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#spodoptera genus
onenicebugperday · 7 months
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@understones submitted: we found this caterpillar in western virginia - I would love to know what this becomes! could you identify it?
It's a noctuid moth caterpillar and I think probably in the genus Spodoptera - so maybe a yellow-striped armyworm moth or a fall armyworm moth, which are both common in your area. There's a wide variety of markings between individuals on the caterpillars so it can be difficult to be sure!
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crevicedwelling · 7 months
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G'day mate, me and me dad have been growing some veggies lately and have noticed these little fellas on the leaves. We've been taking them off and down to the front yard so we don't hurt em but we were wondering what kind they are, reckon you'd have any idea? Area is north Queensland Australia.
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Thank you 👍
it’s a noctuid moth = cutworm caterpillar, many of which are considered crop pests. yours bears a passing resemblance to Spodoptera larvae, a widespread genus found in Australia and where I live in the US, but I hesitate to say anything definite since I’m no expert and larvae are tricky.
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rattyexplores · 11 months
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Armyworm Camouflage
Unidentified, genus Spodoptera
24/03/23
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saturniidays · 5 years
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Bug identification?
Hey! So a couple weeks back I found this caterpillar/larvae boi and I’ve been meaning to figure out what they are.
All I know is that this one’s host plant is narrow leafed plantain and that I’m in southwest British Columbia for climate n such.
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Okay I took a few days on this and the best I can tell you that its genus is Spodoptera, I couldn’t find an armyworm from BC that looks like that. Hopefully it will be easier to ID when it becomes an adult.
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sexempta · 5 years
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Spodoptera exempta is a tropical moth. This is not a porn site. Please don’t post any material unless it’s about insects.
The American cousin of Spodoptera exempta is called Spodoptera exempta. In classic taxonomy, the names of species are shortened by abbreviating the genus name as follows; S.exempta and S.exigua. S.exempta is commonly known as the African Armyworm,a most dangerous pest. It is called so because millions of them can match across a field of young corn, wheat, oats, alfalfa or grass fields and eat everything in a day. It then matches on.
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evoldir · 5 years
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Postdoc: SorbonneU.EvolutionaryBiology
Dear all, Please find below an opportunity for a postdoc position for 24 months at iEES Paris in Chemical Ecology and Evolutionary Biology. Mission A post-doc position is available in the Chemoreception and adaptation team (http://bit.ly/2BC40Rr). Our group is mainly interested in dissecting the mechanisms of olfactory reception in insects and in understanding their evolution in a changing environment. In moths, reproductive success largely depends on mate recognition through the detection of species-specific bouquets of air-borne chemicals called pheromones. The diversification of pheromone signals has likely played a key role in the extensive radiation observed in moths as it seems to be one of the main mechanisms responsible for the evolution of reproductive isolation. Recently we have identified genes underlying pheromone reception in pest moths of the genus Spodoptera, but gene families involved in pheromone production remain poorly studied. Studying the evolution of these genes is crucial to understand how pheromone communication can evolve and participate in reproductive isolation. Activity The candidate will use standard molecular biology and bioinformatics analyses in order to identify genes potentially involved in pheromone production, and characterize their expression patterns (using RT-qPCR) in 4 species of the genus Spodoptera. The candidate will also use biochemistry approaches (yeast transformation, GS-MS analyses) to determine the substrate specificity of candidate enzymes that may be responsible for the evolution of pheromone blends. Skills We are seeking a highly motivated candidate holding a PhD in Life Sciences, and with a strong interest for evolutionary biology. Experience in biochemistry and in molecular biology is mandatory, and a background in bioinformatics would be a plus. The candidate should have strong communication and organization skills, and be fluent in English. Context The post-doc position is available in the sensory ecology department of the Institute of Ecology and Environmental Sciences of Paris. This department involves 10 researchers from Sorbonne University (Paris) and Inra (Versailles), and uses a unique combination of know-how, including bioinformatics, functional genomics, molecular genetics, biochemistry, physico-chemistry, neuroanatomy, imaging, electrophysiology, ethology and modeling, developing approaches from genes to fields, from neurons to biophysical models, from individuals to populations. The lab will provide all the bench equipment and facilities required for the project, which is funded by an ANR grant. Contact The formal selection process will start early 2019. The contract should start before spring 2019. The term of this post is 24 months. CV and motivation letter should be send to [email protected] and [email protected] Camille MESLIN-AUCLAIR Charge de recherche / Researcher iEES Paris, Dpartement Ecosens [email protected] Tl. : +33 (0) 1 30 83 31 64 Fax : +33 (0) 1 30 83 31 19 INRA de Versailles-Grignon Route de Saint-Cyr - RD 10 78026 Versailles Cedex - France http://bit.ly/1nQHjdt Camille Meslin via Gmail
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e-kawantani · 3 years
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Suren (Toona sureni)
a.      Taksonomi
Kingdom: Plantae
Subkingdom: Tracheobionta
Superdivisi: Spermatophyta
Divisi: Magnoliophyta
Kelas: Magnoliopsida
Subkelas: Rosidae
Ordo: Sapindales
Famili: Meliaceae
Genus: Toona
Spesies: Toona sureni (Blume) Merr.[3]
 b.      Karakteristik: 
Suren merupakan tanaman berbentuk pohon dengan batang lurus, tidak bercabang, dan tinggi mencapai 60 m. kulit batang suren kasar, pecah-pecah, dan berwarna coklat. Daun suren berbentuk oval, berukuran 10-15 cm, dan memiliki susunan tulang daun menyirip. Buah berbentuk oval dan berwarna coklat tua kusam, sedangkan bunga berbentuk malai di ujung pohon (terminal) [1]
 c.       Habitat & Penyebaran:
Suren tumbuh pada daerah tebing dengan ketinggian 600-2.700 mdpl dan suhu sekitar 22oC. ciri khas tanaman ini adalah berbau harum khas apabila bagian daun atau buah diremas dan bila bagian batang dilukai atau ditebang. [1]
 d.      Kandungan kimia :
Senyawa kimia yang terkandung dalam suren antara lain surenon, surenin dan surenolakton [4]
 e.       Bagian tanaman yang digunakan :
Daun [2]
 f.        Cara kerja :
Penghambat pertumbuhan (growth regulator), penghambat makan, penolak (repellent), bersifat sebagai insektisisda.[4]
 g.      Bahan dan alat :
500 gram daun suren segar, air, alat penumbuk/ blender, saringan. [2]
h.      Cara Penggunaan :
Daun suren sebanyak 500 gram ditambahkan 500 mL air atau perbandingan 1:1 kemudian dihaluskan, sehingga didapatkan konsentrasi ekstrak 100%. Ekstrak yang didapatkan tersebut disaring menggunakan saringan kasa, kemudian disimpan dalam ruang gelap selama 24 jam. Penyimpanan larutan ekstrak dalam ruang gelap bertujuan agar senyawa yang terkandung dalam ekstrak tersebut tidak mudah terdegradasi. Penyimpanan larutan ekstrak selama 24 jam bertujuan untuk memisahkan endapan yang terdapat dalam ekstrak. Penyemprotan ekstrak daun suren pada tanaman dilakukan dengan konsentrasi ekstrak yang digunakan adalah 6,25 %. [2]
 i.        OPT sasaran :
Ulat grayak [2]
Sumber :
[1] Atika Mayang Sari. 2019. Monograf Biofarmaka untuk Penanganan Diabetes Melitus. PT Penerbit IPB Press
[2] Noviana, Estri, Sholahudin, Sri Widadi. 2011. Uji Potensi Ekstrak Daun Suren (Toona sureni) sebagai Insektisida Ulat Grayak (Spodoptera litura) pada Tanaman Kedelai. Biofarmasi Vol. 10, No. 2, pp. 46-53
[3] Plantamor. 2021. Toona sureni. Diakses melalui : http://plantamor.com/species/info/toona/sureni pada 6 Juli 2021
[4] W. Setiawati, R. Murtiningsih, N. Gunaeni, dan T. Rubiati. 2008. Tumbuhan Bahan Pestisida Nabati dan Cara Pembuatannya untuk Pengendalian Organisme Pengganggu Tumbuhan (OPT). Prima tani Balitsa. Bandung
Gambar :
https://static.inaturalist.org/photos/50943948/large.jpeg?1568136768
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monicamathis001 · 3 years
Text
Is there a Plant-based Treatment for Malaria?
Introduction
Approximately 210 million people get infected with malaria, and close to 440,000 people die from the disease. These numbers affect mostly young children in Africa, and currently, no vaccine has been approved for human use for malaria. The gravity of the situation is clear, for it only takes an infected mosquito to bite and transmit the parasite to numerous people. Preventative measures are key and organizations such as the World Health Organization, chooses to remind individuals in the tropical and subtropical countries to wear protective clothing, set up bed nets at night and use insect repellents. But there are medicines that are currently used as part of the treatment for the disease, which are effective (when diagnosed correctly), even though there is no official vaccine (“Malaria”).  
Malaria, AKA the “King of Diseases”, is caused by protozoan parasites of the genus Plasmodium and the most serious type of it known as Plasmodium falciparum. There are other human species as well, such as P. vivax, P. ovale, and P. malariae. The need for effective and practical diagnosis is increasing, especially since it is a global issue. To do this, diagnosis needs to be more streamlined and for that, it is important that early symptoms are caught at the right moment, especially since they are very nonspecific and variable (Tangpukdee). 
______________________________________________________________________________
Symptoms
Earliest symptoms - make it hard to diagnose and can be overlapping with other viral or bacterial infections (Tangpukdee). These are considered as the more common combination of symptoms: 
Fever
Headache
Myalgia
Chills and weakness
Abdominal pain
Diarrhea
Nausea
Vomiting 
 Malaria “attacks”: some individuals can experience these “attacks” that begin with shivering and chills, followed by high fever, then sweating, then back to normal temperature (“Malaria”). These are considered the stages for the classical malaria attack, as written by the CDC, and lasts for about 6-10 hours. 
Serious, severe malaria occurs when organ complications come into play and failures or abnormalities in the blood or metabolism are observed. According to the CDC, here are the following manifestations:
Cerebral malaria
Abnormal behavior
Impairment of consciousness
Seizures
Coma
Other neurological abnormalities
Severe anemia due to destruction of red blood cells (hemolysis)
Can lead to hemoglobin in the urine (hemoglobinuria) as a result. 
ARDS (Acute Respiratory Distress Syndrome)
It is an inflammatory reaction in the lungs that basically inhibits oxygen exchange, which is what our lungs are responsible for. 
This could occur even after parasite counts have decreased after treatment
Low blood pressure due to cardiovascular system collapse
Acute kidney journey
Excessive acidity in the blood and tissue fluids - Metabolic acidosis
Low blood glucose - Hypoglycemia (can also occur in pregnant women with uncomplicated malaria)
Hyperparasitemia
When more than 5% of the RBCs are infected by malaria parasites
**There are many strains of the parasite and these symptoms are from the common strains observed.**
Malaria Relapses: within P. vivax and P. ovale infections, patients who may have recovered the first time around can suffer from additional attacks - “relapses” - after months or even years without symptoms. These relapses occur due to P.vivax and P. ovale have parasites (“hypnozoites”) that can remain dormant in your liver and can reactivate later. There are treatments to reduce these relapses and should follow the treatment of the first attack (“CDC - Malaria - About Malaria - Disease”). 
______________________________________________________________________________
Treatment
Maximum drug effects, as observed, were between 18-24 hrs of parasite development; once again, showing the importance of early diagnosis. Increase in parasitic metabolic activity correlated with decreased drug sensitivity. 
Chloroquine (CQ)
Quinine (QN)
Artemisinin (AR)
Sodium artelinate (SA)
AR and its related compounds produced the most rapid parasitic clearance, followed by CQ and then QN. Basically, the artemisinin compounds, which behaved similarly, “had an overall broader time window of antimalarial effect than either CQ or QN ''(Terkuile, 91). In severe malaria cases, artemisinin derivatives also showed greater likelihood of inhibiting parasite cycle than other drugs.
CQ shows the most rapid onset of action out of the four drugs by inhibiting the parasite’s protein and nucleic acid synthesis. In contrast, there is a lag time of 1-4 hours before AR compounds begin to show any of the measurable effects, but after this, the reaction is very rapid as compared to CQ and QN. 
Based on this information, the delayed activity of AR and SA would be in favor for those with blood concentrations that were constant or above the concentration that inhibited parasite activity (or the inhibitory concentration) for several hours. Basically, these drugs are stage dependent and thus, the stage of infection will dictate which drug is best fit (Terkuile, 92). 
______________________________________________________________________________
Plant Based Treatment
Based on an assessment conducted by Alshawsh et al., the following information provides an overview of some Yemeni Medicinal plants that have antimalarial properties (specifically against Plasmodium falciparum). 
The following medicinal extracts are commonly used in Yemen by traditional healers and the study conducted evaluated their behavior against isolates of Plasmodium falciparum, in vitro (not in a biological setting, isolated). 
The IC50 of a medicine is the concentration of the medication in the blood that can inhibit the replication of the malarial parasite. It is the concentration at which 50% of the parasitic replication will be inhibited (“Concentration”). A low concentration indicates that less of the medication is needed to have an effect, thus implying the efficiency of the product.
Out of the 6 plants, there were three that were found to have significant positive effects with their IC50 value being less than 4 microgram/ml. 
Tumblr media
  This table shows all the medicines lined up and compared with the SMI or inhibition rate of the parasite of Chloroquine, which is a widely used drug for malaria. Among all of the medicines, only Acalypha fruticosa, Azadirachta indica, and Dendrosicyos socotrana showed any inhibition against parasite growth. 
Acalypha fruticose
Traditional Uses: Antiinflammatory, antimalarial, antibacterial.
Active components: Tannins, terpenoids, flavonoids, proteins, polysaccharides
IC50 = 1.6 microgram/ml
Azadirachta indica
Traditional Uses: Antimalarial, fever, digestive disturbances, skin problems, general fatigue, intestinal parasites, diabetes, fungal infections, inflammatory diseases.
Active components: Flavonoids, terpenoids Polysaccharides, proteins, tannins
IC50 = 2.0 microgram/ml
Dendrosicyos socotrana
Traditional uses: Urinary retention, cystitis, symptoms of diabetes, problems with the liver and burns, constipation 
Active components: Terpenoids, proteins, polysaccharides
IC50 = 2.3 microgram/ml
Based on the commonalities within the active components, the presence of tannins, polysaccharides and proteins in the aqueous extracts (Table 2), might have been responsible for the antiplasmodial (against malaria, stemming from the genus Plasmodium) activity of those products(Alshawsh).
Another plant based on West African Plants, conducted by Zirihi et al., researched 33 plant extracts and found certain plants that have been described with having antiplasmodial activity – which is what we are looking for in medications (Zirihi, G.N.).
The root extract of Rauvolfia vomitoria (IC50 = 2.5 micrograms/ml, SI = 9-10)
Important medicinal plant used for many illnesses such as neuropsychiatry disorders, jaundice, gastro-intestinal, measles, and more.
The stem bark extract of Funtumia elastica (IC50 = 3.3 micrograms/ml, SI >15)
Traditionally used for the treatment of haemorrhoids
The stem bark extract of Fagara macrophylla (IC50 = 2.3 micrograms/ml, SI = 9-12)
Has a potent “antifeedant activity” (naturally occurring substance in the plant that causes an unfavorable reaction in the organism that consumes it) against the larvae of both Spodoptera frugiperdaand Spodoptera littoralis (species of moth)
Hypothesized that these substances also make the plant have antiplasmoidial activity.
Work Cited
 Alshawsh, Mohammed A et al. “Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants.” Evidence-based complementary and alternative medicine : eCAM vol. 6,4 (2009): 453-6. doi:10.1093/ecam/nem148
“CDC - Malaria - About Malaria - Disease.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 4 Jan. 2019, www.cdc.gov/malaria/about/disease.html.
“Concentration.” The Free Dictionary, Farlex,
medical-dictionary.thefreedictionary.com/concentration. 
“Malaria.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 13 Dec. 2018, www.mayoclinic.org/diseases-conditions/malaria/symptoms-causes/syc-20351184. 
Tangpukdee, Noppadon et al. “Malaria diagnosis: a brief review.” The Korean journal of parasitology vol. 47,2 (2009): 93-102. doi:10.3347/kjp.2009.47.2.93
Terkuile, F., et al. “Plasmodium Falciparum: In Vitro Studies of the Pharmacodynamic Properties of Drugs Used for the Treatment of Severe Malaria.” Experimental Parasitology, vol. 76, no. 1, 1993, pp. 85–95., doi:10.1006/expr.1993.1010.
Zirihi, G. N., Mambu, L., Guédé-Guina, F., Bodo, B., & Grellier, P. (2005). In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology, 98(3), 281-285. doi:10.1016/j.jep.2005.01.004
source https://www.nutrav.com/blogs/news/is-there-a-plant-based-treatment-for-malaria source https://nutravllc.blogspot.com/2020/11/is-there-plant-based-treatment-for.html
0 notes
kimberlywoodson002 · 3 years
Text
Is there a Plant-based Treatment for Malaria?
Introduction
Approximately 210 million people get infected with malaria, and close to 440,000 people die from the disease. These numbers affect mostly young children in Africa, and currently, no vaccine has been approved for human use for malaria. The gravity of the situation is clear, for it only takes an infected mosquito to bite and transmit the parasite to numerous people. Preventative measures are key and organizations such as the World Health Organization, chooses to remind individuals in the tropical and subtropical countries to wear protective clothing, set up bed nets at night and use insect repellents. But there are medicines that are currently used as part of the treatment for the disease, which are effective (when diagnosed correctly), even though there is no official vaccine (“Malaria”).  
Malaria, AKA the “King of Diseases”, is caused by protozoan parasites of the genus Plasmodium and the most serious type of it known as Plasmodium falciparum. There are other human species as well, such as P. vivax, P. ovale, and P. malariae. The need for effective and practical diagnosis is increasing, especially since it is a global issue. To do this, diagnosis needs to be more streamlined and for that, it is important that early symptoms are caught at the right moment, especially since they are very nonspecific and variable (Tangpukdee). 
______________________________________________________________________________
Symptoms
Earliest symptoms – make it hard to diagnose and can be overlapping with other viral or bacterial infections (Tangpukdee). These are considered as the more common combination of symptoms: 
Fever
Headache
Myalgia
Chills and weakness
Abdominal pain
Diarrhea
Nausea
Vomiting 
  Malaria “attacks”: some individuals can experience these “attacks” that begin with shivering and chills, followed by high fever, then sweating, then back to normal temperature (“Malaria”). These are considered the stages for the classical malaria attack, as written by the CDC, and lasts for about 6-10 hours. 
Serious, severe malaria occurs when organ complications come into play and failures or abnormalities in the blood or metabolism are observed. According to the CDC, here are the following manifestations:
Cerebral malaria
Abnormal behavior
Impairment of consciousness
Seizures
Coma
Other neurological abnormalities
Severe anemia due to destruction of red blood cells (hemolysis)
Can lead to hemoglobin in the urine (hemoglobinuria) as a result. 
ARDS (Acute Respiratory Distress Syndrome)
It is an inflammatory reaction in the lungs that basically inhibits oxygen exchange, which is what our lungs are responsible for. 
This could occur even after parasite counts have decreased after treatment
Low blood pressure due to cardiovascular system collapse
Acute kidney journey
Excessive acidity in the blood and tissue fluids – Metabolic acidosis
Low blood glucose – Hypoglycemia (can also occur in pregnant women with uncomplicated malaria)
Hyperparasitemia
When more than 5% of the RBCs are infected by malaria parasites
**There are many strains of the parasite and these symptoms are from the common strains observed.**
Malaria Relapses: within P. vivax and P. ovale infections, patients who may have recovered the first time around can suffer from additional attacks – “relapses” – after months or even years without symptoms. These relapses occur due to P.vivax and P. ovale have parasites (“hypnozoites”) that can remain dormant in your liver and can reactivate later. There are treatments to reduce these relapses and should follow the treatment of the first attack (“CDC – Malaria – About Malaria – Disease”). 
______________________________________________________________________________
Treatment
Maximum drug effects, as observed, were between 18-24 hrs of parasite development; once again, showing the importance of early diagnosis. Increase in parasitic metabolic activity correlated with decreased drug sensitivity. 
Chloroquine (CQ)
Quinine (QN)
Artemisinin (AR)
Sodium artelinate (SA)
AR and its related compounds produced the most rapid parasitic clearance, followed by CQ and then QN. Basically, the artemisinin compounds, which behaved similarly, “had an overall broader time window of antimalarial effect than either CQ or QN ”(Terkuile, 91). In severe malaria cases, artemisinin derivatives also showed greater likelihood of inhibiting parasite cycle than other drugs.
CQ shows the most rapid onset of action out of the four drugs by inhibiting the parasite’s protein and nucleic acid synthesis. In contrast, there is a lag time of 1-4 hours before AR compounds begin to show any of the measurable effects, but after this, the reaction is very rapid as compared to CQ and QN. 
Based on this information, the delayed activity of AR and SA would be in favor for those with blood concentrations that were constant or above the concentration that inhibited parasite activity (or the inhibitory concentration) for several hours. Basically, these drugs are stage dependent and thus, the stage of infection will dictate which drug is best fit (Terkuile, 92). 
______________________________________________________________________________
Plant Based Treatment
Based on an assessment conducted by Alshawsh et al., the following information provides an overview of some Yemeni Medicinal plants that have antimalarial properties (specifically against Plasmodium falciparum). 
The following medicinal extracts are commonly used in Yemen by traditional healers and the study conducted evaluated their behavior against isolates of Plasmodium falciparum, in vitro (not in a biological setting, isolated). 
The IC50 of a medicine is the concentration of the medication in the blood that can inhibit the replication of the malarial parasite. It is the concentration at which 50% of the parasitic replication will be inhibited (“Concentration”). A low concentration indicates that less of the medication is needed to have an effect, thus implying the efficiency of the product.
Out of the 6 plants, there were three that were found to have significant positive effects with their IC50 value being less than 4 microgram/ml. 
Tumblr media
   This table shows all the medicines lined up and compared with the SMI or inhibition rate of the parasite of Chloroquine, which is a widely used drug for malaria. Among all of the medicines, only Acalypha fruticosa, Azadirachta indica, and Dendrosicyos socotrana showed any inhibition against parasite growth. 
Acalypha fruticose
Traditional Uses: Antiinflammatory, antimalarial, antibacterial.
Active components: Tannins, terpenoids, flavonoids, proteins, polysaccharides
IC50 = 1.6 microgram/ml
Azadirachta indica
Traditional Uses: Antimalarial, fever, digestive disturbances, skin problems, general fatigue, intestinal parasites, diabetes, fungal infections, inflammatory diseases.
Active components: Flavonoids, terpenoids Polysaccharides, proteins, tannins
IC50 = 2.0 microgram/ml
Dendrosicyos socotrana
Traditional uses: Urinary retention, cystitis, symptoms of diabetes, problems with the liver and burns, constipation 
Active components: Terpenoids, proteins, polysaccharides
IC50 = 2.3 microgram/ml
Based on the commonalities within the active components, the presence of tannins, polysaccharides and proteins in the aqueous extracts (Table 2), might have been responsible for the antiplasmodial (against malaria, stemming from the genus Plasmodium) activity of those products(Alshawsh).
Another plant based on West African Plants, conducted by Zirihi et al., researched 33 plant extracts and found certain plants that have been described with having antiplasmodial activity – which is what we are looking for in medications (Zirihi, G.N.).
The root extract of Rauvolfia vomitoria (IC50 = 2.5 micrograms/ml, SI = 9-10)
Important medicinal plant used for many illnesses such as neuropsychiatry disorders, jaundice, gastro-intestinal, measles, and more.
The stem bark extract of Funtumia elastica (IC50 = 3.3 micrograms/ml, SI >15)
Traditionally used for the treatment of haemorrhoids
The stem bark extract of Fagara macrophylla (IC50 = 2.3 micrograms/ml, SI = 9-12)
Has a potent “antifeedant activity” (naturally occurring substance in the plant that causes an unfavorable reaction in the organism that consumes it) against the larvae of both Spodoptera frugiperdaand Spodoptera littoralis (species of moth)
Hypothesized that these substances also make the plant have antiplasmoidial activity.
Work Cited
  Alshawsh, Mohammed A et al. “Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants.” Evidence-based complementary and alternative medicine : eCAM vol. 6,4 (2009): 453-6. doi:10.1093/ecam/nem148
“CDC – Malaria – About Malaria – Disease.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 4 Jan. 2019, www.cdc.gov/malaria/about/disease.html.
“Concentration.” The Free Dictionary, Farlex,
medical-dictionary.thefreedictionary.com/concentration. 
“Malaria.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 13 Dec. 2018, http://www.mayoclinic.org/diseases-conditions/malaria/symptoms-causes/syc-20351184. 
Tangpukdee, Noppadon et al. “Malaria diagnosis: a brief review.” The Korean journal of parasitology vol. 47,2 (2009): 93-102. doi:10.3347/kjp.2009.47.2.93
Terkuile, F., et al. “Plasmodium Falciparum: In Vitro Studies of the Pharmacodynamic Properties of Drugs Used for the Treatment of Severe Malaria.” Experimental Parasitology, vol. 76, no. 1, 1993, pp. 85–95., doi:10.1006/expr.1993.1010.
Zirihi, G. N., Mambu, L., Guédé-Guina, F., Bodo, B., & Grellier, P. (2005). In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology, 98(3), 281-285. doi:10.1016/j.jep.2005.01.004
source https://www.nutrav.com/blogs/news/is-there-a-plant-based-treatment-for-malaria
source https://nutravllc.wordpress.com/2020/11/18/is-there-a-plant-based-treatment-for-malaria/
0 notes
nutravllc · 3 years
Text
Is there a Plant-based Treatment for Malaria?
Introduction
Approximately 210 million people get infected with malaria, and close to 440,000 people die from the disease. These numbers affect mostly young children in Africa, and currently, no vaccine has been approved for human use for malaria. The gravity of the situation is clear, for it only takes an infected mosquito to bite and transmit the parasite to numerous people. Preventative measures are key and organizations such as the World Health Organization, chooses to remind individuals in the tropical and subtropical countries to wear protective clothing, set up bed nets at night and use insect repellents. But there are medicines that are currently used as part of the treatment for the disease, which are effective (when diagnosed correctly), even though there is no official vaccine (“Malaria”).  
Malaria, AKA the “King of Diseases”, is caused by protozoan parasites of the genus Plasmodium and the most serious type of it known as Plasmodium falciparum. There are other human species as well, such as P. vivax, P. ovale, and P. malariae. The need for effective and practical diagnosis is increasing, especially since it is a global issue. To do this, diagnosis needs to be more streamlined and for that, it is important that early symptoms are caught at the right moment, especially since they are very nonspecific and variable (Tangpukdee). 
______________________________________________________________________________
Symptoms
Earliest symptoms - make it hard to diagnose and can be overlapping with other viral or bacterial infections (Tangpukdee). These are considered as the more common combination of symptoms: 
Fever
Headache
Myalgia
Chills and weakness
Abdominal pain
Diarrhea
Nausea
Vomiting 
  Malaria “attacks”: some individuals can experience these “attacks” that begin with shivering and chills, followed by high fever, then sweating, then back to normal temperature (“Malaria”). These are considered the stages for the classical malaria attack, as written by the CDC, and lasts for about 6-10 hours. 
Serious, severe malaria occurs when organ complications come into play and failures or abnormalities in the blood or metabolism are observed. According to the CDC, here are the following manifestations:
Cerebral malaria
Abnormal behavior
Impairment of consciousness
Seizures
Coma
Other neurological abnormalities
Severe anemia due to destruction of red blood cells (hemolysis)
Can lead to hemoglobin in the urine (hemoglobinuria) as a result. 
ARDS (Acute Respiratory Distress Syndrome)
It is an inflammatory reaction in the lungs that basically inhibits oxygen exchange, which is what our lungs are responsible for. 
This could occur even after parasite counts have decreased after treatment
Low blood pressure due to cardiovascular system collapse
Acute kidney journey
Excessive acidity in the blood and tissue fluids - Metabolic acidosis
Low blood glucose - Hypoglycemia (can also occur in pregnant women with uncomplicated malaria)
Hyperparasitemia
When more than 5% of the RBCs are infected by malaria parasites
**There are many strains of the parasite and these symptoms are from the common strains observed.**
Malaria Relapses: within P. vivax and P. ovale infections, patients who may have recovered the first time around can suffer from additional attacks - “relapses” - after months or even years without symptoms. These relapses occur due to P.vivax and P. ovale have parasites (“hypnozoites”) that can remain dormant in your liver and can reactivate later. There are treatments to reduce these relapses and should follow the treatment of the first attack (“CDC - Malaria - About Malaria - Disease”). 
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Treatment
Maximum drug effects, as observed, were between 18-24 hrs of parasite development; once again, showing the importance of early diagnosis. Increase in parasitic metabolic activity correlated with decreased drug sensitivity. 
Chloroquine (CQ)
Quinine (QN)
Artemisinin (AR)
Sodium artelinate (SA)
AR and its related compounds produced the most rapid parasitic clearance, followed by CQ and then QN. Basically, the artemisinin compounds, which behaved similarly, “had an overall broader time window of antimalarial effect than either CQ or QN ''(Terkuile, 91). In severe malaria cases, artemisinin derivatives also showed greater likelihood of inhibiting parasite cycle than other drugs.
CQ shows the most rapid onset of action out of the four drugs by inhibiting the parasite’s protein and nucleic acid synthesis. In contrast, there is a lag time of 1-4 hours before AR compounds begin to show any of the measurable effects, but after this, the reaction is very rapid as compared to CQ and QN. 
Based on this information, the delayed activity of AR and SA would be in favor for those with blood concentrations that were constant or above the concentration that inhibited parasite activity (or the inhibitory concentration) for several hours. Basically, these drugs are stage dependent and thus, the stage of infection will dictate which drug is best fit (Terkuile, 92). 
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Plant Based Treatment
Based on an assessment conducted by Alshawsh et al., the following information provides an overview of some Yemeni Medicinal plants that have antimalarial properties (specifically against Plasmodium falciparum). 
The following medicinal extracts are commonly used in Yemen by traditional healers and the study conducted evaluated their behavior against isolates of Plasmodium falciparum, in vitro (not in a biological setting, isolated). 
The IC50 of a medicine is the concentration of the medication in the blood that can inhibit the replication of the malarial parasite. It is the concentration at which 50% of the parasitic replication will be inhibited (“Concentration”). A low concentration indicates that less of the medication is needed to have an effect, thus implying the efficiency of the product.
Out of the 6 plants, there were three that were found to have significant positive effects with their IC50 value being less than 4 microgram/ml. 
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   This table shows all the medicines lined up and compared with the SMI or inhibition rate of the parasite of Chloroquine, which is a widely used drug for malaria. Among all of the medicines, only Acalypha fruticosa, Azadirachta indica, and Dendrosicyos socotrana showed any inhibition against parasite growth. 
Acalypha fruticose
Traditional Uses: Antiinflammatory, antimalarial, antibacterial.
Active components: Tannins, terpenoids, flavonoids, proteins, polysaccharides
IC50 = 1.6 microgram/ml
Azadirachta indica
Traditional Uses: Antimalarial, fever, digestive disturbances, skin problems, general fatigue, intestinal parasites, diabetes, fungal infections, inflammatory diseases.
Active components: Flavonoids, terpenoids Polysaccharides, proteins, tannins
IC50 = 2.0 microgram/ml
Dendrosicyos socotrana
Traditional uses: Urinary retention, cystitis, symptoms of diabetes, problems with the liver and burns, constipation 
Active components: Terpenoids, proteins, polysaccharides
IC50 = 2.3 microgram/ml
Based on the commonalities within the active components, the presence of tannins, polysaccharides and proteins in the aqueous extracts (Table 2), might have been responsible for the antiplasmodial (against malaria, stemming from the genus Plasmodium) activity of those products(Alshawsh).
Another plant based on West African Plants, conducted by Zirihi et al., researched 33 plant extracts and found certain plants that have been described with having antiplasmodial activity – which is what we are looking for in medications (Zirihi, G.N.).
The root extract of Rauvolfia vomitoria (IC50 = 2.5 micrograms/ml, SI = 9-10)
Important medicinal plant used for many illnesses such as neuropsychiatry disorders, jaundice, gastro-intestinal, measles, and more.
The stem bark extract of Funtumia elastica (IC50 = 3.3 micrograms/ml, SI >15)
Traditionally used for the treatment of haemorrhoids
The stem bark extract of Fagara macrophylla (IC50 = 2.3 micrograms/ml, SI = 9-12)
Has a potent “antifeedant activity” (naturally occurring substance in the plant that causes an unfavorable reaction in the organism that consumes it) against the larvae of both Spodoptera frugiperdaand Spodoptera littoralis (species of moth)
Hypothesized that these substances also make the plant have antiplasmoidial activity.
Work Cited
  Alshawsh, Mohammed A et al. “Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants.” Evidence-based complementary and alternative medicine : eCAM vol. 6,4 (2009): 453-6. doi:10.1093/ecam/nem148
“CDC - Malaria - About Malaria - Disease.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 4 Jan. 2019, www.cdc.gov/malaria/about/disease.html.
“Concentration.” The Free Dictionary, Farlex,
medical-dictionary.thefreedictionary.com/concentration. 
“Malaria.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 13 Dec. 2018, www.mayoclinic.org/diseases-conditions/malaria/symptoms-causes/syc-20351184. 
Tangpukdee, Noppadon et al. “Malaria diagnosis: a brief review.” The Korean journal of parasitology vol. 47,2 (2009): 93-102. doi:10.3347/kjp.2009.47.2.93
Terkuile, F., et al. “Plasmodium Falciparum: In Vitro Studies of the Pharmacodynamic Properties of Drugs Used for the Treatment of Severe Malaria.” Experimental Parasitology, vol. 76, no. 1, 1993, pp. 85–95., doi:10.1006/expr.1993.1010.
Zirihi, G. N., Mambu, L., Guédé-Guina, F., Bodo, B., & Grellier, P. (2005). In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology, 98(3), 281-285. doi:10.1016/j.jep.2005.01.004
source https://www.nutrav.com/blogs/news/is-there-a-plant-based-treatment-for-malaria
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onenicebugperday · 7 months
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@mistresstaru submitted: Found this caterpillar on my walk in South Jersey. What’s he going to turn into?
Looks like probably an armyworm moth in the genus Spodoptera. Couldn’t say which species, though. They tend to be little brown moths with funky markings :)
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calosoma-amitch · 6 years
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“any idea what kind of guy this is? Found him on my leeks from the farmers market and that seems to be his favorite food. Since this picture he’s gotten much longer and fatter! He’s from the Canadian martimes here on the east coast “
This looks like one of our armyworms (Genus Spodoptera), a group of moths that are found throughout the US and into southern Canada. As caterpillars, they can feed on a wide variety of plants, and some are considered major crop pests (corns, crucifers, cucurbits, legumes, peppers, potatoes, and tomatoes, just to name a few). The name “armyworm” comes from the mass numbers of caterpillars that used to “march” out of agricultural fields following their feeding.  I’d hazard a guess that this caterpillar might be a Yellow-striped armyworm (Spodoptera ornithogalli ), but young instars (molts) are super difficult to ID. If the caterpillar gets any bigger, see if you can get some pictures! Thanks for sharing!
Photograph and submission by: katzjimjam http://katzjimjam.tumblr.com
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rattyexplores · 3 years
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𝑼𝒏𝒅𝒆𝒕𝒆𝒓𝒎𝒊𝒏𝒆𝒅
I do have two possible species though, I might as well take up two index entries. Both species are from the Spodoptera genus
𝑺𝒑𝒐𝒅𝒐𝒑𝒕𝒆𝒓𝒂 𝒆𝒙𝒆𝒎𝒑𝒕𝒂
“African Armyworm”
Order Lepidoptera Superfamily Noctuoidea Family Noctuidae “Cutworms, Armyworms, Whistling Moths, Underwings” Subfamily Acronictinae
The Adult moth has a complex array of brown patterning, mimicking wheat/grass seeds (As you can see above) The wingspan is about 3CM. 
The Larval stage (has yet to be photographed) is a pale green, with two striped patterns vertical striped patterns in a darker shade of green, and a black head. The later instars become brown.
The Larvae feeds on:
Brachiaria mutica “Para Grass”
Oryza sativa “Rice”
Paspalum dilatatum “Dallisgrass”
Pennisetum clandestinum “Kikuyu”
Saccharum officinarum “Sugar Cane”
Sorghum bicolor “Sorghum”
This species is found in these Australian states:
Q.L.D
W.A
N.T
N.S.W
Along with these Countries:
Africa (Presumably across the whole continent)
Hawaii
Japan
New Zealand
U.S.A
𝑺𝒑𝒐𝒅𝒐𝒑𝒕𝒆𝒓𝒂 𝒎𝒂𝒖𝒓𝒊𝒕𝒊𝒂
“Lawn Armyworm”
Order Lepidoptera Superfamily Noctuoidea Family Noctuidae “Cutworms, Armyworms, Whistling Moths, Underwings” Subfamily Acronictinae
The Adult moth Has practically the same patterns as the species listed above, however images I find show a subtle navy-blue tint.
The Larval stage (has yet to be photographed) Start off with smooth-skin and green longitudinal lines. The later instars become brown with two rows of black triangles along the back.
Like other Spodoptera caterpillars, when disturbed they drop, curl into a ball, and stay still.
The Larvae feeds on:
Cynodon species “Bermuda Grass”
Pennisetum clandestinum “Kikuyu”
Sorghum bicolor “Sorghum”
Oryza sativa “Rice” 
This species is found in many Australian states/islands:
Q.L.D
N.S.W
N.T
W.A
Norfolk Island
Lord Howe Island
Along with these Countries:
Borneo
Hawaii
India
U.A.E, “United Arab Emirates”
17/12/20, source - RatteJak
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drhoz · 6 years
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#1286 - Proteuxoa atrisquamata
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AKA Caradrina atrisquamata.
Found by Julie Freestone, in a pile of bricks in their yard at Wunghnu, Northern Victoria.  Probably ready to pupate.
These Noctuids are related to the Armyworms in the Spodoptera genus, and both genera include a lot of agricultural pests. This particular species is found in Victoria and South Australia.
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bobnorthway · 7 years
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Armyworms: The hungry caterpillar threatening a global food crisis | Global Development Professionals Network | The Guardian
Armyworms: The hungry caterpillar threatening a global food crisis | Global Development Professionals Network | The Guardian
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A plague of armyworms is marching across Africa, devastating crops, and claiming new territory at an alarming rate
by Richard Poplak in Johannesburg
Tuesday 16 May 2017 18.14 AEST
Supported by
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About this content
Speaking Darwinistically, the planet should have no truck with the spodoptera genus, commonly known as armyworms. Fat, slow over the ground and unspeakably…
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onenicebugperday · 1 year
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@marshmallow-fluffy​ submitted: Friend and I found a nice moth today! Location is [removed]. Please remove location.
A lovely little dude! Looks like one of the armyworm moths in the genus Spodoptera :)
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