel Carlat, the editor of The Carlat Psychiatry Report, explained on National Public Radio when asked what we know about psychiatric medication:
We don’t know how the medications actually work in the brain…. I’ll often say something like the way Zoloft works, is, it increases the level of serotonin in your brain (or synapses, neurons) and, presumably, the reason you’re depressed or anxious is that you have some sort of a deficiency. And I say that [chuckles] not because I really believe it, because I know the evidence really isn’t there for us to understand the mechanism—I think I say that because patients want to know something. And they want to know that we as physicians have some basic understanding of what we’re doing when we’re prescribing medications. They certainly don’t want to know that a psychiatrist essentially has no idea how these medications work (Qtd. in Lacasse and Leo).
The point in reproducing Carlat (who has made several such admissions on national media) was not to single him out but to stress how widespread the thinking and practice he shared so candidly. In 2007, as Lacasse and Leo pointed out, Frances, Lysaker, and Robinson found that among 237 psychology students interviewed, “46 percent had heard the chemical imbalance explanation from a physician.”
Inevitably, the problem of spreading false scientific information dovetails with that of medical ethics and the risk of enabling medically-induced harms. Because physicians swear to uphold the Hippocratic oath Primum non nocere (“First Do No Harm”), Lacasse and Leo questioned “the ethics of telling a falsehood to patients because you think it is good for them.”
They asked more broadly of those repeating the discredited hypothesis, whether as metaphor or oversimplification: “Do you believe it is ethical to present a falsified scientific theory as a fact to a patient? What are the possible negative effects of doing so?”
A significant consequence they anticipated at the time was that patients would realistically “conclude that they have been misled.”
Cut to the Present-day
A major new review of the research—the first of its kind exhaustively reviewing the evidence, published today in the journal Molecular Psychiatry—reaches a strikingly similar conclusion. In “The Serotonin Theory of Depression: A Systematic Umbrella Review of the Evidence,” University College London Psychiatry Professor Joanna Moncrieff and a team of five other top European researchers found “there is no evidence of a connection between reduced serotonin levels or activity and depression.”
The peer-reviewed umbrella review—representing one of the highest forms of evidence in scientific research—was extrapolated from meta-analyses and systematic reviews on depression and serotonin levels, receptors, and transporters involving tens of thousands of participants.
Although “the serotonin hypothesis of depression is still influential,” Moncrieff and coauthors noted, citing widely adopted textbooks published as recently as 2020 and surveys indicating that “85-90 percent of the public believes that depression is caused by low serotonin or a chemical imbalance,” the primary research indicates there is “no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations.”
Among other key findings:
“Research on serotonin receptors and the serotonin transporter, the protein targeted by most antidepressants, found weak and inconclusive evidence suggestive of higher levels of serotonin activity in people with depression.” Widespread use of antidepressants is seen as the likely cause.
The researchers also looked at studies where serotonin levels had been “artificially lowered in hundreds of people” (by depriving their diets of the necessary amino acid that makes serotonin) and found that “lowering serotonin in this way did not produce depression in hundreds of healthy volunteers,” according to a 2007 meta-analysis and several recent studies.
Numerous other reviews on re-examination were found to provide weak, inconsistent, or nonexistent evidence of a connection between serotonin and depression.
The researchers also probed well-powered studies involving tens of thousands of patients that focused on gene variation, including the gene for the serotonin transporter. These found “no difference in the genes between people with depression and healthy controls.” As such, “high-quality genetic studies effectively exclude an association between genotypes related to the serotonin system and depression, including a proposed interaction with stress.”
The researchers also looked at “the effects of stressful life events and found that these exerted a strong effect on people’s risk of becoming depressed—the more of these a person had experienced, the more likely they were to be depressed.”
Legacy Effects of a Discredited Theory
“The popularity of the chemical imbalance idea of depression has coincided with a huge increase in the use of antidepressants,” note Moncrieff and coauthor Mark A. Horowitz in the study’s press release. “Prescriptions for antidepressants have sky-rocketed since the 1990s, going from being rare to a situation now where one in six adults in England and 2 percent of teenagers are prescribed an antidepressant in a given year.”
The practical ramifications of the umbrella review are thus vast and consequential, involving millions of people across multiple countries because the findings are tied to a discredited theory that is still fueling mass prescribing on a global basis.
Moncrieff explained in the press release:
Patients should not be told that depression is caused by low serotonin or by a chemical imbalance and they should not be led to believe that antidepressants work by targeting these hypothetical and unproven abnormalities. In particular, the idea that antidepressants work in the same way as insulin for diabetes is completely misleading. We do not understand what antidepressants are doing to the brain exactly, and giving people this sort of misinformation prevents them from making an informed decision about whether to take antidepressants or not.
Invited to extrapolate the review’s findings for Psychology Today, Moncrieff added:
Antidepressant use has reached epidemic proportions across the world and is still rising, especially among young people. Many people who take them suffer side effects and withdrawal problems that can be really severe and debilitating. A major driver of this situation is the false belief that depression is due to a chemical imbalance. It is high time to inform the public that this belief is not grounded in science.
End of article.
Also:
Joanna Moncrieff et al. Mol Psychiatry. 2022.
Abstract
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception until December 2020. Systematic reviews, meta-analyses and large data-set analyses in the following areas were identified: serotonin and serotonin metabolite, 5-HIAA, concentrations in body fluids; serotonin 5-HT1A receptor binding; serotonin transporter (SERT) levels measured by imaging or at post-mortem; tryptophan depletion studies; SERT gene associations and SERT gene-environment interactions. Studies of depression associated with physical conditions and specific subtypes of depression (e.g. bipolar depression) were excluded. Two independent reviewers extracted the data and assessed the quality of included studies using the AMSTAR-2, an adapted AMSTAR-2, or the STREGA for a large genetic study. The certainty of study results was assessed using a modified version of the GRADE. We did not synthesise results of individual meta-analyses because they included overlapping studies. The review was registered with PROSPERO (CRD42020207203). 17 studies were included: 12 systematic reviews and meta-analyses, 1 collaborative meta-analysis, 1 meta-analysis of large cohort studies, 1 systematic review and narrative synthesis, 1 genetic association study and 1 umbrella review. Quality of reviews was variable with some genetic studies of high quality. Two meta-analyses of overlapping studies examining the serotonin metabolite, 5-HIAA, showed no association with depression (largest n = 1002). One meta-analysis of cohort studies of plasma serotonin showed no relationship with depression, and evidence that lowered serotonin concentration was associated with antidepressant use (n = 1869). Two meta-analyses of overlapping studies examining the 5-HT1A receptor (largest n = 561), and three meta-analyses of overlapping studies examining SERT binding (largest n = 1845) showed weak and inconsistent evidence of reduced binding in some areas, which would be consistent with increased synaptic availability of serotonin in people with depression, if this was the original, causal abnormaly. However, effects of prior antidepressant use were not reliably excluded. One meta-analysis of tryptophan depletion studies found no effect in most healthy volunteers (n = 566), but weak evidence of an effect in those with a family history of depression (n = 75). Another systematic review (n = 342) and a sample of ten subsequent studies (n = 407) found no effect in volunteers. No systematic review of tryptophan depletion studies has been performed since 2007. The two largest and highest quality studies of the SERT gene, one genetic association study (n = 115,257) and one collaborative meta-analysis (n = 43,165), revealed no evidence of an association with depression, or of an interaction between genotype, stress and depression. The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations. Some evidence was consistent with the possibility that long-term antidepressant use reduces serotonin concentration.
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elytrafemme · 9 months
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THERAPY ACHIEVED!
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angelamontoo · 2 years
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I received The animated Peter Lorre as an early birthday present and I absolutely love it! Its an enthralling read as a fan of both Peter Lorre and animation history(I'm still surprised by how many characters I grew up with, who I didn't know were Peter parodies till I read the book) and I'm thrilled to own it for myself.....but I do have an issue with it(cause god forbid I enjoy anything without finding something to later complain on tumblr about)
OK so this is the epilogue
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And I just.....
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#like im sorry im being such a jerk csuse obviously im eternally grateful that someone took the time to compile an index about every peter#lorre caricature/reference in animation they could find#but how does one compile such an index and not notice that references to the actual peter lorre went out the door a loooong time ago#but anyway this is a very cool book#i remember becoming obsessed with the beatles cartoon for a brief period a few years back for how damn weird it is#and one of the funniest things anout it to me was George harrisons weird ass changeable accent#and i had no clue that he sounded like that because his VA just gave him a peter lorre impression#the one about weevil from yugioh was interesting too#cause i grew up with that anime but ive seen yugioh abriged so many times in my teens that i can only hear him sounding like beavis lol#also im pleased about the chameleon from Tuff puppy#cause thats one i actually did recall all by myself and it was nice to have it confirmed#peter lorre#the animated peter lorre#also i dont agree about petes actual image slipping away#if anything i think its the opposite#in an era where his older films are easier for any jo schmo to watch than ever#(i still have faith that well see more of The missing wife in my life time)#i think petes parodies help new generations discover him#whenever i first discovered peter lorre part of my fascination was the weird familiarity i already had of him from cartoons#and now ive been obsessed with him for over two years#matthew hahn#just realised i spelt his name wrong in the meme fml
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multishipper-baby · 1 year
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Having weird cringefail thoughts tonight.
#mpreg#tmpreg#you've been warned#anyway. been thinking about spamton being pregnant in my au and everything that would entail#I think he would take a while to realize because he's dealing with the whole... freezing stuff#he's got frostbite so bad he can't stand and he's unable to feel his fingers. it's pretty fucking bad#it's so bad that when he does eventually hear that he might be pregnant he doesn't believe it#because if he's this unhealthy and his body is wrecked clearly there's no way there's a baby in there. how could a fetus even survive?#it quickly becomes apparent that he is in fact expecting though. and he takes it very poorly (which makes sense)#he cries. then he rages. then cries. tries to fistfight the lightners despite barely being able to move. then gets heavily depressed#it doesn't help that the pregnancy rolls back on a lot of the progress he was making towards healing#because his body is so small for an addison he feels every symptom tenfold and it pretty much leaves him completely disabled again#ralsei takes care of him the most since he's the healer of the team and the one spamton hates the least#kris sometimes visits but they're generally banned from seeing him since he's so upset at them#he's upset at noelle too but she doesn't want to visit him either so no conflicts there. susie also ignores him#he gets his own room in the castle that's designed after the one he had in his big shot days. it helps calm him a lil but not that much#jevil sometimes visits. they usually just bicker but spamton generally likes having a familiar face around#not for long periods of time though. jevil is very energetic and spamton is too exhausted to keep up with him for long#almost everything sucks until the kid gets there. and then it slowly gets better#it's worse at the start because he's weak and tired and the newborn keeps demanding his attention#but eventually it calms down and his body finally manages to ragain some strength so he can do something other than be depressed#yay I guess?
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vaspider · 6 months
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While I'm writing things that I've been intending to write for a while... one of the things that I think that a lot of people who haven't been involved in like... banking or corporate shenaniganry miss about why our economy is its current flavor of total fuckery is the concept of "fiduciary duty to shareholders."
"Why does every corporation pursue endless growth?" Fiduciary duty to shareholders.
"Why do corporations treat workers the way they do?" Fiduciary duty to shareholders.
"Why do corporations make such bass-ackwards decisions about what's 'good for' the company?" Fiduciary duty to shareholders.
The legal purpose of a corporation with shareholders -- its only true purpose -- is the generation of revenue/returns for shareholders. Period. That's it. Anything else it does is secondary to that. Sustainability of business, treatment of workers, sustainability and quality of product, those things are functionally and legally second to generating revenue for shareholders. Again, period, end of story. There is no other function of a corporation, and all of its extensive legal privileges exist to allow it to do that.
"But Spider," you might say, "that sounds like corporations only exist in current business in order to extract as much money and value as possible from the people actually doing the work and transfer it up to the people who aren't actually doing the work!"
Yes. You are correct. Thank you for coming with me to that realization. You are incredibly smart and also attractive.
You might also say, "but Spider, is this a legal obligation? Could those running a company be held legally responsible for failing their obligations if they prioritize sustainability or quality of product or care of workers above returns for shareholders?"
Yes! They absolutely can! Isn't that terrifying? Also you look great today, you're terribly clever for thinking about these things. The board and officers of a corporation can be held legally responsible to varying degrees for failing to maximize shareholder value.
And that, my friends, is why corporations do things that don't seem to make any fucking sense, and why 'continuous growth' is valued above literally anything else: because it fucking has to be.
If you're thinking that this doesn't sound like a sustainable economic model, you're not alone. People who are much smarter than both of us, and probably nearly as attractive, have written a proposal for how to change corporate law in order to create a more sensible and sustainable economy. This is one of several proposals, and while I don't agree with all of this stuff, I think that reading it will really help people as a springboard to understanding exactly why our economy is as fucked up as it is, and why just saying 'well then don't pursue eternal growth' isn't going to work -- because right now it legally can't. We'd need to change -- and we can change -- the laws around corporate governance.
This concept of 'shareholder primacy' and the fiduciary duty to shareholders is one I had to learn when I was getting my securities licenses, and every time I see people confusedly asking why corporations try to grow grow grow in a way that only makes sense if you're a tumor, I sigh and think, 'yeah, fiduciary duty to shareholders.'
(And this is why Emet and I have refused to seek investors for NK -- we might become beholden to make decisions which maximize investor return, and that would get in the way of being able to fully support our people and our values and say the things we started this company to say.)
Anyway, you should read up on these concepts if you're not familiar. It's pretty eye-opening.
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nkogneatho · 5 months
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"𝐈𝐓'𝐒 𝐑𝐀𝐈𝐍𝐈𝐍𝐆 𝐌𝐈𝐋𝐊"
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𝐉𝐉𝐊 𝐋𝐀𝐂𝐓𝐀𝐓𝐈𝐎𝐍 𝐊𝐈𝐍𝐊
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—cw: lactation kink, mentions of pregnancy, dirty, nasty, depraved stuff, vaginal sex, period oral mention, monsterfucking in kuna's (sukuna's is way too dirty), dry humping, drinking breast milk obv, not proofread (this is too long and i have an event tomorrow)
—a/n: i have officially lost it. is it obvious i have lost it? idk if this is the best or the worst thing you will ever read but this is very depraved and nasty. like...aaaaaaaaaahh okay i am normal. i put my big titties non existent breast milk into this so please read it all and i hope you enjoy.
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𝐆𝐎𝐉𝐎 𝐒𝐀𝐓𝐎𝐑𝐔
— satoru is the man who is always up for something new. especially, if it involves pleasing you because he's a good husband and that's good what husbands do. he knows how to pull out the naughty parts out of you, but he had to work his way up.
"I am just saying. It helps. Believe me," your husband was arguing with you.
"Cut it out, Toru. I am not letting you suck my boobs."
"But why?"
"Because it's gross and weird." The moment those words left your mouth, he audibly gasped.
"Did you just call our baby's food gross?" You rolled your eyes. He's always like this. It's not like you weren't curious of his reaction when he does taste you, you were just scared that he'd be disgusted. Plus the post pregnancy hormones are worst as they make you emotional over the silliest things.
"Please, baby? Just this one time. I'll be a good boy I promise." You hate when he addresses himself as if he's an angel. He is a mischievous devil inside. But rather than having him pester you for the rest of the night and ruin your hard earned sleep (since your baby's cries always wakes you up) You thought maybe let him and just get it over with...
"mmph ffhuck." His moans vibrated through your skin, "mhmm god ywo twaste shwo good." The moment he said that, all the insecurity left your body, and heat forming between your legs.
"Ngh—toru..." you felt so embarrassed—so dirty when his eyes locked with you. Your lashes fluttered and you looked away but you swore you could feel him smiling on your nipples. Your husband really digs out the emotions you never thought existed within you.
He was pressing them together, playing like he had just found a new toy. You had never seen so much amusement in those blue eyes as much as of now. Bright pink tongue lolling out to taste the squirting liquid when he squeezed both your breasts together.
"Feels good, right baby? ah!" *slurp* He wiped the dripping milk at the end of his lips with his tongue, and you couldn't process. You felt so wet. And he knew you very well. After all, you've been together for so many years.
"Lay down baby. I'll fuck you while I drink you." You never thought you'd ever hear that sentence but there it was.
𝐅𝐔𝐒𝐇𝐈𝐆𝐔𝐑𝐎 𝐓𝐎𝐉𝐈
— toji has always been an experienced man. he has definitely tried a lot of things. but there's always areas to expand knowledge and new things to learn. he wouldn't do anything that makes you uncomfortable but he knew the person he was marrying wasn't ordinary. you, deep down, were just very dirty like him.
You had your legs stretched on the sofa, upper body resting on your husband's lap. Since you guys had a baby, it was very rare for you rest. Being a parent is the best thing in the world but it also feels worse than a 9to5 sometimes. Today was a good day though. Your boy was sleeping soundly and you had some quality time to spend with each other. Well, it's hard to go on a date at this time, but you both were just happy to be in each other's presence.
Toji was mindlessly flipping through some channels after he got bored halfway through that one movie he was watching. His emerald eyes fell on your ipad screen where you were scrolling through what seemed like a baby product websites.
"I thought we had bought everything for little gumi." You looked up at him then back to the screen.
"Oh this isn't for gumi bear. This is for me. These are called breast shells."
"What? Show me." He took the ipad from you and carefully observed the product you were supposedly buying. "So what is this a fashion accessory for mommies now?"
"Hehehe," you giggled. "No, baby. My breast oversupplies sometimes and it ruins my dress. They prevent that." You watched him as he sat there in silence, poking his tongue inside his mouth. Within two seconds, he flipped you on the sofa, and gently climbed on you.
"Why are you buying that shitty thing when I am right here?"
"Toji, what do y—OH MY GOD!" he pulled out both your breast pretty quickly, all thanks to your maternity clothes. He knew you won't stop him. He knew you would get wet when he'd do that. And he was right on the money. He started sucking so hard, you felt...foreign. He had sucked them a hundred times before but watching him flick your nipples with his tongue and the milk trailing down, fusing with the tastebuds until it goes transparent and his adam's apple bobs when he gulps it. fuck.
Toji's obvious boner grinds against your heat as he suckled on those pretty tits. The wet patch on your panties were now staining his grey bottoms too.
"Overflowing down there too, mama? Hmph," he chuckled. You were to focused on the feeling of his lips on your nipples that you forgot to see his right hand moving down to cup your heat.
"Ngh—twoji," you mewled.
"Don't worry, baby. I'll take care of you." Thick fingers circled your wet clit, "Ya don't need those shells or whateva when i am right here." He is a great husband. He even saved you so much money that you were gonna spend on those silicones.
𝐆𝐄𝐓𝐎 𝐒𝐔𝐆𝐔𝐑𝐔
—suguru worships you. it isn't obvious but you can feel his devotion towards you. the way his droopy eyes lights up when they fall on you, or his ears turn red when you kiss him. he loves how you take him in, struggling a little at first because he is girthy and a bit long, but when he bottoms out, you finally exhale and relax your walls around him. holy shit. he loves it. but this time, something different struck his curiosity.
"fuck. you sure we can do this baby?" He asked.
"'s okay, sugu. doc said we had to wait like six weeks and it's been three months." You were so busy in your post pregnancy life that you barely got time for just each other. You hadn't even kissed properly in months. "plus," you reached for his cock, "i need you." Those last words came off as a whine. You needed him and who is he to deny you off your pleasure.
You were on top of him as you positioned his boner to your entrance. He watched as your cunt swallowed him. This time, not struggling as much. Thanks to dilation.
"anh! suguuu~ mhmm missed your cock." You moaned so beautifully, he found himself falling in love over and over again. Yet, something was different. Normally, his eyes would focus down on how you well you take him as you ride it, but today he had found something rather more interesting. Your big tits bumped against his face and he couldn't take his eyes of those nipples. Those glistening nipples. He could see droplets of milk settling and honestly, they looked so fucking tempting. He let his intrusive thoughts win as you felt a warm sensation on your boobs.
"haaa—fuck. sugu, mhmm—no, it's gross" He didn't reply. He didn't need to. Pretending he didn't hear that was just right. Why would you even think anything about you is gross. He would kiss the soil you walked on.
"so fucking sweet. my sweet girl." *sucksucksuck* "these are f'me too, right? these were made f'me. hmm...sweet *suck* fucking *suck* girl.
congratulations. you just unlocked his new kink.
𝐍𝐀𝐍𝐀𝐌𝐈 𝐊𝐄𝐍𝐓𝐎
—nanami is a gentke lover. we all know that. he is only mean in bed if you ask him too. that alone needs a lot of convincing because he is scared of hurting you. he is not too kinky but you can't say he's completely vanilla. he enjoys wrapping a tie around wrist as be eats you out. he also found himself getting hard when you called him "daddy." So yeah, he is a little kinky. But not in a million years Nanami Kento would've thought he would get hard watching you wipe the excess milk off your breasts.
"So i just put her down to sleep," you walked out of the baby room, with your left tit out, wiping it with a napkin. "What do you want for lunch—Kento?" He immediately broke the staring contest he was having with your boobs and looked at you.
"Yes, sweetheart?"
"Is everything alright? Is there something on my breasts?"
"Yes—I mean no. of course not." It was rare to hear panic in his voice which only made you mroe curious. You walked closer to him, hsi breath heavier than usual.
"What's wrong, Ken? Talk to me." shit shit shit. you were too close. he could feel your wet boobs rubbing against his cyan blue shirt. If you got any closer, you would loathe him for having a boner for such thing. He was ashamed of himself.
"Why are you looking away, baby? Do you not like me anymore?" Fuck. You're so stupid. Not like you? That man is in love with you so much. He cannot contain himself. You tried to get closer but he tripped on the foot of the couch and felk on it upright, and you on top of him.
oh.
OH.
You could feel it between your legs. You didn't even kiss him and it's not like you were seducing him earlier so you connected the dots pretty quickly on why he was hard.
"hmm hmm" you giggled. "is this what makes you hard you, ken? my lactating tits?"
"don't say it out loud, please." it was so fun seeing him all flustered. you adjusted yourself on top him as you thought of something very dirty.
"wanna taste? i know you're curious." he hesitated a bit, but a man like him can only go so high with his walls before he breaks them and let's his wife take control.
He started off with a few licks, testing his feet into the water. It was sweet with a hint of tanginess. The moment he felt it squirting a lot when he sucked, he fell in love. He acted like a kid who had just discovered magic. You chuckled between your heavy moans as you witnessed him trying to fit in your tits in his mouth as much as he can. You start grinding on him and it only makes him more desperate. He taps your thighs, a cue to pull your dress up and throw it in the floor. You watch as he hungrily latches his lips on your nipples quickly again. Your dress was not even off your arms yet. Nanami had discovered his obsession when he watched you squeeze you tits to squirt your milk on him.
𝐑𝐘𝐎𝐌𝐄𝐍 𝐒𝐔𝐊𝐔𝐍𝐀
—sukuna didn't even think it was possible for him to have a child as him being a curse and you being a human but here you were. he was in love with you. maybe his expression for love was different than others, but you felt it. be wasn't an embodiment of rage, but rather an overflowing confidence in his skills. That's where the cockiness came from. Existing for over a 1000 years, he thought he had experienced everything. Well...he was wrong.
"So...you just out this device on your chest and it gathers your milk?"
"Yes. It's called a "breast pump" and not a device," his vocabulary according to the new era was still weak but he was working on it.
When you detached the the vaccum of the breast pump from your boobs, Sukuna's eyes were fixated on them. He loved your tits. He had his fair share of biting and sucking on them till they were sore, but today they looked so plumped and so...succulent??
"What are you staring at? You want to drink it too or what?" You joked as you closed the lid of the bottle.
"Yes." You stared at him. Two minutes of complete shock snd silence.
"What?"
"What? You said if I want to drink it, and I answered."
"Yeah but—"
"Be a good wife, my little human. Good wives obey their husband's wishes." (Please let the feminist in you shut up for a sec and enjoy cuz i know he'd say smtg like this)
"Kuna...I don't know. It's nasty, y'know?"
"I think you're forgetting that I am a monster, baby. I ate you out during your those days of the month. This is less dirty." He yaps a lot someone shit him up before I die from embarrassment.
Sukuna laid you on the bed gently after getting you undressed. For the first time in so.many years, you were feeling shy again in front of him. It was quite an amusing sight to enjoy for him. He summoned a mouth on both his palm and licked your nipples. He wasn't sucking yet, but the hint of sweetness still laced his tastebuds.
"I am going to squeeze your breasts in my mouth now, okay?" Why did he feel the need to announce it? Weren't you already so flustered?
The tongues on his palm licked the skin of your tits before squeezing it when his mouth crashed against your nipples, spraying the milk. Sukuna sometimes forget you're a human. You're delicate unlike. The strong force of the suction made you whine and moan so loudly, it vibrated through the walls of the bedroom.
"mhmm I did not know my beloved wife enjoyed such depraved acts," he smirked when his thighs brushed against your bare pussy. you were dripping wet.
"Don't worry, little one. Let me please you. Hope you have pumped out enough in that bottle of yours. Because, I am going to milk you dry today."
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taglist: @aztecbrujeria @sachiyoh @hellkaiserinphoenix @his-saiko @kokonoiscoconut @numbinyourchest @shewritesallnight @valiantmilkshakekoala @oreo-creampie @kutabaka @gojoxxluv @desi-the-blue-eyed-kakushi @chronic-claire-universe @katsukichu @shutyourwhoremouthbecky @mostlyhornyandsad @leelee-66 @stargirlstabber
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lockea · 3 months
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I've been seeing a lot of Discourse around outdoor cats that talks past one of the biggest problems addressing community cats/outdoor working cats so I thought I'd chime in with my two cents.
Many arguments I see just... don't think about the cats at all? Or don't consider the logistics of actually addressing the feral cat problem in a humane way. It's always about how outdoor cats shouldn't be outdoors, which is neither realistic nor helpful.
I used to volunteer at an municipal animal shelter in the USA that had a TNR program (Trap, Neuter, Return) and also adopted out community cats to local farms and businesses. Here's my side of the story.
"Your cat doesn't need to be outside" -- Yes, correct. Your domesticated (non-feral) house cat does not need to go outside at all. They can have a fully actualized life safely indoors. When I see this argument, proponents of indoor only cats are correct in most or all their arguments regarding this.
"Outdoor cats are the largest invasive species in the world, and decimate bird populations." -- This is also correct, and part of the reason why you can help by bringing your house cat indoors. Cats are the largest invasive species. Spay and Neuter your cats, bring them inside, and socialize them so they don't become feral.
"TNR doesn't work." -- False. Whether we like it or not, feral cats exist. We have two methods by which we can address the feral cat population -- decimating them (humanely euthanizing the whole colony) or TNR. For a long time, euthanasia was the preferred way to address the feral cat problem. Afterall, if the cats aren't there, doesn't that save the local wildlife population?
Except that we found, studying these colonies, that when a colony is wiped out, the cats of another colony will spread into their territory and continue to have kittens and the population of feral cats is neither controlled nor diminished.
Hence, TNR. What we found performing TNR on cat colonies was that this controlled the population of the colonies, allowing them to stay in their territory, which kept other colonies from spreading (especially colonies we hadn't performed TNR on yet). We at the shelter felt this was the most humane way to control the feral cat population and safely deflate their existence without dealing with the population blooms that euthanasia caused.
"What about kittens?" -- Kittens from these colonies were brought into the shelter, socialized, and fostered out until they could be adopted. Some of these semi-feral kittens needed special homes to be adopted into, but this was the best quality of life for these cats.
"What about cats that get missed during TNR?" -- We would return to the colony several times over a period of several years to perform TNR on the same colony. We mark cats that have been neutered by clipping their ear (this is done humanely, but is the most reliable way to tell if a cat has been neutered so the poor thing doesn't have to have surgery 3-4 times in their life). Also, during the TNR process the cats would be vaccinated to ensure disease did not spread from the colony (i.e. rabies). Still, even getting 60% of the colony TNR'd would dramatically reduce the number of kittens being added to the colony each year. This controlled the population by allowing the territory to naturally deflate in size over time, buying us time to address the larger feral cat problem.
"What if the colony was in an unsafe location?" -- There were two ways we addressed unsafe colony locations -- remember, we know that when the colony is removed, a new colony will move into its place, so we tried not to move the colony unless we really felt the cats or the public was unsafe -- one was to move the whole colony to a new location. Preferably someplace like a warehouse where we have an agreement with the owners of the warehouse. Some of the cats were even relocated to shelter grounds as our community cats. If the colony was small enough we would bring them into our Feral Cats room and adopt them out as community cats.
"What is a community cat?" -- The way the program worked, was that anyone who needed a working cat could apply to the program. These were often rural farmers or businesses with warehouses that needed rodent protection. We trained the farmers and businesses on how to acclimatize the cats to their new home, and as part of the agreement, they had to care for the cats (veterinary care, vaccinations, food and water). This gave businesses and farms an alternative to expensive and environmentally unfriendly rodent control, and also gave these feral cats good places to live out their natural lives.
"Can't you just adopt out feral cats?" -- No. Cats that have not been socialized around humans as kittens, or who have several generations of feral cat in them could not interact with humans in a way that did not cause them undue stress. This was not a humane way to handle feral cats. However, when a cat was brought into the feral cat room, they would be monitored for up to a week. If the cat displayed signs of being semi-social or fully social (hanging out outside of their den, allowing staff to pet them, showing interest in staff in the room), then we would either move the cat into the adoption room or place them in foster to be socialized before adoption. Feral cats who displayed signs of being able to live full and healthy lives with human companions were NOT adopted out as community cats. We also observed this behavior during TNRs and would do the same for those cats too.
"But aren't cats bad hunters?" -- Compared to other species, cats are not the most effective form of rodent control. This is true. However, you have to understand that feral cats exist. There is no "undo" button we can push to stop them from existing. We have to deal with the problem we have right now, which is to safely and humanely decrease the number of feral cats in our communities. And yes, we do that by using cats as rodent control in the community.
"What can I do?" -- Stop saying community cats shouldn't exist. That's not helpful and doesn't solve the problem we have. Bring your cat indoors. Spay and neuter your cats. Adopt from shelters. Volunteer with a TNR team. Support TNR efforts in your community. Recognize that those of us actively dealing with the community/feral problem are trying to do what is in the best interest of our communities and the animals we love. We aren't sitting over here saying these cats should exist -- a feral cat will not have the same quality of life as one that is indoors with a family -- but we have to address the problem in practical terms. We don't have the moral high ground to just do nothing while pontificating solutions that have no basis in actuality.
And yes, it's okay to celebrate community cats. If your local farm has a couple of working cats, that means that farm is helping participate in the safe deflation of the feral cat population. Don't shame a farm or business for using community cats. We're all doing the best we can to solve the problem that we have.
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