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borderlinedolly · 10 months

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The Community & Oversimplification Of HC-DID

I'm making this to talk more in-depth about the aspects of HC-DID that people seem to forget about because I'm sick and tired of people oversimplifying what it means to be RAMCOA. So here's a reminder that HC-DID is nowhere near C-DID.

So the key part of HC-DID is the programming and ritual abuse, it's what makes a system highly complex, but that says nothing about the results, so let's talk about the aspects of HC-DID that come with being highly complex.

HC includes:

- Alters that can be killed by deleting their programs

- Severe and chronic dissociation that makes it extremely difficult if not almost impossible to function

- Alters (programmed) with paraphilias like pedophilia, necrophilia, zoophilia, etc

- Alters programmed with different disorder such as personality disorders

- Therapy interference programming such as eating disorder programming that takes focus away from the RAMCOA/trauma

- More complex layers and goupings (e.g. layers within layers, subsystems within subsystems within subsystems and so on)

- Programmed dissociative structures like concentration camps, mental asylums, carousels, castles, forests, etc

- Internal (sex) trafficking and child sexual abuse

- Extreme and chronic polyfragmentation to hundreds or more commonly, thousands of parts

- Programs such as delta that make you kill or harm people when activated, beta that make you engage in sexual activity when activated, fractaline that make you split at any stressors usually resulting in tens or hundreds of thousands of parts, etc

- Internal handlers and programmers that exist to keep you tortured and programmed

- The ability to change amnesia levels resulting in presenting as different system types, such as C-DID, OSDD-1, DID, or even as a singlet

- P-DID or OSDD-1 presenting shell with no identity programmed to hide the system

- The ability to clock RAMCOA, OA, MC, RA, and other variations of survivors as well as dissociative people in general and sect members to know who is superior to you and who is useable

- Subtypes of HC-DID like Monarch, Alice In Wonderland, Bluebird, French Revolution, etc

- Chronic programmed denial periods/Speaking about your memories of chronic trauma followed with a feeling of fakeness amd 'that can't be real'

- Alters that exist in different tracks of the brain

- Mood swings that are much more severe than in the other dissociative disorders, for people with DID, their moods change too often for it to be considered bipolar type 2 but with HC, it’s constant sudden depression, anxiety, mania-esque symptoms, hallucinations, etc. it’s like suddenly developing a mood or a psychotic disorder out of nowhere for 3 months

- And much more because HC-DID is that complex

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eclipse15 · 6 months

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do you have any information about epsilon programming with dogs?

we think we have multiple types of epsilon with subtypes/classes of dogs - attack dog, breeding dog, trick/exhibitions dog, we think it could be a mixture of epsilon and delta/beta/gamma

TW: DETAILED EPSILON PROGRAMMING (CANINE TYPE) TALK, SNUFF MENTION

So first off epsilon has lots of shit going on with it so thank you for specifying instead of just saying epsilon in general, that’s really helpful.

Anyways, I’m going to break down the types you mentioned here as well as canine epsilon in general.

So dogs are a popular choice in epsilon as far as I’m aware. Theres a few reasons for that, one being that since dogs are domesticated they have so many different “uses”, or traits. Some work for law enforcement, some are house pets, some are guards, and some are meant for looking cute. This means the programmer(s) can use the type for multiple functions.

Attack dogs are usually used for snuff purposes, or other “entertainment” purposes. I honestly couldn’t tell you why people enjoy this, but in our experience many programmers/organization-higher-ups like when the victims behave as animals, especially in snuff? Again I couldn’t even come up with a reason that makes no sense, just something I’ve observed.

Anyways, the attack dog subtype is used for entertainment most of the time, however it can also be a tool for making the victim not understand what they are doing/that they are attacking. This can be used to cut off loose ends in the org, among other things.

Breeding dogs are, obviously, for sexual purposes. It could be a number of reasons, but the main two I see for this subtype are for kink a client and/or programmer has or so the victim doesn’t understand what they’re doing. (Btw if you use this post to start any type of kink discourse on either side I will block tf out of you).

Mindlessly doing something is a common thread of reasoning for all epsilon programs, and canine type is no exception. That’s also why gamma is a very popular choice in canine type programs, because dogs are known for their mindless loyalty. Sure if you’re an absolute scumbag to them dogs won’t exactly like you. But once they form a bond they’ll do anything for their human.

Another reason why these programs are so successful is most people recognize these traits in dogs on their own and so the programmer(s) doesn’t have to do much work internally. All of these otherwise benign traits are things most people see in dogs.

But yeah, that’s what I’ve got. Hope this helped!

#🧩#tw ramcoa #tw tbmc #tbmc #ramcoa #did alter #did osdd #osddid #hc did #polyfragmented #polyfrag #polyfrag system #actually mentally ill #endos dni

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socionicsdatabase · 8 months

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Hi! I'd be so thankful if you'd help me type myself.

I have had so many tests which results are always EII or LII, some of them included relative results, as it determines the percentage of my answers matching each type, and so the result is most of the time in this order: 1)EII 2)LII 3)ILI/IEI 4)ILE 5)IEI and the rest are almost null.

upon reading a little about the information elements I can confirm that both my Ne and Ni are strong and I'm pretty sure that Ne is the valued one, on the other hand both my Se and Si are very weak I don't know which one is the valued one though (I only concluded that it's Si depending on the previous data), this helped me eliminate the ILI and IEI, but still I'm having trouble determining the positions of the judging elements, I tried reading about the quadras values and I can say that I relate to the Alpha quadra primarily, and to a lesser extent the Delta quadra, reading about each type didn't help either I can't say that I don't relate to any or relate to all, I simply don't know if I do relate or not, seeing how the more I read the more confused I get, I thought I should seek assistance before I embark upon reading about the DCNH and the lead/parent subtypes.

if considering my types in other systems would do any help, here's what I'm sure about:

Enneagram core: 6(w5)

Tritype: 694

Instinctual Variants : Sp/Sx (So blind spot)

BigFive: [R]LUAI

Attitudinal Psyche (not super sure but like 60%): 1V2 2E3 3L1 4F4 (VELF)

Thanks in advance!

Hi, thanks for the question.

The problem with personality tests is that it is hard to get an accurate result unless you are absolutely sure you are answering honestly and objectively. And that can be hard to do. However, it sounds like you have tried many different tests and are always scoring either as EII or LII.

So, I would say the easiest way to tell the difference between those two types is to ask yourself how easy it is for you to accurately assess feelings, both of your own and of others. The EII can easily see and understand the way another person feels. They are excellent at reading body language, and can also often accurately determine the feelings between two individuals and the type of relationship between them. They can even see the potential relationship between two people and what is likely to develop. They are not mind readers and are not always right - but they are much more in tune with these things than an LII. They are also highly aware of their own preferences, like/dislikes, and personal feelings towards everything. Their subjective experience of their feelings is what they use to make their judgments and it guides their decisions.

In contrast, the LII has trouble accurately picking up on another person's feelings. They are also often not "in tune" with their own feelings toward people and things, because it is not what they are using to make their judgments and decisions. Instead, the LII relies on their own system of logical reasoning. Of course, LIIs do have feelings like everyone else, but their detection and understanding of emotions is weak. With weak and valued Fe, LIIs need clear, openly expressed emotions in order to be confident about them. They are not able to easily pick up on subtle cues and emotional body language the way that EIIs can. The LII may also be more likely to accidentally offend someone because they are not as aware of how their words and actions may impact the emotions of others. EIIs are also more sensitive and more easily hurt than LIIs, who are less likely to care what people think of them.

Using romantic attraction as an example, the LII is the kind of person who could be around someone for years and have no idea that the person was romantically interested in them. In contrast, the EII would have picked up on that a long time ago, because the EII is highly in tune with subtle cues and body language that give away emotions. Also, with valued Fi, the EII can often understand feelings without words or open expression. In contrast, the LII, with weak ethical functions and valued Fe, needs and prefers open, clear emotional expression. Without that, they may have no idea how another person feels or can only determine it with great difficulty. This is why LIIs are compatible with high Fe users - types like ESEs and SEIs are emotionally expressive and thus easier for the LII to understand.

Also, the EII may be more protective and secretive of their feelings than the LII. The EII is aware of their feelings and emotional reactions, but may be hesitant to make them known. In contrast, the LII may be more willing to express their feelings when prompted, but is less likely to identify what they are to begin with.

As for Quadra values, Delta emphasizes the individual unique characteristics that make us different from each other, while Alpha emphasizes the ways that we are all the same and would prefer to eliminate those differences. Democratic (Alpha and Gamma) vs. Aristocratic (Delta and Beta). Asking yourself which of those resonates more with you could further help differentiate between EII and LII.

So, I hope this helps. Both of them can appear similar on the outside, both are very reserved and analytical, but the EII understands human behavior and emotions much more easily than the LII, who may struggle in that area.

Based on your results, I think the 4 fix in your tritype combined with your Big Five result of RLUAI makes EII seem more likely, as "limbic" types are more sensitive, more easily hurt and more aware of their emotions and emotional reactions. This corresponds more with EII than LII. Also, the way that you described the process of typing yourself sounds more like an Fi/Te approach - you are searching for information (Te) and determining whether or not you can personally relate to it/share the same values (Fi). LIIs would likely take a more organized, impersonal approach of learning the personality system in depth first and then deciding where they fit within that system.

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indiamedicaltourism · 2 months

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Thalassemia Treatment in India at Low Cost

Thalassemia is an inherited blood disease caused by defective hemoglobin production, which causes an insufficient supply of oxygen by red blood cells. This results in anemia, which causes symptoms such as tiredness, weakness, and pale skin. This condition affects approximately 4.4 out of every 10,000 live births worldwide, with prevalence in countries like Iraq, Uzbekistan, Bangladesh, Pakistan, Nigeria, and Liberia. Thalassemia's global prevalence emphasizes its importance as a public health issue, particularly in areas with high rates of consanguineous marriage.

Types of Thalassemia

Alpha-thalassemia: It is caused by irregularities in the alpha-globin genes and can range from silent carriers to severe cases such as Alpha-Thalassemia Major.

Beta-thalassemia: It is caused by mutations in the beta-globin genes and is classified into three types: minor, intermediate, and major.

Delta-Beta Thalassemia: An uncommon subtype that affects the delta- and beta-globin genes.

Epsilon-Gamma-Delta-Beta Thalassemia: Another rare form that affects many globin genes.

Thalassemia Treatment Options

Blood transfusions: These are essential for improving healthy red blood cells.

Iron Chelation Therapy: It treats excess iron levels after transfusions.

Folic acid supplements: They promote red blood cell formation.

Bone Marrow or Stem Cell Transplant: It is used for severe situations to replace damaged blood cells.

Luspatercept: It is a new medicine that promotes red blood cell production.

Hormone therapy, vaccinations, antibiotics, thyroid hormone replacement, and bisphosphonates: These are adjunctive medicines that address specific problems.

Cost of Thalassemia Treatment in India

Thalassemia treatment in India is known for its low cost, which attracts patients from all over the world. The cost varies with the type of treatment required. Blood transfusions are required to manage thalassemia and generally cost approximately $150 each session. On the other hand, bone marrow transplants, a more advanced treatment reserved for serious conditions, can cost between $16,000 and $48,000, depending on the kind of transplant and hospital chosen.

Untreated thalassemia can cause heart failure, liver difficulties, infections, and a shorter life expectancy. Thalassemia, while difficult to treat, may be efficiently controlled with the correct medication. India's modern medical infrastructure, competent staff, and affordable care make it a perfect location for anyone seeking comprehensive thalassemia treatment. Patients with thalassemia can manage the disease with determination and hope for a better quality of life because of early diagnosis, personalized medications, and continued care.

Thalassemia treatment in India combines cost, experience, and modern technologies, making it a popular choice for patients worldwide. With top hospitals, renowned doctors, and wide-ranging therapy choices, those suffering from thalassemia may get the support and care they need to handle this difficult illness.

Al Afiya Medi Tour is a leading medical tourism company in India. We offer medical tourism services such as finding the right doctor, the right hospital, and cost estimation etc. Some of the main countries are Bangladesh, South Africa, Egypt, Uganda, Zambia, Sudan, Dubai, Namibia, Iraq, Kenya, Saudi Arabia, Ethiopia, Nigeria, and so on. We provide free medical assistance for TURP surgery cost, lung cancer treatment, blood cancer treatment, the best hospital for heart valve replacement, bone marrow transplant, best liver transplant hospital, kidney transplant, spine tumor surgery,knee replacement surgery, etc.

Source: https://alafiyameditour1.blogspot.com/2024/02/thalassemia-treatment-in-india-at-low.html

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infosnack · 7 months

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STAT: Long underappreciated gamma-delta T cells may be key to colon cancer defense study says

STAT+: Long underappreciated, gamma-delta T cells may be key to colon cancer defense, study says https://www.statnews.com/2023/10/06/colorectal-cancer-immunotherapy-gamma-delta-t-cells/?utm_campaign=rss Within the linings of our guts, immune cells patrol like sentries on a castle wall. These cells, called intraepithelial T lymphocytes, are constantly probing the cells of the gut barrier for signs of disease, killing any cells that appear suspect due to infections or cancer mutations. A new paper published in Science Immunology on Friday suggests that a subtype of T cells called gamma-delta T cells may be key to that process — and that a protein known as TCF-1 is central to controlling their actions. The work, led by Australian researchers, helps unlock the long underappreciated role of these cells in cancer defense and could open new directions for developing immunotherapies for colorectal cancer, immunologists said. Gamma-delta T cells have been “largely understudied” compared to their immune counterparts, alpha-beta T cells, said Ana Carrizosa Anderson, a cancer researcher at Harvard University who did not work on the study. “This study certainly helps cement the role of gamma-delta T cells in colon malignancy,” she said. “I think it provides a foundation for building understanding of some basic biology or some therapeutic approaches.” Continue to STAT+ to read the full story… via STAT Health - Science, medicine and healthcare news https://www.statnews.com/category/health/ October 06, 2023 at 02:00PM

#IFTTT #STAT Health - Science #medicine and healthcare news

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khartoumnews · 1 year

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12nb34 · 1 year

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📆 18 Jan 2023 📰 How your first brush with COVID warps your immunity ✍️ Rachel Brazil 🗞️ Nature

Imprinting equips the immune system with a memory of an invader that helps it prepare to do battle again. The key players are memory B cells, which are generated in lymph nodes during the body’s first exposure to a virus. These cells then keep watch in the bloodstream for the same foe, ready to develop into plasma cells that then churn out antibodies.

The snag comes when the immune system encounters a similar, but not identical, strain of a virus. In this case, rather than generate new, or ‘naive’, B cells to produce tailored antibodies, the memory-B-cell response kicks in. This often leads to the production of antibodies that bind to features found in both the old and new strains, known as cross-reactive antibodies. They might offer some protection but are not a perfect fit to the new strain.

Imprinting was first observed in 1947 by Jonas Salk and Thomas Francis, the developers of the first flu vaccine, together with another scientist, Joseph Quilligan1. They found that people who had previously had flu, and were then vaccinated against the current circulating strain, produced antibodies against the first strain they had encountered. Francis gave the phenomenon the tongue-in-cheek name ‘original antigenic sin’, although today most researchers prefer to call it imprinting.

Researchers have only recently demonstrated how strongly this process can influence immunity. In 2016, Gostic published an epidemiological study2 that proved imprinting was more than just a curiosity. She analysed data from two pandemics of avian influenza A, caused by the viruses H5N1 in 2009 and H7N9 in 2013. Both strains share some characteristics with seasonal-flu strains, but they come from opposite sides of the flu evolutionary tree. “We saw this really remarkably clear pattern that you seem to be much more susceptible, at least to severe infection, if you had been imprinted in childhood to a mismatched subtype,” says Gostic.

For SARS-CoV-2, too, “your infection history, and your vaccination history in combination, are imprinting your subsequent immune response when you see the live virus”, says immunologist Rosemary Boyton at Imperial College London. Boyton and her colleagues reached this conclusion by studying immunity in a large group of health-care workers at several London hospitals.

Their first study, conducted before Omicron had emerged, looked at the responses of certain facets of the immune system — including antibodies and B and T cells — in individuals who had received two vaccines. Some of them had been infected before their jabs and others after. The researchers found that a person’s immunity to infection by subsequent strains depended strongly on their previous infections or vaccinations. “Some combinations happen to offer better future- proofing against an oncoming variant than others,” says Boyton.

Last June, she and her colleagues published a follow-up study4 looking at immunity in a group of people who had contracted an Omicron infection after triple vaccination, but who had various COVID-19 infection histories. Again, they saw a variety of responses indicating imprinting from previous exposure. For example, even in people whose first COVID-19 infection was with Omicron, the antibodies were a better match to the original strain — against which they had been vaccinated — and to the older Alpha and Delta strains.

For those who had been previously infected with the original strain, and were then vaccinated (with a shot designed to fight that strain), the subsequent Omicron infection didn’t boost their ability to create Omicron-adapted antibodies at all. This is a clear sign of imprinting, Boyton says, and probably explains why Omicron reinfections are so common — although, for most people, even an imprinted response is enough to stop serious illness.

This idea is backed up by a study published last month by Yunlong Cao at Peking University in Beijing. He found that people who had been vaccinated with the original strain and then contracted an Omicron infection produced antibodies that were mainly cross-reactive to both strains, but rarely specific to Omicron itself. By contrast, those without a previous vaccination made antibodies that specifically matched Omicron. Cao says that, as the two strains gradually diverged from each other, the proportion of antibodies that could neutralize the second strain decreased. He expects this effect to be even more pronounced with the newer Omicron subvariants, such as XBB.

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rafnvega83 · 1 year

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Vimentin takes on an important role inside the promotion regarding cancer of the breast mobile migration and intrusion by leucine aminopeptidase Three or more

An emerging position regarding sizes of AHR is in the look at the best answer to people with bronchial asthma.Improved a vitamin (retinol) ingestion continues to be proposed to improve bone tissue fragility. In the present study, many of us looked at effects of retinoids upon bone tissue resorption throughout cultured neonatal mouse calvarial bones as well as their discussion using glucocorticoids (GC). All-trans-retinoic acid solution (ATRA), retinol, retinalaldehyde, and also 9-cis-retinoic chemical p stimulated launch of (45)California from calvarial bones. The resorptive aftereffect of ATRA has been characterized by mRNA phrase involving body's genes associated with osteoclast difference, superior osteoclast number, and also bone matrix destruction. Moreover, the particular RANKL/OPG ratio had been increased through ATRA, relieve (45)Los angeles activated by ATRA has been blocked simply by exogenous OPG, along with mRNA phrase of body's genes associated with navicular bone enhancement has been decreased by ATRA. Almost all retinoid acidity receptors (RAR alpha/beta/gamma) ended up indicated throughout calvarial bone fragments. Agonists using appreciation to all receptor subtypes as well as exclusively to be able to RAR alpha dog superior the discharge associated with (Fortyfive)Ca and also mRNA phrase of Rankl, whilst agonists using thanks to RAR beta/gamma or even RAR gamma did not have any outcomes. Arousal regarding Rankl mRNA by ATRA was both competitively limited read more through the RAR alpha villain GR110. Direct exposure regarding calvarial your bones to be able to GC limited your stimulatory effects of ATRA on 45Ca relieve along with Rankl mRNA along with health proteins phrase. This kind of inhibitory effect was reversed through the glucocorticoid receptor (GR) villain RU 486. Improved Rankl mRNA triggered simply by ATRA has also been obstructed through GC in calvarial bone fragments coming from mice which has a Gary mutation which hindrances dimerization (Gary(darkish) mice). The data advise that ATRA enhances periosteal bone fragments resorption simply by enhancing the RANKL/OPG proportion via RAR leader receptors, a reply that could be limited through monomeric Grms.Aims: Mitochondria are important modulators involving Ca2+ homeostasis. Even so, it's not at all obvious whenever they regulate as well as participate in easy muscles signaling and contraction. The aim of the present operate was to investigate part associated with mitochondria throughout Ca2+ transients as well as shrinkage activated by simply metabotropic muscarinic receptor service inside rat abdominal easy muscle tissue. Main approaches: Carbachol (CC11)-induced contraction was looked into in the lack as well as existence of increasing power mitochondrial protonophore, carbonyl cyanide p-(trifluoro-methoxy)phenyl-hydrazone (FCCP), in stomach fundus pieces. Ca2+ and mitochondrial membrane probable (Delta Psi mirielle) sizes have been carried out in primarily classy abdominal sleek muscle tissues set with FURA-2 or TMRE dyes. Key studies: Outcomes demonstrate that CCh (1 mu Meters)-induced shrinkage ended up being restricted by simply FCCP in a concentration-dependent fashion. Throughout cultured clean muscle cells CCh (One particular mu Michael) caused a new cytosolic Ca2+ increase. Preincubation along with FCCP clearly restricted CCh-evoked Ca2+ transients implying in which mitochondria condition intracellular Ca2+ Alerts. CCh brought on levels of Delta Psi m in 60% of the individual mitochondrion reviewed. Significance: Consumed together each of our outcomes suggest which CCh induces relieve Ca2+ coming from intracellular shops, which might be modulated through mitochondria. Therefore, mitochondria be involved in the intracellular Ca2+ homeostasis inside muscarinic contraction in gastric fundus easy muscles.

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hemp-list · 1 year

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https://herbalcareguide.livejournal.com/6582.html

Today, Delta-8 is displacing Delta-9 and other THC subtypes. This is why Delta-8 extract is available for purchase at many retail establishments. Despite the fact that you can also purchase Delta-8 online, a nearby delta store can be a better choice for you. Read on to find out why we say that.

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ofheroism · 1 year

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{chace crawford; cismale; he/him} hey isn’t that JASPER SINCLAIR? the 33 year old WEREWOLF and a song that plays when you see them is ASTRONAUT IN THE OCEAN by MASKED WOLF. They are known to be BEGUILING and DECEPTIVE. They have been in VALDEZ for HIS ENTIRE LIFE and always remind me of headlights reflected on rainy pavement, an empty glass of scotch, grins that don’t meet your eyes, and expensive cologne. what secrets will they discover?

BASICS

CURRENT ALIAS: jasper elliot sinclair

BIRTH DATE + AGE: november 1, 1989 – 00:00

GENDER: male

PRONOUNS: he/him

ORIENTATION: heterosexual heteroromantic

SPECIES: werewolf (born)

PACK: sinclair

POSITION : delta

ABILITIES: shapeshifting (wolf), superb physical resilience and remarkable regenerative abilities, enhanced senses of smell, hearing, and sight, supernatural strength, durability, reflexes, and speed.

OCCUPATION: stock portfolio manager at sinclair investments

BIRTHPLACE: valdez, alaska

FAMILY: torrance sinclair - father (born werewolf - pack alpha), evelyn sinclair née dawson - mother (born werewolf), xxx sinclair - older sibling (born werewolf - heir of pack), xxx sinclair - younger sibling (born werewolf), roxanne sinclair née wu - wife (born werewolf)

APPEARANCE

FACE CLAIM: chace crawford

EYE COLOR: ocean blue

HAIR: light/medium brown

HEIGHT: 6′0″

TATTOOS: none due to werewolf healing.

SCARS/BIRTH MARKS: none due to werewolf healing.

PERSONALITY

ZODIAC: scorpio sun, sagittarius moon, leo rising

MBTI: entp, the debater.

ENNEAGRAM: 8w7, the non-conformist. sexual/self preservation subtype

ALIGNMENT: chaotic neutral

TEMPERAMENT: sanguine

ARCHETYPE: the jester / the prodigal son

ELEMENT: air

ASSOCIATED CHARACTERS: adrian ivashkov, logan huntzberger, derek from the swan princess, jj parker, barney stinson

AESTHETIC: headlights reflected on rainy pavement, an empty glass of scotch, grins that don’t meet your eyes, expensive cologne, designer brands, golden retrievers, lipstick marks on white collars, sleeves rolled up to elbows, crooked ties, perfectly disheveled hair, being the family disappointment.

BIOGRAPHY TW: cheating, murder

JASPER ELLIOT SINCLAIR was born in valdez, alaska to an upper class pair of werewolves, one of three children. the first image that may come to mind is a lively, bustling household, but jasper’s childhood was far from it. the children were not products of love to the scheming duo, but more bargaining chips into securing a legacy. would they grow up to become the second-in-command of the tyler pack, to marry into the alpha’s family, perhaps to ascend to alpha themselves? with three children, they could mold them like clay into whatever future they desired for them.

this is the story of jasper sinclair, a boy who learned the only way to gain control of his own life was to throw it away like all his potential, the guise of insouciance one that melded to his devil-may-care grins alarmingly well.

born the middle child, jasper managed to avoid the absolute brunt of his parent’s scheming ways. one sibling was the golden child, projected to be one of the youngest pack members to be promoted to beta, thanks to their intellect and dedication to honing their abilities, the throne in their sights. the younger sibling was charm incarnate, wrapping everyone around their little finger, destined to enamor their way into the alpha’s family. where did that leave jasper, too easily caught up in daydreams to excel in his classes and one of the only ones in his class yet to show any manifestation of his shifting even at age 16? was he somehow human by a cosmic mistake?

at sixteen, irresponsibility and mischief incarnate, jasper knew a thing or two about flirting with girls, but one in particular had caught his eye. he’d managed to date her for several months, and a young jasper, certain christa was ‘the one’, never shied away from inviting her along with his best friends. his parents tried to discourage the relationship, but that only made jasper more persistent. he’d been banned from a spring break trip due to it being too close to the full moon, but refusing to miss out on adventure, jasper snuck out to drive to friend’s family beach house on the peninsula. why should a full moon that didn’t affect him stop his shenanigans? except... this time, it did. his werewolf gene finally triggered that spring, and jasper was left alone to deal with the shift. hearing him howling out in pain, christa came to find him, and narrowly escaped the large, hungry wolf in his place.

when he awoke, confusion gave way to horror as jasper realized he was not powerless after all, but that he’d nearly killed his own girlfriend. despite having already discussed spending their lives together like many teenagers certain of the future, christa’s feelings for him took a hard reverse. she refused to forgive him for not telling her, as if she could have been prepared. she swore if he ever came near him again, she’d call the police. the sinclairs were furious but solved the solution by paying christa and her family enough money to disappear and never mention what they’d seen again. it took a couple years, but jasper eventually moved on, dating and eventually proposing the alpha’s only daughter and being promoted to beta. it was exactly the life his parents wanted for him, but he found he actually liked her.

unfortunately, the sinclair family’s ambition could not be sated. happy with the family’s apparent alliance, the alpha promoted torrance sinclair to second-in-command. soon after his rise in position, the leader of the tyler pack and his eldest child were killed in an attack by another werewolf. the wolf was never identified, but torrance blamed the lunar pack for their leader’s death. jasper’s fianceé accusing him of only making her fall for him so that his family could betray hers. he was unsure what to believe, but she left him no choice by ending things first. torrance convinced the back a young wolf was in no position to lead, that she only blamed him because of her secret loyalties to the lunar pack. it was utter nonsense, and yet torrance was charismatic enough to have the pack eating out of his palm. his now ex-fianceé had lost her family and pack in one week, and her last words to jasper were that he never deserved to be loved by anyone.

the sinclair pack hierarchy shifted quickly, the eldest sinclair sibling named heir to the pack, a loyal family made second-in-command. after following his parents’ every wish, jasper found himself less happy than ever. what good was prestige in a pack he didn’t particularly even care for? was power all that anyone in this damned town wanted?

in the nearly 15 years since, jasper has given up on going after anything he’d once wanted. he works at his family’s investment company during the day to ‘pay the bills’, as if his father doesn’t finance most of his opulent life.

at night, he street races. one of the main things to bring him joy in life is a fast car. he chases almost anything that brings him adrenaline: a never-ending line of women to ghost, drunk shenanigans with his fellow rich friends, action movies, grand adventures, etc.

to spite his parents as much as he had the freedom to, jasper and his frenemy of sorts roxanne drunkenly eloped in vegas six months ago. they’d planned to annul the wedding the moment they returned home, but jasper’s father found out first. he was so angry at jasper’s recklessness (and the teeny tiny fact that roxanne was from the lunar pack, the one the sinclair pack believes killed their former leader) that he demoted him to a delta position. for once, jasper felt such a rush of adrenaline, so entertained that he proclaimed his love for roxanne and refused to divorce her. thankfully, out of spite for her own family, she’s agreed. he has no plans to ever commit to anyone again, so he’s not particularly in a hurry to give up the charade.

top 5 theme songs:

the hills by weeknd

i only **** you when it’s half past five, the only time i’d ever call you mine, i only love it when you touch me, not feel me

@ my worst by blackbear

but maybe i’m the worst, the worst you ever had, tell you you’re beautiful then stab you in the back

astronaut in the ocean by masked wolf

i’ma play her for fun, y’all don’t really know my mental, let me give you the pencil, like a stencil, falling out, in a drought

i mean it by g-eazy

if i ever said i’m never scared, just know i mean it. if i ever said i ****ed your *****, just know i mean it. – she calls me, i screen it, only ****ing if it’s convenient – yeah listen, i’m telling you, it’s my world, i does what i wish to

ghost by witt lowry

“now get your shit together” is what i’m told – used to dream of the top, had nightmares at the bottom – when you feel more like a product than a person, that’s a problem

His Pinterest board is here.

His Spotify playlist is here.

— CONNECTIONS:

FAMILIAL:

SIBLING - { 0 / 2 } - one older sibling and one younger sibling, one golden child set to inherit the pack and family business one day and one charismatic child, meant to ally with the second-in-command’s family.

COUSIN - { 0 / ? } - anyone related to either of his parents’ siblings.

PLATONIC:

BEST FRIENDS - { 0 / 2 or 3} - this may not be mutual, but people jasper considers to be his favorite people he’d do anything for

FRENEMIES - { 0 / 3 } - people jasper gets along with at times but also wouldn’t hesitate to laugh at their expense

ROOMMATES - { 1 / 1 } - roxanne sinclair

FRIENDS - { 0 / ? } - jasper is often known to hang out with other rich, arrogant, important people in town, but also has maybe one or two friends that don’t fit into any of those categories that he likes to keep separate from his regular life.

ACQUAINTANCES - { 0 / ? } they’ve met before at a party, around town, etc.

CO-WORKERS - { 0 / ? } - others who work at the investment company

ANTAGONISTIC:

FORMER FRIENDS - { 0 / 2 } people he’s somehow managed to screw over whether on accident or on purpose to prove a point

ENEMIES - { 0 / ? } - did he sleep with their ex/significant other/sister/them and now they hate him? did his general arrogant and careless disposition start it? the possibilities are endless

ROMANTIC:

SPOUSE - { 1 / 1 } - roxanne sinclair - platonic marriage that started as a drunken decision on a vegas trip and was not annulled due to a mutual desire to spite their parents, have been married six months.

EX-FIANCEE - { 0 / 1 } - xxx tyler (pls feel free to change surname!) - the previous alpha’s daughter - she believes jasper father’s killed her father and older sibling to gain the pack and vowed revenge against his family fifteen years ago. he’s sure she’s gotten over that by now... hopefully.

FRIENDS W BENEFITS - { 0 / 2 } - not feeling like he owes a platonic marriage commitment, jasper mostly just hooks up with people out of town to avoid questions. there’s still a couple people he occasionally spends the night with in town because he actually enjoys their company in general too ( i don’t write smut 😂). they either don’t care that he’s married or don’t know? female, any species, 25+

OTHER - feel free to hit me up with any other ideas you have as well !

#jasper sinclair ✫✫ ι gσт ωαѕтє∂ ℓιкє αℓℓ σf му ρσтєитιαℓ #). intro #valdezhqintro

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youngmcwilliams · 1 year

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Point-of-Care Analysis Providers being an Crucial Section of Well being Solutions throughout the Novel Coronavirus 2019 Era

Studies This example sequence provides A few child fluid warmers circumstances seen via 2009-2012 with our own medical center, Kid's Hospital Dallas, tx. These instances were distinctive simply because they supplied proof of auto-immune occasions influencing your central nervous system however with added peripheral axonal pathology. CONCLUSIONS And also Importance All of us illustrate these types of instances regarding studies which suggest a alternative of the problems that possess concomitant nerve-root engagement. These kinds of patients got even worse outcomes compared to common individuals together with transversus myelitis/acute disseminated encephalomyelitis, which observations expand earlier operate by additional private investigators that pointed out prolonged flaccid paralysis and electrophysiological evidence axonal damage portending a lesser prospects. Furthermore, these types of situations suggest a possible part with regard to nearing the way we classify subtypes associated with transversus myelitis as well as severe displayed encephalomyelitis.The particular FS0 [4Fe-4S] group in the catalytic subunit (DmsA) regarding Escherichia coli dimethyl sulfoxide reductase (DmsABC) has a vital part in the electron exchange relay. We've proven a different part for your bunch inside pointing molybdenum cofactor assembly throughout molecule maturation. EPR spectroscopy shows that FS0 carries a higher whirl floor condition (Azines = 3/2) in the diminished form, causing the EPR array having a maximum at grams just like Five.3. The actual chaos is anticipated to stay close proximity to the molybdo-bis(pyranopterin guanine dinucleotide) (Mo-bisPGD) cofactor, which offers your website associated with dimethyl sulfoxide decline. Comparison along with nitrate reductase Any (NarGHI) shows that a sequence of remains ((20)CTVNC(Twenty two)) plays a part in equally FS0 as well as Mo-bisPGD coordination. A new DmsA(Delta N21) mutant averted Mo-bisPGD joining and led to a new transform [3Fe-4S] group form of FS0 staying built. DmsA is probably the Type 2 subclass of Mo-bisPGD-containing catalytic subunits which is known from the Variety My partner and i subclass insurance firms three as opposed to a pair of remains relating to the first two Cys residues coordinating FS0 plus a preserved Arg residue instead of a Lys remains following a last group corresponding Cys. We all released a kind I Cys team in to DmsA in two phases. Many of us altered it's string through (18)Chemical(Any)TVNC(N)GSRC(H)S(Twenty-seven) in order to 18C(Any)TYC(N)GVGC(D)Grams(Twenty six) (just like that relating to formate dehydrogenase (FdnG)) along with revealed that this kind of removed each Mo-bisPGD holding and this website EPR-detectable FS0. Then we put together this transformation having a DmsA(R61K) mutation and revealed that this extra adjust partially ended up saving Mo-bisPGD placement.Track record. In the event that pancreas transplantation is a checked alternative for variety A single diabetics together with end-stage kidney disease, the treating of sufferers who have dropped their main graft is actually inadequately defined. These studies aims at evaluating pancreatic retransplantation outcome. Methods. Between 1976 and '08, 569 pancreatic transplantations had been executed in Lyon and also Geneva, which includes Thirty eight second transplantations. 2nd graft emergency ended up being in contrast to principal graft success of the identical sufferers along with the complete inhabitants.

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loganmoser · 1 year

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Downregulation of Niraparib Audience YTHDC2 Helps bring about the particular Spreading along with Migration regarding Dangerous Bronchi Cells by way of CYLD/NF-κB Walkway

The action of multidrug efflux pumps in MDR (multidrug level of resistance) acquisition continues to be suggested for you to somewhat be determined by the particular transport regarding biological #link# substrates which can indirectly influence substance partition as well as transportation throughout cellular membranes. With the current economic study, the actual PDR18 gene [ORF (wide open looking at shape) YNR070w], coding the putative PDR (pleiotropic medicine opposition) transporter with the ATP-binding cassette superfamily, was found for you to mediate plasma tv's membrane sterol use within candida. The physical part of Pdr18 is actually demonstrated in order to have an effect on lcd membrane layer prospective which is proposed for you to underlie their action being a MDR element, conferring effectiveness against your herbicide 2,4-D (A couple of,4-dichlorophenoxyacetic acid solution). The action of Pdr18 inside candida tolerance to A couple of,4-D, which has been found to give rise to reduce [C-14]2,4-D intra cellular piling up, could be roundabout, because of the statement which A couple of,4-D exposure seriously influences the sterol plasma televisions membrane composition, this kind of effect getting much more resilient in the Delta pdr18 history. PDR18 activation below Two,4-D anxiety will be controlled from the transcription elements Nrg1, controlling as well as source accessibility and also the anxiety reply, and, a smaller amount substantially, Yap 1, associated with oxidative tension and MDR, along with #link# Pdr3, a key regulator of the yeast PDR system, in line with a broad position within anxiety defense. Taken together, the outcomes from the present study suggest that Pdr18 leads to plasma tv's membrane sterol increase, this particular physiological attribute leading to the MDR phenotype.Understanding the reaction regarding cellular material to multiple stimulating elements is critical with regard to projecting contributor certain responses and learning the signaling walkways required. Gefitinib (ZD1839) is regarding distinct value in platelets simply because publicity regarding phosphatidylserine (Ps3) happens on costimulation and not which has a solitary agonist. Niraparib supplier , we identify any multiplexed pairwise agonist scanning-flow cytometry (PAS-FC) way of measuring platelet inside-out reactions to all pairs of six platelet agonists (convulxin, SFLLRN, AYPGKF, ADP, U46619, along with PGE(Only two)) employed in their EC50 concentrations. These kind of agonists granted investigation of platelet signaling downstream of GPVI, PAR-1, PAR-4, P2Y(1), P21Y(14), TP, as well as Ip address receptors. The three-color stream cytometry technique together assessed integrin leader(IIb)'beta'(3) account activation using PAC-1 antibody, P-selectin publicity (by way of alpha dog granule launch) with anti-P-selectin, and also Dsi direct exposure using annexin Versus. These reactions were consistent throughout a wholesome guy contributor pool. Within copy proportions with each contributor, 4 with the 10 contributors stood a completely exclusive 45-parameter (Fifteen twos x #link# 3 shades) phenotype in order to self-cluster (G < 2.001). Using this method has got the possibility of efficiently encoding regarding individual certain reactions over an extensive agonist-receptor room.The particular haemagglutinin (') associated with refroidissement The herpes virus contains two glycopolypeptides designated HA1 and also HA2. see more recognizing HAII prevent computer virus haemagglutination, neutralize virus irritation and still provide very good security in opposition to contamination, along with cross-react using the HA associated with other subtypes. Small is famous about the biological activities of antibodies versus HA2. To study the part involving antibodies directed in opposition to HA2 during influenza trojan an infection, two vaccinia virus recombinants (rVVs) were utilised articulating chimeric substances associated with ', where HA1 and also HA2 had been based on distinct ' subtypes. The actual KG-11 recombinant expressed HA1 coming from A/PR/8/34 (H1N1) trojan and HA2 coming from A/NT/60 (H3N2) trojan, although KG-12 recombinant portrayed HAII through A/NT/60 virus as well as HA2 coming from A/PR/8/34 malware.

#Selinexor #Niraparib #Gefitinib (ZD1839)

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terpboys · 2 years

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Enjoy Intense Vaping With Hybrid Disposable Vape

Ever tried the hybrid version of disposable vape? The current vaping generation is always in the race to experiment. Most vape lovers prefer to try something new. Therefore, the vape industry is also trying to bring more advancement in the product. Among the popular options, the hybrid disposable vape is currently in the spotlight. It has become the most famous choice among the legalized generation. If you haven’t tried it yet, you must give it a go without a second thought. Still, confused about the composition of hybrid vapes? Let’s discuss its facts in detail.

Facts On Hybrid Disposable Vapes

Hybrid disposable delta 8 vape is a combination of both Sativa and Indica. It is derived from Cannabis sativa plants with attributes of both indica and Sativa strains. It makes the perfect blend to form an e-liquid. The high feel you gain from it is extremely spontaneous and hits within a few puffs. You can enjoy the best version of CBD with hybrid vapes. You will get the feel of both strains in one vape, which is awesome. Therefore, people who want the advantage of both cannabis strains must try this.

The final product is produced by breeding the indica with Sativa cultivars. Hence, the hybrid strains are highlighted as the best traits of each major subtype of cannabis. The hybrid disposable vape is different and diverse in terms of taste and aroma. You simply can’t deny the fact of enjoying the best version of the combined vape.

There are hybrid strains that feature 50 % of Sativa genetics and 50 % of indica genetics. But the manufacturers are more inclined towards one side of any of the spectrum strains.

Are The Hybrid Disposable Vapes Easily Available?

Yes, and why not? The hybrid delta 8 disposable vapes are the most popular in the current generation. Therefore, undoubtedly this vape type is available online. Despite the strict rules, some developed and developing regions have come up with a license for the manufacturers and suppliers of CBD. The hybrid disposable vape is easily available in various online stores. Moreover, various flavor options are also available for this vape type. When searching for hybrid vapes, you must research to find the right service provider.

The hybrid disposable vaping gives a securely balanced highness. Moreover, it makes you feel relaxed throughout the day. These are best when you plan to hang out, meet up with friends, go hiking or have intimate moments.

Ref:https://medium.com/@trepboys06/enjoy-intense-vaping-with-hybrid-disposable-vape-1ef4c324f8da

#hybrid disposable vape

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