#Dandere VA

[leeyanyanyaaan]

oc profiles: otaharuryu

Otoha Konagawa

小名川 音葉

VA: Inori Minase / otakoyaki

Nickname: Ota

16yrs, May 28, Gemini

143cm / 4’8”

1st Year, Hanasaki High School, Class 1-B. 

An adorable first year. Her sweet and friendly nature makes her friends with almost everyone, it's hard not to love her!

Adorable, cute, pure, innocent, sweet, bubbly, optimistic, friendly, loving, shy at first. Please protect this cinnamon roll.

Deredere/Dandere

INFJ-T

Even though she's friendly with everyone at school, she doesn't really have anyone to call a true friend

Spends a lot of her time after school working her part-time jobs, doing schoolwork and household chores. She's actually mature and responsible, at least when she's working or taking care of someone.

Her parents died in a plane crash during one of their business trips when she was 9 yrs old. She and her brother, Haruto, were left in the care of their tired, workaholic aunt, Ayane Takamiya

An independent and hardworking girl, she doesn't usually rely on others and instead insists to help them. She’s always determined and refuses to give up when things get tough.

Likes: music, singing, cute aesthetic stuff, simple things, reading, crafting, food, cooking, cleaning, helping others, giving love and affection. Likes anime and manga as well, surprisingly, but usually doesn't have the time for it anymore

She loves to sing the most, but she's too shy to ever show anyone.

Best subject: Home Economics, Arts

Dislikes: mess and disorganization, centre of attention, the dark, criticism and judgment, being belittled (especially for her appearance), being taken advantage of, getting sick, not having anything to do or not being able to do anything, flying planes, heights

Fears: being alone and helpless. Aerophobia and acrophobia.

Primary Love Language: Physical Touch, Quality Time

Ota is a very affectionate person, she will with no doubt shower you with all her love.

Loves giving hugs, kisses and holding hands. Cuddling is also a must.

Doesn’t mind PDA but will also understand if her lover wouldn’t want it, she’ll just make up for it when they’re together alone. 

She’s just as verbally affectionate as she is physically. Will shower her loved ones with “I love you”s and other loving and kind words. 

All she needs from her lover is for them to return her affection with physical touch as well. It gives her a sense of security and is how she feels loved the most.

She will also happily do acts of service for her loved ones. She also appreciates it if they offer to help out but usually turns them down because she’d rather let them depend on her to do it.

Ota has always been a loving person and will continue to be one for her lover, in fact, even more so. You'd be a really lucky person to have won her heart. Don't you ever dare to betray her love, you'll never be able to find someone who loves as much as she does.

Ryūhei Akimoto

明本 竜平

VA: Yūma Uchida

Nickname: Ryu

16yrs, August 3, Leo

168cm / 5’6”

1st Year, Hanasaki High School, Class 1-B

A prideful, arrogant boy that does what he wants and reigns power. A playboy that likes to play with people's feelings for his amusement. Despite this he's quite popular for his good looks and status

Proud, arrogant, cocky, snarky, presumptuous, egotistic, mean, teasing, playful, flirty

Tsundere

ESTP-A

However, he's also rather guarded, closed off even. No matter how many relationships he goes on he's never let anyone close. He can be cruel and hurt others if they try

Spends a lot of time out of the house, hanging out with friends and going on dates with girls - anything to stay out of the house

After an affair scandal of his parents was made public, his parents fought often and left their relationship sour. He could no longer see them the same. He's come to resent them and refuses to simply let them do what they want with him

In fact, he created a bad reputation for himself simply to ruin his parent’s reputation and force them to move him out of his previous private academy.

Likes: going out, shopping, social media, photography, design and editing, modelling, pop music, western media, street food, playing with other people(s feelings).

Goddamn photogenic. He's surprisingly good with the camera just as he is being taken by one.

Best subjects: Physical Education, Business

He can speak English fluently, his mother taught him and they’ve been to America a few times. He is also of American descent, from his mother’s side.

Dislikes: sitting in one place too long, lack of attention, following others, vulnerability and weakness, business parties, superficial and fake people, fancy food, silence, horror movies

Fears: the ultimate betrayal that breaks him apart

Primary Love Language: Physical Touch, Words of Affirmation

Ryu is very touchy. Holding hands, arm around his lover, cuddling, hugging, kisses, nibbling. Literally anything. He just needs to feel his lover's touch.

Enjoys PDA. It shows others who's his.

Playful, or rather, a big tease. Loves teasing his lover and making them flustered. Oh but he'll also welcome the notion of them taking initiative as well.

He'll take every opportunity he has to steal kisses or any affection from his lover.

Good with his words, a smooth talker who knows the right words to set one's heart a flutter. Although his experience comes from being a playboy, when it comes to his lover, he means every word. He makes sure to let you know that he truly loves you.

Words of affirmation back would be greatly appreciated. He's never had a legitimate relationship aside from those past flings of his. He worries that he doesn't do enough to show how much he truly loves them, or that his lover may start to doubt him. In worst-case scenario, he may doubt the trust between the two of you and fear of being betrayed. Not to mention the scandal that happened with his parents. He'll need someone who will reassure him how much he's loved

As much as the guy is a flirt, once he's found someone who truly loves him, he will fully repay it back. He will be a loyal and dedicated boyfriend who makes sure to show how much he loves you. Albeit, he can get jealous easily and a bit possessive. He still has lots to learn.

Haruto Konagawa

小名川 春人

VA: Yuki Kaji

Nickname: Haru

14yrs, January 12, Capricorn

Two years younger than his sister

161cm / 5’3”

2nd Year, Hanasaki Middle School, Class 2-B

At school, he's known to be sporty and get along with his classmates. A bit on the more reserved side, but otherwise pretty friendly! He has a sharp tongue though

Reserved, chill, sporty, sarcastic, snarky, loyal, mature, protective

Kuudere

ISTJ-A

But it's different when he's with Otoha. With his older sister, it’s like he’s grown up. He tries to act more mature so his sister would depend on him more. He cares greatly for her and always puts her first, to the point he's a little overprotective of her - she's the only family he has left

After school, he goes straight home and helps with the household chores as well. Otoha insists that he should go hang out with his friends or join a club, instead of being at home not enjoying his childhood with his friends, but he strongly refuses. 

Likes: sports - mainly soccer and volleyball, outdoor activities, instant ramen, anime and manga (where his sister got it from), video games, media, digital drawing, lo-fi, mixing music

Has an interest in creating things, whether it's drawing or music. He might take on some sort of media-related occupation in the future

Best subjects: Art, Physical Education

Dislikes: Ryūhei, rain and thunderstorms, (TBC)

Fears: losing his only family left

Primary Love Language: Physical Touch, Quality Time

Haru's more on the reserved side. He's the listener rather than the speaker, so he would have more trouble showing affection through words

This is why he prefers physical touch like giving kisses and hugs to even just holding hands. So someone who's affection is through physical touch is enough to assure him that he's loved.

Even if they're not physically touching, Haru also enjoys just hanging out with his loved one, chilling together, and just being in their presence.

He'd also do acts of service for his loved one, but he'd rather his loved one let him do it for them than also receiving acts of service

Haru might need some words of affirmation every now and then, especially if he's gone through rough times. Haru doesn't think highly of himself and thinks he needs to be better for his loved ones, so he kinda beats himself up about it sometimes :"( especially considering Ota and Haru's current situation where Ota and even their aunt is working a lot just to keep their finances stable. Ota is carrying all the burden on herself and doesn't want him to take it on as well, which although he understands his sister's intentions, he feels like he isn't doing enough or he isn't good enough. Please give this boy a hug and tell him he is good enough as he is

Haru is an awkward boi when it comes to love, so during his first stages of dating he'd be flustered and gets shy easily, becoming a blushing mess. But once he's been in the relationship for a good amount of time, he'll feel more comfortable and open to show affection.

[all art created on picrew!]

#original character #oc #oc profile #leeyanyan's work #otaharuryu #otoha konagawa #ryuhei akimoto #haruto konagawa

[aircleaningtechva]

Importance of Indoor Air Quality Services in Sterling, VA and Baltimore, MD

Being able to breathe properly contributes to the quality of life. The air quality is often suspect in urban areas, with millions of individuals residing within a small area. The quality will surely be affected adversely by smoke and other contaminants in the air. An ill-maintained HVAC system can actively contribute to poor air within one’s home. Simply suspecting that the air quality is not as good as it should have been is only speculation. Determining the truth without any doubt can be done by ordering LEED-certified testing included in indoor air quality services in Sterling, VA, and Baltimore, MD.

Inhaling poor-quality air can add to the health woes of most people. Moreover, some contaminants that remain airborne and pass easily into the human body can also be termed silent killers. Thorough air quality testing enables one to understand the nature of pollutants and address the problem as soon as possible. Sure, one may make an enhanced effort to clean the house or workplace. This may reduce the contamination of air to a fair degree. Unfortunately, several environmental factors cannot be eliminated. Securing oneself by taking the proper protection is the only way to lower such risks.

The existence of the following components in the circulating air is sure to have one worried:

· Dust Mites

· Pet Dander

· Mold

· Mildew

· Chemical Cleaning Products

· Choked Vents Of The HVAC System

· Combustion Remnants

· Carbon Monoxide

· Pesticides

· Asbestos

· Radon

· Rodent Droppings

· Volatile Organic Compounds (VOCs)

· Wood Products That Are pressed

Air quality Testing Advantages

While testing and associated services are not free, the expense is fully justified. After testing for pollutants, the report will enable the concerned user to gain the following:

· Reduced Odors- The stale air will be gone after proper steps are taken to remove the contaminants. All associated malodors would be eliminated, making the room smell fresh and inviting once again

· Adjusted Humidity Level- Both inordinately high or low humidity levels can be problematic. While insufficient humidity may make the skin dry and cause breathing issues, high humidity will result in mold formation that affects the health of the residents! The right testing service will reveal the amount of humidity in the air. It can be regulated thereafter to make the environment comfortable

· Improved Concentration- Poor air quality may also affect the individual's mental condition, causing them to lose focus. Instances of absenteeism and low productivity may give rise to workplace problems. Improving the air quality will enable such individuals to become fighting fit again

Identifying one or more of such contaminants can be dangerous for the residents. The problem is aggravated when the home's occupants are children or elderly. Pets are likely to be affected as well. The certified company fulfilling the indoor air quality services in Sterling, VA, and Baltimore, MD, provides remediation, restoration, or replacement of the offending devices/systems in addition to air testing.

#indoor air quality services in Sterling #VA and Baltimore #MD

[procleanmd]

Home Disinfection in Reston and Ashburn, VA for Enhanced Indoor Air Quality

Maintaining good indoor air quality is a priority for homeowners in Reston and Ashburn, Virginia. Clean, fresh air not only contributes to a healthier living environment but also promotes overall well-being. One often overlooked aspect of achieving enhanced indoor air quality is proper disinfection. Effective home disinfection in Reston and Ashburn, VA, can significantly reduce airborne contaminants and allergens, making breathing easier in one's home.   The Link Between Disinfection and Indoor Air Quality   Indoor air quality is a complex interplay of various factors, including the cleanliness of the air. Proper disinfection is a critical component of this equation. Here's how it can contribute to improved indoor air quality:   1. Reducing Allergens: Disinfection helps control common allergens such as dust mites, mold, and pet dander. Regular cleaning and disinfection of surfaces can prevent the buildup of these allergens, reducing the potential for allergic reactions and respiratory issues.   2. Mitigating Mold Growth: Mold thrives in damp and poorly ventilated areas. By disinfecting surfaces in these spaces, one can prevent or eliminate mold growth, reducing the release of mold spores into the air. Mold spores are a common trigger for allergies and respiratory problems.   3. Controlling Bacteria and Viruses: Proper disinfection of high-touch surfaces like doorknobs, light switches, and countertops can help control the spread of bacteria and viruses. This is especially important during cold and flu seasons or when illness is present in the household.   4. Eliminating Odors: Disinfectants can effectively eliminate odor-causing bacteria, improving the overall freshness of the indoor air. This is particularly important in kitchens and bathrooms.   5. Reducing Particulate Matter: Airborne contaminants often attach to dust particles. By reducing the amount of dust through effective disinfection, one can also reduce the number of contaminants suspended in the air.   Disinfection Practices for Better Indoor Air Quality   Now the connection between disinfection and indoor air quality is established, the following are some practical disinfection practices for homeowners in Reston and Ashburn:   1. Regular Cleaning: Make cleaning and disinfecting a regular household routine. Pay special attention to high-touch surfaces, such as doorknobs, light switches, remote controls, and kitchen countertops.   2. Use Appropriate Disinfectants: Choose effective disinfectants against a broad spectrum of pathogens, including bacteria and viruses. Ensure to follow the manufacturer's instructions for proper usage and contact time.   3. Address Humidity Issues: Maintain proper indoor humidity levels to prevent mold growth. Use dehumidifiers in areas prone to excess moisture and ensure good ventilation to keep the air dry.   4. Vacuum and Dust Regularly: Regular vacuuming and dusting help reduce the number of allergens and particulate matter in one's home. Use a vacuum cleaner with a HEPA filter to trap smaller particles.   5. Invest in Air Purifiers: High-quality air purifiers can further enhance indoor air quality by trapping airborne particles and allergens. Look for purifiers with HEPA filters and consider units with UV-C technology for added disinfection.   6. Consider Professional Disinfection Services: Periodically, it may be beneficial to enlist professional disinfection services. These experts have the knowledge and equipment to conduct thorough disinfection, providing peace of mind.   7. Pay Attention to the HVAC System: Regular maintenance of the heating, ventilation, and air conditioning (HVAC) system is crucial. Clean filters and air duct cleaning in Rockville and Potomac, MD, prevent the circulation of airborne contaminants throughout the home.   By incorporating these practices into the home maintenance routine, one can significantly improve indoor air quality. Breathing easier and enjoying a healthier living environment is well within one's reach. 

#air duct cleaning in Rockville and Potomac #MD #home disinfection in Reston and Ashburn #VA

[kegiostoyslut12345]

youtubers i watch part3!

InvertOG

Syrex

7clouds

deadbodyspeaks

NewMelody 

AuraEpics

7th Heaven

FsF Music

CallMeWashi

Patricia V

Sury

Focvs

Danny Phantom exe

Ana

nova

PlanetDorkPeebs

Rap New City

Markiplier Fan 2702

Garbage ASMR

YUZUYA 

Dandere VA

King Akira 

MARTIN

Unus Annus 2

jacksepticeye 

deb smikle 

• Yukiii •

Clever Yui

pyxick

part 4 in a little bit-

[cutiepisenpai]

Dear Stranger Series Ch. 9: House Hunters(Spencer Reid x Female OC)

Masterlist

Warnings: mone just fluff

“Ok, so what do you think about this one.” Spencer says, showing her the webpage  for a house in Woodbridge. From the look on her face he can already tell she does not like this house. “What’s wrong with this one?” He asks. “Did you actually look at the photos? Or just the specs of the house?” Melinda starts by saying, “There is so much wrong with that house and you don't want to renovate. Like look at that kitchen it is atrocious and none of the woods match.” This had been going on for three months, having completely different ideals for the perfect home was making the search that much harder. Spencer wanted a historical house which Melinda was ok with but she wanted the interior to be updated, stating no one wants to live in a haunted house. “Yes I looked at the photos and it looks fine, it’s a part of the history. There are too many ways home renovations can go wrong.” Spencer says. This has been the ongoing argument, having already made their compromises it was just finding a house that had what they were looking for. “Okay, how about this one.” He says showing her a new construction with a historic look but being completely upgraded on the outside. He looks over to see her blank stare followed by an eye roll. “What is wrong with this one?!” He says in a huff. “Really? I know you do not like this house, like at all. I don’t want to just compromise and pick a house. I want us both to like it. It’s not just a house it's a home.” She says cuddling closer. They decide to take a break for now opting to just cuddle and talk,

Several days later on the plane ride home from a case the team is relaxed and just making random conversation. Spencer who had been fixated on the book in his hand turns to Melinda, “Are we going to your place or mine?” Before Melinda can answer Emily interjects, “Wait, you two don’t live together?” “No.” They say in unison. Neither of their apartments had the space to consolidate all their stuff so they continued to go to each other’s apartment. With how much stuff had moved between their homes aside from the furniture you wouldn’t know they didn’t live together. “But aren’t you like always together? Outside of work I just assumed you were attached at the ya know.” Emily says gesturing. “Well we are always together. Sometimes we stay at Mel’s some days we stay at my place.” Spencer says. “Are you waiting until after the wedding to move in?” JJ joins the conversation. “No, we’ve been looking for a house but haven’t found anything that will work yet.” Melinda says, looking to Spencer, “Maybe we should look into getting a realtor to help.” “ We have a combined IQ of 370 we can figure this out on our own.” Spencer responds, he didn’t want to have anyone else get involved they can do this on their own. “I think if IQ alone was enough, we would have found something by now.” “Fine we can try a realtor but when this doesn’t work we go back to just us and we finally make a decision.” 

A week and a half later Melinda and Spencer are getting ready to go with the realtor they chose and look at some of the options she had found for them. The first house they see in Woodbridge VA is a nice upgraded everything Melinda could ask for. Spencer did not like it at all; it had no charm to it. “It has carpet, you said no to carpet it traps dust mites,pet dander, particle pollution, lead, mold spores, pesticides, dirt and dust. Some chemicals they use in padding and adhesives also have potential health harm.” Spencer says trying to talk Melinda out of liking the house. “Yes I know carpet is horrible disgusting. Stop worrying I am not in love with this house.” Melinda says with a smile. “Do you not love it because of the carpet or is there something else?” “Well the carpet is a definite problem and you don’t like it. And that is not safe.” She says pointing out of the window. Outside the window past the desk there is a small yard  but no fence there were stairs leading through a wooded area and to a creek. Spencer missed that, how did he miss that. The next house they see is in Springfield, pulling into the driveway both of them already disliked the house.  Walking inside and everything about this house screams no. “The cabinets have scalloped bottoms.” Melinda whispers to Spencer. “There is nowhere for an office or to put any of our books.” Spencer whispers back. Deciding to end this misery early they let the realtor know this would not work at all. The last house she takes them to see is a 1890’s Historic Farm House in Falls Church. It was a beautiful historic home renovated and restored. It was the perfect home for them. Spencer was impressed but Melinda is quiet and he doesn’t know what she is thinking. Walking behind her wrapping his arms around her waist placing his chin in the crook in her neck. “What are you thinking?” she hums before answering,” It’s nice.. Amazing actually.” “ So should we put in the offer?” “If you let me change the back splash in the kitchen I’d say it was perfect.” Kissing her cheek, “Ok you can change the back splash. So we’re making an offer.” She nods in agreement. After telling the realtor of the decision as they are walking to their car Spencer turns and says, “You know that house actually has 2 more bedrooms then we originally asked for so maybe I can talk you into potentially two more kids than we planned for in our future.” 

#spencer reid x reader #spencer reid x oc #spencer reid fluff #spencer reid #Female reader #female oc #fluff #Dear Stranger Series

[sciencenewsforstudents]

Time magazine’s list of Best Inventions of 2006 included an unusual creation. It wasn’t a gadget; it was a cat.

“Love cats but your nose doesn’t?” the magazine asked. “A San Diego company is breeding felines that are naturally hypoallergenic.” (Hypoallergenic means that something is unlikely to cause an allergic response.) There was a 15-month waiting list for these “sniffle­proof kitties,” which sold for $3,950 or more.

The company selling the cats was Allerca. It had tapped into a tantalizing dream for allergy-prone cat lovers. Just two genes are responsible for making cats a problem for many people. It therefore seemed like a no-brainer to engineer cats that lacked those genes — or to simply breed cats with versions of the genes that made the animals less allergenic.

But so far, itchy-eyed cat lovers have been left disappointed.

By 2010, Allerca had stopped taking orders. Lawsuits were lining up. The sniffle-proof kitties never materialized. Some angry customers said they never received a kitten. Others were sent a cat that set off their allergies.

But for all those who haven’t given up hope, there may be new options around the corner. An allergic owner might pop open a can of allergy-fighting food — for the cat. Or maybe vaccinate the cat to produce fewer allergens. And allergy shots for owners might shift from weekly or monthly injections to a shot that offers immediate relief.

The new gene-editing tool CRISPR/Cas9 might even come to the rescue. This technology might deliver the ultimate dream to those who can afford it: a cat that doesn’t produce allergens at all. One company has made some progress applying CRISPR/Cas9 to cats.

Success in taming cat allergies might even bring good news for people whose allergies have nothing to do with cats. If any of the cat allergy–fighting measures prove safe and effective, they might be deployed against other allergens. They could prove especially useful against airborne ones like pollen, dog dander or dust mites. Up to 30 percent of the world’s population suffers from allergens in the air. So that’s plenty of runny noses to dry up.

When it comes to cat allergies, the main culprit is Fel d1. This small protein is produced primarily in cats’ salivary and sebaceous glands. Fel d1 is found in flakes of dead skin, or dander. It is spread to hair when a cat licks itself. Thus it’s not cat hair that people are allergic to, just hair coated in cat spit.

A singular target

As allergens go, Fel d1 gets around. It sticks to hair and clothing, so it’s easily carried from place to place. It lasts for weeks or months before breaking down. It’s light and easily enters the air. That makes it even more insidious. In fact, even houses without a cat tend to have a little Fel d1 in their dust, says Martin Chapman. This immunologist is president and CEO of Indoor Biotechnologies. It’s a company in Charlottesville, Va., that tests for allergens and allergies.

All cats produce some amount of Fel d1. However, that doesn’t mean that all cats are equally allergenic. In tests of hundreds of cats, Indoor Biotechnologies found levels ranging from just 5 to as much as 2,000 micrograms of Fel d1 per gram of fur. Variations in two key genes explain much of that wide range. But no one knows exactly which versions of the genes result in low-allergen cats.

It’s also not clear what role Fel d1 plays in cats. Lions and other big cats have their own version of the protein, Chapman notes. So it seems to have stuck around during cat evolution. That suggests the protein does something. Male cats that haven’t been neutered tend to have the highest Fel d1 levels, which have been linked to male hormones. Based on that association and the protein’s similarity to other molecules, Fel d1 might be a pheromone. That’s a chemical used to communicate via scent. But no one knows whether the protein plays some role in keeping cats healthy.

It’s not clear what role Fel d1 plays in cats. But lions and other big cats have their own version of the protein, which suggests it must do something

CREDIT: BERNARD BIALORUCKI/ISTOCK/GETTY IMAGES PLUS

All this uncertainty has made allergies to cats difficult to tackle. For now, options are limited. People can take antihistamines and other medications to reduce symptoms. But such drugs don’t stop the allergy.

Traditional allergy shots are known as immuno­therapy or desensitization therapy. They aim to retrain a person’s immune system to be less sensitive to an allergen. But those shots are a commitment. A patient may need up to 100 injections over three to five years.

Some people can avoid needles by taking under-the-tongue daily drops of the same U.S. Food and Drug Administration–approved allergens as in the injections. But this treatment often is not covered by insurance.

“Desensitization therapy has been the only therapy for decades,” says Gerald Nepom. He is director of the Immune Tolerance Network in Seattle, Wash. It’s a research group funded by the National Institutes of Health. Exactly how desensitization works is still not fully understood. But the basic idea is that exposing the immune system to small amounts of allergens causes the body to make antibodies that block part of the allergic response. Unfortunately, Nepom says, desensitization generally doesn’t eliminate all symptoms. And the effects aren’t always permanent.

#scied #sciblr #science #cats #allergies #allergens #cat allergies #immunotherapy #longread #longreads

[patchfrance91]

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Annex B) as a reference to those that have interaction in these sport and facility operators. Organised programmes/classes of up to 5 individuals could proceed, with an additional instructor or a coach. And sanitisers should be positioned in close proximity of the facility entrance and high-touch surfaces like door handles.Visitors ought to be encouraged to sanitise their hands before entering the facility. The SMO might be responsible for formulating the implementation plans, conducting inspections and checks, in addition to maintaining information for subsequent audits by the authorities. Has necessary measures to look after your well being and wellbeing. All beverages must be in a sports topped or re-sealable container. All persons utilizing the amenities are topic to the rules and rules of the University of California and Rec Sports. Smoking isn't permitted inside any CRC facility at any time. Drinking and eating are permitted solely within the RSF Pro Shop area. Gyms take a lot of abuse and going cheap on flooring will price you extra in the lengthy term when you have to replace it. Buying used machines may be less expensive on the time, but you’ll sacrifice entry to the total manufacturer’s warranty protection, as properly as up-to-date expertise to greatest serve your members. We’re all doing our greatest to take care of well being and safety throughout this time. Finest Surface Cleaners, Wipes, And Disinfectants To make fumes much less bothersome, open rest room home windows and door, and activate the bathroom fan for ventilation in case you have one. • Wearing rubber gloves, use a stiff brush to apply the method to 1 small space at a time. Be cautious not to let the liquid splatter on you or surrounding surfaces. To study extra about every ingredient, I turned to the Environmental Working Group’s Guide to Healthy Cleaning. While finest recognized for their Skin Deep database for skincare products, additionally they have one to assist you find the best cleaners that works just about the same method. It lists completely different components in a product along with their security score on a grading scale from A to F, with F, of course, being a failing grade. Before making ready or consuming food you will need to all the time wash your hands with cleaning soap and water for at least seconds. Although vinegar is widely used as a disinfectant in household cleaning, the packaging can not claim the product as a disinfectant because it's not registered with the EPA. Here are a number of more homemade rest room cleaners that can be used on a quantity of surfaces. If you’re too busy to make your own cleaners, Branch Basics is my favorite natural use-it-on-everything cleaner. I’ve also discovered a great firm referred to as Grove Collaborative that I focus on inmore depth in this post. They make nice pure cleaning products and a fantastic glass spray bottle. Greatest Methods To Wash Even The Grimiest Blinds You could must secure the underside slat with a string for stability when dusting vertical blinds. Next, use a non-abrasive microfiber fabric to softly wipe off the dust shifting from prime to backside for vertical shutters and left to proper for horizontal blinds. Use the vacuum cleaner with a gentle brush attachment to filter leftover particles. Next, flip the window shutters, then repeat the dusting process on the rear side. Abrasive and powerful cleaners might scratch the vane's floor. All services and products featured are chosen by our editors. Real Simple might receive compensation for some hyperlinks to services on this e mail on this website. © Copyright 2022 Meredith Corporationthis link opens in a new tab. The material of any window covering is the very first thing to think about when figuring out the way to clear it, no matter fashion. Dirty window coverings stand out and might throw off the aesthetic of an entire room. Have you appeared round your home recently and puzzled why it feels so old and dull? Solar shades are designed to reduce the quantity of daylight that gets into your home, helping to keep rooms cooler and reducing glare. They’re often constructed from a single piece of cloth suspended on a roller. Stress Washing And Home Washing Providers Bluffton Pressure washing your personal home and its exterior can remove algae, mould, and other poisonous contaminants, preventing them from growing into a significant issue. If your personal home has a moldy or mildewy odor, or should you notice algae buildup round your exterior, then your poor cleansing habits could be affecting your health. Generally, for any normal cleaning of your house, deck, or property, soft washing is the best alternative. If soft washing isn’t dislodging a certain bother spot, then you would switch to stress washing. Without additional ado, here are the three major issues to search for in an exterior house cleaning company. You should also use your backyard hose to remove any surface filth and grime from the brick. You’ll want any main problems to be faraway from the brick before shifting onto the subsequent step. Additionally in case you have tinted windows, the ammonia in the product will harm the window tint. The drawback with using Windex is that you are merely shifting the dust across the glass with a paper towel or a rag, when a squeegee will evenly remove all filth from the glass or window. When you utilize Windex to wash your windows, it leaves streaks. If you employ a squeegee to clean them after, no streaks will show up. This will be sure to can simply clear the entire glass. You can wash the removed screens separately with the decrease stress white nozzle or your backyard hose sprayer by spraying water by way of one aspect. If a strain washer breaks away lead paint chips, these can combine within the soil and even be blasted into your house. These chips may be too small to see, but be extraordinarily harmful for youths who play close to them and potentially ingest lead.

#清潔公司

[takiartepa]

Saeran-dere: Aplicando los estereotipos -dere a Saeran

*****WARNING SPOILERS si no conoces todo sobre este personaje*****

Explicación: Los “dere” en manga y anime son estereotipos de personajes, estos suelen presentar ciertos factores como los rasgos físicos, de la personalidad y hasta algún fetiche en especial. El término "dere" se utiliza en conjunción con otros rasgos de la personalidad.

Esto lo he hecho por mero gusto. No debe tomarse al pie de la letra ni busco que sea absolutamente exacto. Todo es por amor a este precioso hacker  ^u^

De nuevo, *WARNING SPOILERS* si no conoces este personaje a fondo o si recién estás iniciando el juego también. Leer bajo esa responsabilidad.

UNKNOWN

Casual story, Deep Story, Secret Ends

Tsundere y Mayadere

Tsundere

Personaje reservado, frío y hostil con algunos personajes de su entorno. Tiene profundo miedo a ser lastimado y se oculta en una coraza de frialdad y hostilidad. Personalidad fuerte y obstinada. Estos personajes suelen ser los mejores en lo que hacen y llegan a autoexigirse al punto de la obsesión. Les cuesta admitir los fracasos. Violentos al inicio, pero mientras la relación avanza, mostrarán finalmente su lado cálido, sensible y amigable, llegando a enamorarse aunque les cueste admitirlo. https://dibujamx.com/cultura-otaku/que-es-una-tsundere/

Mayadere

Son personajes que en un principio odian a morir al protagonista, llegando a ser antagonistas por un lapso de la historia. Pero conforme las circunstancias y diferentes eventos pasan, se vuelven compañeros del protagonista e incluso pueden llegar a formar una amistad. https://dibujamx.com/cultura-otaku/tipos-de-dere/#Mayadere

Mi idea:

De que es tsundere, no hay duda jajaja eso queda super explicado en cada bad end. No es el tipo de tsundere como las chicas enamoradas de un personaje que lo golpean cuando están vergonzudas, pero uno que rechaza las muestras de afecto de cierta persona que ya sabrán bien quién es. Me pareció curioso complementar la idea con la de Mayadere por eso mismo, sabiendo todo lo que sucede en la ruta de Seven y más aún en los Secret Ends. Porque este hermoso niño no nació siendo malo, y lo que sucede al final de los secrets ends fue curioso. Y fue nuestro primer rayo de esperanza para lo que continúa.

*****WARNING SPOILERS, Another Story, Ray****** 

UNKNOWN-RAY (creepy)

Another Story prologue bad end

Yandere

Son personajes que en un principio son amigables e inofensivos pero en realidad ocultan un lado oscuro. Es lo contrario a Tsundere. Van cambiando de forma gradual a lo largo de la historia, pasando de tener una personalidad dulce, tierna e inofensiva a ser recelosos, agresivos y violentos, cayendo en la locura. El cambio se hace gradualmente motivado por un amor muy intenso, un miedo irracional a perderlo originado de paranoias, y altas dosis de estrés. https://dibujamx.com/cultura-otaku/yandere/#Yandere

Mi idea:

Sí pensé catalogar a Unknown de la Casual Story como Yandere, sí que lo pensé. Pero no cuadraba porque Unknown inicialmente no muestra interés romántico. Y porque se muestra hostil desde el inicio, cosa más acorde de los Tsunderes. Los Yanderes llegan a dar hasta más miedo por esa aparente amabilidad inicial y en este contexto sí que hay una implicación romántica. Esa insistencia de “salvarte” es parte de su violencia sutil, además de la creciente obsesión paranóica creepy cuando intentas rechazarlo (por eso Ray-creepy). El resto queda super explicado y confirmado con la propia descripción de la palabra.

La actitud de Ray durante todo el prólogo de la Another Story puede decirse que entra en esta etiqueta también, pues solo cambia cuando lo pasas (y más en su propia ruta) como vemos a continuación.

RAY

Another Story, día 4 en adelante.

Undere

Son un tipo de personaje oscuro. Combina el deredere (personajes muy amorosos que están constantemente expresando su amor), el dandere (personajes callados, algo antisociales y que solo se abren a quienes confían) y un toque de yandere. Este tipo de personajes son capaces de decir siempre "sí" a quienes aman para poder permanecer cerca de ellos. https://goboiano.com/the-14-popular-dere-types-in-every-anime/

Mi idea:

Estuve deliberando qué término podía cuadrar con él, y me terminé decantando por este, uno que no conocía para nada. Como combinaba particularidades de esas otras etiquetas, me pareció acorde. En esta etiqueta entran personajes como Misa Amane de Death Note, personajes que se sacrifican por quien aman :’)

Y ahora nos vamos al lado contrario.

Saeran

Another Story

Yangire y Sadodere

Yangire

A diferencia de los personajes yandere, los yangire son personajes que no necesitan un motivo como el amor o el estrés condensado para mostrar su lado oscuro. Fingen ser amigables, pero no lo son. Son conscientes de sus actos a diferencia de los yandere. Lobos con piel de oveja. https://dibujamx.com/cultura-otaku/yandere/#Que_es_una_Yangire

Sadodere

Personajes sádicos que les gusta volver a los demás sus juguetes física y emocionalmente. Si encuentran un interés romántico, lo mejor será que esté preparado para ser golpeado. https://goboiano.com/the-14-popular-dere-types-in-every-anime/

Mi idea: 

Yangire me pareció más acorde que Yandere, ya que Saeran como lo vemos aquí, en el momento de su auge, es violencia pura y una negación completa a todo lo que Ray amaba. Por lo tanto, lo traté como una entidad separada. Si consideramos a Saeran como un todo, sí podría decirse Yandere. Pero creo que no viene al caso. Los momentos en que finge amabilidad son por pura necesidad de jugar con nosotros. Y Sadodere, pues ya sabemos jajaja si bien no llegó a ser tan violento como esperaba, me sorprendió bastante. Creo que la única restricción fue que esto no era +18, sino, ya me esperaba cosas peores (sí :’D jajaja otras novelas visuales me han trastornado). Estoy conforme de todas maneras. Fue lo justo y estético.

Y ahora vámonos a los ángeles renacidos del caos, al fin...

Saeran

Secret Ends (el Saeran pelirrojo)

Kuudere

Personajes inexpresivos, indiferentes. Les cuesta mucho expresar sus emociones y se caracterizan por ser muy callados. Pueden haber varios motivos, entre ellos el haber pasado traumas y experiencias difíciles que los hicieron cerrar su corazón y ocultar sus sentimientos para no volver a ser lastimados. También pueden ser simplemente apáticos. https://dibujamx.com/cultura-otaku/tipos-de-dere/#Kuudere

Mi idea:

En realidad no tenemos mucho material sobre cómo es el Saeran en esta etapa, más que esta foto y lo que se dice, pues esa ruta está centrada más en Seven. Pero lo que está claro es que es un Saeran que pasó por un proceso de transformación, pero aún carga en cierta manera con la presión de lo que era antes. No lo podemos culpar :’) pensemos un poco. Este Saeran viene de Unknown, y Unknown es el resultado de lo que sucede si MC no aparece a solo 6 meses del proclamado deceso de Rika. Imaginen toda la tortura que le llegaron a producir para que termine así, siendo que en ese momento estaba en su fase “Ray”. Superar ese estado no es algo de un día para otro.

La Another Story sucede como en un momento justo para salvarlos a ambos personajes (Ray y V).

Y nos lleva al ángel que hubieramos querido tener (y finalmente tenemos).

Saeran

Another Story Ray Good End y Normal End

Dandere y Kuudere

Dandere

Personajes callados, a veces tímidos, tranquilos, tal vez algo antisociales. Estos personajes solo se muestran más abiertos y expresivos con quienes realmente confían. https://dibujamx.com/cultura-otaku/tipos-de-dere/#Dandere

Kuudere

Lo acaban de leer en el punto anterior.

Mi idea:

Este Saeran es más expresivo que el Saeran pelirrojo, pero lo sigo englobando en la etiqueta Kuudere por el lado de los traumas a superar. Este Saeran recuperó el control de sí mismo y se dio cuenta que merecía la libertad, pero ahora recién empieza la siguiente fase de su camino, y por suerte, con nuestro amor y deseo por su felicidad como apoyo y aliento. La definición de Dandere va muy bien con él si tomamos en cuenta sus interacciones con los miembros de RFA. Super serias y guardando cierta distancia... hasta que aparecemos nosotras las MC y él es una dulzura. Recuerdo en especial la divertida reacción de Zen y Yoosung la primera vez que hablaron con él.

Qué decir al final. Él ha terminado como mi personaje favorito por lejos desde que vi su historia real en los secret ends. Y ahora solo acabo de afirmarlo. 

Miren nada más todas las facetas que nos brinda. Es un personaje lleno de complejidad y desarrollo de veras. Su transformación es super tangible, y eso lo hace tan memorable.

Y pues, no por nada obtuvo una ruta siendo que comenzó nada más como un antagonista.

Cheritz, GRACIAS, por esto y por la traducción al español del juego también 

TvT

¡Espero les haya gustado! Sigamos dando amor a este bello hacker

#SPOILERS #mysticmessenger #unknown #anime #tsundere #yandere #Cheritz #another story #deep story #saeran #saeran choi #saeran route #ray #ray route #mystic messenger español #español #character analisis #analisis

[bankerseason93]

What Are Handheld Vacuums?

Handheld vacuums have become the latest must have home cleaner tool for homes everywhere. However with so many choices in this fast paced market, how do you know which model is right for you? It can be overwhelming. You want to pick the best but don't have a clue where to begin. Let's take a look at some features that each hand held vacuum model has to offer. Every hand held vacuum cleaner comes with several key features that make it unique. One such key feature is its weight. Each product is individually chosen and tested by editorial staff. Whatever your cleaning concern, there is your new favorite hand held vacuum on this listing. The Handheld Vacuum Cleaners of 2021: Battery life is important in any power tool. Some hand vacuum cleaners are corded while others are cordless. https://www.kickstarter.com/profile/mmarkwalker/about Cordless is great if you are looking for a quick clean or if your particular use will not warrant using a cord. If you plan to use your hand vacuum for extended periods of time, corded is the way to go. Handheld vacuums come in all shapes and sizes. There are corded and cordless models to choose from. It is important to note which one you prefer. Most cordless handheld vacuums have more powerful motors and a broader variety of attachments than their corded cousins. For example, a large messes can be cleaned with a regular vacuum cleaner while smaller messes may require a cordless cleaner. The battery pack is the most important component of the hand vacuum. The size and power of the battery is directly related to the size and amount of time that the cleaner will last. There are two types of battery life: rechargeable and disposable. Rechargeable cordless vacuums have a life span of between eight and ten hours. Durability and efficiency make rechargeable batteries a great choice for consumers. The disposable variety of hand vacuums are similar to cordless vacuums. They use disposable lithium-ion batteries but come with an extended warranty from the manufacturer. Handheld vacuums run on lithium ion batteries. This type of battery has become the most popular for both the commercial and residential markets. The advantage to cordless vacuums is that they are easier to use in a wide variety of settings and require less maintenance. However, many cordless hand vacuums come with limited warranty coverage. For some people, the best choice is a corded vacuum. The cordless vacuum has suction that is much more powerful than that of corded hand vacuums. The battery life for cordless vacuums is usually three hundred hours or more. They are also easier to use and work with on hard floors.

Cleaning messes can be a major bother. In addition to regular vacuuming, handheld vacuums can be used to pick up crumbs, dust, and dirt from hard floors. Handheld vacuum cleaners can be used to pick up pet hair, dander, and mud from carpets and upholstery. If there is a lot of clutter on a hardwood floor, handheld vacuums are able to pick up all of the extra mess. Handheld vacuums can be powered by electricity, batteries, or gas. Gas powered models are more powerful and will need to be plugged into an extension cord. Battery powered models use a small, rechargeable battery that needs to be changed every few months, but will perform better than their gas powered counterparts on hard surfaces like concrete and marble. Both cordless vacuum cleaners and battery powered ones have extension wand assemblies that allow them to reach into tight places. Most handheld vacuums come in one of two forms: corded or cordless. Cordless vacuum cleaners are designed for people with bulky, power cord type backs. The cordless vacuum cleaner is also great for cleaning stairs. They have dustbuster and suction blasting options, as well as an attachment for a power drill. The lithium ion battery type in most cordless handpieces last longer than the nickel metal hydride battery type in most full-sized vacuum cleaners. For smaller dirt spots, the handheld vacuums that have a small dirt cup are perfect. The dirt cup allows you to clean tight spaces without worrying about damaging the walls of your home. One of the best features about the Dirt Crunch is its ability to pick up pet hair. The decker said that this was one of the things he appreciated most about this particular model.

#cordless #cleaner #corded #rechargeable

[candrcarpetandrug]

WHY HARDWOOD FLOORING IS A BETTER OPTION?

Hardwood floors are becoming increasingly popular among homeowners. Some people love wood flooring to carpet or tile because it has a more traditional look, while others favor it because it is simpler to clean and maintain. But, in the long-run, which is more suitable: carpet, tile, or hardwood floors? Today, we'll present the case for wood floors and explain why you should choose them over other forms of flooring.

 ●     Wood floors not only offer a touch of class to your home, but they also add a sense of coziness. Many homeowners consider that having hardwood floors makes a room appear larger than its original size.

●     Hardwood flooring is really simple to maintain. To remove any dirt or debris that has been accumulated for a long time, it can be easily swept, steam-cleaned, or vacuumed. Wood floors are significantly more stain-resistant than carpets, making them even easier to keep clean.

●     Durability is one of the main reasons why people favor solid wood floors. The hardwood surface can last for decades if proper care is maintained.

●     Wood flooring can increase the value of your home. Buyers will always prioritize homes with hardwood flooring instead of carpet when it comes time to sell. Many homebuyers dislike carpet, especially carpet that belongs to someone else.

●     Unlike carpet, it is impossible to accumulate dust, animal dander, pollen, particulate matter, or other allergens on hardwood flooring. This makes raising the quality of your indoor air much easy.

  If you're looking to replace your flooring, solid hardwoods are a terrific option with a lengthy list of advantages. Give C&R Carpet and Rugs, one of the best flooring stores in Fredericksburg, VA, a call to speak with a design professional about your alternatives. To know more about C&R Carpet and Rugs, kindly visit https://candrcarpetandrug.com/.

#flooring stores in fredericksburg VA #flooring stores in stafford VA #Flooring stores in king george VA #carpet flooring Spotsylvania VA #carpet stores king george VA #carpet stores in King George VA #carpet King George VA #carpet Stafford VA #carpet store Fredericksburg #c and r carpet and rugs

[aircleaningtechva]

How Air Systems Cleaning Specialists in Alexandria and Frederick, VA Improve Indoor Air Quality

In the heart of Alexandria, where historic charm meets modern living, residents prioritize the well-being of their homes and families. One critical aspect often overlooked is indoor air quality (IAQ), which is pivotal in creating a healthy and comfortable living environment. This is where the expertise of air systems cleaning specialists in Alexandria and Frederick, VA, becomes essential, ensuring that the air residents breathe is clean and free from contaminants.

The Significance of Indoor Air Quality:

Indoor air quality directly affects the health and comfort of Alexandria homeowners. Poor IAQ can lead to respiratory issues, allergies, and an overall decline in well-being. Air systems cleaning specialists understand the importance of clean air and work to eliminate pollutants that may compromise the quality of the indoor environment.

Contaminants in Alexandria Homes:

Alexandria, like any other urban area, faces challenges related to indoor air contaminants. Dust, mold, pollen, pet dander, and other allergens can accumulate in air ducts, compromising air quality circulated throughout homes. Air systems cleaning specialists are equipped to identify and address these contaminants, improving overall IAQ.

3. Health Benefits of Clean Air:

Clean indoor air is directly linked to better respiratory health. Airborne pollutants can exacerbate asthma, allergies, and other respiratory conditions. Air systems cleaning specialists use specialized techniques to remove these contaminants, contributing to a healthier living environment for Alexandria families.

Energy Efficiency and Air Quality:

Well-maintained HVAC systems operate more efficiently, leading to energy savings. Air systems cleaning specialists ensure that heating and cooling systems in Alexandria homes function optimally, reducing energy consumption and contributing to both cost savings and environmental sustainability.

Extending the Life of HVAC Systems:

Regular air system cleaning improves IAQ and extends the lifespan of heating and cooling systems. Accumulated dust and debris can strain HVAC components, leading to premature wear and potential breakdowns. Air systems cleaning specialists in Alexandria help homeowners avoid costly repairs by maintaining system efficiency.

Seasonal Allergies and IAQ:

Alexandria residents often experience seasonal allergies due to pollen and other allergens. Air systems cleaning specialists address these concerns by eliminating allergens from ductwork, relieving individuals prone to allergies. This proactive approach ensures that homes remain comfortable year-round.

Custom Solutions for Alexandria Homes:

Every home in Alexandria is unique, and air systems cleaning specialists tailor their services to meet the specific needs of each residence. Whether addressing mold issues, pet-related allergens, or other concerns, customization is key to effective solutions that improve IAQ and overall comfort.

Reducing Dust and Odors:

Dust accumulation affects IAQ and contributes to the persistence of unpleasant odors in homes. Air systems cleaning specialists employ techniques to reduce dust levels, leading to a fresher and more inviting indoor atmosphere for Alexandria residents.

The role of air systems cleaning specialists in Alexandria and Frederick, VA, in enhancing indoor air quality is crucial for the well-being of families and the preservation of homes. By investing in regular air system cleaning, homeowners prioritize health and contribute to the longevity and efficiency of their HVAC systems, creating a harmonious and comfortable living space for generations to come.

#air systems cleaning #air systems cleaning specialists in Alexandria and Frederick #VA

[procleanmd]

Revive and Refresh the Furniture: Professional Upholstery Cleaning Services in Silver Spring, MD and Leesburg, VA

Furniture is vital in creating a comfortable and inviting atmosphere in one's home. Over time, however, daily use, spills, and accumulated dust and dirt can take a toll on the appearance and hygiene of the upholstery. That's where professional upholstery cleaning in Silver Spring, MD, and Leesburg, VA, come to the rescue. This can revive and refresh the furniture, giving it a new lease on life. Why is professional upholstery cleaning necessary? Regular vacuuming and spot cleaning can only do so much. Deep-seated dirt, allergens, pet dander, and stains can penetrate the upholstery fibers, making them look worn, dull, and unclean. Professional upholstery cleaning goes beyond surface cleaning, targeting the root of the problem to ensure a thorough and effective cleaning. One of the primary benefits of professional upholstery cleaning is restoring the furniture's appearance. The trained professionals have the knowledge and experience to identify the proper cleaning methods and products for each type of upholstery fabric. They employ techniques that safely and effectively remove stains, dirt, and grime, leaving the furniture looking fresh and vibrant once again. In addition to the aesthetic benefits, professional upholstery cleaning contributes to a healthier indoor environment. Upholstery fibers can trap dust, pollen, allergens, and even mold spores, adversely affecting the air quality in one's home. Regular cleaning by professionals helps eliminate these pollutants, reducing the risk of respiratory problems and allergies for the homeowner and one's family. When choosing a professional upholstery cleaning service in Silver Spring, MD, and Leesburg, VA, selecting a recognized company with a track record of delivering exceptional results is essential. Look for certified technicians skilled in handling different types of upholstery fabrics, ensuring that the furniture receives the appropriate care. Professional upholstery cleaning services utilize advanced cleaning equipment and eco-friendly cleaning solutions that are safe for the family and the environment. These specialized tools and products are designed to deep clean the upholstery without causing any damage or discoloration. Another advantage of professional upholstery cleaning is the potential to extend the furniture's lifespan. Regular cleaning and maintenance can help prevent the buildup of dirt and grime that can weaken the fibers over time. Investing in professional cleaning services can effectively preserve the quality and durability of the furniture, ultimately saving one money in the long run. So, if the furniture shows signs of wear and tear, it's time to consider professional upholstery cleaning services in Silver Spring, MD, and Leesburg, VA. Revive and refresh the furniture, bringing back its original beauty and ensuring a clean and healthy living space. Bathrooms can also be revived with professional tile and grout cleaning in Reston and Silver Spring, MD. Remember, a professional upholstery cleaning service can do wonders for the furniture's appearance, hygiene, and longevity. It's an investment that pays off through improved aesthetics, enhanced indoor air quality, and prolonged furniture lifespan.

#upholstery cleaning in Silver Spring MD and Leesburg VA tile and grout cleaning in Reston and Silver Spring MD

[shehla79]

VAVA Air Purifier Replacement Filter, 3-In-1 True HEPA Filter Compatible with VAVA Air Purifier VA-EE004

VAVA Air Purifier Replacement Filter, 3-In-1 True HEPA Filter Compatible with VAVA Air Purifier VA-EE004

Price: (as of – Details) Advanced 3-Stage Filtration Both pre-filter and activated carbon filter remove large dust particles, pet dander, and household odor while true HEPA filter eliminates 99.97% of pollutants 0.3 μm and larger, like pollen and dust mites and filters air pollution of PM 2.5. Purify Your Home Instantly Purifies the air for easier breathing and more restful sleep This 3-IN-1…

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#health gadgets 2020

[liliannorman]

The many efforts to lick cat allergies

Time magazine’s list of Best Inventions of 2006 included an unusual creation. It wasn’t a gadget; it was a cat.

“Love cats but your nose doesn’t?” the magazine asked. “A San Diego company is breeding felines that are naturally hypoallergenic.” (Hypoallergenic means that something is unlikely to cause an allergic response.) There was a 15-month waiting list for these “sniffle­proof kitties,” which sold for $3,950 or more. 

The company selling the cats was Allerca. It had tapped into a tantalizing dream for allergy-prone cat lovers. Just two genes are responsible for making cats a problem for many people. It therefore seemed like a no-brainer to engineer cats that lacked those genes — or to simply breed cats with versions of the genes that made the animals less allergenic.

But so far, itchy-eyed cat lovers have been left disappointed.

Explainer: What are allergies?

By 2010, Allerca had stopped taking orders. Lawsuits were lining up. The sniffle-proof kitties never materialized. Some angry customers said they never received a kitten. Others were sent a cat that set off their allergies.

But for all those who haven’t given up hope, there may be new options around the corner. An allergic owner might pop open a can of allergy-fighting food — for the cat. Or maybe vaccinate the cat to produce fewer allergens. And allergy shots for owners might shift from weekly or monthly injections to a shot that offers immediate relief.

The new gene-editing tool CRISPR/Cas9 might even come to the rescue. This technology might deliver the ultimate dream to those who can afford it: a cat that doesn’t produce allergens at all. One company has made some progress applying CRISPR/Cas9 to cats.

Success in taming cat allergies might even bring good news for people whose allergies have nothing to do with cats. If any of the cat allergy–fighting measures prove safe and effective, they might be deployed against other allergens. They could prove especially useful against airborne ones like pollen, dog dander or dust mites. Up to 30 percent of the world’s population suffers from allergens in the air. So that’s plenty of runny noses to dry up.

Explainer: What are proteins?

When it comes to cat allergies, the main culprit is Fel d1. This small protein is produced primarily in cats’ salivary and sebaceous glands. Fel d1 is found in flakes of dead skin, or dander. It is spread to hair when a cat licks itself. Thus it’s not cat hair that people are allergic to, just hair coated in cat spit.

A singular target

As allergens go, Fel d1 gets around. It sticks to hair and clothing, so it’s easily carried from place to place. It lasts for weeks or months before breaking down. It’s light and easily enters the air. That makes it even more insidious. In fact, even houses without a cat tend to have a little Fel d1 in their dust, says Martin Chapman. This immunologist is president and CEO of Indoor Biotechnologies. It’s a company in Charlottesville, Va., that tests for allergens and allergies.

All cats produce some amount of Fel d1. However, that doesn’t mean that all cats are equally allergenic. In tests of hundreds of cats, Indoor Biotechnologies found levels ranging from just 5 to as much as 2,000 micrograms of Fel d1 per gram of fur. Variations in two key genes explain much of that wide range. But no one knows exactly which versions of the genes result in low-allergen cats.

It’s also not clear what role Fel d1 plays in cats. Lions and other big cats have their own version of the protein, Chapman notes. So it seems to have stuck around during cat evolution. That suggests the protein does something. Male cats that haven’t been neutered tend to have the highest Fel d1 levels, which have been linked to male hormones. Based on that association and the protein’s similarity to other molecules, Fel d1 might be a pheromone. That’s a chemical used to communicate via scent. But no one knows whether the protein plays some role in keeping cats healthy.

It’s not clear what role Fel d1 plays in cats. But lions and other big cats have their own version of the protein, which suggests it must do something, Martin Chapman says.Bernard Bialorucki/iStock/Getty Images Plus

All this uncertainty has made allergies to cats difficult to tackle. For now, options are limited. People can take antihistamines and other medications to reduce symptoms. But such drugs don’t stop the allergy.

Traditional allergy shots are known as immuno­therapy or desensitization therapy. They aim to retrain a person’s immune system to be less sensitive to an allergen. But those shots are a commitment. A patient may need up to 100 injections over three to five years.

Some people can avoid needles by taking under-the-tongue daily drops of the same U.S. Food and Drug Administration–approved allergens as in the injections. But this treatment often is not covered by insurance.

“Desensitization therapy has been the only therapy for decades,” says Gerald Nepom. He is director of the Immune Tolerance Network in Seattle, Wash. It’s a research group funded by the National Institutes of Health. Exactly how desensitization works is still not fully understood. But the basic idea is that exposing the immune system to small amounts of allergens causes the body to make antibodies that block part of the allergic response. Unfortunately, Nepom says, desensitization generally doesn’t eliminate all symptoms. And the effects aren’t always permanent.

Allergy treatments 

There is no permanent cure for cat allergies, though a number of available treatments can reduce symptoms in many allergy sufferers. New treatments aim to do a better job at this or stop the allergy process in its tracks. 

TREATMENTAVAILABLE NOW?ACTIONPROSCONSAntihistaminesYesBlock histamine productionNewer drugs like cetirizine (Zyrtec) and fexofenadine (Allegra) cause less drowsiness than previous drugsMay not eliminate symptomsNasal steroidsYesReduce inflammation in the noseReduce sneezing, congestion and runny noseOnly treat symptomsTraditional allergy shots or dropsYesExact mechanism unknown; may increase helpful antibodiesThe only current therapy that reverses some allergiesRequires many shots over several yearsAllergy shots of lab-made antibodyNoBlock immune system’s recognition of allergenFast-acting prevention of allergic responseBoosters requiredPet food with antibodiesNoCuts amount of active Fel d1 allergen in cat salivaNo shots neededDoes not eliminate all Fel d1Vaccine for catsNoPrevents human immune system from recognizing cat allergenNo shots needed for peopleDoes not eliminate all Fel d1; more testing needed to confirm safety for catsGenetic engineering of catsNoRemoves genes that direct Fel d1 production in cats With no Fel d1, nearly all cat allergies would be eliminatedEffects on cats are unknown

Newer approaches are focusing on Fel d1. They either directly neutralize it or block its interaction with the human immune system. The competition to devise an effective solution to cat allergies is fierce. Because of the large potential market — about 10 percent (some estimate 20 percent) of people are allergic to cats — a successful approach could make companies a lot of money.

Applying lessons learned here to other allergies is a strong motivator, too.

Improving immunotherapy

One problem with traditional immunotherapy is that it tries to stop one of the later steps in the allergic response. Immunoglobulin E, or IgE, is an antibody that triggers an allergic reaction. Antibodies patrol the body looking for specific interlopers. In people with allergies, the IgE only latches onto the proteins or chemicals — allergens — that trigger their allergy.

When an IgE find its allergen, the antibody raises an alarm. It does that by telling certain cells that something is wrong. Those cells make chemicals called histamines (HIS-tuh-meens). It’s the job of histamines to get rid of bothersome things by any means necessary. Those histamine chemicals might make eyes water, or trigger coughing, sneezing or itching. That’s helpful when the substance poses harm. But it is not pleasant when the substance — like cat dander — is actually harmless. In allergies, this histamine response can go way too far. It can even cause people’s throats to swell shut and other life-threatening consequences.  

Traditional immunotherapy blocks the histamine-producing part of this reaction. Yet that’s only one part of the body’s response to an allergen.

“We now see allergy as an immune-activation symphony,” explains Nepom. Rather than a strict chain of single events, it’s more like an orchestra. And it has many players (molecules) performing on cue.

Today, Nepom says, allergy researchers are getting a clearer understanding of the role of each player. “This is like figuring out which part of the orchestra is creating the problem. Is it the horn section or the strings? Or do you have a single oboe player going rogue?” Knowing that could help researchers target players in the immune system more efficiently, he says.

For example, one research group funded by the Immune Tolerance Network is wrapping up a human trial that goes by the name of CATNIP. This clinical trial is testing what’s called an “allergen-plus” approach. Scientists combine small amounts of Fel d1 with an antibody that blocks a substance important to triggering the allergic response. That substance is a protein that helps spark and maintain allergic reactions. It may be one of those rogue oboists. The idea is that if this treatment works, a patient would develop a long-lasting tolerance from a one-year series of allergy shots. That may sound like a lot, but today’s version of such a therapy requires three to five years of shots.

Other parts of the allergic response are prime targets, too, says Jamie Orengo. She is an immunologist at Regeneron Pharmaceuticals in Tarrytown, N.Y. (Regeneron is a major financial supporter of the Society for Science & the Public. The Society publishes Science News for Students.)

In a test of people with cat allergies, one injection of an antibody that binds to the protein Fel d1 provided more relief from nasal symptoms than did a placebo shot. SOURCE: J.M. Orengo et al/Nature Communications 2018 T. Tibbitts

The company has designed antibodies that are highly specific to Fel d1. These antibodies bind to and lock up the allergen before the immune system can react to it. It’s an amped-up version of traditional immunotherapy. And it’s one that could be used to target other allergens, Orengo notes.

“We don’t have to rely on the human body. We can make those antibodies in the laboratory instead of waiting for them to be generated by the person naturally,” Orengo says. Tests in mice and in people allergic to cats showed fewer allergy symptoms after just one treatment, her team reported in a 2018 paper in Nature Communications. That one treatment gave results that used to be seen only after years of conventional immunotherapy. Most people treated saw as much as a 60 percent reduction in nasal symptoms.

One shortcoming: While this approach is very fast-acting, it doesn’t retrain the person’s immune system. Someone receiving the treatment would need periodic boosters — perhaps every few months.

Special cat food

Cat saliva is the biggest source of Fel d1. Researchers at Nestlé Purina are now testing cat food containing an antibody. It binds to the protein in saliva as a cat eats. This antibody doesn’t prevent the cat from producing the allergen. It does, however, make it almost impossible for the human immune system to recognize the allergen.

“In fact, this was an important strategy behind our research,” says Ebenezer Satyaraj. This immunologist is leading the research at the Purina Institute in St. Louis, Mo. “We didn’t want to stop the production of Fel d1 because currently it is not clear what role it has in the cat.”

When 105 cats were fed an experimental Purina pet food containing a Fel d1 antibody, levels of the allergen dropped below baseline levels over a 10-week period. SOURCE: E. Satyaraj et al/Immun., Inflamm. and Disease 2019T. Tibbitts

Tests so far suggest that the food can knock down the amount of active allergen on cat hair by about half. That may be enough to offer relief to some people with mild to moderate cat allergies. The company expects to begin selling the cat food later this year.

But it won’t help everyone. People with severe allergies or asthma may be unable to tolerate any amount of Fel d1 without causing symptoms, says Michael Blaiss. He is executive medical director of the American College of Allergy, Asthma and Immunology in Augusta, Ga.

Vaccinate the cat

There are cat lovers out there who’d probably be happier letting the cat get the shots. So another new approach aims to vaccinate cats against their own Fel d1. The shot would stimulate a cat’s immune system to produce antibodies that bind to Fel d1. That should make it so that human immune cells no longer recognize — and react — to the protein.

Researchers at HypoPet AG in Zurich, Switzerland, studded an inactive fragment of a virus with dozens of Fel d1 molecules. “If you make the allergen look like a virus, the immune system thinks it is a virus,” says Martin Bachmann. He is chief scientific officer of HypoPet. He’s also an immunologist at the University of Bern in Switzerland. This “Trojan horse” then triggers the cat’s immune system to start seeing Fel d1 — which it normally ignores — as an invader.

An initial test was done in more than 50 cats. Three injections of the vaccine were given three weeks apart. They stimulated the cats to make antibodies specific to the allergen. This reduced the cats’ secretion of the protein by more than half. And it did this without harming the cats, the researchers reported last July in the Journal of Allergy and Clinical Immunology. The company now plans further safety testing, Bachmann says. HypoPet is working with U.S. and European Union regulators to bring the vaccine to market.

The hypoallergenic cat

Producing a cat that makes no allergens at all is still the goal for some researchers. The fact that some cats are naturally low in Fel d1 suggests that such pets could be bred. This is what Allerca tried and failed to do a decade ago. But frustratingly, you can’t just breed two cats with low Fel d1 levels and get a litterful of hypoallergenic kittens.

Tom Lundberg breeds Siberian cats in Oregon. He cautions that breeding two cats that are naturally low in the allergen Fel d1 doesn’t guarantee their kittens will also have low levels of the protein. His advice: If you need a low-allergen cat, get it tested and meet the cat before bringing it home.Sarah Starr

Oregon cat breeder Tom Lundberg has bred Siberian cats for more than 10 years. His goal has been to breed low-allergen cats. Lundberg himself is allergic to cats. He became fascinated by Siberians after owning one to which he was not allergic. But a second one, he recalls, gave him a “snotty nose and itchy eyes.”

Lundberg has long measured his cats’ allergen levels and tracked the results of breeding. He can confirm that there’s no way to guarantee that all the kittens in a litter will hit the genetic jackpot. He and his wife, Meredith, now sell the cats they breed based on their Fel d1 levels. Those tested with the lowest levels, which are the most rare, command the highest prices. These cost up to $5,200 for a kitten in the “extremely low” range of less than 1 microgram of Fel d1 per gram of fur. Only about 1 in 15 of the kittens he breeds from low-allergen cats fall into that category, he says.

Lundberg has received hundreds of calls from people giving up Siberian cats that breeders had claimed were hypoallergenic. “They’ll say the kittens were ‘bred from hypo­allergenic lines,’” he says. “That’s like saying corn was bred from corn — it’s meaningless.”

Anyone interested in buying a low-allergen cat, he says, should insist on seeing test data. He also notes that buyers with severe allergies may not be able to tolerate any amount of Fel d1.

Indoor Biotechnologies is trying to genetically engineer a cat that makes no Fel d1. “We’re working on it,” says Chapman, who founded the company. This company has used CRISPR/Cas9 to delete two genes. The company has filed for a patent on the process. Called Ch1 and Ch2, the genes being deleted would have instructed cells on how to make Fel d1. So far, the gene edits have worked for cat cells growing in cell-culture dishes.

Next, the company will try knocking out these genes in cat salivary tissues, also growing in a lab dish. Researchers will then make sure Fel d1 is no longer being made, says Nicole Brackett. She’s a postdoctoral scientist at the company. She has analyzed the DNA sequence of the Ch1 and Ch2 genes of 50 cats. She now has plans to do the same for 200 more cats. That will help identify the best gene region to target using CRISPR/Cas9.

If the genetic trick works, engineered cats would lack part or all of the genes needed to make Fel d1. Some cats naturally produce very little of this with no ill effects. So the thinking is that preventing cats from making the protein is unlikely to harm them. But scientists won’t know for sure until someone tries it. “That’s precisely the reason to do the experiment,” Chapman says.

Typically, producing such a cat would require deleting the gene from an embryo. The embryo would then be implanted in a female cat until the kitten is born. But Chapman doesn’t want to get into the breeding business. Instead, he hopes to ultimately edit the genes of adult cats. That is similar to gene therapies being developed now for people (which use a harmless virus to deliver gene-editing tools). Recent experiments have successfully edited the genes of adult mice and even people with sickle-cell disease, for instance.

Such a virus could be delivered by having a veterinarian inject it into the cat’s salivary glands. Or it might come as skin treatment to reach the sebaceous glands in the skin. And if it edits the genes for Fel d1, “that would be exciting,” Chapman says.

One researcher working to wipe out cat allergies won’t be standing in line for any injections, however. Bachmann, of HypoPet, says that he and his son are allergic to cats. When asked if he would try any of the new allergy treatments, he replied no. “I don’t love cats that much,” he says. “I’m more a dog person.”

A personal quest

Stoli (shown here) is a Siberian cat that belongs to the author of this article. Siberian cats are considered hypoallergenic by some people. But there’s no evidence that any cat breed is universally low in Fel d1. E. Engelhaupt

I’ve always been a cat person. So when I married Jay, who’s allergic to cats, among other things, I had a problem. Whenever Jay spent time around a cat, his eyes would start to itch. His nose would run.

But Jay loves cats, too. Like many allergy sufferers, he tried all the usual treatments. For a couple of years, he got monthly allergy shots. He now uses daily nasal steroids and the antihistamine cetirizine. Eventually, his allergies didn’t seem so bad. So we wondered if he could tolerate a cat. I’d been seeing a lot of claims about hypoallergenic cat breeds. I was skeptical but curious.

We’re both biologists by training, so we dove into the scientific literature. We didn’t find much. One small study in Veterinary Sciences from 2017 reported on mutations in Siberian cats that could potentially lower their Fel d1 levels or render the protein less allergenic. It was the barest of hints. But we decided to visit a Siberian cat breeder in Georgia and see if we might luck out.

That day we brought home Stoli on a trial basis. Stoli is a nearly 17-pound sweetheart. Jay’s allergic reaction to him was occasional and mild. And over a few months the sniffling seemed to diminish even more. We thought we’d found our low Fel d1 cat!

Then in the course of reporting this story, I decided to test Stoli. I sent off a fur sample to Indoor Biotechnologies. The result: Stoli’s fur tested at 790 micrograms per gram of fur — pretty darn high.

Maybe the immunotherapy that Jay has endured over the years gets more credit than Stoli’s genes. It’s OK. Despite those test results, we are definitely keeping the cat.— Erika Engelhaupt

The many efforts to lick cat allergies published first on https://triviaqaweb.tumblr.com/

[emberashcosplay]

hey, @starlightandmoonfire hope you don't mind me answering you on my cosplay & otomes blog out of the blue.

but, dude! amnesia: memories is this really rad otome that's got great art and pretty decent VAs and translation. your MC wakes up with amnesia and depending on what you picked in the beginning of the game is who you are trying to romance. pretty crazy shit goes down regardless which route you take (*ahem*TOMA*ahem) and it's not just getting your guy but also completing all the routes because there's a fifth character with the "true ending" and an overarching plot.

i might be biased because a friend sent it to me for free, but i really liked it! i powered through it in five days, seriously. it's not a super cheap game but i've seen steam put it on sale for $3 during their summer sale and tbh i had a lot of fun playing it. there's no suggested play through order like some otomes, it's all depending on your tastes. i will say there's a tsundere, yandere, dandere/megane, cassanova and one who is super spoiler to explain but you only get him after the four other routes anyway. i played it toma>shin>kent>ikki>secret and would rate it secret>toma>shin/ikki>kent. the only thing i'd say is probably follow up toma's with kent's to get a breather.

the main failing point of this otome, i think, is a doormat MC, but the amnesia i guess makes it make more sense or i at least can hand-wave a little more away? but it's pretty egregious if you're used to a stronger MC (nameless, code:realize, hakuoki), i'm not gonna lie.

10/10 though, would definitely recommend playing at least once and wait with baited breath for the sequels to get localized. just don't waste any time on the anime, it's complete garbage except for the joke OVA.

#amnesia memories #otomes #otome review #dating sims #otomate #idea factory #emberasks #emberplays #starlightandmoonfire

[gnarcissistic]

I Bought a Dyson and I’ll Never Go Back http://ift.tt/2eNDFai

My amazing Dyson Animal V6

I’ve been tossing around the idea for years now about buying a Dyson vacuum cleaner, but the price tag had always been far too intimidating to take the plunge. Well, after my trusty Bissell needed yet another belt replacement, I decided enough is enough and I bit the bullet. I spent almost $300 on a vacuum cleaner and I’m never going back!

“Why?,” you ask. “Was it worth it?” “Couldn’t you just get the belt replaced?” All valid questions that I mulled over in my mind time and time again until I decided to take adulting to the next level and upped my cleaning game. I had been using the exact same vacuum cleaner since college – a Bissell Powerforce that had carried me through 4 apartments and my current home for over a decade. It was a trusty cleaning machine that was great with pet hair and I had no complaints about its performance, but after living in a 2 story home for quite some time, now it has just proven too heavy to lug up and down the stairs. Not to mention, I was sick of those messy bags that always seemed to fill up way too quickly and wanted my next machine to be bagless.

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In waltzes my Dyson V6 Animal Cord-free Vacuum, like a neat freak prince on a shiny, white horse paving the way for cat-hair-free hallways and dander-less floors. I’m in heaven. This thing picks up clumps of pet fur like a dream and is great on carpet and reliable for my laminate floors as well. It makes me look forward to vacuuming rather than dreading it! I don’t have to carry a 50 lb machine up and down the stairs, but can detach the long neck extension and use to clean the stairs as a handheld. Ah, be still my heart. This vacuum has an amazing turn radius and is compact enough for those hard to reach places. Another perk I didn’t factor in was the fact that since it’s cordless and so lightweight, it’s great for vacuuming out my car!

If you got some extra cash to spare and are in desperate need of a lightweight vacuum that gets the job done, invest in a Dyson.

Find your next apartment in VA/MD/DC with Apartment Showcase.

  Apartment Stories, apartment, cleaning, cleaning products, dyson, Home, products, vacuum, vacuuming

#IFTTT #WordPress #DC #VA #MD #DMV #apartments #apartment #blog #article