Grandis from Nadia - Secret of Blue Water, did!
Old Gainax from the early 90s, Grandis and her two sidekicks were the recurring antivillains with the heart of gold through most of the series. Good stuff, check it out!
Nadia: The Secret of Blue Water (1990)
Studio Gainax, Dir. Hideaki Anno and Shinji Higuchi
Opening “Blue Water”, performed by Miho Morikawa
all-timer anime opening