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#a georg of any data pool
thankstothe · 2 months
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umlewis · 23 days
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Hamilton Loses Australia F1 Engine As Mercedes Uncovers Cause of Failure
Lewis Hamilton has lost the power unit that failed in Formula 1's Australian Grand Prix, Motorsport.com has learned, with Mercedes having got to the bottom of what went wrong.
The seven-time world champion retired in the early stages of the race at Albert Park after his Mercedes engine shut down following sensors detecting an unspecified problem. The power unit was flown back to Mercedes' engine facility at Brixworth for post-race analysis to get an understanding of what happened, with no obvious explanation available immediately and the team unclear about whether or not it could be used again. But, ahead of the Japanese Grand Prix, Mercedes discovered that the issue was a terminal one, which means the engine cannot be brought back into the allocation pool that Hamilton has available Mercedes concluded that the retirement was caused by a bottom end failure, which has been traced back to a quality process issue rather than any specific design problem. The loss of one of the four engines Hamilton has for the season at such an early stage makes it likely that he will need to take an extra power unit, and therefore a grid drop, at some point later in the campaign. It appears that the bottom end failure was a one-off, with analysis of the other engines within the current pool for Hamilton and George Russell showing no concerns of there being the risk of a repeat. Hamilton's retirement from the Australian GP has heaped further misery on a troubled start to the season for Mercedes, which has not delivered the step forward hoped for from its 2024 car. The new W15 has shown a particular weakness in high-speed corners, and the team is trying to improve its tire temperature management to better extract more performance from the car. Despite the troubled first few races, Hamilton remained optimistic about the capabilities Mercedes had to turn things around. "I think it's all about perspective," he said. "I think for us, of course, we've not started the season where we wanted to be, but we've got a long way to go. You've seen in the past-last year, for example-just how things can switch in certain teams, looking like Aston, McLaren last year, who started on the back foot. Anything can happen in the sport. I think we've just got to learn as much as we can, take as much as we can from the data, remain positive, continue to work hard, and I would say it's not how you fall, it's how you get up. We're just going to continue to chase and fight, and hopefully we can be fighting at the front at some stage."
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Movie Review | Gilda (Vidor, 1946)
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This review contains spoilers.
I probably complain with some regularity that movies these days ain’t like they used to be and I’d hate to sound like a broken record, but one specific respect in which movies are definitely worse is that we’ve stopped making ones about characters who are Next Level Hot. Characters who are so distressingly attractive it becomes the driving force behind the decisions of everyone around them. Perhaps the subject has been on my mind since my recent viewing of The Swimming Pool, in which three of the principals are unbelievably attractive and the fourth one is played by Maurice Ronet, and the relative levels of attractiveness are used to direct audience sympathies, having us practically beg for the uggo to be removed from the screen by any means necessary. (Listen, I know there are thorny sexual politics at play, but I am all for opening the borders of Next Level Hotness beyond the confines of ideals of conventional attractiveness. It’s a vibe more than anything.)
Now if anyone comes up with modern examples that I’m not aware of, I don’t actually care, I just needed an in to start talking about this movie, which definitely falls in this category. In the parlance of a wise man, I’ve done the research, I’ve looked at the facts, I’ve analyzed the hard data and my conclusion is that there are few things sexier than the way Rita Hayworth throws her head back and lets her hair bounce for a moment. The movie is best known for a number of performances by Hayworth, most notably the (racy by the standards of the ‘40s) striptease to “Put the Blame on Mame”, which most overtly communicate her most magnetic qualities, but even outside these scenes her character throws the entire screen into a web of sexual tension anytime she appears or is even mentioned.
You have Glenn Ford hired by shady casino owning bigshot George Macready to look after his casino and also his wife Hayworth (introduced with that trademark hair bounce). Ford is trapped initially by the confines of his role and also the situations Hayworth forces him to cover up with her promiscuous behaviour, something Macready may or may not be aware of. So there’s an element of control exerted upon Ford, which reverses when Macready exits the situation by feigning his demise and Ford becomes the one exerting control on Hayworth, driven perhaps by past grievances. So there’s a palpable psychosexual charge to the proceedings from the kinked out dynamic both men have with Hayworth and each other. (Also of importance: the phallic weapon with which Macready kills his enemies. Never trust a man with a spring-loaded blade in his cane.) To paraphrase the words of a high school math teacher when I challenged him on the dimensions of an aesthetically pleasing rectangle, Freud would have a field day with this movie, although I must concede that faking your own death to act out your cuckold fetish seems a bit extreme.
This plays out against a backdrop of a post World War II Argentina milieu, where Macready seems mixed up with a bunch of sinister Germans with whom he forms a tungsten cartel. The movie doesn’t seem terribly interested in the particulars (something about patents and laundering money through the casino) and admits as much when we see Ford looking inattentive as he’s being questioned by a police inspector. I suppose this does give the movie a slight atmosphere of corruption (although the Old Hollywood production values keep this from feeling too seamy), but quite frankly I found the dynamic between the main characters engaging enough that I could do without it.
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literaphobe · 2 years
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have you done your predictions for mcc yet btw? :D
i was thinking id do it when they revealed the games but oh well why not !
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1. honestly this isn’t even copium like based off everything plus stats etc the balancing of stronger duo vs weaker duo dnf are the strongest duo in the event unless u pit them against ranboo n sapnap which we have no prev team up data to fall back on. ranboo has placed higher than george but george feels just more consistent and more mechanically skilled than ranboo, plus foolish + karl is a much stronger duo than jacksepticeye (he hasn’t even started practicing yet) and crankgameplays. unless something seriously goes wrong red should be placing first every single time
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2. might be a controversial opinion and it’s entirely dependent on game selection + order but there are just so few ‘cracked’ people in this event that by virtue of having sapnap and ranboo in a team together this shoots this team’s potential up by a lot. it all comes down to how sapnap & ranboo work together + how they overcome their other two teammate’s lack of mcc experience
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3. i think illumina is a superb player. on a different day i might put this team in 2nd. inthelittlewood is like a potential top 20 player, he could place even higher in a non-canon event like this, but i’m not sure i see it happening unless they all majorly pop off. usually illumina always does well individually, but his teams usually only make dodgebolt if he has another member who can make top 10 on his team. snifferish and elainaexe still lack the experience to place high, but hey given the player pool this event, it’s possible they get top 25
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4. i think the fate of this team depends on how well velvet adjusts + if tapl um…. performs up to his ability. because ant + tapl could put up a really good fight if they brought their A game but if they don’t they could really slip
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5. i give them this for the amount of experienced players they have on this team!! they could really benefit w buildmart being played late lmao or if they were just really coordinated in certain games
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6. i think krtzyy is a very good pvper and ponk also is meant to be good at pvp however if the team i placed below them plays it more serious they could potentially place over this team but i see this team pulling ahead for now
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7. imo skill wise 5up and tubbo could potentially outplace krtzyy and ponk however i get the vibe that tubbo will not be tryharding mcc pride fjdjdjdjd
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8. i feel bad for putting this team here and honestly depending on how hard jojo carries and how well puffy kara and niki adapt they could totally place higher but the fact that puffy is this team’s second strongest player isn’t doing them any favors but perhaps given the lack of experience a lot of this event’s players has this team could pull ahead! i would not be shocked if jojo places top 5 like i trust this girl’s going places
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9. experience factor makes me give this team 9th!
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10. i have not seen sykkuno and rae practice yet and sykkuno is a very talented gamer who’s played minecraft somewhat but mcc is different and he isn’t Always inclined to try hard it will be very interesting to see tho
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mastermover345 · 1 year
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laquintahoustoni · 1 year
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How Might You Ensure That You Book The Right Lodging While Voyaging
At the point when you are voyaging, for business or delight, the inn you are remaining at has an immense effect on how useful and pleasant your visit is. Assuming that you are on business travel, your lodging will be your brief office and you won't believe that issues with the inn's administration should occupy you from work. At the point when you are traveling, any repulsiveness made because you selected facilities will disturb you and nullify the actual point of your movement, unwinding.
 Picking the right facilities is a fundamental piece of your movement arranging. So how would you go about it? To start with, be exceptionally clear about what precisely you need and what your inclinations are. Might it be said that you are searching for an extravagant stay or attempting to track down the most reasonable facilities? Could you like to leave nothing to chance by remaining at a property show to a laid-out and respectable inn network or might your family want to encounter the nearby flavor by choosing a little B&B place? When you settle on your needs, the time has come to make an engaged hunt.
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sfnewsvine · 2 years
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National Archives Busts Trump For False And Misleading Claims About Obama Bush And Clinton
No, Presidents Barack Obama, the 2 Bushes, and Clinton didn’t preserve presidential information. Daniel Dale, senior reporter for CNN, reached out to the Nationwide Archives to fact-check the previous president’s claims about different presidents taking presidential information. “New: The Nationwide Archives and Data Administration calls Trump’s claims about Obama, Clinton, Bush and Bush supposedly taking presidential paperwork ‘false and deceptive.’” New: The Nationwide Archives and Data Administration calls Trump’s claims about Obama, Clinton, Bush and Bush supposedly taking presidential paperwork “false and deceptive.” pic.twitter.com/zxuMskXDRD — Daniel Dale (@ddale8) October 11, 2022 Why would possibly we be needing to fact-check such an apparent lie? Effectively, as a result of Donald Trump retains burying his personal crimes in rhetorical both-siderisms and whataboutisms. This time, at an Arizona rally for his partner-in-unstable-lies Kari Lake, he claimed that former President George H.W. Bush “stored secret authorities paperwork in a mix bowling alley and Chinese language restaurant and must be investigated.” Insider identified the issue with this one: “Bush died in 2018.” Trump repeated his already debunked lies about President Obama – no, Obama didn’t have his information despatched to a furnishings retailer in Chicago, however somebody would possibly need to verify any furnishings shops affiliated with the Trumps because of his propensity for projection. Trump went on, together with his notorious maniacal irrationality, to make different purely fictional if not projections accusations saying different presidents saved paperwork in warehouses “a few of them with out entrance doorways that labored.” Yeah, no. None of that occurred. That is likely to be what Trump did, we don’t know but. We do know that Trump stole paperwork after which lied about having them and had his legal professional lie for him to say all the paperwork had been returned once they weren’t. However nobody however Trump cared so little about this nation as to steal prime secret categorised nuclear weapon paperwork. The previous presidents from each main events – till Trump – didn’t take presidential information, didn’t stuff them of their desks to share with random friends at their nation membership/house, make copies to threaten individuals, or use them to cut price for the discharge of just a few different paperwork that may give the looks of exoneration within the Russia investigation, or any of the opposite doable motives for Trump’s unlawful assault on our nationwide safety. Trump is the present chief of the Republican Celebration. They haven’t denounced his legal thefts from our nation nor his assault on our security. Ms. Jones is the co-founder/ editor-in-chief of PoliticusUSA and a member of the White Home press pool. Sarah hosts Politicus Information and co-hosts Politicus Radio. Her evaluation has been featured on a number of nationwide radio, tv information packages and discuss exhibits, and print retailers together with Stateside with David Shuster, in addition to The Washington Submit, The Atlantic Wire, CNN, MSNBC, The Week, The Hollywood Reporter, and extra. Sarah is a member of the Society of Skilled Journalists. Supply hyperlink Originally published at SF Newsvine
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vicea · 3 years
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dream merch discord recap (june 12, 2021) - disclaimer: i may have missed some things or mistakenly heard other things, apologies in advanced for that!
he has not played the new minecraft update
dream “knows” the date george is coming to florida but he’s not saying it :p
dream doesn’t have anyone muted on twitter
dream guesses his favorite disney princess is belle
sapnap has seen dream’s feet before
he’s not actually connor’s dad in the dsmp lore
dreamnap do not have nicknames for each other D:
dream likes olives but especially black olives
his mother makes homemade pickles
he doesn’t have a phone case
he has dropped his phone from his ear onto concrete in the parking lot before and the screen didn’t crack
dream has six fingers /j
he pours cereal first not milk when making cereal
dream calls sapnap nick most of the time :D
what’s your dream car? “idk the one that gets me to point A to point B consistently”
he finally fixed his sleep schedule, woke up at 8 am today
mrbeast owes dream a tesla because he never sent dream the audio file
dream is a very analytical person - he thinks with numbers/data
creativity is one his strengths that he is the most proud of
3 to 4 years ago, dream used to say george looks like shawn mendes a lot, now he doesn’t resemble him as much
patches is currently sleeping <3
swimming is very relaxing to dream, he swam the other day!
many houses in florida have pools than other places, even the cheapest houses in orlando have pools
dream has merchendise defects (misprints on merch) + milestone merch and he wants to give them away to those who live in orlando (probably to anyone but the event will be held in orlando) though he doesn’t want it to be a covid super-spreader thing so once you pick up your item you gotta dip. just all an idea though
he has been donating them to charity too though :)
dream has likely read Heroes of Olympus before a long time ago
he says that he’ll do a give away of his childhood books with his signature on it
he was obsessed with the series (Percy Jackson) 
he really liked the Alex Rider series
has all of Maximum Ride books, 39 clues books
has read the legend series, the twilight series, and the maze runner
has all/read of the harry potter books, divergent, eragon
he would read all the time, to the point he would read more than one book a day (a book worm he says)
dream had a goal to read 200 books in a year and he wind up reading about 150
he doesn’t want to call it a library but- growing up he had something like that that had 600 or 700 or more books in it (privileged he admits it)
he has not read a book since he started youtube (about 2 years)
dream has a folder called Book that has his own writing in it
word count: 76000 words for one of his stories 
another one he wrote 5 chapters of
he sounds very excited/embarrassed talking about the stories he wrote he’s so endearing
the very first paragraph of one of his stories (he was young when he wrote this) “What exactly is darkness? is it the lack of light? is it a pit of nothingness? ... your mind is full of darkness...” then he couldn’t continue.
the story is about a kid who wakes up in a cell and has no idea where he is with other people who are in the same situation
dream has a world building document
he has a sequel to the first book he has ever written
he found a query letter that he wrote because he wanted to get his book published- he finds it very funny
he’s calling himself a nerd but idk it’s kind of endearing
“as you can tell i’ve always been incredibly cool and not a nerd at all! ever.”
he cringes at his own old videos
dream took a lot of inspiration from witches and wizards by james patterson for writing
the story is written in a way where the main character is actually writing the story so you’re getting input from the main character during it. there’s a lot of sarcasm in it and it’s making dream laugh
very first person narrator
he feels like it’d be very cool if he were to publish his works he wrote when he was 16 on amazon or something but he probably never would because he’d have to read through all of it and it’s just embarrassing for him
dream used to video call sapnap fairly frequently- even before youtube
he strictly remembers, a very long time (at least 7 to 9 years) ago he was at his old childhood house he video called sapnap. he was wearing a (technically) suit and he remembers specifically that he was giving sap a tour... 
“snazzy in a suit”
he had no reason to put on the suit (wow time is a flat circle huh)
drista is pretty close to sapnap’s height, she’s like 5′7″ but sap is still taller than her
dream filmed the whole thing when he and sapnap met but... it’s... gone because when he was clipping that one clip for twitter... it edited the whole video
he’s sure when they meet up with george they will film that too :D
DREAM IS PRETTY SURE THAT HE AND GEORGE WILL MEET THIS YEAR-- HE SAYS A 95% CERTAINTITY the five percent is like either restrictions or visa issues
dream does not play any instruments but he had a guitar hanging on his wall when he was younger...
dream is convinced they’re the same height but also sapnap is probably taller??
they had george compare his height to a door frame and dreamnap were googling for any doorframes to find any possible chance that george is taller than 5′8″ ... nothing came up
there’s a chance they’re both lying about being 5′8″
sap and george will literally just show up in stilts to prove they’re taller than each other /j
dream without shoes is between 6′2″ and 6′3″ with shoes he’s 6′3.5″
dream is talking about awesamdude’s fake height arc again LOL
dreamnap are very private people so they don’t bother each other but george doesn’t care and would just barge into their rooms and start bothering them- they were all joking about that over a voice call
he will visit europe
he thinks that greece would be a cool place to visit because sapnap’s family is from there :) so it’ll be like a nice “treat” to go back with sap :D
dream isn’t entirely sure that the dream team meet up will happen this year but he’s working out the details because he wants to make sure it’s safe
he’s talking to youtube about his face reveal
it’s up to george if he wants to eat healthy when they finally move in
dream just has a lot of meat and vegetables in his house
spinach with chicken is good
not much fruit (only apples and tomatoes)
“DRISTA IS 5″ is trending on twitter LOL (her height got cut off)
dream doesn’t want people flying to different places because he doesn’t want to encourage travel so he wants to do all of the meet ups with a two day heads up at most
he thinks that it’s awesome that ranboo and tubbo are meeting soon !! :D
it’s very cool to dream to see how far everyone’s has come since the beginning of the dsmp. everyone has done so much
dream finalized his youtube plan a couple weeks before he uploaded his video and he was talking to drista about how he was gonna be a big youtuber in a parking lot :”)
she was the first person he really ever talked to about it
dream would love to teach george how to drive it’d be really funny :D (a very good video or a livestream idea) 
dream knows how to ride a bike, he used to have to bike to school
he can’t explain dnf.gay he has no clue he is not responsible. sapnap was the one who found it LOL. he is adamantly exclaiming that it was not him
dream doesn’t worry about views/likes/dislikes a lot- mainly views but that’s for the new uploads
he hasn’t uploaded in like a month and a half (*cries*)
he wants to stream at some point but he doesn’t know when 
he wants to play geoguessr but not now... he doesn’t want to alt stream rn- maybe tomorrow!
he is insisting that the splash text on his minecraft home screen is by callahan
he asked callahan to send him bunch of text files that are dream team related so that the splash can rotate through it but callahan thought it was funny (it is) to put only dreamnotfound <3 so it doesn’t ever change at all and dream doesn’t even know how to change and he has asked callahan to change it but he said no (even though dream pays him LMAO)
the video referenced in the padilla’s video is still in the works, it might be handed over to sapnap though !
he has no idea if he will be in MCC pride yet
padilla got dream’s input for the video, dream found him to be a very nice guy ! :) it’s the first interview that dream did that wasn’t by a person with a negative opinion of dream
dream felt relaxed doing the interview with padilla 
?????? he’s blaming callahan for his “dnfisreal” nickname in bedwars 
he’s blaming callahan for a lot of dnf-related stuff
callahan runs the dream fanart account thus the liking of dnf content
he’s so insistent that it was callahan
dream admits that he was lying about the twitter and other stuff but for sure callahan did code the splash text in LOL
dream liking that tweet “the chances of george doing a hot tub stream is the same of dnf dating” was “funny” he wasnt trying to do any commentary...
the inside joke of “oh it’s all just a joke to you” originates from george and sapnap actually always fighting (like them yelling and shouting at each other) and george said something really mean and sapnap was hurt then geroge said “it was just a joke” and sapnap replied with that line and ever since then it’s been a meme LOL
he says that everyone does the hand-on-the-passenger-seat-while-reversing thing
dream is offline raiding with his chat with 6k people
dream appreciates us and will talk to us soon! 
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superkinkajou · 3 years
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How to Watch NHL Network is your place for the World Juniors!
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Unexpectedly, NHL Network™ will air each game live of the IIHF World Junior Title starting on Friday, December 25 from Edmonton, Alberta. As the elite U.S. Television home of the 2021 competition, NHL Organization's broad inclusion will incorporate broadcasts of Group USA's games, in addition to thorough reviews, features, examination and meetings on NHL Tonight™ and through @NHLNetwork on Facebook, Instagram and Twitter. Paving the way to December 25, NHL Organization will air each presentation round of the competition starting on Sunday, December 20 with Group USA skating against Group Switzerland inhabit 6:00 p.m. ET.
World Junior Championhip
The  BWF World Junior 2022 Titles are being facilitated in Auckland, New Zealand. The Titles will happen from 11-24 January 2021.
During BWF will convey a progression of uprightness instructive exercises at the iZone, like what we have done previously (connect here).
You can download data about the action above.
The BWF World Junior Titles is held every year and comprises of two separate contests: a blended group titles for the Suhandinata Cup followed by a singular titles for the Eye Level Cups – all facilitated more than 12 days and drawing in up to 50 groups and 400 players from around the world.
The Titles furnishes badminton fans with a first look at the stars of things to come. The World Junior Title is the main chance for capable youthful badminton players to address their country in a world occasion in the game.
It is likewise a chance to encounter high level rivalry and maybe put them on the pathway towards becoming one of the stars of things to come.
Draft-Qualified Possibilities
Taylor Gauthier enters the competition in his last year of NHL draft qualification. The Sovereign George Cougars' goalie has begun 137 games once again the beyond three seasons with unassuming achievement however might not have sufficient playing time at the WJC to further develop his 2021 draft stock.
Unavoidable issues
The Canadians don't have many openings in their arrangement, and I don't expect the gathering stage to be a very remarkable test; this group should decoration, and anything less is a mistake. In any case, as is apparently a pattern, Canada's greatest question mark comes in the net. Among the three goalies—Gauthier, Levi, and Garand—none stand apart as a workhorse who can take games like different netminders in Pool A. I don't figure it will be a tragic defect, yet unquestionably, something to screen.
2021 IIFH WORLD Youngsters Show Timetable
Tuesday, December 22
3:00 p.m. — Switzerland versus Austria
6:30 p.m. — Finland versus USA
Wednesday, December 23
3:00 p.m. — Canada versus Russia
6:30 p.m. — Czech Republic versus Slovakia
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valkirsif · 3 years
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Unthinkable CH46/???
Word 3100
Warning Nothing
The days on the set were chaotic and fascinating, Y/N had managed to find all the furniture and Alissa was organizing the expedition, once in LA she would have fixed the house, was preparing breakfast before reaching Phil and leaving for Sammy's house ,
"Day Honey " said feeling Tom's arms wrap her, "One second and the eggs are ready" turned to kiss him,
"Day Darling, excited for the hunt?" the man asked, taking a seat at the table,
"Can't wait" replied carrying the plates, "I can't wait for Sammy since the party will be fun"  laughed as drank her first coffee,
"Don't be swayed by her madness" he laughed, "If you let her, she'll buy you a castle",
"I'll remember my Lord" she laughed with him as finished breakfast,
"See you tomorrow my love, Sammy wants to take me shopping" she kissed him taking the backpack with pajamas and a change,
"Have fun, Darling, see you tomorrow," he greeted her.
Phil was waiting for her at the B&B where slept, luckily he had found a room, with the re- taking in progress all the rooms in the hotels and b&b were full of paparazzi and fans who came to steal some photos,
"Hello, can I help you?" asked the girl at the reception, "Oh Miss Hiddleston .. " said surprised to see her there,
"Good morning, I'm waiting for a friend, thank you" Y/N answered sitting in the living room, Phil joined her after a couple of minutes,
" Poppy here I am sorry but to have breakfast you have to get in line" he said laughing hugging her,
" It's full of paparazzi wandering through the woods", they went out trying not to pay attention to the shots,
"Well tomorrow there will be our stupid photos everywhere" the woman said with a sigh, "Sorry Phil" looked at him sorry, the friend laughed,
"Don't worry, just don't pay attention to it" laughed the man getting into the car, "Since when do you care what people think?" asked amazed, the woman explained to him how she felt and how the photos of the previous days had made her feel bad,
".. you're right, lately I have the feeling that I have lost a part of me .." she said thoughtfully,
".. I think it's because I 'm so in love with him that I'm afraid that one too many smile or a hug can create havoc",
" Poppy that man kisses the earth where you walk I doubt that something about you will not please him" he laughed giving her a loving tap on the shoulder, "Change is natural .. distort what you are not" he said seriously, the woman looked out thinking about the words of her friend he was right was to regain part of her that did not care of the judgments of the people, promised if same to get back what was before I met Tom, a few hours after they arrived at the home of Sammy .
"Y/N bye!!" she said happily going to meet the two, "How nice to see you" the happy hug,
" Sammy thanks for your help" Y/N replied as cheerful as she was, " He is Phil one of my oldest friends" she said introducing him,
"Nice to meet you, I tried to make coffee but I can't assure you it's good" she laughed making his way inside the house, "Take a seat"
"Isn't David there?" asked Y/N following her into the kitchen, Sammy said no, her husband worked,
".. you are all mine today and tomorrow" smiled maliciously, the trio laughed, finished their coffee and they went out,
"Let's take my car if you don't mind so I don't have to give directions to your driver" took the keys while Y/N warned the driver,
"As I told you there are many properties in the area" began turning into a country road that led to the hills, "If you have any idea tell me so let's see if there is something", Y/N roughly described what they were looking for, a large park and a pond could not be missing,
" Mmm everyone here has a garden ... or rather a park" she laughed, stopping at the top of the hill to show her the area, "As you can see the houses are far enough away to have all the privacy you want" said, Y/N admired the landscape dotted with big houses, really big, she thought,
"Er Sammy .. " she said fearfully, "..Thomas and I are looking for a house not a mini castle, these are gigantic", Sammy looked at her seemed not to follow her speech,
" Oh .. uh .. I always forget that you are Italian" she replied thoughtfully, "Here it is customary to have large country houses with many rooms and large lounges, they are usually rented when not in use" concluded,
"I understand, but we seek a home for the exclusive use say, spacious enough to invite friends .. " described what they were looking for explaining best she could, ".. 4/5 bedrooms, a great room and a garden" behind her Phil laughed, "You knew that didn't you?" she scolded him laughing,
"Yes but I could not resist letting you fall from the clouds" he laughed hugging her, even Sammy laughed heartily taking the phone and talking quickly, Y/N couldn't follow her and not even Phil was useful, Scottish was a language apart,
"Ok I found a couple of houses that could be fine" she said getting back in the car, "While we go I cancel the appointments I had made" smiled putting on the earphones, Y/N felt guilty she must be clearer in what they were looking for,
"Sorry Sammy " she said in a low voice, "I didn't mean to waste your time like this",
"Imagine Y/N, it is true that you could have explained yourself better .. but I had to ask .. we are even" she laughed, the woman managed to find something and they headed towards the first property, a man was waiting for them at the gate,
"Hi Miss, I'm Gerald Connor the caretaker" he said cheerfully shaking hands with the group,
"I'm amazed you're looking for such a small house" he laughed as led the way
"They just told me that in England they use much larger" smiled Y/N explaining the reasons for their choice, the caretaker laughed opening the door,
"Take a seat" gestured Gerald making them pass, "the central hall has a beautiful fireplace that works perfectly" he said showing the great room, the marble inlaid fireplace was spectacular, a large table was placed next to the fire could seat a dozen people , two twin sofas on the opposite side were turned towards the large window overlooking the park, you could see a stream passing through the property, the deer grazed placidly in the park, Y/N was ecstatic,
"The kitchen is habitable .. " he says and continuing his visit, ".. as soon as outside there is an old bread oven, but it needs to be fixed", they went upstairs passing through the turret
"There are 6 bedrooms and 3 bathrooms, the master bedroom has a private bathroom" he said, letting the group wander around the rooms,
"There are some work to be done, it was used as a hunting lodge" he led the way outside and there Y/N understood that it was the right one, the large park was hidden behind the house by a grove of centuries-old oaks and horse chestnuts, fruit trees were scattered around, missing only a pool but it would have made to install if the deal was successful, tried to stay on longer neutral and calm as possible but she was so happy that he had trouble,
" Sammy is her .. is perfect!!" she said softly taking her aside, "You seem much better at bargaining .. " smiled at her,
"It seems very small to me" she answered unconvinced, "But if that's what you want .. " called the caretaker to find out the price
"One moment Miss phone the owner" he answered, 10 minutes later reached them, "Mister McGregor is coming if you want to wait", the group nodded and they sat on the porch talking about the work to be done, the furniture was perfect so they would only change sofas and carpets, they saw a car arrive .
"Nice to meet you, I 'm George McGregor " said the man introducing himself smiling, "Sorry if I made you wait, you are the first to be interested in the shed for years" laughed, taking a seat in the house followed by the group,
"Don't worry" replied Sammy , "The house is for my friends" said introducing Y/N,
"Calling it home is a great compliment" he laughed, "Space is limited .. "
"My partner and I were not looking for something big but rather a little house to enjoy when not working" replied Y/N, "This is perfect for us",
"Before talking about money I have only one request .. more than the neighbors .. " he said worried, ".. many VIPs live in the area so there is a private surveillance service .. you should leave your data at the office in town ..", Sammy and Phil looked at Y/N trying not to laugh,
"Um my friend is Tom Hiddleston's girlfriend " she said cheerfully, "They will certainly appreciate the service .. I hope knowing that doesn't increase the price of the house" laughed in practice, for Y/N it was strange to be so direct, in Italy you would arrive at the price calmly, the man laughed,
"I could actually think about it .. " he said, "..but my family wants to get rid of the property, it's very far from the main house and the maintenance is not worth the money" the man and Sammy started talking in Scottish, cutting out Y/N and Phil from the bargaining, the woman picked up the phone,
"Tommy boy .. 200" said practice, " Sure .. yes park included .. 6 .. 3 .. beautiful in marble .. " answered the questions nodding, "He wants you" said passing the cell phone to Y/N,
" Honey do you like it?" asked the sweet man,
"Thomas I love it, I sent you some pictures, don't say yes just to make me happy there are other properties to see" she laughed hoping he liked it too,
"I saw them, there are some works to be done .. " he began, "..but it's a good thing I don't want to distort it, instead of the pool I'd make an artificial lake in the grove" said cheerfully,
"Sure? You really like it?" Y/N asked happily,
"Of course I like it, I wonder Sammy was so malleable" they laughed together,
"Come back to me please .. I love you" he said greeting her, the woman gave the cell phone to Sammy who greeted Tom before hanging up,
"Thomas wants to know when he is free to sign, he likes the house and the price is perfect" she said shaking the man's hand,
"I'll leave you my number, call me when your boyfriend is available" he said passing Y/N a business card, "I'm glad the house is in good hands",
"We will have the utmost care" she replied cheerfully, "Thanks for your availability at such short notice", they said goodbye and got back in the car to go to London,
"Aren't we going back to you?" asked Y/N on the way
"We're going to see me in London" she laughed seeing the woman's expression, "Tomorrow shopping and I don't know a better place than London to shop",
"Since we're going to London then I'll stop at home so we're all more comfortable, Phil will you stay with me?" asked his friend who nodded, “ Sammy do you think you can even get a hairdresser in shopping? I can't stand long hair anymore and you have to redo the color .. "
"Of course dear even if it is a pity they give you long hair, I also take advantage of it then, as soon as we arrive I call mine so we do not risk horrible things" they laughed, it took 2 hours to arrive, Sammy left them at home they would see them again the next morning .
" Poppy the house is really nice, once it's whitewashed and fixed it will be lovely" said Phil taking a drink,
" It's how we wanted it, small and semi-hidden" she replied, "And if there is surveillance, I'm more quiet", called Tom while Phil was in the shower,
"My love ailment?" she was always afraid of disturbing him at work,
"My Queen, imagine, I'm getting dressed to go to the canteen before going to the set" he replied cheerfully, "I looked at the photos, I like the house more and more .. how did you convince Sammy ?"
"I told her the truth .. we wanted a house for us not a hostel" she laughed "I have the owner's number waiting for your call when you are free .. are you sure you like it?" You're not doing it just for me .. "she asked shyly,
"You know that I love you and that I would do anything to make you happy .. " he began, "..but I wouldn't say yes just to make you happy, you're not the kind of woman who would accept such a thing" laughed hearing the woman hold back , "I really like the house, I can't wait to watch you bathe naked in the woods .. my nymph"
"Oh Thomas .. I love you" Y/N answered moved, he too had noticed that it wasn't her but he hadn't told her anything, " As long as I 'm at home do you need anything?"
"I would say no, maybe check your mail" he laughed before greeting her,
"I ordered Chinese so we don't go out," Phil informed her, " What's the schedule tomorrow ?"
"There's a couple of things missing for the house," said, "Then I don't know what Sammy wants to see .. "
"It 'a nice lady ..i remember you .. " he teased his friend, "..funny and sparkling"
“I don't know her very much but she always makes me laugh” Y/N answered opening to the bellboy, they had dinner and watched a movie before collapsing in bed.
Sammy arrived at 10 am doing something new .. rang the bell,
"Day" Y/N said sleepily, "You could have entered without ringing" she laughed going into the kitchen,
"I didn't want to disturb, one thing is when Tommy is around .. another is when you have guests" Sammy laughed over the coffee, "I know you and Phil are just friends don't look at me like that"
"Sorry I get constant attacks from paparazzi and fans I have become rigid about these things .. it's not like me" she said in a low voice, "But today I get my temper back just bend over and be afraid .. " she said seriously, Sammy stared at her and burst out laughing,
"Tommy will be happy" she said telling her some conversations she and Tom had in the last few days, ".. I think he wants hers back .. how is it that described you .. yes wilde kitty" she concluded, Y/N blushed violently the man called her so only in private, "I strangle him" thought as passed the coffee to Phil who was letting go of laughter, they went out and headed towards the center,
"Hair first!" Sammy said finding parking in front of the salon, "Phil are you coming with us?" asked the man,
"I guess not thanks" he laughed, " Poppy, I'll drop by the office and go home, see you when you get back to town for Tom's departure?" he asked hugging her,
"Sure darling and thanks for the company" she answered kissing him, they said goodbye and the women entered the hall,
" Mat hi here we are" she said cheerfully hugging the hairdresser, "She is Y/N .. bring out the colors",
"Nice to meet you" he said shaking her hand, "Let's start with you then, what did you have in mind?" asked making her sit down and putting a cape around her shoulders,
"I want to get rid of the extensions , shave the sides and go back to my fuchsia and blue" she said happy to get rid of that good girl hair that didn't belong to her,
"Great, Sabine prepares for the bleaching" told her assistant before starting to shave the woman's hair, the fake locks fell to the ground lightly, he took some scissors and removed the extensions one at a time, fixed the cut and put the bleach on first to get to work on Sammy ,
"Do you know that I almost copy you?" she said looking at Y/N cheerfully, "Not the cut of course .. but I've always wanted to try something bold",
"Are you sure?" Mat asked , "How about keeping your color above and below purple and pre-oil ?" he asked taking the color palette and trying them on, "Bold is fine but I know you dear .. " he laughed,
"I like the idea, they would only show when I move my hair or tie it" replied Sammy now convinced, Mat put the bleach on her too and moved to prepare the colors,
"Come on, let's take a picture like this with the bleach on our head .. let's terrorize our men" laughed Y/N posing sexy with the woman, they laughed like little girls, they waited for the answers that were not long in coming,
"David is horrified" Sammy laughed , "He says you have a bad influence on me",
"Thomas seems curious to see you with colored hair" she laughed, "Is this the first time?" asked puzzled,
"What a color change no .. that I do my hair purple absolutely yes " she laughed, "You have to be a little crazy sometimes .. and besides there is always total black in case", after half an hour they had white hair ready for the color,
"Do you have any preference for mixing?" Mat asked before applying the colors,
"Usually I put blue on the roots and blend up to fuchsia on the tips .. more fuchsia than blue though" she smiled, it was the first time someone made her the color she was no longer used to it,
"Perfect, let's start then, Sabine .. " the assistant called and they set to work, "If you like the result, I'll prepare you an envelope with the colors I used to make them yourself", the woman thanked and enjoyed the pampering , they brought an aperitif and ate something while they waited, once washed and dried Y/N looked at herself and found herself in the reflection of the mirror, she smiled happily,
"OMG !!" she turned to hear Sammy scream as looked at herself, "I don't know what to say I'm confused .. " laughed astonished,
" Sammy they look great on you," Y/N said, moving her locks behind to make the colors shine through,
"I like the result, with long hair like yours it's a great idea", Sammy kept looking at herself undecided,
" They are .. weird .. beautiful but really weird .. " she laughed, ".. why do they look so good on you?" she asked jealous,
" Because I am fabulous with these colors!!" laughed Y/N making the grimace, "And because I feel at ease, I look beautiful with these tones", they paid the bill and went out, they spent the rest of the morning wandering around the shops, Y/N ordered pillows and puofs for the house over there,
" Sammy, is there a florist in the area?" asked Y/N looking around, the woman nodded and led the way, around the corner there was a kiosk full of flowers,
"Day I would like a bouquet of yellow roses please" she said to the boy, "And if has them also one of sunflowers", Sammy looked at her curiously,
"I understand sunflowers .. why roses?" asked, "If I remember correctly they indicate jealousy .. are you all right dear?"
"Very well, I wanted to make a gift to "that" that's all" she replied cheerfully, Sammy looked at her sideways asking why,
" Well in the end she behaved like an ignoble being .. but if Thomas hadn't done it and I would never have met" she replied calmly, "It seemed nice to thank her"
"You are really twisted" said bursting out laughing, "I wish I was a fly to see his face", they finished the purchases and left for the set.
She found Thomas on the sofa going over, "as if he needed it" thought putting the flowers in the water,
"My King I missed you," she said, putting herself in his arms to kiss him,
" Honey welcome back" he said kissing her, ruffling her forelock, "You look great, like when I met you .. ruffled and colored" he laughed looking at her,
"How did the shopping go?" he asked not seeing envelopes or packages, "Weren't you inspired?"
"Have found something for the house, I did take home and warned Ali because mail it with the rest," smiled when she saw the startled face of the man at the mention of her pr , "And I took the flowers .. "
"I saw ..yellow roses?" he asked curiously, staring at her,
"Um really I'm for "that".. " Y/N answered laughing, "..and I apologize in advance" she concluded, staring at him to try to understand what he was thinking, the man kept staring at her undecided,
"Please explain Darling why I don't follow you .. " he answered curiously, "..I have some ideas but I want to hear it from you",
"I know it will seem absurd to you .. " she exposed almost guilty, suddenly was lacking the courage, ".. but if she hadn't behaved like a bitch we two will not be together now .. " said in a low voice,
" Darling .. " he said amazed, smiling at her, ".. I don't know what to say, if when it happened they told me that I would find the woman of my life I would have laughed .." he continued taking her in his arms,
".. Rice told me you're a vengeful type .. I see Lady Loki .. " he whispered biting her earlobe, Y/N meowed close to him,
"You are angry? I know how much it made you suffer and I don't want to seem numb but you have to understand that you have to start away" said Y/N embarrassed , the man stared at her smiling, hugged and stood up with his precious load in his arms going towards the bedroom,
"You'll see how angry I am Kitty " he growled smiling throwing her on the bed, Y/N smiled anticipating the punishment.
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96thdayofrage · 3 years
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What the defense has planned
During the jury selection process, Nelson tried to humanize Chauvin beyond the image of the white police officer who knelt on a Black man’s neck as he struggled to breathe and begged for his mother.
When the first batch of potential jurors was being questioned, Chauvin — with half his face obscured by a black mask — sat taking notes and rarely making eye contact. At one point, a juror said she could not forget the “hateful look” on Chauvin’s face in the videos. The comment altered the way Nelson later introduced his client to potential jurors, with Chauvin removing his mask to show his full face and nodding at the group.
To avoid convicting Chauvin of the second-degree unintentional murder charge, the defense must prove he did not cause Floyd’s death while also committing a felony — in this case, assault. The defense will argue that Chauvin did not cause Floyd’s death, that it was a combination of excessive drug use and preexisting conditions that killed him. They will call on the county medical examiner who said Floyd’s toxicology report showed high traces of drugs during the incident — but the examiner also noted that it’s hard to say whether Floyd would have died of other causes, like Chauvin’s knee on his neck. If convicted, under Minnesota law, the charge is punishable by up to 40 years in prison.
To avoid conviction on the second-degree manslaughter charge, the defense needs to prove that Chauvin didn’t cause Floyd’s death due to negligence that created an unreasonable risk — meaning, he didn’t know that pinning him down by his neck for nearly nine minutes would lead to severe injury or death. In Minnesota, this charge carries a maximum sentence of up to 10 years.
The third-degree murder charge, under Minnesota law, means the perpetrator acted in a way that was reckless at the risk of causing death and carries a sentence of no more than 25 years. Prosecutors argued to add the third-degree murder charge because not only is it easier to prove than second-degree unintentional felony murder, but it also gives jurors more options about how to convict. If convicted of any of these charges, Chauvin’s status as a first-time offender will also play into how long his prison sentence will be.
Ultimately, the defense’s central strategy is proving that something else ended Floyd’s life — and that it was not Chauvin’s knee. Nelson pushed for a pre-trial motion to include evidence of Floyd’s drug-related arrest by Minneapolis police in 2019. After reviewing Nelson’s arguments, in which the attorney called Floyd’s “emotional responses” during both arrests a “common modus operandi,” Judge Cahill has allowed the defense to show only a portion of the 2019 arrest video as evidence during the trial, adding that Floyd’s interactions with the police in 2019 mirrored the 2020 arrest that led to his death. Cahill also agreed that there were signs that Floyd may have taken drugs in both incidents.
The defense has also tried to argue that Chauvin was terminated due to prejudice, not for cause, and that Minneapolis Police Chief Medaria Arradondo only fired him out of public pressure. However, prosecutors successfully motioned to exclude any evidence or testimony that speaks to the police department’s decision to fire Chauvin and the other three officers involved since it’s unrelated to how and why Floyd died.
Nelson’s arguments so far give observers a glimpse of how he expects to approach the trial — that the entire investigation leading to Floyd’s death was fundamentally biased against his client, including the ongoing federal civil rights investigation and Chauvin’s immediate firing. Arradondo, the city’s first Black police chief, said he fired the officers after reviewing all the evidence including body-camera videos.
During the month-long trial, several witnesses are expected to testify, including Arradondo, the county medical examiner, and the bystander who videotaped Chauvin kneeling on Floyd’s neck.
The prosecution also plans to introduce “spark of life” witnesses, which under Minnesota law allows family and friends to be called to the stand to deliver testimony that would humanize the victim. Floyd’s brother, Philonise Floyd, and former girlfriend Courteney Ross are among those expected to speak.
However, the spark-of-life testimonies won’t be considered “evidence” and will be tightly managed by Cahill. The judge said he would draw a line if witnesses talk about Floyd’s character rather than how much they loved him since it would “open the door” for the defense to introduce Floyd’s criminal history as evidence, which so far has been ruled inadmissible. Cahill, nonetheless, added he may allow witnesses to talk about Floyd’s struggles with opioid addiction.
“This is not a hard case,” Ben Crump, the attorney who helped the Floyd family secure the $27 million settlement, said in a news release after the jury selections were completed. “George Floyd had more witnesses to his death than any other person ever — white or Black. We all saw the same thing — the indisputable and unjustified torture and murder by a police officer of a Black man who was handcuffed, restrained, and posed no harm.”
What we know about the jury
The initial jury pool had 326 people, but only about 60 were questioned. Cahill decided 15 needed to be selected, including two alternates and another who will be dropped if the first 14 jurors show up for duty (only 12 will be on the actual jury).
Even though the jury selection process was broadcasted live, the faces of the prospective jurors were not shown to the public for their safety and privacy, and they will not be seen for the duration of the trial. Among the 15 selected jurors, we do know six are people of color — one Black woman, three Black men, and two mixed-race women — while nine are white, six of whom are women. Despite being a white majority, the jury is actually more diverse than the county and the city: According to 2019 data from the US Census Bureau, Hennepin County is about 74 percent white and 14 percent Black while Minneapolis is about 64 percent white and 19 percent Black.
The jurors also come from an array of backgrounds, ranging from an accountant to a chemist to a nurse who has been caring for patients throughout the Covid-19 pandemic. Some are extremely familiar with the case while others haven’t been actively following monthslong developments. According to USA Today, seven are in their 20s or 30s, three in their 40s, four in their 50s, and one in her 60s.
Prior to the selection, each potential juror was asked to fill out a 14-page written questionnaire. During the selection process, the jurors were questioned and vetted by Judge Cahill, prosecution, and defense lawyers. The general line of questioning included if their views have changed since filling out the questionnaire, whether they could set aside their personal opinions on the case and social movements to remain impartial, and also about personal safety concerns. Those who expressed major anxiety and fears of being on the jury were ultimately dismissed.
The jurors were also asked about their thoughts or whether they’ve seen the video of Chauvin pinning his knee on Floyd’s neck as well as their views on the Black Lives Matter and Blue Lives Matter movements. One of the selected jurors, who said he plans to move out of Minnesota in late May, noted he has a neutral opinion of Floyd and also generally favors the Black Lives Matter movement but also believes it was “a contributing factor” in the unrest that erupted following Floyd’s death last summer.
Another juror, a white man who works in sales, called the Blue Lives Matter movement “not offensive but shortsighted.” The man, who is supposed to get married in May but said he is willing to postpone the wedding if the trial continues, noted he generally supports law enforcement.
Some of the jurors’ responses also indicated how they would approach the final verdict of the trial. One juror said she wanted to know more about police training and whether placing a knee on someone’s neck was allowed while another said he wanted to hear Chauvin offer his side of the story.
However, one potential juror last week was dismissed by Chauvin’s defense attorney after sharing his thoughts and personal experience with the Minneapolis Police Department and the criminal justice system as a whole.
“As a Black man, you see a lot of Black people get killed and no one’s held accountable for it, and you wonder why or what was the decision, and so with this, maybe I’ll be in the room to know why,” the potential juror told the court.
Although the Army veteran said he could put his personal opinions aside to hear the case solely based on the evidence presented in court, he was still dismissed by the defense arguing that he was biased against the Minneapolis Police Department.
“That was his actual lived experiences with the Minneapolis police, but he was disqualified because it was assumed he couldn’t look past that in order to look at the facts of the case,” Bullock told Vox. “It’s an insult to Black Minneapolis residents because we have to forgo our bias and lived experiences all the time to fit in the system. It just shines a light on some of the inherent unfairness about the system.”
Cahill said he plans to reveal the names of the jurors when it is “safe” to do so. In the meantime, government buildings in downtown Minneapolis remain heavily barricaded by fencing and concrete barriers while members of the Minnesota National Guard remain stationed outside the courthouse. The heavy police presence, Bullock said, has left the community on edge.
Still, activist groups like Reclaim the Block and Black Visions Collective will keep a close eye on the trial while also protesting outside the courthouse and rallying at what’s now George Floyd Square. What they ultimately hope comes out of Floyd’s death is what they’ve always wanted: replacing Minneapolis police with a new public safety department, which means first changing the city charter and knocking door to door to collect signatures to do so.
“Regardless of the outcome of the verdict, we know that true justice would have to reflect in a fundamental change in the way we address public safety. If we’re not doing that, true justice is not served,” Bullock said. “We want justice for George Floyd and his family, of course, but we know that true justice means changing our public safety system.”
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mittencone16 · 3 years
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Modern Technology
European Peptide Culture
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" Anabolic Steroids Are Understood For An Entire Host Of Unpleasant Adverse Effects "
What Are The Kinds Of Sarms.
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Improving Cattle Production By Counting Chromosomes.
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Life depends on the complex interplay of multitudes of various biomolecules, however just how such interdependent molecular networks occurred at the origin of life stays a mystery. Such job can likewise give the structure for the design and also building and construction of molecular systems with life-like residential or commercial properties such as growth, department and also evolution. In this webinar, the speaker will lead you via the individual steps for synthesis of peptides applying Molecular Hiving ™ Innovation. Recap on Give Application Hydrogels are of large technological as well as scientific interest due to the fact that they are composed generally of water, typically similar to that of physical tissue. Hydrogels are made use of for applications consisting of contact lenses, cells engineering, medicine launch, as well as biosensing. Each of these applications needs gels with different materials residential or commercial properties.
Matteo Spreafico out of Giro d'Italia after doping positive - Cyclingnews.com
Matteo Spreafico out of Giro d'Italia after doping positive.
Posted: Thu, 22 Oct 2020 07:00:00 GMT [source]
For that reason, intermediate seclusion of the tag-bound peptide and too much washing steps are not required for Molecular Hiving ™ Technology. Scancell has also recognized and also patented a series of customized epitopes that stimulate the manufacturing of killer CD4+ T cells that ruin tumors without poisoning. The Directors think that the Moditope ® platform could play a major function in the growth of risk-free as well as efficient cancer immunotherapies in the future. The PepMix ™ variety of top quality peptide pools for the artificial insemination excitement of CD4+ and CD8+ T-cell reactions covers more than 100 antigens or blended epitope pools, consisting of tumor associated and infectious disease antigens. The PepMix ™ peptide pools are produced by antigenic healthy protein sequences being split into overlapping peptides, chemically synthesised and after that analysed to adhere to the demands of T-cell assays. Our novel, proprietary phage display testing system integrates biology with chemistry.
" Anabolic Steroids Are Known For An Entire Host Of Unpleasant Negative Effects "
This technology utilizes a hydrophobic tag, which is used similarly as the material for solid-phase peptide synthesis processes. The same standard Fmoc amino acid by-products as for SPPS are applied for assembling the peptide chain. However, all combinings and also cleavages of the Fmoc shielding group are executed in option allowing for rapid responses as well as direct in-process controls, e.g. by HPLC.
How long does LGD 4033 stay in your system?
While clinical trial participants on Ligandrol did have a higher rate of throat infections, it was concluded this was not due to the drug. Ligandrol can be detected for up to 21 days in the urine of those who take it.
growth targets. Remarkably, a solitary booster shot with customized peptide, up to 14 days after lump dental implant, resulted in lasting survival in 60 %to 90 %of animals without any linked poisoning. This introductory phase covers the basic ideas connected with cyclic peptides and is meant to set the stage for the following areas of this publication. Hence, a brief description of the architectural space of cyclic peptides and their connection to proteins is offered. After that, the principle of conformational constraints is presented defining the various modes of peptide cyclization. Ultimately, assurances and premises for cyclic peptides to be made use of as pharmaceutical representatives are laid out. These concealed nasties can cause the failure of proteins such as collagen and also elastin. Basically, Vitamin C is aiding to safeguard the cellular structures that peptides are working hard to produce. Harpreet Singh obtained his PhD in Immunology at the College of Tuebingen, operating in the group of Professor Hans-Georg Rammensee. He is the co-founder of immatics biotechnologies, a Tuebingen-based business. As Chief Scientific Policeman of the business, he is responsible for the growth of unique peptide-based cancer cells injections from medication discovery to medical development. Additionally, the XPRESIDENT platform is not limited to renal cell carcinoma however has also been efficiently put on other tumour entities. Better, multi-peptide item candidates will quickly be introduced right into clinical growth. It remains to be seen whether this unique course of normally provided antigens will certainly be able to make a difference to cancer cells immunotherapy. The first outcomes have provided some hope-a hope driven by data and brand-new knowledge. Peptide as well as healthy protein bioanalysis brings better complexity compared to small particle analysis. High history noise because of endogenous peptides and healthy proteins can lower signal and call for more complex sample preparation. https://direct-sarms.com/product/post-cycle-therapy-support/ have more multiply-charged types, raised fragmentation patterns, and a range of reduced wealth pieces, all of which decrease signal-to-noise ratio. Furthermore, a substantial variety of biologics have longer half-lives than small particles; for that reason, numerous are dosed at reduced concentrations. Monoclonal antibodies comprise a broadening group of restorative substances, which are made use of to deal with cancer, auto-immune conditions, as well as systemic infections. Mass spectrometry is the analytical device of selection for quantitation of mAbs, due to its selectivity, multiplexing, and dynamic array advantages over ligand binding assays. Waters' Xevo tandem quad household, columns as well as chemistries have been used to perform bioanalysis of large healthy protein particles, such as the monoclonal antibodies and antibody-drug conjugates like Bevacizumab, Infliximab, and Trastuzumab Emtansine. This innovation has applications in injection and medical diagnosis advancement. For vaccines, it can be utilized alone or in mix with various other treatments to treat a vast array of human cancers cells or transmittable illness. The innovation can likewise be used in diagnosis to assess T cell resistance which is necessary for monitoring and also regulating cancer cells and microbial infections. The ROP innovation platform has a number of distinctive advantages over existing methods of turning on or checking cellular resistance. This bicyclic peptide of eight amino acids is one of the most lethal of all the toxins found in a number of varieties of the Amanita category of mushrooms.
What Are The Types Of Sarms.
The network that catches the water is commonly polymeric, however current researches have actually revealed that brief peptides can be utilized, using advantages when it come to biocompatibility and also flexibility of layout. As a result, generating hydrogels for particular applications is a hit-and-miss event, calling for repetitive synthesis and testing. This job focuses on the underpinning scientific research of hydrogel formation from oligopeptides as well as the growth of full design guidelines for such products. Such policies will certainly relocate the area onward dramatically, establishing layout standards for certain applications and permitting the full exploitation of this amazing technology. The evaluation, whose lead writer is Teacher Lindy Durrant, Scancell's Principal Scientific Police officer, discusses the concept that citrullinated peptides created during autophagy deal appealing vaccination targets for cancer cells treatment.
Molecular Hiving ™ additionally enables the synthesis of peptides without making use of solvents as well as reagents which are carcinogenic, mutagenic, or hazardous to recreation. This makes peptide products produced by this modern technology highly appealing for the pharmaceutical and cosmetics sector.
Our creator Sir Greg Wintertime, a leader in phage screen, used this modern technology, including a cyclization action that develops Bikes from these direct peptides. Consequently, we can rapidly select phage that bind to a selected biological target and also utilize evolution-driven, enlightened choice to derive maximum particles. A succeeding testimonial section on the use of classic chemistry strategies for cyclic peptides will include an initial component gone along with by chosen details instances (Phases 6-- 9). Then, an example of how synthesis and biological approaches can be combined will be explained followed by a section focusing on the evaluation of cyclic peptides (Phases 11-- 13).
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paired arg-diaminobutyric acid ring, showed the highest possible receptor affinity and also agonist strength. The pharmacokinetic data of 177Lu/68Ga-AM 3 make this peptide an outstanding candidate for imaging and also as a positron discharge tomography radiotracer. This represents an unique strategy to take on the current shortage in Gram-negative prescription antibiotics and will swiftly prolong the currently available collection via the combination of regulative authorized Gram-positive medications as well as our peptide platform. The self-assembly peptide hydrogels made use of as tissue society scaffolds have attracted terrific interest in the last few years. They have the benefits of natural polymer hydrogels including biocompatibility, biodegradability and also the advantages of artificial products such as controlled architectural homes as well as mechanical homes. In Buy bulking stacks , the bioactive ligands which can advertise bioactivities as well as control cell behaviours can be easily introduced to the peptide foundation through peptide synthesis. In this task, the self-assembly and also gelation homes of FEFEFKFK peptide were additionally explored, evaluating the effect of pH as well as ionic toughness on the self-assembly and gelation behaviour. The biomimetic nanofibrous hydrogels of FEFEFKFK were likewise examined for their ability to sustain human dermal fibroblast cells. The methods of gel preparation were created for both 2 dimensional and also 3 dimensional cell society. The functionalised peptide hydrogels boosted cell attachment on gel surface area, with cell interaction examined utilizing numerous imaging and also spectroscopic techniques. An initial 3D cell society research likewise revealed possibility of these peptide gels to be used for encapsulated human dermal fibroblast cell studies. RGD peptide is an adhesive peptide which can be used in a biomaterial context to connect cells to a series of products. It is located within extracellular matrix proteins as the integrin binding domain. The benefit of using RGD peptides over entire ECM proteins is that it decreases the immune sensitivity risk. Immunization with these peptides induced CD4 T cells in action to autophagic
It is a helpful tool in figuring out kinds of ribonucleic acid polymerase existing in a tissue example. These bicyclic and also polycyclic peptides might have better infiltration and also diffusion properties with bigger options of administration than mAbs. They offer much better target uniqueness with raised capacity to interfere with protein-protein communications. The only caution here is the problem in generating polycyclic peptides with suitable binding homes. Bicyclic peptides have actually been prepared by service phase and solid phase synthesis. Greater levels of orthogonality and regioselectivity of amides are crucial while making the artificial systems for bicyclic peptides. API Provider & Chemical Growth Giving solutions for all phases of medicine development for little particles and peptides. Providing solutions for all phases of medication advancement for tiny molecules as well as peptides. Over the previous decade, Dr. Iegre and her group have actually established high-quality specialized reagents as well as methods that can modify peptides as well as overcome these downsides. In the short term they are exploring supplying their existing set of reagents to research study teams and also the pharmaceutical industry, along with
Improving Livestock Production By Counting Chromosomes.
Wolfgang Seufert researched chemistry at the colleges of Giessen and also Leipzig, and also got his PhD from the College of Basel for his deal with cyclization reactions of changed amino acids as well as peptides. Molecular Hiving ™ is a tag-assisted liquid-phase peptide synthesis modern technology established by Professor Kazuhiro Chiba at Tokyo College of Technology and also Agriculture.
We make use of artificial biology to display a considerable variety of linear peptides externally of engineered bacteriophage as well as chemistry to change them right into Bicycles. Phage can be utilized to determine Bicycles by splicing DNA right into the phage genome to ensure that linear peptides encoding Bikes are presented on the phage surface area.
S4 Sarm Sarms S4 Fluid Research Study Substance.
The last 4 phases (Phases 14-- 17) of guide will highlight making use of cyclic peptides in biology and also in drug exploration. In you can find more information on direct-sarms.com's Home page here. , oral delivery of peptides drugs is incredibly challenging purpose. Digestive system is likely to cleave the peptides prior to assimilation. Remedy to the reduced bioavailability of such medicines stays to be established. Development in biotechnology as well as genetics technology aided in the development of a many possible restorative polypeptides in commercial scale.
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Peptides have large chemical convenience as a result of the varying nature of their amino acid R-group. They can be made use of to develop materials with really certain performances as well as with the possible to affix a variety of molecules including drugs, for this reason their use within medication delivery. We have actually created a generic and durable technology for the site-specific add-on of small particles, large polymers and also peptides to various proteins. This method, which produces a targeted, site-specific ligation at the C-terminus, enables total control over the conjugation procedure. Benefits of peptides include their capability to interact with a different collection of targets to various other courses of medicines, low production expenses and reduced in vivo immune responses. Disadvantages include them breaking down promptly in vivo as well as usually not having the ability to participate in living cells where the majority of the medication targets are located. In this webinar, the speaker will assist you through the specific steps for synthesis of peptides applying Molecular Hiving ™ modern technology.
Our publication in Acta Biomaterialia has actually confirmed peptide nanotubes have the ability to transverse the external membrane layer of Gram-negative germs. We are progressing to study their capability to be utilized in combination with existing certified antibiotics. A significant number of chronic clinical problems suffer from made complex medicine treatment regimens that people discover trouble adhering to, adversely impacting therapeutic outcomes. Our group examine using peptide-based hydrogelas as a new modern technology system for growth of long-acting injectable medicines within these medical care areas.
As a result of the way Cardarine functions customers as well as animal researches showed that Cardarine is connected with considerable decrease in body fat.
Throughout this moment good cholesterol boosted by 17% and poor cholesterol was reduced by 7%.
As a result of the means GW functions it is safe to assume it was all or mostly LBM.
In this area, you will certainly discover both SARMS, and items that resemble SARM items.
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In phase 1 and stage 2 tests which lasted 12 weeks 268 individuals with low HDL levels were given 2.5,5,10 mg daily.
Bodyweight also enhanced typically 1.3 kg however a LBM vs fat mass evaluation was not completed.
supplying working as a consultant solutions to recommend on exactly how best to functionalise peptides of rate of interest. In the longer term they intend to develop their very own collections of cell-permeable peptides that they have actually effectively synthesized and also examined, with collaboration with identified partners.
Excess reagents as well as combining and cleavage related byproducts are exclusively removed by aqueous extractions. Consequently, intermediate seclusion of the tag-bound peptide and extreme cleaning actions are not needed for Molecular Hiving ™ modern technology.
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Scancell's Moditope ® system utilises this device to promote the manufacturing of extremely active CD4+ T cells that get rid of self-tolerance as well as ruin tumor cells. Without doubt, all-natural product-derived and also artificial cyclic peptides have gotten expanding interest from the clinical area recently. This has actually been gone along with by a noticeable renaissance of tasks by the pharmaceutical sector in the area of peptide-based drugs. In this regard, the macrocyclization motif uses a number of benefits over linear analogs, like enhanced security, strength, and membrane leaks in the structure. These beneficial chemical as well as physical buildings can be manipulated for various applications, which are definitely not limited to pharmaceutical exercises. This has been an encouraging example for a compound with oral bioavailability far beyond the Lipinski space, which promoted additional examinations of the possibilities to develop peptide-based medicines for oral consumption. Nevertheless, applications where oral management is not the preferred path, like e.g. topical treatment of wounds or lung distribution into contaminated lungs, can conveniently utilize cyclic peptides as therapeutic representatives. Priming of just one kind of cytotoxic T-cell with one TUMAP is generally not enough to get rid of all tumour cells. Tumours are extremely mutagenic and are hence able to react quickly to CTL assaults by altering their pattern of shared proteins, enabling them to run away from the acknowledgment by CTLs. Several turned on T-cells can act synergistically by all at once assaulting a corresponding variety of separately encoded tumor antigens decreasing the opportunities of a tumour cell to avert the immune feedback by down-regulating single targets. Recombinant as well as wild type pVIII major coat proteins displaying hundreds/thousands of copies of therapeutic peptides. The principle of hydrolysed healthy proteins is that by enzymatically cleaving nutritional healthy protein molecules into peptides, the molecular weight is lowered to listed below the limit needed to turn on the immune system. C-peptide is short for linking peptide because it is in charge of joining the An and also B chains of insulin within the proinsulin particle. The enzymatic bosom of proinsulin causes the launch of insulin into blood circulation and also c-peptide being developed. Connecting peptides have no metabolic feature as well as often tend to be 31 amino acid peptide deposits that have a half-life in blood circulation that can be between 2-5 times much longer when compared to insulin. Cyclic peptides can bind as well as move metal cations across membranes in organic systems. Monocyclic peptides are too versatile as well as non-specifically bind to metal ions, whereas bicyclic peptides are a lot more inflexible and also particularly bind cations. A collection of bicyclic peptides have been made as well as synthesised by scientists to supply ammonium ion complexation websites by means of hydrogen bonding in a tetrahedral geometry. This helps to identify the precision degrees of ammonium ions in the visibility of potassium ions for the scientific evaluation of urea as well as creatinine degrees utilized in blood evaluation applications. An additional class of bicyclic peptides in the onset of development are substances targeting arginine-glycineaspartic acid vectors that bind to the receptors connected with angiogenesis-like integrin receptors. These bicyclic substances might be used for the diagnosis or therapy of malignancy, heart problem, endometriosis, inflammation-related diseases, rheumatoid arthritis and also Kaposi's sarcoma. The license WO 03/ describes peptide-based compounds targeting integrin receptors associated with angiogenesis. The European EP license defines a brand-new course of the bicyclic peptide and also the analogues used as imaging representatives. Radiolabeled somatostatin analogues have actually been made use of to target somatostatin receptor tumours. Recently developed bicyclic somatostatin-based radiopeptides are a new kind of radiotherapy for neuroendocrine tumours and also can be made use of as analysis imaging representatives. These brand-new analogues showed high fondness for sst2 as well as sst3 and modest fondness in the direction of sst1, sst4 as well as sst5. The analogue AM3, consisting of an octreotide ring and also a head-to-tail
LAI nanosuspensions composed of water-insoluble medicines are frequently suggested for the treatment of illness with minimized individual adherence to medication such as schizophrenia. This platform has big capacity within biomedical applications to prevent as well as treat a vast variety of conditions by means of boosted shipment of medications. Our molecules have several benefits over current artificial products made use of in health care.
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We probably won't ever befriend Percy tbh...but I'm holding out hope that we'll befriend Ismelda cause of that post that seemed like they were teasing it. Probably just wasting my time though. :,) I'm so mad at JC rn. First they take Ismelda away from the dating pool, and now this???
It just doesn’t seem fair that we don’t get Percy, but we do befriend Fred and George, even though we hardly know them, and Cedric, who we don’t even have the previous Weasley connection to. At least Beatrice has plot relevance and a character arc. When was the last time Cedric and the Twins did anything that wasn’t fan-service? Hell, Percy arguably has more plot relevance than them because he’s the one who currently has Scabbers. And yet he’s the only Weasley we cannot befriend. Considering his story, that just...feels mean. 
I didn’t see any post where they teased an Ismelda friendship,  but if it hasn’t been discovered in the data-mines, I’m afraid that was probably just one of Jam City’s infamously inconclusive tweets. It’s not impossible, because she has main story relevance for the first time since third year, but I’m not sure if they want to focus on her right now....
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for the 200 ask thingy, i actually dare you to do all of them. :D
delgaskarthalexhere we go, anon: 
200: My crush’s name is: I don’t have one right now, I don’t get them often (if I ever had a crush at all)
199: I was born in: 2003
198: I am really: A 2005 emo kid x a 2008 scene kid x a 2014 tumblr fangirl x Kyle himself
 197: My cellphone company is: Apple
194: My ring size is: Honestly? No idea. Propose to me with a sword.
 193: My height is: Somewhere between 5′7″ and 5′8″
192: I am allergic to: Nothing I’m aware of 
191: My 1st car was:  94 Station Wagon, by request
190: My 1st job was: being this funny is a full-time gig
 189: Last book you read: Bone Gap by Laura Ruby
188: My bed is: “made”
187: My pet: I have a cat, I love her very much and I will show her to you if you dm me a cursed image
186: My best friend: We don’t use “best friend” for personal reasons, but they’ve been with me since I was 5 so, my one and only Bro
185: My favorite shampoo is: anything with “silky smooth” or “strawberries” on the bottle. i’m not that picky anymore.
184: Xbox or ps3: xbox or ps4  xbox
183: Piggy banks are: really useful
 182: In my pockets: wallet, keys, phone, earbuds, black pen/pencil, earplugs, mini flashlight
 181: On my calendar:  i’m meeting a friend for smoothies tomorrow
 180: Marriage is: something we shouldn’t push so much onto people. it’s a declaration of love, not an end-all fix-all to your life. i can’t ever see myself getting married but who knows!
 179: Spongebob can: continue to be a relevant meme
178: My mom: i mean. we function. i can’t really complain about my family at large but i am defiantly looking forward to living literally as far away from them as i can. 
 177: The last three songs I bought were? psh, you think i pay for music? (folie a deux, lake effect kid, believers never die volume two) (those are albums but its okay)
176: Last YouTube video watched: I watched Markiplier play Uno
175: How many cousins do you have? 11? 12? I lost count
174: Do you have any siblings? I have a brother
 173: Are your parents divorced? Nope!
172: Are you taller than your mom? Yes, I have been for a while
171: Do you play an instrument? dude HECK yeah! i vibe on piano, guitar, ukulele, clarinet, and im a drum major
170: What did you do yesterday? I went on a drive by myself.
 [ I Believe In ] 
169: Love at first sight: Nope.
168: Luck: Yes, but luck is something that can be engineered
167: Fate: To an extent
 166: Yourself: I’d say overall, yeah. I still have doubts tho
165: Aliens: Mmmmmm yeah
 164: Heaven: Yes
163: Hell: Yes
162: God: Yeup
 161: Horoscopes: without an ounce of truth, they would have died a long time ago
160: Soul mates: the greeks had seven words for love. i think we have multiple soul mates to fit each of those categories. there are definitely people we’re just meant to vibe with
159: Ghosts: i want to say yes but i really dont know
158: Gay Marriage: yes. its 2020. grow up.
157: War: in theory? no. war is kinda messed up. in reality? not everyone is going to be down to nice diplomatic conflict resolution, and not everyone is just gonna leave people *countries* they don’t like alone, so...
156: Orbs: ??? energies are real
155: Magic: vibes are real
 [ This or That ]
 154: Hugs or Kisses: hugs
153: Drunk or High: i am a child of jesus
152: Phone or Online: online
 151: Red heads or Black haired:  irdc but black hair bc i am Emo
150: Blondes or Brunettes: blonde?? ig?? easier to dye
149: Hot or cold: hot weather + cold rooms
148: Summer or winter: summer
147: Autumn or Spring: autum (screw spring)
 146: Chocolate or vanilla: vanilla
145: Night or Day: night
 144: Oranges or Apples: oranges (better to share with homies)
 143: Curly or Straight hair: i dont care but curly
 142: McDonalds or Burger King: mcdonald give iced coffee
141: White Chocolate or Milk Chocolate: dark chocolate
 140: Mac or PC: pc for vidgya gaemes
139: Flip flops or high heals: ...converse. please. i cant walk properly in either of those
 138: Ugly and rich OR sweet and poor: sweet and poor 
 137: Coke or Pepsi: pepsi
136: Hillary or Obama: this is kinda outdated but obama
135: Burried or cremated: cremated i aint watch spn for nothin
134: Singing or Dancing: singing. at least that gets better with practice
133: Coach or Chanel: chanel (thank u mr frank ocean and also the neighborhood)
 132: Kat McPhee or Taylor Hicks: whomst
 131: Small town or Big city: big city and if you say small town you’ve never lived in a small town
 130: Wal-Mart or Target: target
 129: Ben Stiller or Adam Sandler: who tf is this
 128: Manicure or Pedicure: idk dude probably pedicure i don’t like people touching my hands and i use them for too much to get my nails done
127: East Coast or West Coast: hnngggggggg west coast has more to do but east coast has better beaches and 
126: Your Birthday or Christmas: birthday 
125: Chocolate or Flowers: chocolate bc then i can give u some
124: Disney or Six Flags: ive only been to disney so disney (though i AM a HARDCORE rollercoaster stan so it wouldnt take much for me to say six flags)
123: Yankees or Red Sox: what 
 [ Here’s What I Think About ]
 122: War: unfortunately sometimes necessary but not as a first resort i went over this already 
 121: George Bush: is that the shoe guy?
 120: Gay Marriage:  be gay. do crime. kiss wife. or husband. or partner. basically, hell yeah
119: The presidential election: america need 2 b single and focus on herself
 118: Abortion: pro-choice and that choice should be made by the one carrying the baby
117: MySpace: tumblr’s dad
116: Reality TV: don’t talk to about abt this
 115: Parents: disgusting. go to therapy. 
114: Back stabbers: if you’re gonna stab me in the back, pull my lungs through my ribcage bc that’s what my ancestor’s ghosts are gonna do to you (thanks great (x a few times) grandma viking ily thanks for the hair:) )
113: Ebay: good for merch and selling books
 112: Facebook: zuck my dick, data-theif
111: Work: i like doing work? like- i enjoy completing tasks and seeing my hard work pay off? it’s not that bad?
110: My Neighbors: old. boring. want me to babysit for free.
109: Gas Prices: i cant really complain rn they’re kinda low and im a little broke so
108: Designer Clothes: i vibe to them, honestly
 107: College: not for everyone but definitely for me
106: Sports: marching band is a sport marching band is a sport marching band is a sport marching band is a sport marching band is a sport but only technically speaking though you can make fair comparisons to sports such as cheer, and gymnastics where the idea is to put on a show and receive a score in the form of competition. 
 105: My family: disgusting
104: The future: the future doesn’t exist
 [ Last time I ] 
103: Hugged someone: god, don’t ask me this
 102: Last time you ate: uhhh like 9 hours ago? it was dinner and i had pizza
 101: Saw someone I haven’t seen in awhile: three or four weeks ago by best bro came to visit and we vibed
100: Cried in front of someone: i finished twist and shout at school at the end of a very bad week. it was only a few tears but that’s as close as i get to crying
99: Went to a movie theater: whenever the last star wars movie came out
98: Took a vacation: last year i went to dc over summer break to see the Smithsonian, it was a lot of fun. i was supposed to go to altanta and florida this year but that didn’t happen for reasons
 97: Swam in a pool: last week
 96: Changed a diaper: never
 95: Got my nails done: never
 94: Went to a wedding: its been at least 6 years dude
93: Broke a bone: never, somehow
 92: Got a peircing: nope
91: Broke the law: technically, yesterday. 55 is too slow
90: Texted: just now
 [ MISC ] 
89: Who makes you laugh the most: the person in my snap named “junior”
88: Something I will really miss when I leave home is: my cat
87: The last movie I saw: probably into the spiderverse
86: The thing that I’m looking forward to the most: things going back to normal. or somewhat normal. i need school to have a schedule bc i absolutely cannot force myself to function without outside influence
 85: The thing im not looking forward to: ironically, school in the fall. the way we’re going back is going to wreck me more than lockdown already has
 84: People call me: i only ft one of my bros and they know who tf they are if you ask to ft you’re getting fuckin blocked mate i dont do that shit video calls are for WORK and SCHOOL thats IT. but ppl call me by my nickname irl, i go by screech on here. 
83: The most difficult thing to do is: listen to my parent’s political opinions? live in a small town? force myself to be productive without a physical influence and reminder? put up with that one dude?
82: I have gotten a speeding ticket: nope
 81: My zodiac sign is: scoprio/leo/gemini
80: The first person i talked to today was: the potential bassist for our potential band? 
79: First time you had a crush: uhh im still not sure if it was a crush but i wanted them to myself and they wanted (and got) someone better. we were just friends so it doesn’t really matter
 78: The one person who i can’t hide things from: the person on snap named “the great oracle”
77: Last time someone said something you were thinking: yesterday, it was my brother
 76: Right now I am talking to: in order of snap names, “vibin ~[^.^]~”, “russian umbrella”, and “mom” (not really)
75: What are you going to do when you grow up: hopefully, a job that makes me happy
74: I have/will get a job: as soon as i know what’s going on with school. but like as an adult? wherever will hire me and pay my fairly. being a barista would be fun, but at a local place (not in my current town)
73: Tomorrow: ???? time for bad poetry: tomorrow i will see my friend/ admist this lasting chaos/ we will be each other’s solitude/ while sharing fruity drinks/ and when we both come home/ a smile we will bring
72: Today: idk what this means so more poetry: today i will be sleep deprived as always/ i will think of them and weep/ but no tears will fall from my eyes/ for i know there is a reason/ we went our own way
 71: Next Summer: i fr dont know whats goin on so: next summer i will be/ as happy as can be/ because i will be in pain no longer/ the earth is sure to heal/ and i will heal with her/ so i can enjoy/ the heatwave of next summer
70: Next Weekend: next weekend i will spend/ my days wasting away/ maybe ill finish hannibal/ again/ not that serial killers make the dopamine stay/ i will not see my friends/ or talk to my family/ i will seldom eat/ and live off coffee/ this has been my life/ all quarintine/ god someone please help me
 69: I have these pets: i have four cats, three chickens, and a dog
 68: The worst sound in the world: my dad and grandpa talking
 67: The person that makes me cry the most is: Them
 66: People that make you happy: snap name time: the great oracle, junior, vibin ~[^.^]~, russian umbrella, mom, hero, booby-king 48, go to bed, son, pooper trooper, mac&cheese, plain egg biscuit, apple pie
 65: Last time I cried: i dont cry bitch (last week over officals that cant make up they gottdamned mindes)
64: My friends are: my family and i would die for each and all of them
 63: My computer is: an old hp but it play gaemes real good so it okie
 62: My School: is trash but the band pops off
61: My Car: old, fast, clean
60: I lose all respect for people who: are my dad
 59: The movie I cried at was: i cried over big hero six
 58: Your hair color is: blonde
57: TV shows you watch: supernatural, good omens, hannibal, parks and rec
56: Favorite web site: this hellsite or youtube
 55: Your dream vacation: out of the country with beautiful beaches, amazing food, and my best friend
54: The worst pain I was ever in was: the time i split the back of my head open, the time i split my chin open, and the time my then best friend said they didn’t want to talk to me anymore. i’ll let you guess which one hurt the most and which one i think about every fucking day
53: How do you like your steak cooked: medium or medium well. 
52: My room is: clean and a reflection of myself, or so i’ve been told
51: My favorite celebrity is: i do not engage in celebrity worship. ill follow them and reblog gifs/interviews but i dont really have a favorite. the less i know abt them the better.
 50: Where would you like to be: my own apartment in nyc
49: Do you want children: FUCK THEM KIDS BRO
 48: Ever been in love: i dont know if it was love. i dont know if it was a crush. what i do know id that i was attached and they didn’t feel the same, and why would they?
 47: Who’s your best friend: we dont really use best friend bc but “the great oracle” “junior” and “vibin ~[^.^]~”
46: More guy friends or girl friends: its 50/50
45: One thing that makes you feel great is: goin fast, the beach, playin video games
44: One person that you wish you could see right now: them
43: Do you have a 5 year plan: go to college, earn degree
 42: Have you made a list of things to do before you die: commit arson
 41: Have you pre-named your children: FUCK. THEM. KIDS. BRO.
40: Last person I got mad at: they do not understand that they do not know everything about something they’re not even involved in yet
39: I would like to move to: new zealand
38: I wish I was a professional: artist? musican? youtuber? who knows
 [ My Favorites ] 
37: Candy: nerds
36: Vehicle: 1970 mustang gt
 35: President: jfk only bc his assassination is the only good thing abt american history the rest of it is fucked up and shouldn’t have happened. also jfk’s song in assassians the musical goes hard
34: State visited: california
 33: Cellphone provider: verizon? apple? idfk
32: Athlete: what is sport
31: Actor: i don't watch shows or movies
30: Actress: i do not consume media
29: Singer: alex gaskarth or alexander deleon
 28: Band: fall out boy 
 27: Clothing store: hot topic (i will not apologize)
 26: Grocery store: okay harris teeter fucks but lidil’s has aloe vera juice and target at 9 pm energy so idk man 
25: TV show: supernatural...
24: Movie: big hero 6
 23: Website: tumblr or youtube
 22: Animal: snow leopard 
 21: Theme park: busch gardens bc roller coaster go fast
20: Holiday: christmas
19: Sport to watch: snowboarding bc its like skateboarding but on snow
18: Sport to play: anything with havy footwork (marching band is a sport)
17: Magazine: i do not condume media
16: Book: the ranger’s apprentice series as a whole makes up my all-time one favorite book
 15: Day of the week: friday bc its game day baybey
14: Beach: cocoa beach in florida but also i have so much left to experience 
13: Concert attended: i havent been to any notable gigs but i was supposed to go to hella mega
 12: Thing to cook: pancakes
11: Food: pizza or shushi
 10: Restaurant: chiplote
 9: Radio station: i like my local rock station and my local edm/top 40 station
8: Yankee candle scent: anything smoky or vanilla idc
7: Perfume: chanel no. 5 if i even wear it
6: Flower: Hydrangea
5: Color: orange
 4: Talk show host: cecil palmer
 3: Comedian: john maulaney
 2: Dog breed: yes
1: Did you answer all these truthfully? ;)
That was a trip. But it was fun, please do things like this more often. Also, I don’t consume media by choice. I’m not sheltered I just can’t be bothered, and I have enough going on. That being said I will now be sleeping. Thanks again, Anon, I hope you have fun reading this :D
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phroyd · 5 years
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Reports showing farmers hurt by the president’s policies have drawn the ire of top officials.
By RYAN MCCRIMMON
Economists in the Agriculture Department's research branch say the Trump administration is retaliating against them for publishing reports that shed negative light on White House policies, spurring an exodus that included six of them quitting the department on a single day in late April.
The Economic Research Service — a source of closely read reports on farm income and other topics that can shape federal policy, planting decisions and commodity markets — has run afoul of Agriculture Secretary Sonny Perdue with its findings on how farmers have been financially harmed by President Donald Trump's trade feuds, the Republican tax code rewrite and other sensitive issues, according to current and former agency employees.
The reports highlight the continued decline under Trump’s watch in farm income, which has dropped about 50 percent since 2013. Rural voters were a crucial source of support for Trump in 2016, and analysts say even a small retreat in 2020 could jeopardize the president’s standing in several battleground states.
“The administration didn’t appreciate some of our findings, so this is retaliation to harm the agency and send a message,” said one current ERS employee, who asked not to be named to avoid retribution.
For example, two ERS researchers presented a paper at an economic conference in early 2018 that indicated the GOP tax overhaul would largely benefit the wealthiest farmers — generating negative press coverage that staff members said irked senior officials at USDA.
Then, in August, Perdue stunned members of the roughly 300-member research service by announcing plans to bring ERS under the control of USDA’s chief economist, who reports more directly to the secretary. Equally significant, he said the USDA would move the agency out of Washington to a location closer to the U.S. heartland.
Members of the agency were also caught off-guard last summer when Perdue’s office issued an internal memo directing ERS and other research branches to include disclaimers in their peer-reviewed publications stating that the findings were “preliminary” and “should not be construed to represent any agency determination or policy” — seen as a way of watering down any unflattering data from the department’s own experts.
The move to uproot the agency has led to a brain-drain of experienced researchers. So far in fiscal 2019, non-retirement departures from the agency have more than doubled on an annualized basis compared to the previous three-year average, according to data collected by employees.
Six of the economists — made up of specialists in the agricultural economy, farm taxation and food programs with more than 50 years of combined experience at ERS — left the agency at the end of April, out of frustration with the relocation process or in some cases suspicion about Perdue’s efforts to reshape USDA’s research wing, according to coworkers. More are planning to leave in the coming months.
For his part, Perdue has said the relocation was motivated by his desire to save taxpayer dollars, bring the research service closer to major farming regions, and help attract economists who could be deterred by Washington’s high cost of living.
“I really have been a little surprised with the naysayers on this,” he said last month at a Senate Appropriations hearing, touting the move as a common-sense, cost-cutting measure.
Perdue’s office declined to provide information on the numbers of employees who’ve quit or respond to allegations of political interference in the research service.
But the secretary alluded to frustrations with the quality of USDA research in comments to POLITICO on April 30, saying that all decision-making in the department must be “fact-based.”
“In USDA, we want good scientific discovery,” Perdue said, when asked about the mandated research-disclosure language. “We want peer-based evidence there. We know that research, some has been found in the past to not have been adequately peer-reviewed in a way that created wrong information, and we’re very serious when we say we’re fact-based, data-driven decision makers. That relies on sound, replicatable science rather than opinion. What I see unfortunately happening many times is that we tried to make policy decisions based on political science rather than on sound science.”
Reports from the Economic Research Service highlight the continued decline under President Donald Trump’s watch in farm income, which has dropped about 50 percent since 2013. | Oliver Douliery-Pool/Getty Images
Perdue and Trump made clear in their budget request in March that they wanted to reduce the scope of the ERS, eliminating “low priority research” into such politically sensitive areas as food stamps and environmental issues.
The White House blueprint called for slashing ERS staff levels by more than 50 percent, cutting the total number of positions from about 329 to 160.
The budget is unlikely to be approved by Congress, but members of the service say they’ve already seen the effects of Trump’s and Perdue’s preferences.
“Things like conservation, rural development, food assistance, have just been de-emphasized” in favor of the administration’s preferred topics, said one economist who left ERS because of the relocation plan.
Former ERS Administrator Susan Offutt, who oversaw the service under Presidents Bill Clinton and George W. Bush, said the agency’s studies showing how USDA’s farm-subsidy programs disproportionately benefit wealthier farmers have been a “perennial irritant” to influential lobbying groups, but an “over-the-top reaction” to clamp down on such reports would be unprecedented.
“Of course, this is not the story the farm lobby wants to tell about struggling farmers,” said Offutt. “Controlling ERS would stop unflattering news about federal farm subsidies favoring high-income, high-wealth farm households from reaching the public.”
Lawmakers have complained that USDA has yet to provide a full cost-benefit analysis of its plan to move the office closer to the heartland. Republicans have increasingly supported the relocation plan, while House Democrats have filed legislation to block the move.
On Friday, the USDA announced three finalists for the new headquarters of the service and the National Institute of Food and Agriculture, which is also being moved out of Washington. The finalists are Kansas City, the North Carolina research triangle region and multiple locations in Indiana.
Perdue’s office has promised to release further data justifying the move when he announces a final site recommendation this month.
Within the service, skeptical employees view the secretary’s rationale for the move and the months-long site selection process carried out by accounting firm Ernst & Young as a smokescreen.
“The message we’ve been getting is, ‘The cost-benefit analysis doesn’t matter. Being close to stakeholders doesn’t matter. The only thing that matters for you is the fact that the secretary wants you to move, thinks it’s in your best interest, and that’s what we’re doing,’” said another senior ERS economist who declined to use his name for fear of retaliation.
Brian Stacy, a former ERS economist who left in February, said he thinks the move is a way for the administration to force out staff members and reduce the size of the ERS without congressional approval.
“Part of me wonders whether this relocation is just a way to get at that staff reduction,” Stacy said, referring to the president’s budget request. “I don’t know how else to read some of the moves being made.”
ERS employees are planning to vote on unionization on Thursday.
USDA intends to keep 76 ERS employees in Washington and relocate 253 positions to the new location, USDA senior adviser Kristi Boswell told a House Appropriations panel in March.
“This is the spiraling down of the fantastic work that the ERS has done for years,” said Sonny Ramaswamy, who headed the National Institute of Food and Agriculture under the Obama and early Trump administrations. “It’s one way to drain the swamp, as it were.”
Phroyd
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intubatedangel · 5 years
Text
Barista’s Bad Heart - part 10
Part 1: https://intubatedangel.tumblr.com/post/183302348002/baristas-bad-heart-part-1
Other links at the bottom.
***
No body spoke in Resus 1, but it was far from silent. The refrigeration unit of the Temperature Management Vest filled the room with a baseline humming. On top of that, the high-pitched whine of the flatlined monitor screamed that the patient was still asystolic. Louder than those background noises was the occasional hiss as Kirstie, one of the nurses tending to the young woman on the table, squeezed the ambu-bag. The loudest sound came from on top of the table itself. A large blocky device stood over the patient, her wrists strapped to the side. A plunger sticking out the underside forced her chest down with a hiss and a click, beating down 100 times a minute.
 There was little other activity in the room. Two paramedics, Dave and Lucy, stood in the corner, flanking a young man, George who had ended up sitting on the floor, his head in his hands. Nearby, Zainab, a junior doctor who was only observing, kept herself out of the way but took in every detail. Roger and Jessica were stood by the crash cart. Roger was behind it, unobtrusive as he recorded every drug administered, every procedure tried and a minute-by-minute list of the patient’s vital signs. Jessica was ready to work the defibrillator at a moment’s notice.
 Sarah had the drug drawer of the crash cart laid out on a counter. She silently prepared another round of epi, ready to give it when ordered. The lead doctor, Carl, was stood across the bed from the crash cart, gaze on the monitor, ready to react as soon as something broke through the flatline. The last person standing in the room was Anna Swift, lead nurse, who stood at the foot of the bed, gripping the bottom rail of the trauma bed. She breathed slowly and deeply, paying off the oxygen debt from the near 7 minutes of chest compressions she had administered.
 Anna was the only one not watching the monitors. She was staring at the young woman who was laying lifeless on the table. Amelia Preston looked eerily similar to Anna, to the point the Anna couldn’t help but picture herself on that table, totally naked, wrapped in the special vest that cooled her body, ecg tabs and defib pads visible through the clear plastic. Her abdomen bulging rhythmically as the Lucas thumped her chest over and over.
 A chill ran down her spine, mostly dread at the thought of being in full cardiac arrest. But there was also a thin undercurrent of arousal. Having so many people working to bring her back from the brink of death. It was not the first time such thoughts had come to her mind. But it was by far the strongest occurrence. Her grip tightened on the rail as she forced the thoughts away, there would be time to explore them later, when a young woman’s life wasn’t in the balance.
 The wide door of Resus 1 swung open as Trish returned from the lab. “No drugs and her white cell count is normal so no infection.” She stated, her voice sounding loud from the lack of talking in the past two minutes.
 “So, we’re left with a purely cardiac diagnosis.” Carl said sighing. “I’ll chase them up personally. Anna, call the shots.” He said as he stalked towards the phone in the corner.
 Anna released the end rail, stepping around the bed to get a better view of the monitor. It still showed asystole. “Where are we on time?”
 “31 minutes.” Roger stated, not even having to read off the chart.
 “Sarah, go ahead with that Epi.” Anna watched her colleague push the drug into the central line. “Let’s give it a minute to circulate, then do a pulse check.”
 While everyone waited, watching the Lucas squeeze Amelia’s heart with mechanical precision, Anna glanced over at Carl. He was frowning. “Just put her on.” He growled through gritted teeth.
Anna’s attention was pulled back to the monitor as the whining alarm cut out, replaced by a rising and falling tone. The flatline had changed, waving slightly over and beneath the baseline. The peaks and throughs were random and unorganised. “That’s fine V-Fib. Jess.”
 “On it, charging to 360.”
 “Come on Amelia, time to come back.” Anna whispered as the charge indicator raced up the defib’s screen. She checked to make sure everyone was clear, Kirstie had let go of the amub, leaving it sat beside Amelia’s head, and had reached up to pause the Lucas. The defib indicator flashed. “All clear Jess.”
 “Shocking!”
 Amelia spasmed, her chest held in place by the plunger of the Lucas. Her legs twitched aggressively squeaking slightly as she rubbed against the inside of the plastic cooling vest. Her arms, strapped to the Lucas, shuddered as much they were able, her fingernails clicking against the hard shell of the Lucas.
 Anna watched the monitor for a moment, but the fine Vfib returned. She didn’t need to ask Kirstie to resume the Lucas, the nurse had already reached up and with the turn of a dial the device returned to pressing down on Amelia’s bruised and battered chest. “Get ready to shock again in one minute.” Anna told the team. She looked back over to Carl.
 He was quickly explaining the main points of the case. That they’d ruled out other factors, that she had been wearing a monitor and the resus team needed to read it. “She’s been down for 32 minutes, but pupil response is still present. Ok. See you in 5.” He sighed, hanging the phone back on the wall.
 “Charged to 360.” Jess stated from the defib. Anna nodded, as once again the Lucas was paused and everyone stepped back. “Shocking.”
 Amelia spasmed again, with the same squeak of plastic and clack of fingernails. Her head fell to the side, her open, sightless eyes staring right into Anna’s. Anna felt a sudden spike of discomfort that cast aside any erotic thoughts and shattered her focus. Amelia’s eyes were exactly the same colour as her own. Anna was momentarily trapped, staring into those chestnut lined pools. Then Amelia’s head began to shake gently, the Lucas had resumed its work.
 Anna tore her gaze away from her doppelganger, back to the monitor. It continued the same alarm, but it sounded strange, muffled. The fine VF had become even finer, the erratic movements of the line barely discernible. “Still no response.” She heard someone mutter, before realising it was herself.
 “Anna. You ok?” She turned her head slowly, to see Carl standing next to her, a hand on her shoulder that she couldn’t feel. “You with us?” He asked again, his concern clear in his voice.
 Anna realised she’d been holding her breath. She breathed out slowly, fighting to find her centre. It had never been this difficult before. She could feel her own heartbeat as she took a deep breath. There seemed to be a moment where her heart just stopped. But then her mind kicked back into gear. Everything sprang back into focus. With a shake of the head she dismissed the skipped beat as a figment of her imagination.
 “I’m fine. Sorry, I just spaced out a little.” The other nurses looked at her, also concerned.
 “I know she looks like you.” Carl said quietly. “You can step out if you want.”
 Anna shook her head. “I’m fine.” She repeated. “I’m focused.”
 Carl nodded, dropping the matter, then turned back to the resuscitation efforts. “Charge again, be ready to shock her on the minute.”
 Amelia jerked, her heart struck for the 10th time. And likely the last. The monitor began to whine as her heart stopped completely. Anna felt the sensation of defeat, and she could see it on the faces of the rest of the team. She hesitated for a moment, then reached up and restarted the Lucas.
 Two minutes passed with no response. The monitor showing nothing but the perfectly flat line despite the Epi that had been pushed in. The cardiologist arrived, a silver haired woman pushing towards her 60s. She apologised to Carl, then set up a laptop, connecting the pocket monitor. It took another minute to extract the data recording, and a further two for her to study the data. The whole time Amelia remained asystolic, her abdomen bulging as the Lucas slammed her ribs down.
 The cardiologist waved Carl over. “Long QT syndrome.” She told him, pointing to the distance between the small dip before the spike and the little bump after the main heart beat waveform on the screen. She scrolled it on. “Complicated by 1st degree AV block. Inciting incident induced Torsade de pointes.” She pointed at the sawtoothed V-tach and the way it became larger and smaller in a pattern, taking on the appearance of a twisted ribbon.
 She progressed through the recording, to the point where shocks were being delivered. “See the way the defibs barely even touch the rhythm. There’s not enough depolarisation.”
 “Would a dual-sequential shock do the trick?” Carl asked, looking at the girl on the table.
 “It’s possible, but…” The cardiologist sighed, glancing at the asystolic monitor then the clock. “It’s probably too late. Getting a shockable rhythm at this point....”
 Carl looked like he was about to argue, then sagged with defeat. He walked over to the table, looking at Anna, making sure that it wasn’t her lying lifeless before him.  He seemed to hesitate, that heroic, determined part of him wanting to make a final stand. To battle every inch for one last attempt. Anna knew what she had to do. She squeezed his shoulder gently as she passed him on the way to the head of the bed. She took out her penlight, softly opening Amelia’s eyes.
 She saw her own eyes again, but her focus held this time. She passed the light across the pupils. They remained wide, dark, unmoving pools, with a chestnut ring around the edge.
 “Pupils fixed and dilated.” She announced, watching as Carl almost visibly deflated. She was almost glad. She didn’t want to be cruel, but she’d seen what happened when he threw everything in. When it still didn’t work. It would crush him, leave him with a dark cloud over him for weeks. It was a mercy, in a way, to save him from that. But it meant declaring a young woman dead.
 “She’s been down for 45 minutes, no pupil response and no cardiac activity. Are we all agreed?” The rest of the room seemed to be averting their gazes from Amelia’s body, still shaking and shifting from the brutal compressions of the Lucas. Anna reached up and turned off the machine. Sarah did the same with the monitor, and Kirstie disconnected the ambu bag. For the first time in the best part of an hour, Amelia became still.
 “Time of death, 16:22.” Carl stated with a flat voice. He signed off on the clipboard.
 The team stood in silence for a few moments, processing the loss as Dave and Lucy escorted a weeping George from Resus 1. Then they carefully, gently, began to clean up the body of their young patient.
***
Part 2: https://intubatedangel.tumblr.com/post/183345519857/baristas-bad-heart-part-2
Part 3: https://intubatedangel.tumblr.com/post/183380872877/baristas-bad-heart-part-3
Part 4: https://intubatedangel.tumblr.com/post/183471507287/barristas-bad-heart-part-4
Part 5: https://intubatedangel.tumblr.com/post/183491865107/barristas-bad-heart-part-5
Part 6: https://intubatedangel.tumblr.com/post/183594682567/barristas-bad-heart-part-6
Part 7: https://intubatedangel.tumblr.com/post/183658697742/baristas-bad-heart-part-7
Part 8: https://intubatedangel.tumblr.com/post/183678245687/baristas-bad-heart-part-8
Part 9: https://intubatedangel.tumblr.com/post/183733501567/baristas-bad-heart-part-9
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