This is primarily going off the titles that were dropped recently: The Vanishing of ***** Wheeler and Escape from Camazotz.
I took note yesterday that Camazotz is the name of a planet in the novel A Wrinkle in Time. It's a world controlled by the main antagonist IT, a malicious brain that subjugates the inhabitants to its will, similar to how Vecna/The Mind Flayer uses the hive mind to control the monsters of the Upside Down.
In the novel, Meg Murray (the protagonist) has her father go missing while working on a scientific concept called a tesseract. It's later revealed he's being held prisoner on Camazotz, and (with the help of Mrs. Whatsit, Mrs. Who, and Mrs. Witch) Meg undertakes a journey with her brother Charles Wallace and her love interest Calvin to rescue her father.
Now, in regards to the title referring to a Wheeler vanishing, there is a possibility it could refer to Nancy or Holly, or even Karen, just based on the number of asterisks. However, this number could also be misleading, and it might actually be referring to Mike (I seriously doubt it's Ted).
What if Vecna somehow takes Mike prisoner to a Camazotz-like location (either in the Upside Down, or a different location that will be revealed in S5 as Camazotz) as a means of luring both Will and El into a trap to either kill them or enslave them? The journey both characters could undertake to rescue Mike could have parallels to the journey Meg undertakes to rescue her dad (and later to rescue Charles Wallace when he falls under ITs influence).
Maybe the Duffer Brothers plan to use parts of the novel as a blueprint for S5's story? It's always a possibility.
You, a heroic paladin have successfully slain a fearsome dragon. But the dragon warns you that death is but a door, and dragons don’t die, they reincarnate. You paid it no mind….until your son was born with golden, slitted eyes.
Stranger Things Spoilers on X: "BREAKING: According to Jeff Sneider, these are the episode titles of the next 6 episodes of #StrangerThings5: Episode 1 - The Crawl Episode 2 - The Vanishing of ***** Wheeler Episode 3 - The Turbow Trap Episode 4 - Sorcerer Episode 5 - Shock Jock Episode 6 - Escape From Camazotz…" / X
So.........which Wheeler? Mike or Nancy? Or even Holly (as both @skellybonesandtrees and @stillhidden have noted in the replies)?
I could see Vecna coming after Mike as a way of hurting both Will and El, and even using Mike as bait to lure them into a trap.
However, I could also see Vecna coming after Nancy as revenge for how her plan to take him down in the season 4 finale nearly resulted in him being killed.
Or he could also target Holly as a means of hurting both Mike and Nancy.
Also, isn't Camazotz the planet IT controls in the novel A Wrinkle in Time? 🤔
EDIT: Camazotz could also refer to the Mayan "bat spirit" who served the Lords of the Underworld. Maybe a reference to either the demobats in service to Vecna in the Upside Down, or the progenitor of the demobats that the Party will have to inevitably fight?
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i know nothing about youtuber whatsoever. every time someone talks about a popular youtuber it feels like theyre conjuring a dude from thin air. hearing about youtuber drama is like seeing everyone spontaneously pull a guy out of their hat and start beating him to death with hammers