Long after the Fall of Hope's Peak Academy and the influence of Junko Enoshima, the world soon returned to its peaceful norm. Schools for Ultimates also began to branch overseas and enroll international students. The Rising Academy of the Talented is a small but also unpopular branch. However, unlike other schools, the academy is most known for enrolling Ultimates with bad reputations to help use their talents for the good of the future.
One day, the 16 students of Class 33-A must all report to the Academy during the middle of the night without alerting anyone else. Soon after, the government suddenly forces an immediate shut down on the city. All students retreat to the gym where Monokuma, the headmaster of the academy, appears and announces that a Killing Game among the students has begun.