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thecanonboyfriend · 21 days

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F/O list

Romantic F/Os

→ Ches ( Metal Family ) // DNI if we share !! /nm

→ Rodef ( Nonincluded / невошедшие )

→ Mephistopheles ( Welcome to Hell )

→ Olezha , Dima , Anton ( Дух моей общаги )

→ Riccardo DeCarlie ( криминарт only !! )

→ Mr. Kandinsky ( Strange Hill High )

→ Angel Dust ( Hazbin Hotel ) ( @cakedupincywincy )

→ Devi and Reg ( Butter Lover )

→ Doc ( Бесит! )

→ Mike Watson ( Scream Street ) - BBC show only

Platonic F/Os:

→ Norton Williams ( Bully )

→ Johnny Cade ( The Outsiders )

→ Kieran Duffy ( RDR2 )

→ Fizzarolli and Moxxie ( Helluva Boss )

Familial F/Os

→ Seaweed ( Swashbuckle ) ( Older brother )

→ Dee and Heavy ( Metal Family ) ( Nephews )

→ Goat ( MTV's Downtown ) ( Older brother / Guardian )

→ Tony Prince ( Grand Theft Auto ) ( Father )

→ Charlie B. Barkin ( All Dogs go to Heaven ) ( Fatherly Mentor thing )

→ Sedgewick Sable ( Lackadaisy ) ( Father )

→ Bo, Vincent and Lester ( House of Wax ) ( Older brothers )

→ Lucky Luke ( Father )

→ Ricky Bobby ( Talladega Nights ) ( Cousin )

#self shipping community #f/o community #self shipper #self ship #fictional other

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aron1265 · 1 year

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View this post on Instagram

A post shared by SIMONE DECARLI IFBB (@simonedecarli_ifbb)

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Simone Decarli 🇮🇹💪💪

#Instagram

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warningsine · 21 days

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As healthy people get older, the brain decreases slightlyTrusted Source in size. However, in people with dementia, as nerve cells are damaged and die, many regions of the brain shrink, a process known as brain atrophy. So, could a larger brain help reduce a person’s risk of dementia?

A new study, from UC Davis Health, has suggested that it might. Researchers found that people born in the 1970s had brains that were, on average, 6.6% larger than those of people born in the 1930s. They suggest that larger brain size means increased brain reserve — which may reduce the risk of age-related dementias.

The study is published in JAMA NeurologyTrusted Source.

“While these newly published results add to the body of literature on brain size and changes over time, this study was largely conducted in healthy, well-educated, non-Hispanic White individuals, and so [these findings] are not necessarily generalizable to other groups or individuals.” — Ozama Ismail, PhD, Alzheimer’s Association director of scientific programs, who was not involved in the study.

Dementia’s effects on the brain

Currently, around 58 millionTrusted Source people worldwide have dementia, and that number is projected to reach 152.8 million by 2050.

Although some memory loss is a natural part of aging, dementia is not. Dementia describes a range of diseases, with the most common, being Alzheimer’s disease, causing 60-80% of cases. Others include vascular dementia, Lewy body dementia (which may be associated with Parkinson’s disease), frontotemporal dementia, and mixed dementia.

Symptoms of dementia, which worsen over time, may include:

memory problems

asking the same question repeatedly

difficulty finding or understanding words

feeling confused in unfamiliar environments

problems dealing with money and numbers

anxiety and withdrawal

difficulty planning and carrying out tasks

mood, personality and behavior changes

sleep disturbances

obsessive tendencies

In all types of dementia, as brain cells are damaged and die, there is some degree of brain shrinkageTrusted Source, with this being particularly pronounced in Alzheimer’s disease and vascular dementia.

Human brain sizes are increasing

This study looked at participants in the Framingham Heart Study (FHS). This long-term study has followed 15,000 individuals for more than 75 years.

Of the FHS cohort, 3,226 people had two MRI scans that were suitable for this study. Of them, 1,706 (53%) were women, and 1,520 (47%) were men. The scans measured intracranial volume (ICV), cortical gray matter, cerebral white matter, hippocampal volume, cortical surface area, and cortical thickness measures.

The participants were all born between 1930 and 1970, with the median decade of birth being the 1950s. People born in the 1970s were, on average, 1.6 inches taller than those born in the 1930s, so the researchers adjusted for this when comparing brain measurements.

People born in the 1970s had greater brain volumes than those born in the 1930s.

They had a 6.6% greater ICV, 7.7% more white matter, 2.2% more cortical gray matter, 5.7% greater hippocampal volume, and 14.9% larger cortical surface area. The one measure that had decreased was cortical thickness, which was 20.9% lower. These differences remained significant when the researchers adjusted for height differences.

“The decade someone is born appears to impact brain size and potentially long-term brain health,” said Charles DeCarli, MD, first author of the study, distinguished professor of neurology, and director of the UC Davis Alzheimer’s Disease Research Center in a press release.

“Genetics plays a major role in determining brain size, but our findings indicate external influences — such as health, social, cultural and educational factors — may also play a role,” he said.

“Larger brain structures like those observed in our study may reflect improved brain development and improved brain health. A larger brain structure represents a larger brain reserve and may buffer the late-life effects of age-related brain diseases like Alzheimer’s and related dementias.” — Charles DeCarli, MD

Larger brain size may indicate lower dementia risk

Previous studiesTrusted Source have suggested that larger brain volume protects against the effects of dementia pathology, arguing that those with a greater head circumference can endure a greater degree of damage before they start to show cognitive impairment.

This ‘brain reserve hypothesis’Trusted Source suggests that a larger brain volume, with more neurons and synaptic connections, could provide protection against cognitive decline from brain atrophy. Experts use ICV on MRI and head circumference as indicators of brain volume.

However, this observed effect could be due to other factors, as Ismail told Medical News Today:

“Larger brain volumes may be beneficial in maintaining resilience to cognitive decline and dementia, but many other factors can contribute to resilience, including genetics, environment, socioeconomic status, education, and active vs. sedentary lifestyle.”

Other studiesTrusted Source have stressed that cognitive reserve — how well the brain functions — is more important than actual brain size in relation to dementia risk. People with a higher cognitive reserve tend to show dementia symptoms later, but then decline faster once symptoms become evident.

The researchers in this study suggest that the increase in brain volumes over the four birth decades in their study could predict a lower risk of dementia in people born later in the FHS.

Call for more diverse studies

The researchers acknowledge that their study cohort was predominantly non-Hispanic White, healthy, and well-educated, so not representative of the general population of the United States. However, they emphasize that the strengths of the study include the fact that it has followed 3 generations, spanning more than 80 years of births.

Ismail called for further studies that include a greater diversity of people:

“More diversity in research populations is needed before conclusions can be made about changes in brain size over generations and the influence it may have on cognition, resilience, and dementia risk.”

“This is particularly important given the known sociocultural and health disparities that exist in underrepresented populations,” he added.

The Alzheimer’s Association’s U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER), which should publish results next year, aims to help address this gap in the research, as Ismail told MNT:

“In the U.S. POINTER Study, more than 2,000 volunteer older adults who are at increased risk for cognitive decline are enrolled and will be followed for two years. Nearly 30% of current participants are from populations historically underrepresented in Alzheimer’s/dementia research.”

#neuroscience #dementia #health

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rnomics · 6 months

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Nutrients, Vol. 15, Pages 4397: Tributyrin Mitigates Ethanol-Induced Lysine Acetylation of Histone-H3 and p65-NFκB Downregulating CCL2 Expression and Consequent Liver Inflammation and Injury

Purpose: Chemokine-driven leukocyte infiltration and sustained inflammation contribute to alcohol-associated liver disease (ALD). Elevated hepatic CCL2 expression, seen in ALD, is associated with disease severity. However, mechanisms of CCL2 regulation are not completely elucidated. Post-translational modifications (PTMs) of proteins, particularly acetylation, modulate gene expression. This study examined the acetylation changes of promoter-associated histone-H3 and key transcription factor-NFκB in regulating hepatic CCL2 expression and subsequent inflammation and injury. Further, the effect of therapeutic modulation of the acetylation state by tributyrin (TB), a butyrate prodrug, was assessed. Methods: Hepatic CCL2 expression was assessed in mice fed control (PF) or an ethanol-containing Lieber–DeCarli (5% v/v, EF) diet for 7 weeks with or without oral administration of tributyrin (TB, 2 g/kg, 5 days/week). A chromatin immunoprecipitation (ChIP) assay evaluated promoter-associated modifications. Nuclear association between SIRT1, p300, and NFκB-p65 and acetylation changes of p65 were determined using immunoprecipitation and Western blot analyses. A Student’s t-test and one-way ANOVA determined the significance. Results: Ethanol significantly increased promoter-associated histone-H3-lysine-9 acetylation (H3K9Ac), reflecting a transcriptionally permissive state with a resultant increase in hepatic CCL2 #mRNA and protein expression. Moreover, increased lysine-310-acetylation of nuclear RelA/p65 decreased its association with SIRT1, a class III HDAC, but concomitantly increased with p300, a histone acetyltransferase. This further led to enhanced recruitment of NF-κB/p65 and #RNA polymerase-II to the CCL2 promoter. Oral TB administration prevented ethanol-associated acetylation changes, thus downregulating CCL2 expression, hepatic neutrophil infiltration, and inflammation/ injury. Conclusion: The modulation of a protein acetylation state via ethanol or TB mechanistically regulates hepatic CCL2 upregulation in ALD. https://www.mdpi.com/2072-6643/15/20/4397?utm_source=dlvr.it&utm_medium=tumblr

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thekuraning · 7 months

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Hi!! Sorry to be a bother but we were wondering if you had any art of Sotiris and Decarli from Ditto Fangs and Zubat Slime? We’re a System and we recently split fictives of the two and were wondering if you had any art we could use for their pfps on our system apps!! (If you’d be okay with that of course!)

Hi anon! Please don't!

These are my OCs of over a decade, and they are very precious to me. I have never given anyone permission to use or repost any of my OCs, art of my OCs, or any fic or art I've drawn.

#kurasays #kuraocs

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usstatesguide · 10 months

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#IFTTT #Blogger

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slarty1 · 1 year

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My February update from Google Maps Timeline:

Google Maps Timeline Location History: ON Manage Settings Your February places 1 Country/Region4 Cities73 Places1 new34 new Your February activity 9 mi 9 hr 2 mi 94 mi 15 hr Highlights Cities visited Gresham New Portland Beaverton Highlights Places visited decarli restaurant New Shari’s Cafe and Pies New OOO.NOBIBI New See all visited places Your all time data 1…

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abingtoncenter22 · 1 year

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He was born and raised in Archbald, Pennsylvania, graduating from the University of Scranton in 1989. He attended Temple University School of Dentistry in Philadelphia the place he received his Doctorate degree of Dental Medicine. After receipt of his diploma, Dr. DeCarli continued his research finishing a residency program at the Veterans Medical Center in Wilkes-Barre, Pennsylvania.

She moved to New York City to attend NYU for each undergraduate and dental school. She has participated in dental outreach applications and was awarded honors in esthetic dentistry. After graduation, she completed her general follow residency at Lutheran Hospital in Brooklyn, where she handled cosmetic dentist scranton pa children, adults and particular needs sufferers. Dr. Schraner has been practicing dentistry in Manhattan for the previous 7 years. Dr. Anthony DeCarli has been offering the highest high quality of family and cosmetic dentistry since 1993.

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lucioborges · 1 year

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RS Notícias: Alvaro Decarli é eleito o próximo prefeito de Cerro Grande (RS)

Fonte: RS Notícias: Alvaro Decarli é eleito o próximo prefeito de Cerro Grande (RS)

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rodadecuia · 1 year

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#ALVARODECARLI #CERROGRANDE #ELEIÇÕES2022 #ELEIÇÕESSUPLEMENTAR

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cosihejut · 2 years

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indianfitnesscare · 2 years

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Can a Health Scorecard Predict Dementia Risk?

“We may have insights that indicate a person’s risks are very low. Or maybe the person’s risks are very high, but there are contributing factors like diabetes or hypertension that we can address,” said Charles DeCarli, principal investigator for the study. DeCarli is a professor of neurology and the director of the UC Davis Alzheimer’s Disease Research Center. “We hope that having a risk profile…