#kidney diseases

[reasonsforhope]

"For the first time, genetically modified pig kidneys provided “life-sustaining kidney function” during the course of a planned seven-day clinical study—a first step in addressing the critical crisis worldwide of kidney donor organ shortage.

The University of Alabama’s pre-clinical human study at Birmingham also advances the science and promise of xenotransplantation as a therapy to potentially cure end-stage kidney disease—just as a human-to-human transplants can.

“It has been truly extraordinary to see the first-ever preclinical demonstration that appropriately modified pig kidneys can provide normal, life-sustaining kidney function in a human safely and be achieved using a standard immunosuppression regimen,” said UAB transplant surgeon scientist Jayme Locke, M.D., director of UAB’s Comprehensive Transplant Institute and lead author of the paper...

The peer-reviewed findings published last month in JAMA Surgery describes the pioneering pre-clinical human research performed on a recipient experiencing brain death...

The pre-clinical human brain death model developed at UAB can evaluate the safety and feasibility of pig-to-human kidney xenografts, or transplants, without risk to a living human. It is named for transplant pioneer Jim Parsons, an organ donor whose family generously donated his body to advance xenotransplant kidney research, like the latest patient did.

A Critical Need

Kidney disease kills more people each year than breast or prostate cancer, while more than 90,000 people are on the transplant waiting list. More than 800,000 Americans are living with kidney failure and 240 Americans on dialysis die every day. The wait for a deceased donor kidney can be as long as five to 10 years, and almost 5,000 people per year die waiting for a kidney transplant.

Groundbreaking Study Details

The 52-year-old study subject for this research lived with hypertension and stage 2 chronic kidney disease, which affects more than one in seven U.S. adults, or an estimated 37 million Americans. As part of this study, the subject had both of his native kidneys removed and dialysis stopped, followed by a crossmatch-compatible xenotransplant with two 10 gene-edited pig kidneys, or UKidney.

The transplanted pig kidneys made urine within four minutes of re-perfusion and produced more than 37 liters of urine in the first 24 hours. The pig kidneys continued to function as they would in a living human for the entirety of the seven-day study. Also, the kidneys were still viable at the time the study was concluded.

“In the first 24 hours these kidneys made over 37 liters of urine,” said Dr. Locke. “It was really a remarkable thing to see.” ...

Gene editing in pigs to reduce immune rejection has made organ transplants from pigs to humans possible. The natural lifespan of a pig is 30 years, they are easily bred, and they have organs of similar size to humans. Genetically modified pig kidneys have been extensively tested in non-human primates, and the addition of UAB’s preclinical human research model—the Parsons Model—now provides important information about the safety and efficacy of kidneys in human transplant recipients."

-via Good News Network, September 17, 2023

#organ donation #organ donor #organ transplant #medical news #medical research #pigs #kidney transplant #kidney diseases #dialysis #good news #hope #hope posting #human biology

[beakers-and-telescopes]

Artificial kidneys for people with kidney failure may be closer than we think

More than 500k people in the US require dialysis every week due to kidney failure. Some of those people are able to receive organ transplants, but the waiting list is incredibly long and only about 20k people receive transplants every year. On top of that, a person's body can reject the transplanted organ, and even if it is successful the patient will have to take immunosuppressant drugs for the rest of their life.

However, scientists at the University of California San Francisco hope that can be changed. They have created a bioreactor, a sort of artificial organ that can safely perform the functions of a kidney. It is connected directly to the blood vessels and veins, allowing passage of nutrients and oxygen like the actual kidney would. This bioreactor was tested using a type of kidney cell called a proximal tubule cell, which regulates water. These cells are encased in a silicon membrane with nanopores, which allows the cells to do their job while preventing the body's immune system from identifying and attacking them. These bioreactors were tested in pigs, and after a week the animals experienced no ill effects or rejection.

The next steps will be expanding to month long trials, and including more different kinds of cells in the reactor to perform more of the kidney's functions. Though this technology is still far from being perfected, this is a huge step in the direction of treating kidney disease far more easily and effectively!

#science #stem #science side of tumblr #stemblr #biology #biochemistry #studyblr #medicine #health #healthcare #kidney transplant #kidney diseases

[kimmikreates]

W.T.F

Don't you just love it when you have to prove you're still disabled and that incurable things haven't magically cured over night🙄.

I deal with chronic pain 24/7 because of a kidney disease I inherited off my dad's side of the family, Polycystic kidney disease is something that has no cure and like other diseases affects people differently, for me thankfully for now my kidneys work just fine but are riddled inside and out with cysts which causes me crippling pain all day everyday, because of the medical neglect I received at the start of the pain 8 years ago, I now have other issues, and lets not get start on the mental lol.

Now I have to prove to PIP, AGAIN, that I have not magically gotten better, I understand people lie but they have all my medical proof off good doctors and hospitals.

Sorry just needed to get this off my chest so to speak.

#kidney diseases #polycystic kidney disease #disability #scoliosis #chronic illness #chronic pain #chronic fatigue #PIP #disability rights #physical disability #disability awareness #hidden disability #disability pride #medical neglect #disabilities

[pigeoninabowl69]

2 months ago, i got my blood and urine results back

Its all shits and giggles until i remember one of my kidneys don't work as it should

according to doc, i have high cholesterol and proteine in urine

PISS FULL OF PROTEIN HELL YEAH🗣️🗣️ (thats not good)

So i started to go work out

And....im still a fatso (and my piss still has protein)

But hey at least i lost half a KG (idk how many pounds since im not american

Why tf do i post this type of shit

Anyways

Losing weight kinda hard ngl

#overweight #protein #doctor #health problems #kidneyhealth #kidney diseases

[kauveryblogs]

#kauvery hospital #healthcare #healthy #healthcare blog #healthcare news #health care blog #kauveryhospital #kidney transplants #kidney transplant #kidney diseases

[drpriya]

Dialysis is a medical procedure used to filter waste products and excess fluids from the blood when the kidneys are no longer able to perform this function adequately. It's often necessary for people with kidney failure or kidney disease.

There are two main types: hemodialysis, where blood is filtered externally through a machine, and peritoneal dialysis, where a special solution is introduced into the abdomen to absorb waste products through the peritoneum.

Dialysis is typically required when the kidneys are unable to adequately filter waste products and excess fluids from the blood.

The primary causes of kidney failure or kidney disease, which may lead to the need for dialysis, include:

Diabetes: High blood sugar levels can damage the small blood vessels in the kidneys over time, leading to kidney damage or failure.

Hypertension (High Blood Pressure): Uncontrolled high blood pressure can damage the blood vessels in the kidneys, reducing their ability to function properly.

Chronic Glomerulonephritis: This is a group of diseases that cause inflammation and damage to the kidney's filtering units (glomeruli).

Polycystic Kidney Disease: A genetic disorder where fluid-filled cysts develop in the kidneys, impairing their function over time.

Autoimmune Diseases: Conditions like lupus and certain types of vasculitis can cause inflammation and damage to the kidneys.

Kidney Stones: Recurrent or severe kidney stones can lead to kidney damage if left untreated.

Infections: Severe or recurrent infections, especially those affecting the kidneys directly, can lead to kidney damage.

Certain Medications: Prolonged use of certain medications, especially if not properly monitored, can cause kidney damage.

Congenital Conditions: Some people are born with abnormalities in the structure or function of their kidneys, which may lead to kidney failure over time.

These are just some of the main causes of kidney failure or kidney disease that may necessitate dialysis.

Get the best treatments for various diseases and full body health checkup at the best hospitals in India.

#full body health checkup #health #healthcheckup #surgery #heart #heart diseases #heart attack #kidney diseases #kidney failure #kidney cancer #kidneyhealth

[dangerdust2]

Occupational exposure to crystalline silica also causes diseases such as kidney disease, immune system problems, chronic bronchitis, emphysema, silicosis and lung cancer .

In conclusion, the average exposure to crystalline silica in carvers was higher than the permissible limit. Some workers were at risk of acquiring cancer and the majority of them were at an unacceptable non-cancerous risk. Therefore, it is necessary to implement engineering control measures and appropriate respiratory protection programs.

One of the most important ways of control is raising the awareness of workers and monitoring their work.

#silica exposure #autoimmune diseases #kidney diseases #anca vasculitis #silicosis #lung cancer

[avionkidneyhospital]

Best Kidney Doctor in Gujarat | Best Dialysis Specialist Doctor in Gujarat - Avion Kidney Hospital

No 1 kidney Transplation hospital in Gujarat - Avion Kidney Hospital best kidney Transplation hospital clinic in Gujarat, India. For more information call us on 91 7600616316.

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#Best Dialysis Specialist Doctor in Gujarat #No 1 Kidney Hospital in Gujarat #Kidney Infection Hospital in Gujarat #Kidney Transplation Hospital in Gujarat #Best Kidney Transplant Doctor in Gujarat #Best Kidney Clinic in Gujarat #kidney diseases #www.avionkidneyhospital.com/best-kidney-specialist-doctor-in-gujarat.php #Avion Kidney Hospital

[newshuntermag]

RENEF Foundation To Screen The Kidneys Of 50,000 Ghanaians Freely

Reproductive Needs and Fitness (RENEF) Foundation, a non-governmental organization in Ghana has launched its latest project. About 50,000 Ghanaians will benefit from this project which was launched in Sunyani, the capital of the Bono Region on Tuesday, February 20, 2024. RENEF Foundation is set to screen the kidneys of 50,000 Ghanaians across the country. The Executive Director of the…

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#Abigail Antwi-Baafi #Executive Director of RENEF Foundation #Health #Kidney #Kidney Diseases #Mr Atta Akoto Senior #RENEF Foundation

[healthdost]

Kidneys play a vital role in filtering waste and excess fluids from your blood, helping to maintain your overall health.

Kidney disease, if it develops, can lead to serious health complications making things challenging to manage.

Explore some key practices to keep your kidneys functioning optimally.

#kidney diseases #tip for healthy kidney #kidneyhealth #kidney stone specialist

[drforambhuta]

Urine analysis plays a crucial role in various aspects of healthcare, including:

1. Detection and Diagnosis of Diseases: Serving as a sentinel for health, urine analysis goes beyond symptoms to reveal latent conditions like diabetes, kidney disorders, urinary tract infections (UTIs), and liver diseases. By scrutinizing specific substances, healthcare providers diagnose symptoms and delve into the roots of ailments.

2. Monitoring Chronic Conditions: For those with chronic diseases like diabetes or kidney issues, regular urine analysis acts as a vigilant custodian. Changes in urine composition signal disease progression, allowing healthcare providers to adjust treatment regimens and provide tailored care.

3. Drug Screening: With precision, urine analysis contributes to societal well-being in employment, sports, and rehabilitation programs. It not only detects substances but also ensures compliance with treatment regimens or abstinence requirements, preserving integrity in professional and athletic spheres.

4. Pregnancy Monitoring: In obstetrics, urine analysis guides the journey of pregnancy beyond standard tests. It uncovers complexities like gestational diabetes and preeclampsia, acting as a storyteller that foresees potential complications and safeguards the health of both mother and baby.

5. Kidney Function Assessment: Acting as a filtration maestro, urine analysis identifies kidney dysfunction through indicators like blood, protein, and chemical imbalances. Timely intervention based on these indicators prevents disharmony, ensuring optimal kidney health.

6. Infections and Inflammation: Like a diagnostic troubadour, urinalysis detects urinary tract infections (UTIs) and inflammatory conditions. Early detection through this diagnostic tool allows targeted treatment, preventing the escalation of infections and reducing the risk of complications.

7. Hydration and Metabolic Health: Through microscopic examination, urine analysis provides insights into an individual's hydroscape and metabolic kaleidoscope. Observing urine color, specific gravity, and substance levels guides healthcare providers in tailoring personalized recommendations for dietary and lifestyle interventions.

Urine analysis is a part of most full body health checkups and helps in the early detection and management of various medical conditions.

#urine analysis #full body checkups #full body health checkups #regular full body checkups #regular health checkups #kidney diseases #kidney function #urinary tract infection #diabetes #liver diseases #kidney disorders

[amri-hospital]

#Kidney Diseases #Kidney Doctor #Kidney Specialist #Kidney Treatment #Kidney Transplant

[kimmikreates]

8 years ago my world stopped, out of nowhere a crippling pain starter, even though I know the cause sadly there is no cure.

Many times I get told that "You don't LOOK sick/in pain" "Are you sure its not just in your head?", due to pain I had to stop everything I enjoyed as I could not even sit in my chair for long.

Thankfully now I am at a doctors who care, who want to help me, who don't tell me to "Just get on with it", my pain will never no away but thanks to the caring doctors I can not sit and sew for a little while.

"Just get on with it" was from a 'specialist' who fobbed me off for 3 years at the start of the pain, thanks to him I have developed scoliosis due to how I was holding myself to tey and cope with the crippling pain, I did work at this time as well dragging myself in and getting talked down to or threatened to be fired because of my health.

It has taken so long to feel heard and fell like I am being listened to, taken seriously.

#invisible illness #hidden disability #kidney diseases #chronic pain #chronic illness #crippling anxiety #crippling pain #disability #adhd brain #pkd #polycystic kidney disease #medical malpractice #ignored #hidden illness #hidden illness club

[jesssurvives]

Here’s my first video log for all of you out there struggling with mental health and chronic kidney failure or kidney disease. Or even just a chronic illness. I am really embarrassed by how i look but it felt important to share this with you guys.

#depressing shit #kidney dialysis #kidney transplant #kidney diseases #kidney failure #chronic pain #chronic illness #chronically ill #im so tired #mental health #actually mentally ill #mental illness #positive mental attitude #trying #centeal venous catheter #autoimmune

[thatwritererinoriordan]

I love Rob Base for doing this. Some of you know my hubby had a kidney transplant. That's how I know early detection is so important. Make all your Gen X aunties and uncles watch this.

#rob base #it takes two #kidney diseases #'80s music #Youtube

[drpriya]

Proteinuria condition is diagnosed through a combination of medical history, physical examination, and various diagnostic tests. Here are the common steps and tests involved in diagnosing proteinuria:

Medical History: The healthcare provider will start by taking a detailed medical history, including information about any existing medical conditions, medications, family history of kidney disease, and symptoms such as swelling, changes in urination, or high blood pressure.

Physical Examination: A physical examination may be performed to assess your overall health and look for signs of conditions associated with proteinuria, such as edema (swelling) or high blood pressure.

Urinalysis: A urinalysis is a fundamental test that involves analyzing a urine sample. A dipstick is typically used to detect the presence of proteins in the urine. The dipstick changes color in the presence of protein, and the intensity of the color change can provide an estimate of the amount of protein present. If proteinuria is detected, further testing is usually warranted.

24-Hour Urine Collection: In some cases, a 24-hour urine collection may be ordered. This involves collecting all urine passed over a 24-hour period. The total amount of protein in the collected urine can be measured accurately to determine the extent of proteinuria.

Urine Protein-to-Creatinine Ratio: Another way to assess proteinuria is by measuring the urine protein-to-creatinine ratio in a random urine sample. This ratio helps correct for variations in urine concentration, making it a convenient and reliable method for estimating protein excretion.

Blood Tests: Blood tests may be performed to evaluate kidney function and identify underlying causes of proteinuria. These tests can include measurements of serum creatinine, blood urea nitrogen (BUN), and glomerular filtration rate (GFR). Additional blood tests may be ordered to assess for conditions like diabetes or autoimmune diseases.

Imaging Studies: In some cases, imaging studies such as ultrasound or CT scans may be used to assess the structure and size of the kidneys and to look for any structural abnormalities that might be causing proteinuria.

Kidney Biopsy: If proteinuria is severe or not responsive to treatment, a kidney biopsy may be recommended. This involves the removal of a small sample of kidney tissue for detailed examination under a microscope. A kidney biopsy can help determine the specific cause of kidney damage and guide treatment decisions.

The approach to diagnosing proteinuria condition may vary depending on the suspected underlying cause and the patient's clinical presentation. Get proteinuria detected with full body checkups at H N Reliance Hospital Mumbai.

#health #kidney failure #kidney disease #kidney diseases #kidney #biopsy #full body health checkup #health checkup #kidney stone #uti symptoms