#motorneuron disease

[thegaitguys]

Leg exercise is critical to brain and nervous system health: Clues into why motorneuron diseases decline so quickly.

Leg exercise is critical to brain and nervous system health "New research shows that using the legs, particularly in weight-bearing exercise, sends signals to the brain that are vital for the production of healthy neural cells." This research supports what we already know, but in a new spin, that sensory input is just as important as motor output. This study gives new clues into why people with motorneuron diseases (spinalmuscular atrophy etc) decline so quickly as their movement impairment deepens. This research might suggest that those who do not continue to weight bear load, such as bedridden or chronically ill patients and even the aging population, are at risk for faster decline. "Not only (do they) lose muscle mass, but their body chemistry is altered at the cellular level and even their nervous system is adversely impacted," says Dr. Raffaella Adami from the Università degli Studi di Milano, Italy. "Limiting physical activity decreased the number of neural stem cells by 70 percent compared to a control group of mice, which were allowed to roam. Furthermore, both neurons and oligodendrocytes -- specialized cells that support and insulate nerve cells -- didn't fully mature when exercise was severely reduced." "Reducing exercise also seems to impact two genes, one of which, CDK5Rap1, is very important for the health of mitochondria -- the cellular powerhouse that releases energy the body can then use. This represents another feedback loop." Bottom line here folks, you have to move, you have to load, especially if you have a neurologic disorder and especially if you are declining in age. At the very least, throw some lunges or body weight squats into your day. Walk the stairs, don't ride the elevator. Move. Lift. Strain. https://www.sciencedaily.com/rel.../2018/05/180523080214.htm the gait guys, shawn & Ivo #gait, #gaitproblems, #exercise, #legstrength, #squats, #lunges, #neuronhealth, #SMA, #neurologicdisease

#gait #thegaitguys #motorneuron disease #SMA #leg exercises #running #runners injuries #walking

[studyslt]

Excited to share the latest addition to my #etsy shop: Motor Neurone Disease/ALS: Speech Therapy Notes https://etsy.me/3ukqtuQ #als #motorneurone #mnd #studynotes #speechtherapy #speechpathology #speech #notes #therapy #studentspeechie https://www.instagram.com/p/CNNJzjZgWBl/?igshid=15lhhlqoe5819

#etsy #als #motorneurone #mnd #studynotes #speechtherapy #speechpathology #speech #notes #therapy #studentspeechie

[biomedicool]

Physiology of Ageing - Muscles

Loss of lean body mass 

Infiltration of fat and connective tissue 

Altered muscle metabolism 

Insulin resistance 

Reduced levels of key regulatory hormones 

Impaired oxidative defence 

Muscle strength peaks at approx. 20-40 years 

Strength dictated by muscle cross-sectional area 

Age-associated decline in concentric strength (leg > arm) 

Decline in concentric strength occurs earlier than decline in eccentric strength 

Power generation ability declines faster than max. strength  

Sarcopenia 

= loss of muscle mass (and strength) due to ageing 

Two phases: 

‘slow’ from 25 to 50 years (approx. 10% lost) 

 ‘rapid’ from 50 onwards (approx. 40% lost from 50-80) 

Deterioration in motor unit remodelling 

Reduced cross-sectional area and functionality 

Disuse atrophy (ageing is associated with becoming more sedentary(not as active)) may contribute to changes 

Reduced regenerative capacity 

Stem cell function affected by circulating factors? 

‘Systemic inflammation’ theory of ageing? 

Increased apoptosis 

Anabolic resistance 

Protein degradation (muscle & nerve) 

Motor Unit

Entire motor unit affected: 

Alpha-motorneuron 

Fibres innervated 

Shift to predominance of slow-twitch fibres 

Force transfer

Network of cytoskeletal proteins align and transmit force produced by actin and myosin along muscle fibres and out to extracellular matrix 

 E.g. Costameres = sub-sarcolemmal proteins that connect sarcomere to cell membrane 

Found in Z and M lines 

Transmit force laterally 

Significant decrease in costameres and lateral force in ageing

Muscle protein metabolism in ageing 

Basal muscle protein synthesis unchanged 

Protein/amino acid feeding leads to increase in muscle protein synthesis in both groups 

BUT, response is smaller in the elderly 

Resistance exercise leads to increase in muscle protein synthesis AND breakdown 

BUT, synthesis rates lower in the elderly 

Food + exercise needed for anabolic response 

Response delayed in elderly, but can achieve similar rates 

Metabolic Capacity

Decrease in Mitochondria 

Decrease in capillary density 

Reduced ability of muscle to extract O2 from blood 

Decrease in enzymes for metabolic pathways 

Reduced speed of O2 utilisation 

Therefore ↓ (a-v)O2 diff (and ↓VO2max) 

Co-morbitities

Decline in muscle mass and oxidative capacity, plus increased fat mass leads to greater risk of developing: 

insulin resistance and/or type II diabetes 

hyperlipidaemia 

hypertension 

Cardiovascular disease

Reduced bone mass contributes to loss of functional capacity and risk of injury 

#muscles #ageing #physiology #muscle physiology #muscle #science #biology #human biology #biomedicine #Biomed #Biomedical Science #studyblr #notes #medblr #medicine #human physiology #2

[tinastrich]

Just Pinned to LastRites: My grandfather meeting his great nephew 2 months before he passed away from motorneuron disease. I miss you Papa. http://bit.ly/2MSUgpP

#LastRites #tina strich #anti Christ #evil

[whatabeautifulworldblog]

Drug for common liver condition may be an effective treatment for <b>dementia</b>

... treating Frontotemporal Dementia and motorneuron disease, but it does not ... Fiona Carragher, Director of Research and Influencing at Alzheimer's ... from Google Alert - Stopping Dementia https://ift.tt/3bXsHrS via Preventing Dementia Naturally Dementia Prevention Programs

#Google Alert - Stopping Dementia

[medicomunicare]

ALS gene therapy: viral vector trying to SOD 1 right message to motorneurons

ALS gene therapy: viral vector trying to SOD 1 right message to motorneurons

Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS) hits over 5000 Americans each year, and about 30,000 people in the US have this disease at present. ALS is a fatal condition caused by degeneration of the motor neurons in the spinal cord that connect the brain with the muscle cells responsible for voluntary action. Since these nerve cells no longer function, skeletal muscle cells that…

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#adenovirus #ALS #amyotrophic lateral sclerosis #enzyme #gene mutation #gene therapy #genetic disease #motoneurons #nervous system #neurodegeneration #oxidative stress #RNA splicing #spine cord #superoxide #viral vector

[thegaitguys]

Leg exercise is critical to brain and nervous system health

Leg exercise is critical to brain and nervous system health

"New research shows that using the legs, particularly in weight-bearing exercise, sends signals to the brain that are vital for the production of healthy neural cells."

This research supports what we already know, but in a new spin, that sensory input is just as important as motor output. This study gives new clues into why people with motorneuron diseases (spinalmuscular atrophy etc) decline so quickly as their movement impairment deepens.

This research might suggest that those who do not continue to weight bear load, such as bedridden or chronically ill patients and even the aging population, are at risk for faster decline. "Not only (do they) lose muscle mass, but their body chemistry is altered at the cellular level and even their nervous system is adversely impacted," says Dr. Raffaella Adami from the Università degli Studi di Milano, Italy.

"Limiting physical activity decreased the number of neural stem cells by 70 percent compared to a control group of mice, which were allowed to roam. Furthermore, both neurons and oligodendrocytes -- specialized cells that support and insulate nerve cells -- didn't fully mature when exercise was severely reduced."

"Reducing exercise also seems to impact two genes, one of which, CDK5Rap1, is very important for the health of mitochondria -- the cellular powerhouse that releases energy the body can then use. This represents another feedback loop."

Bottom line here folks, you have to move, you have to load, especially if you have a neurologic disorder and especially if you are declining in age. At the very least, throw some lunges or body weight squats into your day. Walk the stairs, don't ride the elevator. Move. Lift. Strain.

https://www.sciencedaily.com/releases/2018/05/180523080214.htm

#gait #gait problems #gait compensations #SMA #neurologic disease #mitochondria #squats

[studyslt]

Excited to share the latest addition to my #etsy shop: Motor Neurone Disease/ALS: Speech Therapy Notes https://etsy.me/3ukqtuQ #als #motorneurone #mnd #studynotes #speechtherapy #speechpathology #speech #notes #therapy #studentspeechie https://www.instagram.com/p/CNNJzjZgWBl/?igshid=12vxsczwsbhd8

#etsy #als #motorneurone #mnd #studynotes #speechtherapy #speechpathology #speech #notes #therapy #studentspeechie