#iron man: fatal frontier

[avengerscompound]

Iron Man: Fatal Frontier Infinite Comic (2013)

#marvel #avengers #marveledit #comicedit #tonystarkedit #ironmanedit #tony stark #iron man #iron man: fatal frontier infinite comic #616 #neil edwards #marvel comics #avengerscompoundedit

[the-faultofdaedalus]

heist comic but it’s victor breaking into mephisto’s casino to fuck with him

#we got tony heist comic ft dr doom in fatal frontier #NOW we can get victor heist comic ft iron man in this #it’s perfect listen. listen.

[kayvsworld]

completely forgot abt fatal frontier and the sentence “sheriff iron man, governor of the moon” knocked me right the fuck over

#i have no context for anything in 616 on account of i have not read anything else published after the 70s #but the moon one was good i remember this. frantically trying to consume content abt comics tony that will not fry my brain #kayvswords

[flyonthewallmedstudent]

Rhizopus & Mucor

Both belong under the umbrella term, mucorales. These are bread moulds naturally on fruit and bread that we breathe in and out without much issue particularly if immunocompetent, but in some immunocompromised it causes rapidly fatal and progressive disease: mucormycosis. Due to the weakened immune system.

Spores released either land on skin or into blood via open wounds, then deposit tehre, invading local vessels, thrombosing them and cutting off supply. this rapidly leads to ischaemia and necrosis. Dead tissue.

Now for a Case Report. This one in Frontiers of Medicine. A 35 yo man with diabetes presents with a facial rash, that rapidly progresses to an eschar and ulcer. To note, there are graphic images in the link of his face.

This was initially associated with nasal discharge and epistaxis. Diagnosis was initially a peridontal infection which did not resolve with standard antibiotics for this, similarly he was next diagnosed with uncomplicated, stock standard cellulitis (usually staph or strep pyogenes caused). Both treatments failed.

eventually he was diagnosed with mucormycosis, but by then he had extensive damage to his face, the subcut tissues, muscles and facial bones. He also had significant weight loss, fevers, splenomegaly and thrombosis.

To muddy the waters, he was concurrently diagnosed with a T cell lymphoma but the authors also picked up Rhizopus.

What is Rhizopus? (also related to mucor, another mucorales) It's a fungi, more specifically an opportunistic pathogen commonly associated with diabetics (esp poorly controlled) and the immunocompromised (in particular solid organ transplants, see further case report in resources below, HIV, malnutrition, haematological malignancies - eg leukaemias).

Also associated with steroid use, form of immunosuppression so has been seen in severe COVID patients requiring dexamethasone (Rare though).

As a mould it likes the acidotic states in DKA and iron, so any iron overload states as well.

Why poorly controlled diabetics - it becomes an immunocormposed state in and of itself. The sugars suppress local inflammatory responses like neutrophil chemotaxis or phagocytosis etc. You can however, get chronic forms too. So don't rule it out if it's not wildly acute. These occur over weeks, slowly. Considering it's a mould, it's particularly "prolific" in hot weather and warm/hot climates.

Classically it is an infection that affects the face, parasinuses, nose and even the brain. You'll often hear the term rhinocerebral with it.

Consider it if you see discolouration around the face and definitely if you see a necrotic eschar. Actually, any black spots, fevers, rash, call ID urgently. Unsurprisingly, it is also called the black fungus.

Is also possible to have it affect the skin (particularly in IVDU and in burns), lungs and GI (more rare). IN lung involvement symptoms are typical for the organ - SOB, fevers, chest pain, haemoptysis. in GI: nausea/vomiting/GIB.

Thrombosis can occur as a complication as it invades the blood vessels.

In brain involvement from disseminated disease, expect confusion and altered state if not reduced GCS.

It's also been recently featured in the fungi podcast by the Curbsiders. Which is worth a listen.

It's filamentous and has hyphae.

You'll also hear the term mucormycosis = which just refers to the disease process that is rapidly fatal. Mortality is 30-70% of rhinocerebral cases, 90% in disseminated and 100% in AIDs --numbers from StatPearls. Survival improves with antifungals and surgery to 70%.

Early diagnosis and intervention is essential, as illustrated in the case report above. but is rare, so not infrequently missed.

It's also missed, as early symptoms are very non specific depending on how it affects the host. You can simply get lethargy, headache and eye pain. Blurry vision too, or simply epistaxis and rhinorrhoea.

Image from Wiki

Now that you know the clinical presentation and the increased risk groups to think of this diagnosis in,

How do you confirm your suspicions?

investigations:

It's associated with neutropaenic states and one hypothesis is acidosis in diabetics with poorly managed sugars (so really unwell). No serology (as compared to other bugs), would come up in fungal cultures and on tissue biopsy. key words on biopsy: Ribbon like hyphae branching at 90 degree angles.

Also from wiki, that suggests it looks like Moose antlers.

Pathologists will also note or look for necrosis and haemorrhage.

Blood cultures rarely pick up it, so consider it if they're unwell and culture negative.

On imaging - gold standard in rhino cerebral is MRI but CT is most accessible and fast. Looking for signs of blood vessel invasion and reverse halo or less specific halo sign.

Reverse halo per radiopaedia: ground glass within a consolidated crescent shape.

From radiopaedia:

Okay, this sounds both difficult to pick up and investigate. No magical PCR or serology.

Pro tip from stat pearls: just maintain a high index of suspicion in anyone with increased risk or risk factors. Biopsy tissue quickly particularly if necrosis is apparent. Early detection method is unsurprisngly CT --> we all seem to have a low threshold for this, but looking for hyperdensity (mucosal thickening) and erosion of the facial bones.

Also essential is the age old adage that most clinicians follow --> empirical therapy for the most common organisms, close monitoring/observations. then failing that, broaden the differentials and keep investigating or altering treatment quickly.

Treatment:

The strong stuff. Liposomal Amphotericin B for 4-6 weeks (the long duration) as it is highly invasive/progressive. Alternatives; itraconazole.

You may also hear of hyperbaric O2 therapy, which aids the neutrophils to kill the fungi. Also in stat pearls

Surgical debridement after antifungal therapy with washout depending on extent of damage.

Sources used for post:

Case reports, wiki and radiopaedia as above And largely Statpearls --> there is much more further detail and more to read on differentials and complications.

I'll try to use free resources as much as possible.

Another Case Reports of interest include: NEJM - lengthy one reminding all to consider this diagnosis in an unexplained rash in an immunocompromised host.

#infectious diseases #mucorales #mucor #rhizopus #mucormycosis #medblr

[lovelytonys]

do y’all have some iron man comic recs. I just need SOMETHING. I’ve already read every solo series issue from 1992-2020 and…..I wanna say Fatal Frontier as well and Demon in a Bottle and then like the civil wars or whatever but we don’t need to talk about those.

IRON MAN NATION PLEASE SHOW UP FOR ME do you have any hidden gems or favorite classic arcs that I should seek out. please help

#iron man #616 tony stark #tony stark #marvel comics #comic recs

[tratshka]

Hi:D Hope you don't mind me asking, but I wanna get into reading comics and was wondering if you had any doom/tony recommendations?:')

Not at all, of course I have;

*the Darkhold recent comics

*Invincible iron man (2015) and infamous iron man (2016)

*King in black: Iron man/Doom (2020)

“Doomquest” and “Knightmare ”

*Iron Man: Fatal Frontier (2013)

*Iron Man: Exiles (2001) #23

this are some rec of comics that I really like.

there should be more but I'm fucking awful at remembering

#asks🖤

[laufire]

about me™

I decided between one thing and the other, it was time to make a new version of my “what could you reasonably expect from this blog” post. Since it’s my birthday, here it is!

[edited on 01/01/2024]

General stuff

-Anon is open, for now; don’t abuse it, and follow the usual “don’t be an asshole” guideliness. I don’t post anon hate (unless I think it would be really funny of me to do so), so I suggest you don’t bother sending it.

-I block at the drop of a hat. The main reasons are usually bigotry and conservative rhetoric, general assholery (especially on the tags I track), and noticing someone blocked me first (I don't want you to reblog my posts if I can't reply to you or even see anything you add to them).

-In my pinned posts you can see a few links of interest (this post, my edits or fics, my author newsletter, etc.).

-I add image descriptions to everything in my blog (for my original posts, I usually use alt text). Feel free to send me an ask if I ever miss anything.

-I’m an Opinionated Person and I sometimes post negativity™ just for the sake of bitching (which I consider different from general, grounded criticism and the like). It’s all tagged with “bitter lau tag”, and “antiX for ts” tags, X being a fandom/character/ship. I.e. “antidelena for ts”; “antidamonsalvatore for ts”. That way it doesn't appear on main searches for those things. In general, I’m an exhaustive tagger, so filtering anything shouldn’t be a problem; and of course, you can always ask me to tag something specific I might've missed in order to filter it.

Fandoms

I’m very multifandom, but I'm prone to have one or two hyperfixations at the forefront. Sometimes they're new favourites, but more often than not they're old favourites that get their claws back on me.

-Main fandoms:

DCU. My interests in this very large fandom are diversified, but my entry point of obsession is often Jason Todd in particular and the Bat Cult Clan in general. Add some Young Justice, Gotham, Wonder Woman, Zatanna, the early DCEU, various female characters of dubious moral qualities, multiple teamups and adaptations and elseworlds… I always return to this world, basically. My primary area interest is the post-crisis/new earth comics continuity, but I dabble in many others.

-

Some of my favourite shows: Angel & BTVS, Attack on Titan, Black Sails, Desperate Housewives, Dollhouse, Killjoys, MARVEL’S Agents of S.H.I.E.L.D., Nikita, Person of Interest, Reign, Scandal, Severance, Terminator: Sarah Connor Chronicles, The Good Wife, The Sopranos, The Vampire Diaries & Co, The Wire, Underground, Veronica Mars, Xena: Warrior Princess.

Some of my favourite films: the Alien franchise, Barbie and the Magic of Pegasus, Batman Returns, Black Swan, Blancanieves (2012), Colombiana, D.E.B.S., El verdugo, Jennifer’s Body, Jupiter Ascending, Lust Caution, Mulan, Pan’s Labyrinth, Practical Magic, The Handmaiden, The Lion in Winter, The Mask of Zorro, The Terminator (1 & 2).

Some of my favourite authors: Agatha Christie, Ana María Matute, Angela Carter, Camilla Andrew, Charlotte Perkins Gilman, Daphne du Maurier, Mary Wollstonecraft Shelley, Miguel Hernández, Philip Pullman, Shirley Jackson, Terry Pratchett, Ursula K. Le Guin.

Other favourite books: Beauty and the Beast (Madame de Villeneuve), Carmilla, Dangerous Liaisons, Frankenstein, El cordero carnívoro, Fuenteovejuna, His Dark Materials, Hymn to Demeter, Medea, Pygmalion, Rebecca, The Essence of the Equinox, the Seven Kingdoms series, We Have Always Lived in the Castle.

Some other favourite comics: IDW (Beneath the Trees Where Nobody Sees, Dark Spaces), Image (Monstress, Paper Girls, Saga), Iron Man (Fatal Frontier, Doomquest, Legacy of Doom, vol 1. & 3).

Favourite music artists: Aaliyah, Amistades Peligrosas, Amy Winehouse, Ani DiFranco, Antonio Vivaldi, Bear McCreary, Christopher Beck, Clint Mansell, Dessa, Ennio Morricone, Fiona Apple, FKA twigs, Florence + the Machine, Georges Bizet, Hole, Julie London, Kate Bush, Mägo de Oz, Mirel Wagner, Montserrat Caballé, Nancy Sinatra, Nina Simone, Peggy Seeger, Pyotr Ilyich Tchaikovsky, Queen, Richard Wagner, Serguéi Serguéievich Prokófiev, Siouxsie and the Banshees, The Pretty Reckless, Tracy Chapman.

Other interests: art history, creative writing, photography, history, historiography, languages, criminal and international law, orcas, owls… countless others.

- ⚖️🔥 -

#intro post #talking to the void #me me me #red queue theory

[chocolatte-del-lago]

Strange Frontier

"Bloody, righteous, and mentally slow"

Created by Leila Spears to fight Daemons, Strange Frontier is known for being a bunch of bastards who got together to fight in weird outfits against monsters nobody cares about!

°-Story

As said before, Strange Frontier was created after Leila had her friends killed by a Daemon, which made her seek revenge, until she met Lionel, who had also suffered at the hands of another Daemon, and then she decided to found the group to recruit more people to rid Greece of the Emotional Beasts.

°-Members

-Leila Spears (Age 28), "Femme Fatale" (Leader/Amazon)

Leila Spears founded Strange Frontier after having her friends from her old group killed by a Daemon. Even though she is serious, she cares deeply for her friends. She received her training at a young age and carries a large spear in her hands. Many who have seen her strength call her the "Femme Fatale".

-Lionel Limoni Astler (Age 33), "The One Who Never Gives Up" (Vice-Leader/Knight)

Lionel joined Strange Frontier after his friends were turned into Emo-Beasts and his others (Siara, Arocel and Voltel) were attacked. He has a gambling addiction and is often pessimistic, but he still believes in his group's potential. He carries an axe and, because of his many bets (which sometimes work out), he is called "The One Who Never Gives Up".

-Siara Wineaus (Age 24), "Bad Romantic" (Archer)

Siara joined Strange Frontier after the orphanage where she worked was attacked by a Daemon and her sister Arocel decided to join the group, so without much choice she followed her. She often tries to strike up a romance in the towns she visits, but it always goes wrong (as she's always travelling), earning her the nickname "Bad Romantic", but otherwise she's quite friendly and tries to cheer up the group. She carries a bow and shoots quite hard.

-Arocel Wineaus (Age 23), "The Hundredth Death" (Archer)

Arocel joined the Strange Frontier after having her brother Sidra and other members of the orphanage and her town killed, before they found her alive they believed her to be the "Hundredth Death". She is quiet but harbours a deep hatred of the Daemones, but she also cares deeply for Siara and Lionel. She has realistic artistic skills and also wields a bow, which she uses to shoot very quickly.

-Cole Meadows (Age 20), "Man On Fire" (Rogue)

Cole joined the Strange Frontier when Erik did too. Cole is a very humble man who has a strange love of fire - when he once set a man on fire (in self-defence) he began to be hunted in the town where he lived and earned the nickname "Man on Fire". He attacks with his metallic nails (which Erik made for him) and is also very flexible and resilient. He studied biology.

-Alphania "Erik Mercury" Bulszara (Age 19), "Mr. BadGuy" (Doll Mage)

Erik joined the Strange Frontier just to make money. He earned his nickname "Mr Bad Guy" because of his "magic shows" that always ended up with children and adults dying (there are rumours that he even ate their bodies). He knows how to fool people and uses optical illusions to simulate magic, but for the most part he attacks with his puppets which are controlled by cerol lines (a mixture of thread and glass (sometimes iron)). He studies psychology.

The whole thing (in Portuguese): Strange Frontier | A Kind of Magic (umtipodemagica.blogspot.com)

#original character #oc lore #my oc art #oc gang whatever idk

[captainhandsome]

I am Sheriff Iron Man. Just doing my duty, folks.

#marveledit #comicedit #ironmanedit #tonystarkedit #dailymarvelcomics #tony stark #iron man #iron man: fatal frontier #&

[davidmann95]

What's the best Iron Man story and why is it obviously Armor Wars?

Haven’t read it yet; I’m an Extremis/Fatal Frontier man myself.

#Iron Man #Iron Man: Armor Wars #Iron Man: Extremis #Iron Man: Fatal Frontier #Opinion

[avengerscompound]

Tony Stark & James ‘Rhodey’ Rhodes

Iron Man: Fatal Frontier Infinite Comic

#marvel #avengers #marveledit #comicedit #tonystarkedit #ironmanedit #warmachineedit #iron husbands #tony stark #iron man #james rhodes #rhodey #war machine #carmine di giandomenico #616 #marvel comics #avengerscompoundedit #iron man: fatal frontier infinite comic

[tin-can-iron-man]

You ever see posts about how a character is bad and you're just like "bro that isn't even their final form" (and I still love them)

#yes this is about tony stark #and how people have problems with the mcu version of him #I genuinely think these people would faint if they read civil war. the ORIGINAL civil war about the superhero registration act #or illuminati #like! yes! my fave is a war criminal #It's comics and in the comics yours is too #enjoy your Tony Stark Lite MCU flavored I'm going to go watch him mindwipe Steve Rogers and cry on the bathroom floor #and become the ''sheath'' for Dr. Doom to stick his ''excalibur'' into #there's also the entire Superior Iron Man and to a lesser extent Fatal Frontier disasters #which is just him losing his entire ass mind and low key subjugating a portion of San Francisco/ the moon respectively #but to be fair those two are due to brainwashing and brianmelting respectively as well. #sometimes you don't become the hulk. sometimes you just blow up part of the moon because the moon juice radiation said it was a good idea #ok he made everyone leave the moon because it's way too fuckin dangerous but like. poor Russian robot. #''come back. bring everyone again'' I'M SORRY MR ROBOT HE CAN'T BC HE CAN'T GIVE PEOPLE SPACE CANCER. IT'D WIPE OUT HUMANITY #MY POOR ROBO PAL IS JUST STUCK ON THE MOON ALL ALONE WATCHING THE MOON ROCKS ALL BY HIMSELF IN AN EMPTY CITY #AND TONY DOESN'T EVEN GO SEE HIM BECAUSE HE KNOWS HE DOESN'T WANT HIS COMPANY #''we...we should've been friends'' ''I'm sorry'' YEAH WELL I'M CRYING TONY #anyway I got distracted from the point the point is it's funny that people say Tony is a problem in the mcu like he's not supposed to be #just a LITTLE #at times like this I'd say ''and do NOT get me started on ults'' but actually. ironically. ults Tony is ok. #all Tony's are ok I love him #I love him very very much #but sometimes I see posts meant to bash him and I just go ''lmao yeah you get it'' (very sad it's the only part you get) #it's also because Iron Man is MEANT to be perceived as a TRAGEDY. in his very first issue the very first thing told to you. #''this is a tale of the most tragic figure on earth'' and SOMETIMES (ok. a lot of times) that tragedy comes out by Tony fucking up some way #because that's how tragedys WORK. something happens to someone and some of the time it's the result of their own hubris! #that's basic writing! #and the message is meant to be ''even if you make mistakes. make colossal. stupid mistakes. it doesn't mean you can't strive to be better.' #''in fact. you have an OBLIGATION to try to be better. to yourself. to the people around you. don't wallow in self pity.'' #''you have to get back up. you HAVE to. or all you are is a testament to your failures. get back up'' THAT'S what Iron Man about.

[micswho]

Tony calling himself necessary monster through Yinsen in his hallucination because he doesn’t want to wake up but he has to always fucks me up

#tony stark #iron man #mics reads comics #tony has the fucking worst nightmares i swear #tony stop making me cry it's not ok #i just want to protect him #fatal frontier #i really love him so much #can he be happy for once please #marvel

[in-a-cave-with]

“but tony stark’s a dick in the comics” he was a perfectly okay person up until the past decade or so where he got put into the hands of writers who didn’t understand his character. read iron man vol 3 and calm down maybe

#alternatively: iron man fatal frontier / hunt for wolverine adamantium agenda / the first couple issues of invincible iron man 2015 #(that one's on thin fucking ice because civil war ii is another characterization murder) #additionally: iron man vol 4 / avengers prime / 1872 / iron man noir

[tonystarkisafruit]

Tony's superhero landing

Iron Man: Fatal Frontier #4

#tony stark #marvel 616 #ben reads comics #fatal frontier #iron man #i love this nerd

[starkly-tony]

Fatal Frontier, or

three times Tony couldn’t stop talking about Steve

...and one time he finally got called out for it

#tony stark #iron man #stevetony #stony #super husbands #iron man comics #tony stark comics #earth 616 #616 tony #fatal frontier