#BeCraft

[craft2eu]

Thérèse Lebrun - Glaneuse de porcelaine: Mons (B) bis 27.08.2023

Erinnerungen an eine ferne Flut oder Relikte aus der Eiszeit: Die Kreationen von Thérèse Lebrun offenbaren ein Universum der Metamorphosen, das die sensible Seele der Welt widerspiegelt. Die Ausstellung zeigt das Werk der belgischen Keramikerin Thérèse Lebrun, von ihren Anfängen in der Werkstatt des Meisters Mirko Orlandini, wo sie gedrehte und glasierte Erde bearbeitete, bis zu ihren aktuellen…

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#angewandte Kunst #BeCraft #Chloé Noyon #Handwerkskunst #Inspiration #Keramik #Kunsthandwerk #Metamorphosen #Mirko Orlandini #Schmuck #Thérèse Lebrun

[exquisitereds]

Photography by @jontaylorphoto

#Melissa Becraft #Redhead #Ginger

[bruce-wyatt-burner]

👀👀

#isabella fonte #melissa becraft #cute #pretty #lovely #gorgeous #selfie #beauty #beauties #ig story #ig reels

[fab1guy]

#melissa becraft

[jcmarchi]

Unlocking mRNA’s cancer-fighting potential

New Post has been published on https://thedigitalinsider.com/unlocking-mrnas-cancer-fighting-potential/

Unlocking mRNA’s cancer-fighting potential

What if training your immune system to attack cancer cells was as easy as training it to fight Covid-19? Many people believe the technology behind some Covid-19 vaccines, messenger RNA, holds great promise for stimulating immune responses to cancer.

But using messenger RNA, or mRNA, to get the immune system to mount a prolonged and aggressive attack on cancer cells — while leaving healthy cells alone — has been a major challenge.

The MIT spinout Strand Therapeutics is attempting to solve that problem with an advanced class of mRNA molecules that are designed to sense what type of cells they encounter in the body and to express therapeutic proteins only once they have entered diseased cells.

“It’s about finding ways to deal with the signal-to-noise ratio, the signal being expression in the target tissue and the noise being expression in the nontarget tissue,” Strand CEO Jacob Becraft PhD ’19 explains. “Our technology amplifies the signal to express more proteins for longer while at the same time effectively eliminating the mRNA’s off-target expression.”

Strand is set to begin its first clinical trial in April, which is testing a proprietary, self-replicating mRNA molecule’s ability to express immune signals directly from a tumor, eliciting the immune system to attack and kill the tumor cells directly. It’s also being tested as a possible improvement for existing treatments to a number of solid tumors.

As they work to commercialize its early innovations, Strand’s team is continuing to add capabilities to what it calls its “programmable medicines,” improving mRNA molecules’ ability to sense their environment and generate potent, targeted responses where they’re needed most.

“Self-replicating mRNA was the first thing that we pioneered when we were at MIT and in the first couple years at Strand,” Becraft says. “Now we’ve also moved into approaches like circular mRNAs, which allow each molecule of mRNA to express more of a protein for longer, potentially for weeks at a time. And the bigger our cell-type specific datasets become, the better we are at differentiating cell types, which makes these molecules so targeted we can have a higher level of safety at higher doses and create stronger treatments.”

Making mRNA smarter

Becraft got his first taste of MIT as an undergraduate at the University of Illinois when he secured a summer internship in the lab of MIT Institute Professor Bob Langer.

“That’s where I learned how lab research could be translated into spinout companies,” Becraft recalls.

The experience left enough of an impression on Becraft that he returned to MIT the next fall to earn his PhD, where he worked in the Synthetic Biology Center under professor of bioengineering and electrical engineering and computer science Ron Weiss. During that time, he collaborated with postdoc Tasuku Kitada to create genetic “switches” that could control protein expression in cells.

Becraft and Kitada realized their research could be the foundation of a company around 2017 and started spending time in the Martin Trust Center for MIT Entrepreneurship. They also received support from MIT Sandbox and eventually worked with the Technology Licensing Office to establish Strand’s early intellectual property.

“We started by asking, where is the highest unmet need that also allows us to prove out the thesis of this technology? And where will this approach have therapeutic relevance that is a quantum leap forward from what anyone else is doing?” Becraft says. “The first place we looked was oncology.”

People have been working on cancer immunotherapy, which turns a patient’s immune system against cancer cells, for decades. Scientists in the field have developed drugs that produce some remarkable results in patients with aggressive, late-stage cancers. But most next-generation cancer immunotherapies are based on recombinant (lab-made) proteins that are difficult to deliver to specific targets in the body and don’t remain active for long enough to consistently create a durable response.

More recently, companies like Moderna, whose founders also include MIT alumni, have pioneered the use of mRNAs to create proteins in cells. But to date, those mRNA molecules have not been able to change behavior based on the type of cells they enter, and don’t last for very long in the body.

“If you’re trying to engage the immune system with a tumor cell, the mRNA needs to be expressing from the tumor cell itself, and it needs to be expressing over a long period of time,” Becraft says. “Those challenges are hard to overcome with the first generation of mRNA technologies.”

Strand has developed what it calls the world’s first mRNA programming language that allows the company to specify the tissues its mRNAs express proteins in.

“We built a database that says, ‘Here are all of the different cells that the mRNA could be delivered to, and here are all of their microRNA signatures,’ and then we use computational tools and machine learning to differentiate the cells,” Becraft explains. “For instance, I need to make sure that the messenger RNA turns off when it’s in the liver cell, and I need to make sure that it turns on when it’s in a tumor cell or a T-cell.”

Strand also uses techniques like mRNA self-replication to create more durable protein expression and immune responses.

“The first versions of mRNA therapeutics, like the Covid-19 vaccines, just recapitulate how our body’s natural mRNAs work,” Becraft explains. “Natural mRNAs last for a few days, maybe less, and they express a single protein. They have no context-dependent actions. That means wherever the mRNA is delivered, it’s only going to express a molecule for a short period of time. That’s perfect for a vaccine, but it’s much more limiting when you want to create a protein that’s actually engaging in a biological process, like activating an immune response against a tumor that could take many days or weeks.”

Technology with broad potential

Strand’s first clinical trial is targeting solid tumors like melanoma and triple-negative breast cancer. The company is also actively developing mRNA therapies that could be used to treat blood cancers.

“We’ll be expanding into new areas as we continue to de-risk the translation of the science and create new technologies,” Becraft says.

Strand plans to partner with large pharmaceutical companies as well as investors to continue developing drugs. Further down the line, the founders believe future versions of its mRNA therapies could be used to treat a broad range of diseases.

“Our thesis is: amplified expression in specific, programmed target cells for long periods of time,” Becraft says. “That approach can be utilized for [immunotherapies like] CAR T-cell therapy, both in oncology and autoimmune conditions. There are also many diseases that require cell-type specific delivery and expression of proteins in treatment, everything from kidney disease to types of liver disease. We can envision our technology being used for all of that.”

#Alumni/ae #approach #Behavior #bioengineering #Bioengineering and biotechnology #Biological engineering #Biology #blood #breast cancer #Cancer #cancer cells #cell #cell therapy #cell types #Cells #CEO #challenge #change #Companies #computer #Computer Science #covid #Database #datasets #deal #Disease #Diseases #drug development #drugs #easy

[sporadiceagleheart]

This is Thursday April 11th 2024 is for those victims that was gunned down and also for the Manchester Arena victims that was bombed down as well they aren't just rappers wrestlers kids or dreamers but they are angels sent back to heaven Ava Jordan Wood, Olivia Pratt Korbel, Saffie Rose Roussos, Pop Smoke, Young Dolph, Tupac Shakur and Christopher George Latore Wallace, Natalia Victoria Wallace, Shinzo Abe, Abraham Lincoln, Dr. Rev, Martin Luther King Jr., Secoriea Turner, Royta De'Marco Layfield Giles Jr., Davon McNeal, Dajore Wilson, Mekhi James, Judith and Maria Barsi, Janari A. Ricks, Carolyn Kay “Katy” Davis, Christiana Mae “Chrissy” Duarte, Shirley Virginia Ferrell Drouet, Stacee Ann Etcheber, Brisenia Ylianna Flores, Keri Lynn Galvan, Christian Riley Garcia, Angela Christine “Angie” Gomez, Jaime Taylor Guttenberg, Nicole Marie Hadley, Caitlin Millar Hammaren, Linda Sue Miller Hathorn, Aubrey Wright Hawkins, Demetrius C. “D” Hewlin, Rachael Elizabeth Hill, Emily Jane Hilscher, Dawn Alyson Lafferty Hochsprung, Anah Michelle Hodges, Winter Ashley Hodges, Kenzie Marie Houk, Lisa Rachelle Huff Huff, Cynthia Marie Graham Hurd, Caleb Curtis Jackson, Dwayne Clifford Jackson Jr., Honesty Faith Jackson, Jonah Curtis Jackson, Trinity Hope Jackson, Jessica Jeanette James, Veronica Lynn “Tina” Jefferson, SGT Kent Dean Kincaid, Lawrence Fobes “Larry” King, Kandy Janell Kirtland, Russell Dennis King Jr., Amy Michelle Kitchen, Carly Anne Buchholtz Kreibaum, Matthew Joseph La Porte VVETERAN, Cara Marie Loughran, Trayvon Benjamin Martin, Rhonda M. LeRocque, Rebecka Ann Carnes, Adriana “Adri” Dukić, Cassie Bernall, Ross Abdallah Alameddine, Arielle Anderson, Lucero Alcaraz, PnB Rock, Nipsey Hussle, Takeoff, Dayvon Daquan Bennett, Jahseh Dwayne Onfroy, Janette Becraft, Eddie Graham, Shannon Claire Spruill, Dino Bravo, Lena Marie Nunez-Anaya, Sincere Gaston, Rebecka Ann Carnes, Annabelle Renee Pomeroy, Darius “DJ” Dugas II, Jason Leonard Abbott, Hannah Lassette Magiera Ahlers, Tammy Jo Alexander, Alyssa Miriam Alhadeff, Teresa Carol Allen, Cory Adam Andrewski, Thomas Aquinas Ashton, Charlotte Helen “Char” Bacon, Daniel Gerard “Danny” Barden, Carrie Rae Barnette, and more

[ms-cartoon]

Hello soleilisa what I'm showing you is a design of paimon for helluva boss by an artist name grace becraft. this was made in 2021 before the official design for paimon any thoughts?

Hello!!

This look is definitely more exact. I think that in the show, they wanted Paimon more bird-like to make him more relatable to Stolas. They could just follow through with the demonology. (Not that the appearances need to be 100% exact. Just, make it make sense.)

Honestly, the only good thing about Paimon's design is that he looks more like an owl than Stolas. As a demon, Stolas don't exactly look as intimidating. Maybe Stolas should have Paimon's appearance and Paimon can look like this fanart here.

I don't know a lot about demonology. I'm just speaking out of my head. Is Paimon Stolas's father? I know he's the king of hell, but I didn't read anything about him and Stolas having any relationships when looking up demonology.

Other than that, the art looks good!! It would be interesting to see him like this.

#ask #helluva boss stolas #helluva boss critique #helluva boss criticism

[tokowo-reliure]

Actuellement en librairie, dans le numéro 362 du magazine "Art & Métiers du Livre" aux Éditions Faton une interview de Nadia Corazzini (merci !) avec l'Atelier du Livre de Mariemont les Métiers d'Art du Hainaut, Esperluète éditions et les Éditions Faton. (Merci à vous !)

BeCraft#artetmetiersdulivre

#reliure #bookbinding #article #magazine #arts and crafts #vigneron grégoire

[uinterview]

Former professional wrestler Billy Jack Haynes, known as William Albert Haynes Jr., has been arrested and charged with second-degree murder following the fatal shooting of his wife, Janette Becraft.

Full Story Here: https://uinterview.com/news/former-pro-wrestler-billy-jack-haynes-charged-with-second-degree-murder-in-wifes-death/

#williamalberthaynesjr #janetteberaft #wrestling #crime #news

[biotechtv]

The next generation of mRNA beyond vaccines with Strand Therapeutics.

#mRNA #biotechnology

[zetscht]

Muses

Asier Abaroa (42) ft. Lee Pace, a past prime smuggler turned vineyardist pulling strings backstage.

Liese “Anneliese” Becraft (36) ft. Adwoa Aboah, a cult survivor headteacher.

Rachelle Liu (30) ft. Lauren Tsai, an all-round artist dabbling in cultural goods trafficking.

Sohail Ghazi (31) ft. Tamino Amir, a famed bespoke tailor hiding skeletons in the closet.

#muses #dni

[cyberbenb]

Brothers Brick creates four more LEGO minifigs of Mariupol defenders

The wife of Azov soldier Valerii Petrenko (call sign ‘Teyvaz’) asked the founder of The Brothers Brick, Andrew Becraft, to design the figures for her husband.

After his release from captivity, Valerii received a long-awaited gift — 4 LEGO figures. They were handed over to Teivaz by Kateryna Prokopenko, head of the Association of Families of Azovstal Defenders, who recently returned from America, where she met Andrew Becraft. In the United States, she held a series of meetings with influential figures as part of a campaign for the captured Mariupol defenders.

“Memories of the fallen. A set of LEGO minifigs made for former POW Teyvaz to honor his brothers who didn’t make it out of Azovstal. No Photoshop — a sunbeam came out and shone on the fallen as I took this photo,” wrote the figures’ creator Andrew Becraft.

Source

[asbfyi]

OFFSITE BOOK LAUNCH AND SCREENING | LIFE AND LIMBS & DUEL Oct 06 2022 Austrian Cultural Forum New York 11 E 52nd St, New York, NY 10022 Please join us at the Austrian Cultural Forum New York to celebrate the launch of life and limbs, co-published by Swiss Institute and Lenz Press. On the occasion of the launch, Anna-Sophie Berger will screen her video work Duel (2020). RSVP to [email protected]. life and limbs The gallery becomes a mouth. It has four pointy teeth and is an aged, even sickly, shade of off-white. The teeth are walls, and on them hang artworks selected by Austrian artist Anna-Sophie Berger for the exhibition life and limbs, Swiss Institute’s fourth installment of its Architecture and Design Series. Berger’s premise for the show considers the body an experimental testing ground for design, a living site that is both vulnerable and resilient. As the title implies, life and limbs exists in a world where the human body, unadorned, is at risk and often confronts threat with dark and knowing humor but also with grace. Across these works, which draw from speculative architectures, Surrealism, late twentieth-century fashion design, and Viennese Actionism, among many other subsects of modern visual culture, Berger’s singular understanding of corporeal awareness unfolds. In the clutches of this jaw, bodies find ways to disappear, though some stretch, reach, and metamorphosize in attempts to escape themselves. This book is a means to further explore Berger’s thesis. Three remarkable essays, by Annie Godfrey Larmon, Philipp Ekardt and Berger herself, ponder the works that populate this wunderkammer and question design’s transformative potential. Duel Duel was first presented as part of Berger’s exhibition “Duel” at the Bonner Kunstverein, curated by Susanne Mierzwiak in 2020. The relationship between destruction and construction forms the core of the work. By combining her own videos with found footage from opera, classic film, advertising and animations, Berger portrays the fragile life of the metropolis, the conditions of which are seemingly shaped by fate. Duel, 2020 HD-Video 49′ 06’’ Sound and video editing: Steffen Martin Camera and sound (Tokyo): Robert Becraft Assistance (Tokyo): Teuta Jonuzi Text edit and German translation: Nina Franz With Teak Ramos

[fab1guy]

#melissa becraft

[arietisart]

This is my ABC list of Ocs for the Challenge I work on, parallel to the canons you can see the list here: ABC Canon Challenge, list I don't have ocs with all the letters, so that will make me create more ocs! It will also help me to regain the love I had for them when I created them.

A- August Annick (Marvel oc, Mutant)

B- Blake Waser (FullMetal Alchemist oc)

C- Cassia Van Der Zee (Original, Pirate)

D- Daniel (Original, Angel)

E- Elisa Font and Ellen (DcComics oc, Mother and daughter from alternate universe; I take advantage of the fact that both are from the same fandom and that they begin with)

F- Frederico MacLaren (Original)

G- Gustav Laraway (Original, half Mirrows)

H- Harper Rangel (Marvel oc, Mutant)

I- Isaac Bonham (Original)

J- Jurian Fawkes (GOT oc)

K- Kaori Takanaka (Pokemon oc)

L- Leonardo (Original, Vampire)

M- Matías Centeno (D.Grey-Man oc)

N- Narcissus of Piscis (Saint Seiya oc)

O- Orodreth Narmolanya (Original, Elf)

P- Paris of Aries (Saint Seiya oc)

Q-?

R- Raynald Castiglione (Marvel oc)

S- Sean Becraft (Original)

T- Thomas Molinett (Resident Evil oc)

U- Umiko Hitsuki (Naruto oc)

V- Vachel Leblanc (Original)

W- Wyatt Fonts (DcComcis oc)

X-?

Y-?

Z- Zhi of Virgo (Saint Seiya)

#random #arietis talk #abc characters #abc drawing #abc challenge #abc oc

[lensandpenpress]

Gentrification of an Outlaw Hangout on the Osage River

Gentrification of an Outlaw Hangout on the Osage River

Club House, Monegaw Springs, real photo postcard by Becraft Between bank, stage, and train robberies, the Younger Brothers’ gang found refuge and recreation in the rugged hills of the Osage. Grandfather Younger had settled here in the 1840s. Relatives and even former slaves of the family took pride in sheltering the outlaws. Frank and Jesse James on occasion joined the Youngers at the billiard…

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#Becraft #Damming the Osage #Frank James #Henry County Democrat #Jesse James #Kansas City Journal #Monegaw #Osage River #Osceola #Younger Brothers