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#treatments and medications
reality-detective · 1 month
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The Overlooked Miracle Drug for Cancer? Why Big Pharma Fears Fenbendazole
"Fenbendazole has at least 12 proven anti-cancer mechanisms in vitro and in vivo," wrote cancer researcher Dr. William Makis
"So why are there no Fenbendazole clinical trials for cancer? The answer seems rather obvious: it’s very cheap, it’s safe, and it seems to be very effective. Fenbendazole is not going to make anyone rich, and in cancer treatments, that is a non-starter."
"What an enemy of the people," Joe Rogan responded. "They're preventing information and preventing people from using things that save them." 🤔
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reasonsforhope · 22 days
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"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.
The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.
The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.
“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.
“These clusters alert the immune system in a much more profound way than single particles would.”
Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.
“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.
“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).
Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.
The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.
In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.
The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...
While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.
The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."
-via Good News Network, May 11, 2024
youtube
-video via University of Florida Health, May 1, 2024
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crimeronan · 1 year
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house md is wild cause it feels like in creating a show based on "irreverent doctor who is garbage, unlike the saint docs on all the boring medical soap operas rn" they completely accidentally created one of the most compelling and important concepts of all time, in "disabled chronic pain doctor distrusts medical institutions because of his experiences with addiction and disability, therefore he is constantly breaking the law and hospital administrative policy rules to get marginalized patients care that they would otherwise be denied, and the show uses this as a way to spotlight various forms of institutional patient inequity"
but BECAUSE the writers lucked into this concept by accident and have no idea WHY it's important, half of the show is Also "doctor commits constant heinous malpractice on vulnerable patients and treats them like shit and traumatizes them and this is considered a normal good protag thing to do because it will always be shown to be retroactively justified, because actually the patient always Was lying or being unreasonable, and this doctor is so so so smart and special that no rules ever apply to him, and no consequences will ever be shown" which is obviously. eaugh
so when it's good it's SO SO SO SO SO FUCKING GOOOOOD but it's also like. not something i can in good conscience recommend to Any other chronic illness people. u feel me.
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medication should be free. yes including that one.
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whumpacabra · 7 days
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I am so weak for consent during recovery. Consent to be touched, consent to medical treatment, consent to medical procedures, consent to medication, consent to be helped. It’s about acknowledging autonomy and giving someone who had no control over how they were hurt the power to control how they heal.
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gee i wonder if the issue could be at all related to the fact that the current treatment plan for his chronic pain consists solely of FUCKING IBUPROFEN
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parachutingkitten · 8 months
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*clears throat*
The reason everyone likes Kai this season is that he is both very wise, and incredibly dumb. If you don't have both of those, you don't have Kai.
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intersectionalpraxis · 3 months
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Capitalism is killing people in so many ways, and the medical industrial complex is one of them. Healthcare should always be a universal right -both fair and equitable access, but in many cases it is not... the mass injustices.
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kirby-the-gorb · 4 months
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bet-on-me-13 · 10 months
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Vlad has Pit Rage
So, we all know the idea of Pit Rage. When you are submerged in a Lazarus Pit, you will become insanely mad for a while, and in the Fanon it is permanent.
Well, in Danny Phantom we do know of one other person who was infused with Ectoplasm (aka Lazarus), who had a personality change after his accident, who had years to build up his hatred, who never got the help he needed.
Vald. It's Vlad. Due to a fuckup when making the Proto-Portal, Vlad was blasted with Corrupted Ectoplasm rather than the Pure Stuff, which gave him Pit Rage.
Pit Rage is basically a Chronic Condition, and once Vlad figures out that he needs help while on his whole Redemption Arc (read A Glitch In Time, I beg you), he goes to the Far Frozen to seek their help.
He gets some Medication that helps suppress the Pit Rage, and goes on with his journey of Redemption.
Then, one day while he is wandering through Gotham, he meets a Kid who is seriously I'll. Like, he's almost as Bad as Vlad himself was before he got the Medication he needed!
So, he gets some of his Emergency Medication and has the kid take some. Thankfully it helps him calm down and gets him to stop Shooting Vlad. (He jad been unloading clip after clip into Vlad until he finally calmed down)
Now he needs to take this Kid to Frostbite so he can get his own source of Medication, and the easiest way is to just kidnap him. Not like he was being watched at all, honestly people need to take better care of their Kids.
...
Batman is panicking.
Some Vampire guy just fed Jason some weird drugs that made him calm down significantly and them kidnapped him through a Glowing Green Portal.
Was his son just Drugged and Kidnapped?
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murk888 · 3 months
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YOOO is this NOT the big shot Spamton???? no way (°□°;) somehow it feels a little bit uncomfortable to draw him with glasses..
other variants below ↓
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bamsara · 1 year
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aaaaaaaaaaaaaaaaaaaaaaaaaaaughhhhhhhhhhhhhhhhhhhgauhghhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhuhghgg
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sukimas · 6 months
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neo-traditionalism of japan
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ghostonly · 3 months
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This is so fucked up. This article is from 2017 but afaik is still accurate. Let me know if anything has been done about this since then - possibly during the early pandemic?
TL;DR most medications seem to be stable for leagues longer than their expiration dates say, and their expiration dates have been extended federally after doing periodic potency testing with the drugs hoarded by the US government, but the FDA refuses to extend the official expiration dates. It's illegal for medical professionals to dispense expired drugs, so perfectly good medications are being thrown out constantly.
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bonefall · 7 months
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The more I consider the "Smoky gets Frostpaw sterilized against her will" thing, the more I dislike it even on a thematic level...
This book seems to be trying to put Frostpaw through an arc of learning to trust people. Riverstar magically appears in her dreams to send her to the Park Cats who are meant to teach her this lesson, but... starting and resolving that arc more than halfway through the book was sloppy, and a waste.
Instead of Smoky forcing medical treatment on her in spite of how she tells him point blank "please no," SHE should have called for the human.
A creature that the Clan cats have never trusted, that they have great reason to fear. Caught between dying with her pride like a good warrior and taking a risk on the kindness of an unknowable beast, in spite of all the betrayal, she chooses the chance.
Play it like this; Make it so the reason she becomes chosen by Riverstar at all is because he SEES this glimmer of potential within her, because of this very choice.
Instead of that bizarre opening chapter where he seems to have magically gifted her some kind of spiritual connection as a plot device, INSTEAD make it that they were sadly overseeing the end of her life. That this was her destiny, to die as a young, proud warrior apprentice. To trust no cat, as her mother told her.
But instead, she tricks the wording of the self-fulfilling prophecy Curlfeather told her. It said nothing about trusting a human!
THEN follow it up with teaching her how to trust cats again. But make the road down this character arc be something she truly initiated, instead of the weird bullshit they did with her being mad at Smoky for violating her consent while also exonerating him for "Doing The Right Thing :)"
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ME, MY DISABLED PARTNER, AND OUR PETS ARE GOING TO DIE IF PEOPLE DO NOT START MAKING IMMEDIATE MEANINGFUL EFFORTS TO HELP US.
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We need immediate emergency relief. But everyone pretends I don't Exist.
I am so. Tired. Of writing these posts. They never go anywhere. They never do any good. People never seem to care.
I have stopped writing posts because I am always too sick, now. I am too sick to get out of bed and I AM ACTIVELY DYING.
I LITERALLY HAVE SKIN CANCER AND A HERNIATED DISC IN MY NECK CAUSING SEIZURES AND THREATENING TO LEAVE ME PARALYZED AND I CANNOT EVEN GET PEOPLE TO DONATE ENOUGH TO FEED MYSELF OR AFFORD MY MEDICATION MUCH LESS GO TO THE DOCTOR OR PURSUE TREATMENT
I haven't been able to afford my medication since NOVEMBER and nobody cares except for 1 or 2 people who can only afford 20 here & there which doesn't cover my $1500.00/month medication & I am at the point of risking Death every single day.
I have done LITERALLY EVERYTHING IN MY POWER TO HELP MYSELF AND IT ISN'T ENOUGH. Texas holds EVERY BAR deliberately out of reach of the disabled, trans, and mentally ill-- and I fall into every single category. I am fully disabled, handicapped, autistic, trans with suicidal dysphoria-- and I had my gender affirming care ~ripped away~, and own a uterus which is basically a death sentence in this state, now. The system is completely backed up, has been since Covid, all applications have been on hold for basically 3 years, now. And, yeah. People decided to Kill me.
PEOPLE ARE BEING STOLEN OFF THE STREETS, HERE.
But no one can seem to handle caring, reblogging my posts, offering advice that actually applies to my circumstances (most people spout some highly ignorant 'got mine' bullshit when I have clearly stated that I have already sought every possible government means and was basically told 'hurry up and die already'), or making an effort to proactively help me SEEK HELP from others.
I was thrown on the streets to die homeless in winter. I am HOMELESS, bouncing from place to place, and I have run out of places to bounce. I have NOWHERE to go. I have NO FRIENDS. I have NO FAMILY. I have NO support group. I have NO insurance. I have NO doctors. Yet
all people do is scroll.
Please. HELP ME.
DO YOU UNDERSTAND HOW ABJECTLY TERRIFYING IT IS KNOWING THAT PEOPLE WHO HAVE THE MONEY FOR CANCER TREATMENT RARELY SURVIVE BUT YOU DON'T EVEN GET TO START TREATMENT BECAUSE YOU HAVE NO FRIENDS, FAMILY, SUPPORT GROUP, TRANSPORTATION, INSURANCE, OR MONEY???!?!
If you have ever liked a piece of art I've made, or a meme, or a video, or a stream, why do I not deserve to live????? Do you literally think I deserve to DIE-- literally DIE-- because I am disabled??? Because that is PRECISELY what my ableist & transphobic ex-friends & family have decided, and they are getting away with it. Why.............???
-> Ko-Fi | PayPal | Art Shop | Aether Adoptable
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