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doyouknowthismusical · 6 months

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#musical theater #do you know this musical #poll #mel hornyak #elliot valentine lee #elliot lee #elliot valentine #language: english

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midgemoment · 1 year

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WHERE CAN I RUN?

ADAMANDI BY MELLIOT (MEL HORNYAK AND ELLIOT VALENTINE LEE)

#adamandi #melliot #mel hornyak #elliot valentine lee #vincent aurelius lin #vincent lin #tobias nguyen #gif

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melliotwrites · 2 days

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youtube

Something a little different from the usual Melliot fare! Here is our song for Ring of Keys's Queering the Gala event: "The New and Improved Boyfriend Experience"! (Warning for some raunchy lyrics.) The event was based around queering the canon of Alan Menken's music, so this song was based on "Friend Like Me" from Aladdin.

Music by Elliot Valentine, lyrics by Mel Hornyak

Performed at Joe's Pub by Hennessy Winkler on 1/29/24

Orchestrated by Elliot Valentine

#melliot #musical theater #musical theatre #ring of keys #hennessy winkler #standalone songs #Youtube

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remylong · 4 months

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for the three people who followed me from my situationship rant post (HOW DID YOU GET HERE) 😭 um pls listen to ghost story musical it's a Story About Ghosts... and also America and Desire and History but mostly about Ghosts

#if people are going to look at me oversharing im going to leverage it to get more people into this show #SoundCloud

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coinermayhem · 9 months

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ID: A thirteen striped flag, its colors going as follows from top to bottom, muted coffee brown, muted mocha brown, muted beige, pale olive green, dark white, muted white, gold, muted white, dark white, dark red, red-beige, russet brown, dark russet brown.

Adamandical: - a gender related to the musical 'Adamandi' by Elliot Valentine Lee and Mel Hornyak.

tagging @radiomogai

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realtalk-princeton · 1 year

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Where can I find other trans people on campus?

Response from Ocean:

Right here! (It's me, I'm the trans people on campus.)

The places I have met my trans friends are: Quad, Terrace, Marriage Pact (long story), quirky humanities courses (the specific class is no longer offered unfortunately), a CWR poetry class, and mostly through the friends that I met at those places.

I also met some trans folks at GSRC events. I know they offer Gender Group, but I'm not sure what time it's offered -- if you stop by the GSRC on the second floor of Frist, they'll have more info.

It seems like a lot of the trans folks I know are involved in various theatre productions. If that's your thing, I'm sure you'll find plenty of trans people in the cast, crew, and audience of any Melliot production (that's Mel Hornyak and Elliot Lee, they are students who write musicals and plays).

Don't be scared to approach cool-looking people and introduce yourself! We could all use more trans friends and I don't know anyone who isn't excited to make a new friend. Good luck!

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tumimmtxpapers · 6 years

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17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.

Related Articles 17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model. PLoS One. 2018;13(2):e0191264 Authors: Joshi SS, Jiang S, Unni E, Goding SR, Fan T, Antony PA, Hornyak TJ Abstract Heat shock protein 90 (HSP90) is a molecular chaperone which stabilizes client proteins with important roles in tumor growth. 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabilizes client proteins and directs them towards proteosomal degradation. Malignant melanomas have active RAF-MEK-ERK signaling which can occur either through an activating mutation in BRAF (BRAFV600E) or through activation of signal transduction upstream of BRAF. Prior work showed that 17-AAG inhibits cell growth in BRAFV600E and BRAF wildtype (BRAFWT) melanomas, although there were conflicting reports about the dependence of BRAFV600E and BRAFWT upon HSP90 activity for stability. Here, we demonstrate that BRAFWT and CRAF are bound by HSP90 in BRAFWT, NRAS mutant melanoma cells. HSP90 inhibition by 17-AAG inhibits ERK signaling and cell growth by destabilizing CRAF but not BRAFWT in the majority of NRAS mutant melanoma cells. The highly-selective BRAFV600E inhibitor, PLX4032 (vemurafenib), inhibits ERK signaling and cell growth in mutant BRAF melanoma cells, but paradoxically enhances signaling in cells with wild-type BRAF. In our study, we examined whether 17-AAG could inhibit PLX4032-enhanced ERK signaling in BRAFWT melanoma cells. As expected, PLX4032 alone enhanced ERK signaling in the BRAFWT melanoma cell lines Mel-Juso, SK-Mel-2, and SK-Mel-30, and inhibited signaling and cell growth in BRAFV600E A375 cells. However, HSP90 inhibition by 17-AAG inhibited PLX4032-enhanced ERK signaling and inhibited cell growth by destabilizing CRAF. Surprisingly, 17-AAG also stimulated melanin production in SK-Mel-30 cells and enhanced TYRP1 and DCT expression without stimulating TYR production in all three BRAFWT cell lines studied as well as in B16F10 mouse melanoma cells. In vivo, the combination of 17-AAG and cellular immunotherapy directed against Tyrp1 enhanced the inhibition of tumor growth compared to either therapy alone. Our studies support a role for 17-AAG and HSP90 inhibition in enhancing cellular immunotherapy for melanoma. PMID: 29481571 [PubMed - indexed for MEDLINE] http://dlvr.it/QKqQ10

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midgemoment · 1 year

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