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mostlysignssomeportents · 6 months

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Uncle Sam paid to develop a cancer drug and now one guy will get to charge whatever he wants for it

Today (Oct 19), I'm in Charleston, WV to give the 41st annual McCreight Lecture in the Humanities. Tomorrow (Oct 20), I'm at Charleston's Taylor Books from 12h-14h.

The argument for pharma patents: making new medicines is expensive, and medicines are how we save ourselves from cancer and other diseases. Therefore, we will award government-backed monopolies – patents – to pharma companies so they will have an incentive to invest their shareholders' capital in research.

There's plenty wrong with this argument. For one thing, pharma companies use their monopoly winnings to sell drugs, not invent drugs. For every dollar pharma spends on research, it spends three dollars on marketing:

https://www.bu.edu/sph/files/2015/05/Pharmaceutical-Marketing-and-Research-Spending-APHA-21-Oct-01.pdf

And that "R&D" isn't what you're thinking of, either. Most R&D spending goes to "evergreening" – coming up with minor variations on existing drugs in a bid to extend those patents for years or decades:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680578/

Evergreening got a lot of attention recently when John Green rained down righteous fire upon Johnson & Johnson for their sneaky tricks to prevent poor people from accessing affordable TB meds, prompting this excellent explainer from the Arm and A Leg Podcast:

https://armandalegshow.com/episode/john-green-part-1/

Another thing those monopoly profits are useful for: "pay for delay," where pharma companies bribe generic manufacturers not to make cheap versions of drugs whose patents have expired. Sure, it's illegal, but that doesn't stop 'em:

https://www.ftc.gov/news-events/topics/competition-enforcement/pay-delay

But it's their money, right? If they want to spend it on bribes or evergreening or marketing, at least some of that money is going into drugs that'll keep you and the people you love from enduring unimaginable pain or dying slowly and hard. Surely that warrants a patent.

Let's say it does. But what about when a pharma company gets a patent on a life-saving drug that the public paid to develop, test and refine? Publicly funded work is presumptively in the public domain, from NASA R&D to the photos that park rangers shoot of our national parks. The public pays to produce this work, so it should belong to the public, right?

That was the deal – until Congress passed the Bayh-Dole Act in 1980. Under Bayh-Dole, government-funded inventions are given away – to for-profit corporations, who get to charge us whatever they want to access the things we paid to make. The basis for this is a racist hoax called "The Tragedy Of the Commons," written by the eugenicist white supremacist Garrett Hardin and published by Science in 1968:

https://memex.craphound.com/2019/10/01/the-tragedy-of-the-commons-how-ecofascism-was-smuggled-into-mainstream-thought/

Hardin invented an imaginary history in which "commons" – things owned and shared by a community – are inevitably overrun by selfish assholes, a fact that prompts nice people to also overrun these commons, so as to get some value out of them before they are gobbled up by people who read Garrett Hardin essays.

Hardin asserted this as a historical fact, but he cited no instances in which it happened. But when the Nobel-winning Elinor Ostrom actually went and looked at how commons are managed, she found that they are robust and stable over long time periods, and are a supremely efficient way of managing resources:

https://pluralistic.net/2023/05/04/analytical-democratic-theory/#epistocratic-delusions

The reason Hardin invented an imaginary history of tragic commons was to justify enclosure: moving things that the public owned and used freely into private ownership. Or, to put it more bluntly, Hardin invented a pseudoscientific justification for giving away parks, roads and schools to rich people and letting them charge us to use them.

To arrive at this fantasy, Hardin deployed one of the most important analytical tools of modern economics: introspection. As Ely Devons put it: "If economists wished to study the horse, they wouldn’t go and look at horses. They’d sit in their studies and say to themselves, ‘What would I do if I were a horse?’"

https://pluralistic.net/2022/10/27/economism/#what-would-i-do-if-i-were-a-horse

Hardin's hoax swept from the fringes to the center and became received wisdom – so much so that by 1980, Senators Birch Bayh and Bob Dole were able to pass a law that gave away publicly funded medicine to private firms, because otherwise these inventions would be "overgrazed" by greedy people, denying the public access to livesaving drugs.

On September 21, the NIH quietly published an announcement of one of these pharmaceutical transfers, buried in a list of 31 patent assignments in the Federal Register:

https://public-inspection.federalregister.gov/2023-20487.pdf

The transfer in question is a patent for using T-cell receptors (TCRs) to treat solid tumors from HPV, one of the only patents for treating solid tumors with TCRs. The beneficiary of this transfer is Scarlet TCR, a Delaware company with no website or SEC filings and ownership shrouded in mystery:

https://www.bizapedia.com/de/scarlet-tcr-inc.html

One person who pays attention to this sort of thing is James Love, co-founder of Knowledge Ecology International, a nonprofit that has worked for decades for access to medicines. Love sleuthed out at least one person behind Scarlet TCR: Christian Hinrichs, a researcher at Rutgers who used to work at the NIH's National Cancer Institute:

https://www.nih.gov/research-training/lasker-clinical-research-scholars/tenured-former-scholars

Love presumes Hinrichs is the owner of Scarlet TCR, but neither the NIH nor Scarlet TCR nor Hinrichs will confirm it. Hinrichs was one of the publicly-funded researchers who worked on the new TCR therapy, for which he received a salary.

This new drug was paid for out of the public purse. The basic R&D – salaries for Hinrichs and his collaborators, as well as funding for their facilities – came out of NIH grants. So did the funding for the initial Phase I trial, and the ongoing large Phase II trial.

As David Dayen writes in The American Prospect, the proposed patent transfer will make Hinrichs a very wealthy man (Love calls it "generational wealth"):

https://prospect.org/health/2023-10-18-nih-how-to-become-billionaire-program/

This wealth will come by charging us – the public – to access a drug that we paid to produce. The public took all the risks to develop this drug, and Hinrichs stands to become a billionaire by reaping the rewards – rewards that will come by extracting fortunes from terrified people who don't want to die from tumors that are eating them alive.

The transfer of this patent is indefensible. The government isn't even waiting until the Phase II trials are complete to hand over our commonly owned science.

But there's still time. The NIH is about to get a new director, Monica Bertagnolli – Hinrichs's former boss – who will need to go before the Senate Health, Education, Labor and Pensions Committee for confirmation. Love is hoping that the confirmation hearing will present an opportunity to question Bertagnolli about the transfer – specifically, why the drug isn't being nonexclusively licensed to lots of drug companies who will have to compete to sell the cheapest possible version.

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/10/19/solid-tumors/#t-cell-receptors

My next novel is The Lost Cause, a hopeful novel of the climate emergency. Amazon won't sell the audiobook, so I made my own and I'm pre-selling it on Kickstarter!

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fraugoethe · 1 year

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Nur drei Tage Zeit

Viktoria Berg und Christian Hinrichts haben es schon wieder getan. Zum vierten Mal lässt @Elsa Dix sie gemeinsam auf Norderney ermitteln. Es ist ein düsteres Verbrechen und eine Überraschung (erschienen im @Goldmann Verlag).

Das verschwundene Fräulein von Elsa Dix Norderney, 1914. Es ist Sommer und es kommen immer mehr Besucher auf die Nordseeinsel, um sich in der Sommerfrische zu erholen. Die Nachrichten klingen besorgniserregend, aber noch scheint alles seinen normalen Gang zu nehmen. Auch Viktoria Berg reist gemeinsam mit ihrer Tante Rosamunde ins Seebad, wo Christian Hinrichs noch immer auf eine Antwort wartet,…

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#Christian Hinrichs #Norderney #Nordsee #Seebad #Sommerfrische #Viktoria Berg

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clamarcap · 3 months

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Per due fagotti - I

Hinrich Philip Johnsen (1716 o 1717 - 12 febbraio 1779): Concerto in fa maggiore per due fagotti e orchestra (c1751). Mats Klingfors e Christian Beuse, fagotti; Concerto Copenhagen, dir. Andrew Manze. Moderato Cantabile, largo e staccato [6:26] Vivace [10:17]

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#Andrew Manze #Christian Beuse #Concerto Copenhagen #Hinrich Philip Johnsen #Mats Klingfors #Youtube

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intellectures · 10 months

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Holger Fock und Sabine Müller erhalten Paul-Celan-Preis

Der vom Deutschen Literaturfonds alljährlich vergebene, mit 20.000 Euro dotierte Paul-Celan-Preis für herausragende Übersetzungen geht in diesem Jahr an das Übersetzungstandem Holger Fock und Sabine Müller. Damit erhalten zwei verdiente Übersetzer:innen aus dem Französischen den wichtigsten deutschen Übersetzerpreis. Dass auch sie auf das Preisgeld angewiesen sind, haben sie erst kürzlich in…

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travelella · 17 days

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Impala in Akagera National Park, Kayonza, Rwanda

Max Christian

Speed: 47 – 56 mph (Running, In a zig-zag)

Mass: 88 – 170 lbs (Male, Adult), 66 – 110 lbs (Female, Adult)

Animal sounds: an explosive 'chuff' alarm bark – wildambience.com

Gestation period: 183 – 213 days

Scientific name: Aepyceros melampus

Trophic level: Herbivorous

The impala or rooibok is a medium-sized antelope found in eastern and southern Africa. The only extant member of the genus Aepyceros, and tribe Aepycerotini, it was first described to Europeans by German zoologist Hinrich Lichtenstein in 1812.

The impala inhabits woodlands due to its preference for shade; it can also be found on the interface (ecotone) between woodlands and savannahs. Places near water sources are preferred. In southern Africa, populations tend to be associated with Colophospermum mopane and Acacia woodlands.

Impalas are herbivores (folivores). As grazers, these antelopes consume grass, while as browsers, they feed upon wide variety of vegetation, including fruits, seedpods, shoots as well as leaves of trees and bushes.

Most impalas are currently not endangered, about two million impala live in the wild or on private land today. About one quarter of these live in protected areas in Botswana, Kenya, South Africa, Tanzania, Zambia, and Zimbabwe.Oct 21, 2023

#Akagera National Park #Kayonza #Rwanda #Africa #Wildlife #RwandaWildlife #Impala #Antelope #Aepyceros melampus

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metamoonshots · 6 months

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[ad_1] Railroad big CSX Corp. on Thursday stated it anticipated the subdued delivery developments it noticed within the third quarter to proceed for the remainder of the yr, as retailers keep cautious on the gadgets they get shipped to their warehouses and shops. Executives made these remarks to debate combined third-quarter outcomes for the corporate, whose rail traces cowl a lot of the jap U.S. They usually comply with what one analyst stated had been “low expectations” for the rail business, as greater costs for important items go away much less room for client spending on different merchandise that will get shipped by rail. “Retailers stay involved concerning the well being of the patron, and although destocking could have slowed, we haven’t seen this flip into sustained will increase so as charges or imports,” Chief Business Officer Kevin Boone stated on CSX’s CSX, -0.42% earnings name. Nevertheless, he stated he noticed the corporate’s home enterprise “progressively strengthening” for the remainder of the yr. The shift in demand final yr towards fundamentals left retailers caught with warehouses and stockrooms filled with issues like clothes, TVs and electronics that they couldn’t promote with out chopping costs. Since then, shops have been extra conservative on what they order and have shipped. Trucking and transport-services supplier J.B. Hunt Transport Inc. JBHT, +0.08% on Tuesday said that while there were signs of positive trends, “we aren't at some extent but to say we’re out of the freight recession.” CSX reported third-quarter web earnings of $846 million, or 42 cents a share, in contrast with $1.11 billion, or 52 cents a share, in the identical quarter final yr. Income fell to $3.57 billion from $3.89 billion within the prior-year quarter. Analysts polled by FactSet anticipated CSX to report adjusted earnings of 43 cents a share on income of $3.55 billion. Gross sales had been hit by less-frequent connections with different types of transportation to haul items to completely different places. These connections, generally known as “intermodal” shipments, remained “challenged,” Chief Govt Joe Hinrichs stated in an announcement. The corporate shipped extra coal, however coal costs fell, it stated. Nevertheless, it additionally reported “strong positive factors in merchandise pricing.” And through the name, it stated it had been “profitable in changing site visitors off the freeway in a market dealing with plentiful truck capability.” Rails and vehicles compete for shipments, with the latter dealing with a downturn in demand and costs, leaving extra trailers ready to be stuffed. Shares of CSX fell 0.9% in after-hours commerce. CSX reported outcomes after its western U.S. counterpart, Union Pacific Corp. UNP, +2.14%, put up a third-quarter profit that topped analysts’ expectations, regardless of a lower in railcar shipments and “continued inflationary pressures.” Citi analyst Christian Wetherbee stated Union Pacific’s outcomes marked a “strong begin to rail earnings towards low expectations.” The outcomes for each rail carriers arrive because the delivery business tries to rebound after supply-chain disruptions through the pandemic, after a surge in on-line shopping for caught the world’s distribution networks off-guard and drove costs and income greater. Issues since have additionally grown over rail security, following Norfolk Southern’s NSC, -1.65% derailment in Ohio earlier this yr, and rail service, after years of chopping prices and guarding income led to longer cargo instances. Main rail operators say they’re making an attempt to employees up and enhance service. However after a rail-worker strike was averted final yr, labor tensions have lingered via this yr as rail operators and unions tried to resolve variations over day off and sick go away, which employees stated was deeply inadequate.

Forward of the earnings, CSX on Thursday introduced the ratification of a paid sick go away settlement with a railroad signalmen union that coated almost 400 workers. BofA analysts final month upgraded CSX shares to a purchase, after the corporate named Mike Cory, an business veteran, as chief working officer. The analysts stated Cory was an operations protégé of Hunter Harrison, a rail government, generally known as an business turnaround artist, together with at CSX. Shares of CSX are up 2% to date this yr. [ad_2]

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hauntedsharkstrawberry · 1 year

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Protestant missionary in Japan, shared with his predecessors an interest in the development and decline of the first Japanese mission during the preceding three and a half centuries. His history of Christianity in Japan6 is worth citing because its discussion of missionary failure considered also the changing political and economic environment of European- Japanese diplomatic relations. Like his ecclesiastical contemporaries, however, Cary was unable to revise the written observations of early modern Roman Catholic correspondents. In the same decade as the monographs of Haas and Cary, a more comprehensive history appeared in print. A History of Japan during the Early Foreign Intercourse is the second volume of James Murdoch’s three-volume history.7 In an attempt to revise the ecclesiastical approach that had been dominant since Charlevoix, Murdoch consulted not only European documents but also Japanese sources. For this demanding endeavour, he sought help from his Japanese colleague Isoo Yamagata. Murdoch’s secular background also escaped glorification of the Christian converts. To a considerable extent, he examined non-religious incidents in politics and international relations when discussing the mission. Consequently his monograph placed greater emphasis on political relations between missionaries and the Japanese authorities.

Specialists in Ecclesiastical Archives in the Twentieth Century It was only after the 1920s that German historians began to investigate the Japanese mission. These historians, who never visited Japan, let alone lived there, formed part of a third group. They uncovered new archival missionary sources. Among this group is the Franciscan Father Dorotheus Schilling (1886–ca.1960s) and two Jesuits, Georg Schurhammer (1882–1971) and Josef Franz Schütte. While sharing Christentum (Leipzig: J. C. Hinrichs, 1922), Buddha in der abendländlichen Legende (Leipzig: J. C. Hinrichs, 1923). His interest in Japan grew to include the Ainu in his Die Ainu und ihre Religion (Leipzig: A. Deichert, 1925). 6 Otis Cary, A History of Christianity in Japan: Roman Catholic, Greek Orthodox, and Protestant Missions (2 vols., New York: Fleming H. Revell, 1909; reprint in 1976 as one volume by Tuttle in Ruthland, Vermont, & Tokyo, Japan). 7 James Murdoch and Isoh (sic) Yamagata, A History of Japan during the Century of Early Foreign Intercourse (1542–1651) (Kobe: Kobe Chronicle, 1903). He first published this work as an independent monograph. He later expanded his work into three volumes. He published a book on the previous period of Japan as the first volume of A History of Japan in 1910. Although he passed away before seeing a printed copy of the third volume which dealt with the years 16

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lomahivohop · 2 years

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Statistik handbuch

STATISTIK HANDBUCH >> DOWNLOAD LINK vk.cc/c7jKeU

STATISTIK HANDBUCH >> READ ONLINE bit.do/fSmfG

Handbuch der Geographie und Statistik, Volume 4. Front Cover · Christian Gottlieb Daniel Stein, Ferd Hörschelmann. Hinrich, 1854. Das Handbuch der Essener Statistik ermöglicht einen breiten inhaltlichen und des Handbuches der Essener Statistik als Gesamtdokument aufzurufen. Handbuch Statistik, Methoden und Evaluation. herausgegeben von Heinz Holling, Bernhard Schmitz. Reihe: Handbuch der Psychologie - Band 13. Handbuch Der Vergleichenden Statistik Der Völkerzustands-Und Staatenkunde: Für Den Allgemeinen Praktischen Gebrauch (Classic Reprint): Kolb, SPSS - Umfassendes Handbuch zu Statistik und Datenanalyse. ISBN: 9783958456686. von Felix Brosius 8. Auflage 2018 1176 Seiten. Buch 15,00 € Sofort lieferbar. Der Statistik der BA ist es wichtig, den Partnern im Meldeprozess und den Nutzern der Statistiken möglichst weitgehende Transparenz über alle wesentlichen Handbuch der Geographie und Statistik für die Gebildeten Stände Band 1. Abtheilung 1: Stein, Christian Gottfried Daniel, Hörschelmann, Ferd: 9785519209373: Vollst Ndiges Handbuch Der Neuesten Erdbeschreibung Und Statistik by Hassel Georg from Flipkart.com. Only Genuine Products. 30 Day Replacement GuaranteeHandbuch der Statistik. Front Cover · Maurice Block. Veit, 1879 - Statistics - 344 pages. 0 Reviews. Reviews aren't verified, but Google checks for and

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xtruss · 2 years

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Eye-Catching Cancer Drug Trial Results Have Researchers Asking: What’s Next?

— By Kim Bellware and Lenny Bernstein | June 10, 2022 | The Washington Post

Christian Hinrichs, an investigator at the National Cancer Institute, shows patient Fred Janick, a survivor of metastatic cancer, the difference between his CT scan showing cancerous tumors, right, and a clean scan after treatment in Bethesda, Md., on Feb. 8, 2018. (Saul Loeb/AFP/Getty Images)

After a small cancer drug study yielded the unprecedented result of 100 percent of participants entering remission, oncologists — and patients — wonder if the approach from the experimental drug trial can apply to other types of cancer.

The study out of Memorial Sloan Kettering Cancer Center in New York has oncologists excited over the prospect that immunotherapy, the treatment type used in the trial, has increasingly shown effectiveness — without surgery — against tumors with a specific abnormality. All of the trial’s participants had tumors with the abnormality known as mismatch repair (MMR) deficiency, a mutation that occurs in between 5 and 10 percent of rectal cancer cases and is also present in endometrial, bladder, breast and prostate tumors.

Though the trial was tested in patients whose tumor mutation is present in roughly 4 percent of all cancer cases, the results provide a template for how to tailor immunotherapy drugs to attack specific tumors that, due to their mutation, tend to be more resistant to traditional therapies, according to Julie Gralow, chief medical officer and executive vice president of American Society of Clinical Oncology.

“That’s the promise of this: It’s really the concept of being able to match a tumor, and the genomics of what’s driving it, with a therapy,” Gralow told The Washington Post on Thursday. “Because we can move this beyond just this subset of rectal cancer.”

The Sloan Kettering trial, which began in late 2019, took 18 early-stage rectal cancer patients with the same tumor mutation who had no prior treatment and gave them the drug dostarlimab every three weeks for six months. Tumors completely disappeared in all 14 patients who had completed the treatment by the time the study published (four more remain on track with similar results), and none have required follow-up treatment.

The results mark the first time immunotherapy alone eliminated the need for chemotherapy, radiation or surgery, which can cure patients but leave them with life-altering effects like infertility, bowel and sexual dysfunction or permanent reliance on a colostomy bag.

The study authors note the earliest patient to complete the trial is more than two years post-treatment, and all patients will be monitored for at least five years to ensure no tumor regrowth or reemergence.

Scott Kopetz, a professor of gastrointestinal medical oncology at MD Anderson Cancer Center in Houston, called the study “a solid advancement in the field” and described the way immunotherapy has been used to treat MMR deficient tumors as “absolutely game-changing.”

“The idea of using immunotherapy in patients that have localized early stage colorectal cancers certainly has been gaining momentum,” he said. The new study “provides recognition that if we can get the immune system properly engaged … we can eradicate” those cancers.

Even cancers in advanced stages have shown sensitivity to drugs like the one used in the trial. Known as “checkpoint inhibitors,” the drugs block a specific cancer cell protein that can cause the immune system to hold back its cancer-fighting response rather than identify and eradicate the cancer. Once eradicated for a number of years, the cancers rarely return, Kopetz said.

Data from other research show 70 percent of people with metastatic colorectal tumors treated with immunotherapeutic drugs to be cancer-free five years later, he said, a huge advance in treatment for a terrible disease. Metastatic cancers are even more difficult to treat than tumors that are confined to the rectum or colon.

The study does come with caveats. Kopetz and others cautioned that six months is not long enough to know whether the patients will remain permanently cancer-free. These drugs often need to be taken for a year or two before patients can come off them and remain confident that their cancer has been eliminated, he said. Unlike chemotherapy and radiation, however, the drugs are usually well-tolerated during that period.

Perhaps more importantly, the genetic defect in these patients’ tumors that allows the drugs to be so effective, is much less common in other forms of cancer than in colon and endometrial cancers. So a person with a lung or brain cancer that lacks that defect would have a much lower chance of this kind of cure, Kopetz said.

David Ryan, the director of clinical oncology at Massachusetts General Hospital, previously told The Post that while the treatment used in the trial could become more widely available, not everyone who can receive the treatment will have access to the specialists who will help monitor patients like the trial participants and intervene if tumors come back.

“We do worry that if recurrences happen, that they have to be picked up as soon as possible to give people the best chance,” Ryan said.

Gralow, of ASCO, said the study affirms that the future of cancer treatment is a narrower approach based on cancer type, such as a tailored plan that addresses the specific characteristics of a tumor.

“I’m excited when you see such a dramatic response,” she said of the trial results. “It gives me hope we can find such a dramatic match for other cancers, too.”

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evoldir · 2 years

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Fwd: Conference: Kiel.SMBEsatelliteEvolutionaryRescue.Sep11-14

Begin forwarded message: > From: [email protected] > Subject: Conference: Kiel.SMBEsatelliteEvolutionaryRescue.Sep11-14 > Date: 9 May 2022 at 05:19:14 BST > To: [email protected] > > > SMBE Satellite Meeting on Evolutionary Rescue > Kiel University, Germany, 11-14 September 2022 > > Conference website: https://ift.tt/47RpFxy > > We are currently living in the Anthropocene and thus an era shaped by > human impact. The environmental conditions imposed by these human-driven > rapid environmental changes exert selective pressure on natural systems > and can result in an evolutionary mismatch between slowly evolving > organisms and their new environment, and rapid adaptation of many > short-lived species. Evolutionary rescue, which occurs when populations > subjected to stress avoid extinction by adaptation through natural > selection, is relevant to both consequences: it can help to overcome the > evolutionary mismatch and is at the basis of rapid evolution of pathogens. > > In this SMBE Satellite meeting we aim to focus on evolutionary > rescue in three main fields: species conservation, agriculture, and > medicine. These three main fields currently face unforetold challenges > due to evolutionary processes invoked by the dramatic human-mediated > changes of the Anthropocene, including: > > - Risk of species extinction and thus dramatic reductions in > biodiversity due to an evolutionary mismatch caused by climate change, > globalization, and pathogen evolution > - Risk of dramatic yield reductions in food production due to an > evolutionary mismatch caused by climate change, globalization, and > pathogen evolution > - Major threats to human health because of rapid pathogen evolution and > increased pathogen spread due to globalization > - Rapid evolution of pathogens, parasites, and pest species and > especially fast evolution of resistance to chemotherapy and pesticides > > By incorporating diverse perspective from multiple fields, we hope to > identify knowledge gaps and putative novel research directions in the > context of evolutionary rescue in the Anthropocene. > > FIRST CALL �" ABSTRACTS AND REGISTRATION > > Early bird registration and abstract submission deadline: 20 June 2022 > Registration deadline: July 4 > Registration for virtual attendance: August 29 > > Contributed talks will be selected from among the submitted abstracts. > Travel fellowships are available upon application. > > CONFIRMED SPEAKERS: > Richard Gomulkiewicz, Washington state University > Helen Alexander, University of Edinbourgh > Matt Osmond, University of Toronto > Moi Expósito-Alonso, Stanford University > Rachel Morgan, Bergen University > Hildegard Uecker, MPI Evolutionary Biology Plön > Reid Brennan, Geomar Institue > Hinrich Schulenburg, Kiel University > Brendan Bohannan, Oregon University > Yaara Oren, Broad Institute > > Looking forward to welcome you in Kiel, > > Tal Dagan > Reid Brennan > Hildegard Uecker > > > > > > Prof. Dr. Tal Dagan > > Genomic Microbiology Group > Institute of Microbiology > Christian-Albrechts-University Kiel > ZMB, Am Botanischen Garten 11 > 24118 Kiel, Germany > > Tel: +49 431 880 5712 > Fax: +49 431 880 5747 > e-mail: [email protected] > web: www.uni-kiel.de/genomik > > Tal Dagan > via IFTTT

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one-flower-blue · 6 years

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Kieler Schloss, 1860

#kiel #history #19th century #architecture #christian hinrichs #stadtarchiv kiel #castle

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cinematografieliebhaber · 4 years

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Die Tote in der Sommerfrische - Ein Seebad-Krimi von Elsa Dix ist der erste Kriminalfall für Viktoria Berg und Christian Hinrichs. Der Krimi spielt in den 1910er Jahren auf der deutschen Nordseeinsel Norderney. Viktoria Berg ist eine unabhängige junge Frau und angehende Lehrerin, Christian Hinrichs ist ein, aus der Arbeiterklasse stammende Journalist. Beide sind gefangen in den Zwängen ihrer Klassen, wollen einen Mord aufklären und müssen sich über ihre Gefühle klar werden.

#1910er #Belle Époque #Christian Hinrichs #Deutschland #Elsa Dix #featured #Goldmann #Kaiserreich #Mord #Norderney #Sommerfrische #Viktoria Berg #Bücher

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fraugoethe · 2 years

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Leichen im Eiskeller

Endlich geht es zum 3. Mal mit @Elsa Dix in die #Sommerfrische nach #Norderney. Viktoria und Christian sind auch da und müssen schon wieder gemeinsam ermitteln. 1913 konnte man zum Transport sogar einen #Zeppelin wählen (erschienen im @Goldmann Verlag).

Die kalte Mamsell von Elsa Dix Norderney, 1913. Viktoria Berg ist erneut auf der Nordseeinsel. Ihr Vater erholt sich von einem Herzinfarkt und sie nutzt die Chance, Christian Hinrichs wiederzutreffen. Die beiden hatten sich bereits zwei Mal im Seebad getroffen und beide Male gab es etwas zu ermitteln. Inzwischen hat der Journalist seinen Wirkungskreis gewechselt und ist nun Kriminalassistent. Er…

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#Christian Hinrichs #Norderney #Nordsee #Seebad #Sommerfrische #Viktoria Berg

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prolifeproliberty · 2 years

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History of the Advent Wreath

It’s the first Sunday in Advent! This is New Year’s Day for Christians - it’s the first Sunday of the Church Year.

Advent is a solemn time of preparation for the four weeks leading up to Christmas. Liturgical colors are often either blue (for Mary) or purple (for repentance).

One traditional way of marking the season is an advent wreath. Advent wreaths can take many forms, but today the standard one looks something like this:

Each Sunday in Advent, one of the outer candles is lit. So one candle the first Sunday, two the second Sunday, and so on. The center candle is lit on Christmas Day.

Each candle has a different meaning:

Week 1 (purple): hope

Week 2 (purple): peace

Week 3 (pink): joy

Week 4 (purple): love

Christmas Day (white): Christ (this candle is called the Christ Candle)

The whole wreath is lit during the Christmas season, which begins on Christmas Day and lasts until Epiphany (January 6th).

The concept of the Advent wreath began in the 16th century among German Lutherans and Catholics, but our modern wreath developed in the 19th century with Pastor Johann Hinrich Wichern, who used it to help schoolchildren count down to Christmas. That wreath looked something like this:

Shortly after, the wreath became popular among many Christian churches in Europe, evolving into the wreath we know today.

Have a blessed Advent everyone!

#advent #advent wreath #advent candles #Catholic #Lutheran #traditions #Christmas

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mariberlyn · 5 years

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8 Tage: Feiern bis zum Weltuntergang

Die Ankündigung machte mich neugierig: Eine neue deutsche Serie von Sky, die von den letzten acht Tagen vor dem Weltuntergang erzählt: Ein Asteroid rast auf die Erde zu. Aufgrund seiner besonders lichtabsorbierenden Oberfläche hatte man ihn nicht kommen sehen. In vorletzter Minute wird versucht, ihn mit Atomraketen vom Kurs abzubringen, aber das Manöver misslingt. Für die Menschen in Europa, wo…

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#8 Tage #Christiane Paul #Deutschland #Devid Striesow #Endzeit #Fabian Hinrichs #Henry Hübchen #Kritik #Luisa-Céline Gaffron #Mark Waschke #Nora Waldstätten #Serie #Sky #TV

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belovedarise · 3 years

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What is Advent?

Advent is a season of waiting for the birth of Jesus on Christmas day. It's often an underrated and overlooked way to experience a deeper meaning of Christmas. Just as the season of Lent helps us to prepare for the full impact of the resurrection on Easter, Advent is a way for people to brace their spirits for the incarnation (God becoming a human) on Christmas. Swipe through for some more info on Advent!

First of all Advent is the beginning of the Liturgical Year on The Church Calendar which is also an often overlooked and underrated way for Christians to engage their faith. The Liturgical Year includes scripture readings, feast days, traditions, music, food and all sorts of traditions that unites Christians from all over the world regardless of their denomination or background as they follow these yearly rhythms together.

Practices like Advent and following the Liturgical Year are particularly important to us at Beloved Arise because we are an ecumenical Christian organization. Ecumenical is a fancy way of saying that we include all Christian expressions; we aren’t associated with any one particular denomination. One way we see this expressed every week is at our virtual youth group where we have Baptists, Pentecostals, Presbyterians, “Non- Denoms”, Catholics, and many more participating in our weekly virtual youth group. Collectively following The Liturgical Year connects us to our more ancient roots instead of focusing on some of the more modern expressions of Christianity that sometimes divide us.

But wait! Isn’t this supposed to be a slide guide about ADVENT!? Yes- we just wanted you to have some brief backstory and context before moving forward.

The word advent can be translated as “coming” or “arrival” and observing this season (which starts on November 29) is about anticipating the arrival of Jesus. On a more meta level it can also be about anticipating the arrival of Christ our hearts and the second coming of Jesus.

Christians from around the world celebrate Advent in a variety of ways that you probably already engage in as part of the Christmas season. Putting up a Christmas tree is traditionally a part of advent along with daily readings, special music, and even a designated traditional color- PURPLE. In many Churches around the world sanctuaries and pastors will be decked out in purple which is a royal color and is yet another way to anticipate the coming of the Prince of Peace- Jesus. There are many resources for daily advent readings, but here is one we would recommend: https://lectionary.library.vanderbilt.edu/daily.php?year=B

These days one of the most common ways of celebrating Advent is to light an Advent wreath. Advent wreaths are actually a fairly new tradition as far as Christianity is concerned. The modern Advent wreath was conceived of by a German pastor named Johann Hinrich Wichern in 1839 and involves the lighting of a different candle each Sunday along with daily readings. The Advent wreath is loaded with symbols and meaning that we encourage you to look up, but the most obvious symbol is the slow steady emergence of light in darkness.

Advent traditions and celebrations are just like Christmas traditions in that there is always a surprising depth and richness to these practices that get lost in the modern commercialization of our sacred traditions. There is a deep well of traditions and practices to help guide your experience of Advent that will most likely enhance your experience of Christmas, but we are also invited to add our own traditions to this season as well. Whatever you can do during this time to cultivate a sense of waiting and anticipation for the celebration of the birth of Christ is a way for you to more deeply engage with the spirit of the season and join the global Church in a yearly practice.

Beloved Arise wants to invite you to join us this year in observing Advent. Let’s collectively join together in anticipation of Emmanuel- God with us. It is this message of hope that fuels our call to spread a message of hope and affirmation to queer youth of faith all over the world. God’s love is for everybody and ultimately the message of Christianity is that God broke through the forces of darkness and evil to communicate to spread hope and love to every human and that’s the message that we exist to amplify.

We’d like to conclude this slide guide on Advent with an Advent poem from Rowan Williams who was the Archbishop of Canterberry from 2002 to 2012.

He will come like last leaf’s fall.

One night when the November wind has flayed the trees to bone, and earth wakes choking on the mould, the soft shroud’s folding.

He will come like frost. One morning when the shrinking earth opens on mist, to find itself arrested in the net of alien, sword-set beauty.

He will come like dark. One evening when the bursting red December sun draws up the sheet and penny-masks its eye to yield the star-snowed fields of sky.

He will come, will come, will come like crying in the night, like blood, like breaking, as the earth writhes to toss him free. He will come like child.

To view this in slide guide form, go here.

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