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sebstanaddict · 2 years

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Always You

Chapter 22 - Dying To Be Alive

Summary : A love story chronicling the love and life of Sebastian Stan and Female!Reader. Inspired by Sebastian Stan's recent love life.

In this chapter we'll find out what happens to reader after Sebastian was told that her condition had gotten worst overnight

Pairings : Sebastian Stan x Female!Reader

Chapters: 22 / 25 (added chapter count as I wrote more)

Chapter List >

Warning : angst, grief, fluff

Word count : 5.7k

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I'm dying to be alive yeah

Lets not go through our lives

Without just dying to be alive

The people you've touched

They way you've touched them

I hope they've touched you too.

'cause in this life, its hard to tell

What's false and what is true yea

We're all on the ground just cryin' out

Would somebody save me please

I won't sit around just thinking about

The troubles that tomorrow brings

And we all come tumbling down

No matter how strong

We all return to the ground

In the days to come you'll say why did I wait

You can't just leave your life up to fate.

You've gotta turn it around before it's too late.

Dying to be Alive - Hanson

-----

The Brooklyn Hospital Center, Brooklyn, New York - March 2022

When Sebastian arrived in front of the ICU, dr.Jake was there waiting for him. His heart beat faster as he saw him. He braced himself and got ready to hear the worst.

"Doctor.. how is she?" Sebastian asked.

"Mr.Stan, Ms. Y/l/n's oxygen saturation went as low as 90% last night. It seems the antibiotic we gave her didn't work as well as we had hoped. She had fluid build up in her lungs and we had to drain them." dr.Jake explained.

"Oh.. So, what do we do now? How can we help her?" Sebastian asked, his heart plummeted as he listened to the doctor.

"I've prescribed a different antibiotic for her. And I would like to suggest to put her on CPAP to help increase her oxygen saturation." dr.Jake continued.

"What's a CPAP doctor?" Sebastian asked.

"CPAP is short for Continuous Positive Airway Pressure. It's a machine that provides positive pressure of air through a mask and into the airway, which helps to keep the airway open. It will hopefully help increase the level of oxygen in her lungs. It's our last resort in order to avoid putting her on a ventilator. If you put her on a ventilator, we have to sedate her and put her to sleep because it will be very painful. So it's better if we can avoid that." dr.Jake explained.

"Oh I see.. I didn't know about the ventilator. The CPAP.. it will not hurt her, will it?" Sebastian asked.

"No, we'll just put a mask that will cover her mouth and nose." dr.Jake said.

"Okay. If you think putting her on CPAP will help her, then please do it." Sebastian said.

"Alright. We'll put her on it as soon as possible. And one more thing Mr.Stan, I would also like to suggest to give her a transfusion of convalescent plasma. I originally hoped that we didn't have to give it to her. But as I see her progress, I believe it's needed for her." dr.Jake said.

"Convalescent plasma?" Sebastian asked in confusion.

"Yes, it's blood plasma collected from patients who have recovered from Covid. It has the necessary antibodies that can help suppress viral replication of the virus." dr.Jake explained.

"Oh I see. Well if you think it will help her, please give it to her." Sebastian said.

"Alright Mr.Stan. We'll put her on CPAP and put in a request for the convalescent plasma." dr.Jake said.

"Thank you doctor. What about the baby? Is she okay?" Sebastian asked.

"We've checked with a doppler ultrasound and she seems to be in a little distress. Which is why we need to put Ms.Y/l/n on CPAP as soon as possible. We don't want her to go into preterm labour." dr.Jake said.

Sebastian's heart sank into his stomach as he heard what the doctor had to say.

"Oh okay. Yes, please put her on CPAP as soon as possible." Sebastian said.

"Will do, Mr.Stan." dr.Jake said, nodding his head.

"Can I.. can I see her?" Sebastian asked, his voice shook as he tried to control his emotion.

"We're currently having her do proning position to help with her breathing. You may see her while we prepare the CPAP machine." dr.Jake said.

"Thank you doctor." Sebastian said.

Moments later Sebastian stood by Y/n's side wearing a hazmat suit and protective gear while holding her hand tight. She was lying on her left side, trying to take deeper breaths. Sebastian glanced at the pulse oxymeter on her finger that showed her current oxygen saturation. It was showing 92%, not high enough to keep their baby comfortable.

"Seb.." Y/n called out.

"Yes, honey. I'm here.." Sebastian said, picking her hand up and kissed it from behind his N95 mask.

"It.. hurts.. to.. breathe." She said slowly.

Sebastian felt like a dagger had pierced his heart as he listened to her. He wished he could take all the pain away from her. Let him take her place instead. He deserved it after all. It was him who messed up but why did Y/n and his baby had to suffer the consequences.

"Oh sweetheart, hang in there.. you're doing great. Dr.Jake is preparing a CPAP machine that can help you breathe better, okay? Don't you worry, sweetheart, everything is going to be okay." Sebastian said, squeezing her hand tight.

He said it to comfort her but he also said it to comfort himself. To be honest he wasn't sure how things would turn out for her. Just yesterday it seemed she and his baby was doing fine, but just over night her condition suddenly became worst. He tried so hard not to think of the worst. He couldn't. He couldn't deal losing her or his baby.

"I'm.. sorry.." Y/n said in between her breaths.

"Baby, why are you saying sorry? It's me who should be saying sorry. I messed up. I really did." Sebastian said, tears started to fall from his eyes, making his mask wet.

Y/n smiled and looked up at him. She noticed that he had started to cry.

"Don't.. cry.. Seb.. I.. love.. you.." she said.

"I love you too, Y/n.. my love." Sebastian said, stroking her hand gently as he tried to blink back tears from his eyes. He had to be strong. For her and for their baby. He wasn't going to let himself cry in front of her again. He wiped the tears from his eyes with his hand and took a deep breath.

"I wish I could kiss you.. " he murmured, making Y/n smiled.

"I wish.. that.. too.." she said as she reached her hand out to touch his face shield.

Just then dr.Jake came into the room accompanied by a male nurse behind him. The male nurse were pushing what Sebastian suspected to be the CPAP machine.

"Mr.Stan, I'm sorry but we're going to put the CPAP on her. Would you please wait outside?" dr.Jake said.

"Oh okay. Sure." Sebastian said, releasing Y/n's hand from his grip.

"No..Seb.. can't he.. stay here..please.." Y/n said, pleading as she reached her hand to Sebastian's hand and held it close to her.

"I'm sorry Ms.Y/l/n. We need to focus as we put the CPAP mask on you. It's better if he stays outside. We'll let him back in once we're done. Okay?" dr.Jake said.

"Okay.." Y/n said dejectedly.

"It's okay, sweetheart. I'll be right outside. You can still see me." Sebastian said and Y/n nodded slowly.

He kissed her hand again and stroked her cheek gently. Then he reluctantly left her side to wait right outside the isolation room.

As he watched the doctor and his team put on the CPAP mask on her, he continuously offered a prayer in his heart. He was never much of a religious person. But he had never felt so powerless like he did that day.

"Dear God, I know you're out there and can listen to my prayers. I'm sorry if I haven't been close to you. I promise I will. Please safe Y/n, please safe my baby girl. They deserve to live. They deserve to be happy.. I don't know what I would do if I lose them. Please God.. please.. " Sebastian prayed. He held both his hands in front of him, his head bowed down as tears fell down freely from his eyes, soaking his mask.

It didn't take too long for dr.Jake to put the CPAP mask on Y/n and set the machine. After he was done he went out of the isolation room to meet Sebastian.

"Mr.Stan, as you can see we've put on the CPAP mask on her. So far it has helped increase her oxygen saturation. It's at 94% now." dr.Jake said.

"Oh thank God. Thank you doctor." Sebastian said, hope started to fill his heart.

"I suggest not to have her talk too much. It's hard for her to talk anyway because of the mask. And she needs to rest." dr.Jake said.

"Alright doctor. But is it okay if I stay here?" Sebastian asked.

"Yes but not too long. I can give you an hour but after that we need you to stay outside. You can visit her again this afternoon." dr.Jake said.

"Oh okay. Thank you doctor. What about the plasma?" He asked.

"We've put in a request through the blood bank because we don't have it available here. We haven't received a confirmation yet from the blood bank. We'll let you know as soon as we do." dr.Jake said.

Sebastian's heart plummeted again as he heard the news from dr.Jake.

"Oh alright. I hope we can get it as soon as possible. Is there anything I can do to help make the process faster? In case the blood bank doesn't have it maybe I can announce it on my social media account. I'm sure someone out there can help." Sebastian asked.

"I'm sorry Mr.Stan, I wouldn't recommend getting plasma through social media. We don't know for sure if they're of good quality or not. The ones provided through the blood bank have been screened to make sure they have a high titer count of the Covid antibody. They've also been screened against infectious diseases like AIDS. So I suggest we just wait for the response from the blood bank." dr.Jake explained.

"Oh..okay..yeah..I didn't realize that. Thanks doctor. Would you please let me know immediately once they've responded?" He asked.

"Of course Mr.Stan. Well, if there's nothing else, would you please excuse me." dr.Jake said.

"Okay. Thank you doctor.. for everything." Sebastian said.

"Of course Mr.Stan." dr.Jake nodded then left him alone in front of the door to the isolation room.

As soon as dr.Jake left, Sebastian pushed the button to open the door of the isolation room. He went inside and walked slowy to Y/n's side. Y/n was lying on her back again. Her mouth and nose were completely covered with the CPAP mask. A tube was inserted into one of her nose. He wondered what the tube was for. It seemed familiar to him but he couldn't place it. A nurse was standing on Y/n's other side, checking the pulse oxymeter on her finger. It was showing 95% much to Sebastian's relief.

"Well your oxygen saturation is at a good level Ms.Y/l/n.. that's great to see." The nurse said while writing on Y/n's medical record.

Y/n put up a thumb up to the nurse and nodded at her.

"Well, I better leave you two. I'll be back in an hour with your breakfast." The nurse said.

"Thank you, nurse." Sebastian said.

"Please just call me Stacy." Nurse Stacy said.

"Alright, Stacy. Thank you." Sebastian said, nodding his head at her.

"You're welcome Mr.Stan." Nurse Stacy said then she left the isolation room, giving Y/n and Sebastian some privacy. Sebastian reached out and held Y/n's hand and caressed it gently.

"How are you feeling, sweetheart? Can you breathe better?" He asked.

Y/n just nodded and put her thumb up.

"Good.. I'm glad." He said, taking a seat on a chair next to the bed.

Y/n then reached out her hand to his and put it on her stomach. Sebastian could immediately feel fluttering movement on her stomach. His baby seemed to be restless.

"Little bean.. how are you today? It's daddy.. don't worry okay? You just stay there and be comfortable. It's all going to be okay." He caressed her stomach gently, leaned down and spoke near Y/n's stomach, hoping his baby could hear him. As soon as he finished speaking, the fluttering movement subsided.

"She heard me, sweetheart.." he said in awe.

Y/n squeezed his hand and nodded and gave him a wide smile. He couldn't believe how responsive their baby was to him. He continued caressing her stomach gently, hoping his touch would soothe their baby and helped make her more comfortable.

"You know, I think it's time for us to start thinking of baby names now that we know we're having a baby girl." Sebastian said.

Y/n's eyebrows furrowed and she shook her head.

"Why not, sweetheart? I'll Google some baby girl names and say them and you can nod if you like it or shake your head if you don't like it." He suggested.

Y/n finally nodded her head after a while.

"Okay. Wait." Sebastian said as he pulled out his cellphone from a pocket on his hazmat suit.

After browsing on his cellphone for several moments, he finally stopped.

"Okay.. Anastasia?" He asked.

Y/n shook her head.

"Yeah no, that's my godmother's name." Sebastian said, shaking his head. He then proceeded to say baby girl names in alphabetical order while Y/n listened.

"Alexis? Amelia? Angelica? Aurora?" He asked.

Y/n shook her head on all of them.

"Bianca? Bree? Catalina? Christine? Claire?" He continued but Y/n kept shaking her head.

"Romanian.." she finally said from behind her mask.

"Oh.. you want Romanian names?" Sebastian asked, touched that Y/n would consider it at all. She nodded and smiled.

"Okay, let me take a look." He said as he changed his search on Google into Romanian girl names.

"Alina? Adelina? Andrea? Antonia? Aurelia?" Sebastian asked.

Y/n shook her head but reached out to hold his hand when he reached Aurelia and nodded.

"Aurelia huh? Well it means gold." He said, furrowing his brow.

"I don't know, baby, it's beautiful but maybe we should keep it now and consider other names too." He said, looking up at her expectantly.

Y/n nodded in agreement and squeezed his hand, encouraging him to continue.

"Okay. Let's see. Crina? Dorina? Elena? Felicia? Iona? Luminita?"

Y/n shook her head but squeezed his hand and nodded when he reached Luminita.

"Luminita?" Sebastian asked and Y/n nodded.

"Well it means little light. I love it. Let's keep it too." He said, nodding his head. He then continued saying many Romanian girl names. They ended up liking three other names which were Sorina meaning sun like, Starlene meaning star and Ylenia meaning light.

"Honey, I'm happy that you would name our baby with Romanian names, really I am. But maybe we should also consider names from other languages. You know? Like.. I feel she's a miracle, coming to us in such an unexpected moment and becoming a light for us in the midst of all the crazy things happening in my life. So.." he trailed as he consulted his cellphone.

"How about Mirielle or Nasya? Both means miracle." He said, looking at her, and studying her, hoping she would agree.

Y/n smiled and nodded.

"I.. love.. them." She said slowly.

"Okay, I'm glad you do, honey." Sebastian said, smiling from behind his mask as he stroked her cheek gently.

"Let's keep all the names we've liked for now and decide later on." He said and she nodded in agreement.

He turned his cellphone screen off and returned it to the pocket on his hazmat suit. He then held both her hands in his.

"I still can't believe we're gonna be parents." He said.

"Yeah." Y/n responded and nodded.

"There's no one else in this world I'd rather do this with but you, honey. So, I'm grateful. I'm so happy I'm with you. And whatever is in front of us, good or bad, we'll handle it together. Everything is gonna be okay as long as we have each other." Sebastian said as he gently caressed the side of her face with his hand.

"I know.. Seb.. I know.." Y/n said, smiling at him.

Just then nurse Stacy came back, bringing a tray with two large glasses on it. One was filled with water and the other one was filled with white liquid that seemed to be milk.

"Hello Ms.Y/l/n. It's time for your feeding." She said cheerfully.

"Is that all you're going to give her?" Sebastian asked, dumbfounded.

"Yes Mr.Stan. With the CPAP mask on we can only give her food through the Nasogastric tube through her nose. So she can only have liquid food." Nurse Stacy explained.

"Oh I see." Sebastian said, his heart ached realizing how much sacrifice Y/n had to endure. He realized then what the tube that was inserted through her nose was for.

He watched as Nurse Stacy started to feed Y/n through the Nasogastric tube. Y/n grimaced as the white liquid was pushed with a large syringe through the tube and into her nose. She involuntarily swallowed as the liquid passed her throat and entered her stomach. She looked at Sebastian and smiled but he didn't return it. Sebastian's heart sank as he watched her. He was suddenly reminded of the time when he saw his grandmother being fed through a Nasogastric tube at a hospital in Romania as she battled with her illness. A couple of days after he saw her, his grandmother passed away.

He blinked back tears as the painful memory emerged in his mind. He couldn't stay any longer. He needed to get out. It was too much for him. He tried to be strong for Y/n, for his baby girl. But the sight of her being fed through the Nasogastric tube made him realize he could lose her too, just like he had lost his grandmother.

"Sweetheart.. I'm sorry.. I..uh..need to go to the restroom. I'll see you again this afternoon, okay?" Sebastian said as he released her hand and stood up quickly.

Y/n was surprised at his sudden change of behavior but just nodded.

"I'll see you later nurse Stacy." Sebastian said.

"Sure thing Mr.Stan. Don't worry, she's in good hands." Nurse Stacy said.

"Thank you." He nodded then turned around and went quickly out of the isolation room.

He took off the protective gear and hazmat suit and went out of the ICU quickly as the familiar weight of grief came creeping into his heart, threatening to paralyze him.

When he got out of the ICU he was slightly shocked to see his mother, sitting on the waiting area right outside the ICU. The sight of his mother triggered him, breaking the dam that blocked all of the emotions he had since that morning when he found out Y/n's condition had become worst. He ran to her and hugged her tight, crying and sobbing in her arms as grief, desperation, fear and hopelessness came crashing through him like a wave.

-----

Los Angeles, California - March 2022

Merida put the last of her clothing items into her suitcase. She checked the wardrobe in front of her and upon finding out it was empty of all her clothes and belongings, she closed it then pulled the zipper of her suitcase and closed it too. For the past couple of months she was in LA accompanying Ana as she shot her first Hollywood movie. The shooting of the movie was just finished the day before, a couple of days early because Shannon, Ana's co-star, had requested to finish her shoots early. As it happened, she had an emergency situation back in New York where she lived. Since Shannon was also one of the main stars, the whole movie ended up finishing shooting early. It made Merida happy because she missed Spain. She wanted to go back home as soon as possible. Unfortunately Ana had a different idea. She was still obsessed with Sebastian. She had overheard from Shannon that Sebastian was in New York, visiting Y/n who was critically ill. She also had overheard that Y/n was pregnant. She was outraged when she found out and she made plans to visit them and confront them about it. Granted, she wasn't supposed to see Sebastian. But Sebastian wasn't supposed to see Y/n either. She figured since Sebastian wasn't honoring the contract, it wouldn't be a problem if she did the same. So she asked Merida to accompany her to New York before they go back to Spain.

At first Merida didn't want to come. She persuaded Ana to drop her plans and just go back to Spain with her, but Ana was adamant. She didn't want to let Sebastian just go off the hook like that. Merida finally agreed to come even though she hated it. Ana was still her best friend. She felt an obligation to keep her company and help her.

Throughout her stay in LA, Merida became somewhat close to Shannon. They exchanged cellphone numbers and texted each other. She also became somewhat of a bridge between Ana and Shannon. It was clear Shannon hated Ana, seeing how she was friends with Y/n and Sebastian. But she was nice to Merida and trusted her enough that she shared what Ana had done to Y/n and Sebastian. Merida didn't know all of what Ana has done to Y/n and Sebastian. So it became quite a shock to her when she found out how far Ana had done to make sure Sebastian followed the contract. Merida thought she needed to help Ana go back to the right track. So she quietly made some plans to help Ana.

"Merida.. are you ready?" Ana's voice came through her bedroom's door.

"Yeah, I was just finished packing." Merida said as she stood up and pulled her suitcase toward the door.

She opened the door and found Ana already wearing her jacket and shoes. Her suitcase stood behind her, and her backpack on her shoulders.

"Let me just go get my hand bag." Merida said, turning around back into her room and grabbing her hand bag from the top of her bed.

Half an hour later she found herself sitting in a cab next to Ana as they went toward the airport. Ana was telling her what she was going to do to Sebastian and Y/n and Merida was horrified.

"Ana.. please rethink what you're about to do. You're not a criminal, Ana. If the authorities found out what you're about to do, you can go to jail!" Merida said.

"I won't.. My dad will bail me out anyway if I ended up in jail." Ana shrugged.

"But.. Ana.. you're going to hurt him. How do you expect him to want to be with you if you keep hurting the people he loves most." Merida stated.

"I don't care about being with him anymore, Merida. I just think that if I can't be with him then no one else can." Ana said defiantly.

Merida just sat there flabbergasted as she listened to her best friend. There was no doubt about it, she needed to do something. She couldn't just let Ana continue on with her plans. So she pulled out her handbag, pulled out her cellphone and decided to send Shannon a text message. She could at least warn Shannon and Shannon could warn Sebastian. But Ana knew what she was going to do and she snatched Merida's phone from her hands.

"Ana! What are you doing?" Merida cried out in surprise.

"I know what you're about to do. You're gonna tell Shannon aren't you? I'm not gonna let you." Ana said, her eyes looked at Merida in contempt. She then put Merida's cellphone inside her own bag and crossed her arms in front of her, angry that Merida was siding with Y/n and Sebastian instead of her.

Merida sighed in defeat. She needed to figure out how else she could help Sebastian and Y/n, and she needed to do it fast.

-----

The Brooklyn Hospital Center, Brooklyn, New York - March 2022

Sebastian was so glad to see his mother. He wasn't sure he would've been able to keep himself from breaking down and had an anxiety attack if his mother wasn't there for him. It felt like he was back when he was a kid, crying and sobbing on his mother's shoulder when someone at school bullied him.

It took awhile for Sebastian to finally calm down. As soon as he was calm, he explained Y/n's condition to his mother. His mother was very concerned but was also optimistic that Y/n and their baby was going to make it. She had read about treatments for Covid and she was certain that Y/n was getting the best things available at that time to heal from Covid.

Sebastian's mother stayed at the hospital with him until it was time for his visit to Y/n. She promised she would be back the next morning to accompany him.

"Thank you so much, mom, for being here." Sebastian said as he hugged his mother tight.

"Of course, honey. I would never leave you at a time like this. Send my love to Y/n and my granddaughter, will you. I can't wait to meet them." His mother said, hugging him back tightly.

His mother originally wanted to come inside the ICU to see Y/n, but Sebastian wouldn't let her. He didn't want to risk his mother catching Covid. So she agreed to just stay outside the ICU and accompany Sebastian.

"I'll tell them, mom. Thank you again." Sebastian said, releasing his mother from his embrace reluctantly.

"Take care, Sebby honey. And don't forget to pray. God listens. Believe in Him and He will give His miracles to you." Sebastian's mother said as she held Sebastian's sides with her hands and looked at him in the eyes.

Sebastian nodded. "Thanks mom, I will."

"Good boy." She said while pinching his cheek, making Sebastian smile.

"Mom, I'm not a baby anymore. Don't do that." He protested.

"No matter how old you are, you'll always be my baby. You'll know what I mean once your baby is born." Sebastian's mother said, winking at him.

Somehow he understood what she meant even though his baby wasn't even born yet. The love he felt for his unborn child was overwhelming. He didn't know he could love someone even though he had never met them. He would do anything for her, that much was true.

After his mother left, he went inside the ICU to visit Y/n. To his relief, Y/n was just been given her afternoon feeding when he came. He didn't think he could see her being fed through a tube again. The image was too traumatic for him.

"Hi sweetheart. How are you? Are you breathing okay?" Sebastian asked as soon as he reached Y/n's side.

Y/n smiled as she looked at him and gave him a thumb up. He glanced at the pulse oxymeter on her finger and it was showing 94%. He was hoping it would be at least 95%, but as long as Y/n was still comfortable that should be good enough, he thought.

He sat down on a chair next to her and put his hand on her stomach. He felt a fluttering movement as soon as his hand touched her stomach. He smiled and greeted his daughter.

"Hey little bean.. are you excited that I'm here?" He leaned closer to her stomach and caressed it gently. Immediately he could feel his baby moved again.

"She's happy." Y/n said, squeezing his hand that was on her stomach and smiled.

"And I'm happy to see you both again." He said, squeezing her hand back.

"My mom sends her love for you and our baby, Y/n. She came this morning to visit you." He said.

"Oh. Please tell her.. thank you.." she said.

"She can't wait to meet both of you. She actually wanted to come in here.." Sebastian said and Y/n shook her head as she heard what Sebastian said.

"I know, sweetheart. I didn't let her in. It's too risky for her. Thankfully she understood. She stayed with me from this morning until it was my time to visit you." Sebastian explained.

"Good. You need some company." She said slowly.

Sebastian nodded. Just then a nurse came in. She hung a bag of liquid on the IV pole and connected the IV tube on Y/n's hand to the bag.

"I'm sorry, may I ask what is in the bag, nurse?" Sebastian asked.

"Oh it's antibiotic, sir." The nurse answered.

"Oh I see. By the way, is there any news on the convalescent plasma?" Sebastian asked.

"Yes, Mr.Stan. Unfortunately there is a shortage of convalescent plasma supply at the blood bank. They're trying to source it from the Red Cross and from other states." The nurse explained.

Sebastian's heart plummeted as he heard the news. He hoped the blood bank would be able to provide them with the plasma soon.

"Oh, okay, thank you. Would you please let me know as soon as we get an update from them?" Sebastian requested.

"Of course Mr.Stan." the nurse nodded then she excused herself from the room, leaving them with more privacy.

Sebastian suddenly had a brilliant idea regarding choosing the name of their baby. He would ask his baby directly on what name she would like to be called. The fact that his baby was responsive to his voice encouraged him to do it even more. He explained his idea to Y/n and she agreed wholeheartedly.

Out of all the names Sebastian and Y/n had liked previously, their baby responded on two names Nasya and Starlene.

"Hmm. Maybe we can use both. Nasya Starlene Stan." Sebastian said.

"I like it. But..it's bad luck Seb to name a baby before they are born. Maybe we can decide later and just keep this for now." Y/n said.

"Yeah, okay. I've heard that too. I must say though I like what she liked." Sebastian said.

"Me too." Y/n said, smiling at him.

Thirty minutes passed by so quickly. It was time for him to leave. But he didn't feel like leaving just yet. For the past ten minutes Y/n had been coughing more frequently and her oxygen saturation had decreased to 93%. He called the nurse and after she checked on Y/n she contacted dr.Jake.

"I'm sorry Mr.Stan, it seems there is liquid build up in her lungs again. We have to drain it. Would you please wait outside." dr.Jake said.

Sebastian's heart sank as he heard it.

"Okay, doctor." He said.

He squeezed Y/n's hand and caressed her cheek.

"I'll be right outside, sweetheart." Sebastian said. Y/n nodded and coughed. His heart broke seeing her suffer like that. He went out of the ICU with a heavy and anxious heart.

After dr.Jake was done draining liquid from Y/n's lungs, Sebastian was allowed to come in again for a short while. He was relieved to see that Y/n's oxygen saturation had increased again to 95% and that she was able to breathe better.

Throughout that night Sebastian stayed on the waiting area outside of the ICU. He didn't want to go and sleep in his room. He wanted to be there when there was update on the convalescent plasma.

It was 10 pm when the nurse informed him that the blood bank was able to secure convalescent plasma for Y/n. And it was 2 in the morning when it finally arrived. Sebastian waited anxiously as Y/n was given a transfusion of the plasma. He prayed continuously that the plasma would help her heal.

"There may not be immediate changes after the transfusion. But hopefully we'll get positive progress everyday." dr.Jake had informed Sebastian after the plasma had been given to her.

As it turned out dr.Jake was right. After being given the convalescent plasma, Y/n's condition didn't become immediately better. She still needed occasional draining of liquid from her lungs. But as days passed she gradually became better. Her oxygen saturation had increased to 96% and had stabilized between 95-96%. Her coughs had lessened. And she didn't need to have liquid draining from her lungs again.

It was on the third day after Y/n was given the convalescent plasma that the unthinkable happened. Nurse Stacy came into the isolation room that morning when Sebastian had his visit. She brought in a box of cupcakes and gave it to Sebastian.

"Mr.Stan, these came for you." Nurse Stacy said.

"Oh.. thank you." Sebastian took the box from her and opened it.

The box contained six cupcakes that looked absolutely delicious. There was a card attached on top of the box. Apparently it was from Shannon. She was sorry she couldn't yet visit and promised to visit as soon as she was able.

"Y/n, this is from Shannon." Sebastian said, showing her the cupcakes.

"Oh that's so sweet of her. Pity I can't eat them." Y/n said dejectedly. She still had the CPAP mask on so she was still eating through the tube in her nose.

"Yeah, I can't eat them either. I swore off simple carbs and this will ruin it for me." Sebastian said.

"Give it to the nurses." Y/n suggested.

"Good idea, sweetheart." Sebastian nodded. He then gave the cupcakes to Nurse Stacy who received it happily.

After his visit to Y/n that morning concluded, Sebastian decided to go to the cafeteria downstairs to have breakfast. He was just about to go toward the elevators when he heard someone screaming from the nurse station.

He ran to the nurse station and was shocked beyond belief. Nurse Stacy was lying down on the floor with foam coming out of her mouth. Her colleague sat next to her in panic as they watched her frothing at the mouth.

Chapter 23>

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adnan07 · 1 year

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The interferon response is one of the major innate immunity defences against virus invasion. Interferons induce the expression of diverse interferon-stimulated genes, which can interfere with every step of virus replication. Previous studies identified type I interfer- ons as a promising therapeutic candidate for SARS. In vitro data showed SARS-CoV-2 is even more senSitive to type I interferons than SARS-CoV, suggesting the potential effectiveness of type I interferons in the early treatment of COVID-19 (REF15). In China, vapor inhalation of interferon-a is included in the COVID-19 treatment guideline!5. Clinical trials are ongoing across the world to evaluate the efficacy of different therapies involving interferons, either alone or in combination with other agents52. Immunoglobulin therapy. Convalescent plasma treat- ment is another potential adjunctive therapy for COVID-19. Preliminary findings have suggested improved clinical status after the treatmentl55.1s, The FDA has provided guidance for the use of COVID-19 convalescent plasma under an emergency investigational new drugapplication. However, this treatment may have adverse effects by causing antibody-mediated enhance- ment of infection, transfusion-associated acute lung injury and allergic transfusion reactions. Monoclonal antibody therapy is an effective immuno- therapy for the treatment of some viral infections in select patients. Recent studies reported specific mon- oclonal antibodies neutralizing SARS-CoV-2 infection Inhibition of virus replication. Replication inhibitors include remdesivir (GS-5734), favilavir (T-705), ribavirin, lopinavir and ritonavir. Except for lopinavir and ritonavir, which inhibit 3Clpro, the other three all target RdRp28135 (FIG. 5). Remdesivir has shown activity against SARS-CoV-2 in vitro and in vivo28.136. A clinical study revealed a lower need for oxygen support in patients with COVID-19 (REF 137). Preliminary results of the Adaptive COVID-19 Treatment Trial (ACTT) clinical trial by the National Institute of Allergy and Infectious Diseases (NIAID) reported that remdesivir can shorten the recovery time in hospitalized adults with COVID-19 by a couple days compared with placebo, but the differ- ence in mortality was not statistically significant38, The FDA has issued an emergency use authorization for rem- desivir for the treatment of hospitalized patients with severe COVID-19. It is also the first approved option by the European Union for treatment of adults and adoles- cents with pneumonia requiring supplemental oxygen. Several international phase III clinical trials are contin- uing to evaluate the safety and efficacy of remdesivir for The treatment of COVID-19. Favilavir (T-705), which is an antiviral drug devel- oped in Japan to treat influenza, has been approved in China, Russia and India for the treatment of COVID-19. A clinical study in China showed that favilavir signif- icantly reduced the signs of improved disease signs on chest imaging and shortened the time to viral learancel, A preliminary report in Japan showed rates of clinical improvement of 73.8% and 87.8%

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maamulticarehospital · 3 months

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In the realm of health innovation, Ahmedabad's top hospitals are at the forefront, harnessing the transformative power of plasma therapy in Ahmedabad. These healthcare leaders recognize the efficacy of utilizing convalescent plasma to bolster patient recovery. Pioneering the integration of this cutting-edge treatment, hospitals like Maa MultiCare Hospital are rewriting the narrative of healthcare in the city. With a commitment to patient well-being, these institutions are leveraging plasma therapy to navigate health challenges, providing a beacon of hope for those seeking advanced and effective medical solutions in Ahmedabad.

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moleculardepot · 4 months

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Immunoglobulin G from Human COVID-19 Convalescent Plasma

Immunoglobulin G from Human COVID-19 Convalescent Plasma Catalog number: B2014889 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 50 µg Molecular Weight or Concentration: N/A Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20°C Keywords: Immunoglobulin G (IgG), Human COVID-19 Convalescent Plasma Grade: Biotechnology grade. All…

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pranay-234 · 5 months

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Platelet And Plasma Market: Insights, Trends, and Industry Forecast 2023-2032

In the intricate world of healthcare, the Platelet and Plasma market stands as a cornerstone of innovation, promising groundbreaking advancements in transfusion medicine. This article delves into the dynamic landscape of these vital fluids, exploring the trends, challenges, and transformative dynamics that define the Platelet and Plasma market.

𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐒𝐚𝐦𝐩𝐥𝐞 𝐂𝐨𝐩𝐲 𝐨𝐟 𝐑𝐞𝐩𝐨𝐫𝐭 : https://www.alliedmarketresearch.com/request-toc-and-sample/11298

Global COVID-19 Impact: The global COVID-19 pandemic continues to escalate, with confirmed cases surpassing 3.76 million worldwide. The relentless spread of the virus has prompted an urgent need for effective treatments and therapies. With vaccination trials in progress globally, various countries are exploring alternative approaches to combat the virus. India, for instance, is actively promoting plasma therapy as a potential treatment option, emphasizing the importance of convalescent plasma in the fight against COVID-19.

India's Embrace of Plasma Therapy: In the face of the pandemic, India is strategically turning to convalescent plasma therapy as a mode of treatment. The Indian Council of Medical Research (ICMR), the country's premier medical research organization, is actively formulating protocols to facilitate the use of plasma therapy. Convalescent plasma therapy harnesses the concept of passive immunity, utilizing antibodies developed in recovered individuals to treat those currently battling the virus. The plasma market is poised for a significant boost as this approach gains prominence in the country's efforts to combat COVID-19.

Plasma Market Surge: The increased emphasis on convalescent plasma therapy amid the COVID-19 pandemic is expected to propel the plasma market forward. Plasma, rich in antibodies, plays a crucial role in fighting foreign pathogens. As convalescent plasma therapy gains traction, there is a heightened demand for plasma in the market. The therapy leverages the memory cells in the blood that store information about previously encountered pathogens, providing a rapid and targeted response upon reexposure. This surge in demand underscores the pivotal role of plasma in the ongoing battle against COVID-19 and positions the plasma market as a critical component of pandemic response strategies.

Unlocking Therapeutic Potential:

Platelets and plasma, often overshadowed by their red blood cell counterpart, play a pivotal role in transfusion medicine. The Platelet and Plasma market is witnessing a surge in research and development, unlocking the therapeutic potential of these vital fluids. From treating bleeding disorders to supporting patients undergoing complex medical procedures, the market is experiencing a renaissance in understanding and leveraging the healing properties of platelets and plasma.

𝐏𝐫𝐞-𝐛𝐨𝐨𝐤 𝐭𝐡𝐢𝐬 𝐑𝐞𝐩𝐨𝐫𝐭 𝐍𝐨𝐰 : https://www.alliedmarketresearch.com/platelet-and-plasma-market/purchase-options

Precision in Transfusion Medicine:

As technology advances, the Platelet and Plasma market is navigating towards precision in transfusion medicine. Innovations in separation techniques, storage methodologies, and compatibility testing are reshaping the landscape, ensuring that patients receive precisely what they need. This precision not only enhances the efficacy of transfusions but also minimizes the risk of complications, marking a significant stride forward in patient care.

Thrombopoiesis Trends and Beyond:

Beyond traditional transfusion approaches, the Platelet and Plasma market is witnessing a focus on thrombopoiesis trends—understanding the production of platelets. This nuanced exploration of platelet formation opens avenues for targeted therapies, personalized treatments, and a deeper comprehension of hematological disorders. The evolving dynamics in thrombopoiesis research are shaping the future of platelet-focused interventions.

Global Impact and Accessibility:

In navigating the Platelet and Plasma market dynamics, a key consideration is global impact and accessibility. Efforts are underway to bridge gaps in availability, improve storage and transportation infrastructures, and enhance awareness of the therapeutic potential of platelets and plasma worldwide. The goal is to ensure that patients across the globe can benefit from advancements in transfusion medicine.

𝐈𝐧𝐭𝐞𝐫𝐞𝐬𝐭𝐞𝐝 𝐭𝐨 𝐏𝐫𝐨𝐜𝐮𝐫𝐞 𝐭𝐡𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐑𝐞𝐩𝐨𝐫𝐭? 𝐈𝐧𝐪𝐮𝐢𝐫𝐞 𝐁𝐞𝐟𝐨𝐫𝐞 𝐁𝐮𝐲𝐢𝐧𝐠 : https://www.alliedmarketresearch.com/purchase-enquiry/11298

Challenges and Opportunities:

While the Platelet and Plasma market is marked by innovation, it also faces challenges. These include ensuring a stable supply chain, addressing storage limitations, and optimizing compatibility testing. However, each challenge presents an opportunity for innovation and improvement. The industry is resilient, with stakeholders collaboratively working to overcome barriers and drive positive change.

In conclusion, "Vital Fluids Unleashed" is not just a title—it encapsulates the essence of the Platelet and Plasma market dynamics. As we navigate this landscape, we witness the unleashing of therapeutic potential, the precision in transfusion medicine, and a global commitment to accessibility. The vital fluids, once confined to the background, are now taking center stage, reshaping the narrative of transfusion medicine and offering new hope for patients worldwide.

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Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Wilmington, Delaware. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of "Market Research Reports" and "Business Intelligence Solutions." AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain.

Pawan Kumar, the CEO of Allied Market Research, is leading the organization toward providing high-quality data and insights. We are in professional corporate relations with various companies and this helps us in digging out market data that helps us generate accurate research data tables and confirms utmost accuracy in our market forecasting. Each and every data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry.

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leedsomics · 6 months

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Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 months following their acute phase of infection to comprehensively profile and assess changes in cytokines, proteome, and metabolome. Network analysis reveals sustained inflammatory response, platelet degranulation, and cellular activation during convalescence accompanied by... http://dlvr.it/Sy7vbh

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shahananasrin-blog · 7 months

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[ad_1] FOR IMMEDIATE RELEASENewswise — Findings from a nationwide, multicenter study led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health suggest that patients with COVID-19 have less chance of developing post-COVID conditions — commonly known as long COVID — if they receive early treatment with plasma from convalescent (recovered) COVID patients that contain antibodies against SARS-CoV-2, the virus that causes COVID-19.The new research, first posted online today in mBio, a journal from the American Society for Microbiology, is a follow-up investigation to the 2021 clinical trial that showed convalescent plasma is an effective and safe option as an early outpatient treatment for COVID-19. The latest study looked at the long-term outcomes of a large portion of the participants from the 2021 clinical trial.“Following our initial study, health care professionals kept SARS-CoV-2 antibody-rich blood plasma available in their blood banks as part of the treatment arsenal against COVID-19 in people who are immunocompromised; and now, our new findings show it also may lower the risk of post-COVID conditions,” says study co-lead author David Sullivan, M.D., professor of molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health with a joint appointment in infectious diseases at the Johns Hopkins University School of Medicine.The original outpatient early treatment clinical trial was conducted between June 2020 and October 2021. The researchers provided 1,181 randomized participants with one unit each of either polyclonal high-titer convalescent plasma (containing a concentrated mixture of antibodies specific to SARS-CoV-2) or placebo control plasma (with no SARS-CoV-2 antibodies). The participants were 18 and older, and had tested positive for SARS-CoV-2 within eight days prior to transfusion. A successful outcome was defined as not requiring hospitalization within 28 days after plasma transfusion.The original clinical trial found that 17 participants out of 592 (2.9%) who received the convalescent plasma required hospitalization within 28 days of their transfusion, while 37 out of 589 (6.3%) who received placebo control plasma did. This translated to a relative risk reduction for hospitalization of 54%.As part of the clinical trial, 882 participants also were evaluated for their levels of 21 different cytokines and chemokines at screening, and at 14 days and 90 days after they received either convalescent plasma or placebo control plasma. Cytokines and chemokines are signaling proteins secreted by cells in response to infection, and as a result, activate specific immune system functions such as inflammation. In turn, excessive or unchecked inflammation is believed to be a key factor in the development of post-COVID conditions.For the latest study, the researchers used the cytokine and chemokine measurements, along with reports by patients of any post-COVID conditions at the 90-day examination, to determine if there was any association between early convalescent plasma therapy and long COVID symptoms. Statistical analyses were conducted to validate the findings, after adjusting for other factors that could make someone more prone to post-COVID conditions, such as demographics (e.g., age and race), competing diseases (e.g., diabetes) and vaccine status.At 90 days after receiving either convalescent or control plasma, 590 (66.9%) of the study participants showed no post-COVID conditions, while 292 (33.1%) did. Of the latter group, the most commonly reported symptoms were fatigue and anosmia (loss of smell).Levels of cytokines and chemokines were elevated at screening for most of the study participants, and decreased more by day 90 in those who had received convalescent plasma,” says study senior author Aaron Tobian, M.D., Ph.D., director of the Transfusion Medicine Division and professor of pathology at the Johns Hopkins University School of Medicine.Additionally, study participants who had higher-than-normal levels of one particular cytokine, interleukin-6 (IL6), at screening were more likely to be among those with post-COVID symptoms by day 90. IL6 is known to trigger an inflammatory response in humans.“Our study is among the first to show that elevation of IL6 early after the onset of infection is associated with post-COVID conditions,” says study co-lead author Kelly Gebo, M.D., M.P.H., professor of medicine at the Johns Hopkins University School of Medicine. “While cytokine levels decreased throughout the study population from infection to day 90, they dropped more significantly in those who received convalescent plasma early in the course of their illness. So, it appears that when IL6 levels remain elevated during the COVID-19 recovery phase, it likely contributes to post-COVID conditions.”Future studies, says Gebo, could examine the impact of anti-IL6 agents combined with other treatments against COVID-19 among outpatients.Because of the large number of co-authors on this study, their names, financial disclosures and conflict-of-interest statements are not listed here. That information may be found in the published paper.The study was principally funded by the U.S. Department of Defense’s Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (DOD JPEO-CBRND), in collaboration with the Defense Health Agency (DHA). Initial support was received from the Bloomberg Philanthropies and the state of Maryland, with additional support coming from National Institute of Allergy and Infectious Diseases grant 3R01AI152078-01S1 and the agency’s Division of Intramural Research, National Center for Advancing Translational Sciences grant U24TR001609, the Mental Wellness Foundation, the Moriah Fund, Octapharma Plasma, the HealthNetwork Foundation and the Shear Family Foundation.The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the U.S. Department of Defense. The data and opinions presented do not reflect the view of the U.S. government. window.fbAsyncInit = function () FB.init( appId: '890013651056181', xfbml: true, version: 'v2.2' ); ; (function (d, s, id) var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = " fjs.parentNode.insertBefore(js, fjs); (document, 'script', 'facebook-jssdk')); [ad_2]

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