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megaclaudiolis · 1 year

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"你批评批评我，批评批评我。" Xiao Ruoteng on Yang Haonan // CHN Team Nats 2022

#❤️👌#xiao ruoteng #yang haonan #肖若腾 #杨皓楠 #made by me #isn't Xiao brother goal #Xiao being a thoughtful big brother and Haonan being his modest self #😭😭😭#also you really can only hear this kind of things from Xiao #like he's so willing to telling stories like this and presenting fellow gymnasts and teammates as human beings #and just telling you their likeable qualities and make you love them too #all we knew about Haonan was that he's an introverted kid #but in Xiao's little story he painted him as a humorous cute and modest character #ugh literally no one handled this better than Xiao

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bogotamusicvideofestival · 7 months

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// Bogotá Music Video Festival 2023 // Selección Oficial // Competencia Internacional //

Anne Müller - Nummer 2 (Arthur Chaumay, Simon Duong Van Huyen, Francia) Big Freedia - Training Day (Wilberto Lucci; EEUU) Brendan Void - Love is Hell (Brendan Void; Reino Unido) Charlie Cunningham - End Of The NIght (Mawrgan Shaw; Francia) Eddie Beatz - The Healing (Haonan Wang; China) El Morabba’ - Biban (Dany Chamoun; Jordania) Funkindustry & Eri Takenaka - We Need Love (Romain Wagner; Francia) Gana - Neon Gold (Ganael Dumreicher; Austria) Heilung - Anoana (Line Klungseth Johansen, Noruega) Hurray For The Riff Raff - Resistance Rockers (Kelly Gallagher; EEUU) Internet Islands - Passenger (Yang Wen; EEUU) Lea Lustenberger - Crossroad (Piet Esch; Suiza) Lisa Pac - All In (René Rodlauer; Austria) Matt Storm - What Do Ya Miss? (Darion Trotmanm; Canadá) Narova - Moby Dick (Antonio Michele Stea; Italia) Nikhil D’souza - Because Because Because (Anthony Karbhari; India) River Harmony - Empaths & Apples (Kelli Reilly; EEUU) Soda Blonde - Bad Machine (Adam O'Regan; Irlanda)

Nota: El vídeo MGZAVREBI - Waltz ha sido retirado de la Selección Oficial BMVF por sus autores.

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gymnasticscoaching · 2 years

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Chinese Championships Men’s Results

Zhang Boheng Sun Wei Yang Jiaxing Yin Dehang Yang Haonan Wei Guozheng Full results. Zhang Boheng won Floor and H Bar. Lu Chongcan won Pommels. You Hao won Rings and P Bars. A strong candidate for the Worlds team. Chen Yilu won Vault. Convincingly. Zhang Boheng related – Highlights of National Artistic Gymnastics Championship in Hangzhou

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endlessthoughtsofafangirl · 3 years

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"Why must you think that a person's every action, every word bears ill intent?"

#穆桂英大破天门阵 #the heroine of the yangs #hkdrama #annie man #gilbert lam #my gifs #my edit #文颂娴 #林韦辰 #haonan is starting to not be so mean #he's contemplating her words

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taekwondolifemagazine · 2 years

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The Emperor's Sword- Movie Review

The Emperor's Sword- Movie Review #TheEmperorsSword @HiYAHTV @wellgousa

“During the chaos of war, swords and knives are like toys to children.”-The Emperor’s Sword. November 2, 2021 (NYC)-The Emperor’s Sword- Movie Review. Chaos, swords, and knives is the best, one sentence, summation of the new Well Go USA Entertainment release, The Emperor’s Sword. This 90 minute adventure and action movie is an homage to the films that littered the Saturday “Kung Fu Theater”…

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#Chinese martial arts movies #Fengbin Mu #Haonan Chen #Qihang Zhao #Quiyu Yang #THE EMPEROR’S SWORD #Well Go USA Entertainment #Yilin Hao #Yingli Zhang

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healthcarebiz · 7 years

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A first full-length class B GPCR crystal structure reveals novel receptor activation mechanisms

- Structure of the full-length human glucagon receptor ignites new excitement in GPCR research

SHANGHAI, May 18, 2017 /PRNewswire/ -- A team of scientists from Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences has determined the high-resolution atomic structure of a full-length class B G protein-coupled receptor (GPCR) that plays a key role in glucose homeostasis. This structure reveals, for the first time, the structural framework of different domains of a class B GPCR at high resolution and unexpectedly discloses many exciting molecular features, greatly deepening our understanding of signaling mechanisms of class B GPCRs.

The new Nature study reports the crystal structure of the full-length human glucagon receptor (GCGR) that plays a key role in glucose homeostasis and serves as an important drug target for type 2 diabetes. The image shows the overall architecture of GCGR (grey cartoon, on the right), which consists of an extracellular domain and a transmembrane domain, in complex with an antibody mAb1 and a negative allosteric modulator NNC0640 (yellow sticks). The recently published cryo-electron microscopy structure of calcitonin receptor (cyan cartoon, on the left) bound to G protein, together with the full-length GCGR structure, highlighting the recent breakthroughs in class B GPCR research. (Image courtesy of Yekaterina Kadyshevskaya of the Bridge Institute at the University of Southern California.)

In an article published online in Nature on May 17, 2017 (18:00PM, London time) titled "Structure of the full-length glucagon class B G protein-coupled receptor", scientists at SIMM, in collaboration with several groups based in China (ShanghaiTech University, Zhengzhou University and Fudan University), United States (University of Southern California, The Scripps Research Institute, Arizona State University and GPCR Consortium), the Netherlands (Vrije Universiteit Amsterdam) and Denmark (Novo Nordisk), provided a detailed molecular map of the full-length human glucagon receptor (GCGR) in complex with a negative allosteric modulator (NNC0640) and the antigen-binding fragment of an inhibitory antibody (mAb1). This study is published together in Nature with a companion paper led by colleagues at the iHuman Institute, ShanghaiTech University describing the glucagon-like peptide-1 receptor (GLP-1R).

Class B GPCRs are essential to numerous physiological processes and serve as important drug targets for many human diseases such as type 2 diabetes, metabolic syndrome, osteoporosis, migraine, depression and anxiety. According to team leader and SIMM professor Dr. Beili Wu, "The GCGR structure provides a clear picture of a full-length class B GPCR at high resolution, and helps us understand how different domains cooperate in modulating the receptor function at the molecular level."

Class B GPCR receptors consist of an extracellular domain (ECD) and a transmembrane domain (TMD), both of which are required to interact with their cognate peptide ligands and to regulate downstream signal transduction. Due to difficulties in high-quality protein preparation, structures of full-length class B GPCRs remained elusive, thus limiting a comprehensive understanding of molecular mechanisms of receptor action.

This study gives some valuable insights into the structure of GCGR. The most exciting finding is that the linker region connecting the ECD and TMD of the receptor, termed the "stalk", works together with an extracellular loop of the TMD to regulate peptide binding through conformational changes, serving like a modulator in receptor activation. "Although the stalk region only contains 12 amino acids, it acts as a 'switch' to turn on or turn off the receptor," said Dr. Wu. "It is amazing to observe how a GPCR regulates its function in such a precise and efficient way."

Based on the full-length GCGR structure, the researchers performed a series of functional studies using hydrogen-deuterium exchange, disulfide cross-linking, competitive ligand binding and cell signaling assays as well as molecular dynamics simulations. The results are in support of the GCGR structure and confirm the interactions between different domains in modulating its functionality via conformational alterations. "This study was carried out in a team effort with experts from different fields and different countries. International collaboration is of paramount importance in solving major problems in science nowadays," said Dr. Hualiang Jiang, Director of SIMM.

"The full-length GCGR structure not only expands our knowledge about GPCR signaling mechanisms, but also offers new opportunities in drug discovery targeting class B GPCRs," said Dr. Ming-Wei Wang, Director of the National Center for Drug Screening. "With the information gained from this structure, we are in a better position to devise new therapeutic strategies involving both GCGR and glucagon-like peptide-1 receptor for obesity and type 2 diabetes."

In addition to Drs. Wu, Wang and Jiang, other study investigators included Dr. Qiang Zhao, Dr. Dehua Yang and two graduate students (Haonan Zhang and Anna Qiao) from SIMM, Dr. Linlin Yang of Zhengzhou University and Dr. Raymond Stevens from the iHuman Institute, ShanghaiTech University. The study was funded by the National Basic Research Programs, the National Health and Family Planning Commission, the National Natural Science Foundation, Chinese Academy of Sciences, Shanghai Science and Technology Development Fund, GPCR Consortium and National Institutes of Health (U.S.A.).

To view the original version on PR Newswire, visit:http://ift.tt/2pXdspq

Read this news on PR Newswire Asia website: A first full-length class B GPCR crystal structure reveals novel receptor activation mechanisms

#Healthcare

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megaclaudiolis · 2 years

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