#B.1.617

[12nb34]

📆 Apr 2021 📰 How Novel Coronavirus Variants Could Complicate Our COVID-19 Vaccination Drive ✍️ Dr Vipin Vashishtha

Some of my peers working in the bigger COVID-19 hospitals in metropolitan cities have also observed that those who received vaccines and tested positive for COVID-19 within two weeks are both outnumbering those who haven’t been vaccinated and are running a more severe course of the disease. India’s health ministry hasn’t shared any such data thus far, however.

Could these apprehensions be true? Let’s find out.

Speculation that vaccines could paradoxically increase the risk of infections possibly originated following the 2009 influenza A (H1N1pdm09) pandemic, when 4 Canadian studies suggested that getting the seasonal influenza vaccine increased the risk of laboratory-confirmed infections. This led to 5 additional studies, each of which substantiated these initial findings.

One proposed mechanism for this phenomenon is called original antigenic sin. It was first used to describe how one’s first exposure to the influenza virus shapes the outcome of subsequent exposures to antigenically related strains. (The antigen is the part of the object that provokes the immune response – like the novel coronavirus’s spike protein.) This specific immune phenomenon explains the failure of the immune system to generate an immune response against related antigens.

When an individual is infected by an evolved strain with a new dominant antigen, slightly different from the original strain against which the person has been vaccinated, the immune system produces antibodies against the original strain. This happens through high-affinity memory B-cells that inhibit activation of naïve B-cells, resulting in a weak immune response against the newer strain. So the risk of infection paradoxically increased in vaccinated individuals compared to unvaccinated individuals.

This phenomenon could be at work when different variants of the SARS-CoV-2 virus are in play. As you may know, most existing COVID-19 vaccines are based on the wild strain that was circulating around the world last year. However, towards the end of 2020, many variants with mutations in the spike protein have emerged. These new variants have replaced their predecessors in most countries. In India as well, one or two key variants (B.1.1.7 and B.1.617) are feared to be circulating around the country.

So a vaccine may mount a strong immune response against the original epitopes contained in the ‘original’ strain due to preformed B-cells. (“The antibody recognises a particular part of the virus, called the epitope, and forms a bond with it using a part called the paratope” – source.) These preformed committed B-cells outnumber naïve B cells and prevent them from mounting a strong response that is specific to the epitopes contained in the new mutant.

As a result, the immune system becomes unable to mount a faster, stronger secondary response. The implication is that when the epitope varies slightly, then the immune system relies on the memories of the previous infection (with the wild variant) rather than mount another primary or secondary response to the new epitopes present in the new variant (B.1.617 or B.1.1.7).

As a result, the immunological response may be inadequate against the new variant – because the immune system depends on a memory instead of launching into a fresh response.

[nerdwelt]

Faktencheck: Indien will Indische Variante als Begriff nicht, aber zweifelt nicht an der Mutation (Linksammlung)

Die Behauptung, dass die indische Regierung die Existenz der B.1.617-Variante des Coronavirus leugnet, ist falsch. Die indische Regierung hat lediglich die Verwendung des Begriffs “indische Variante” kritisiert und soziale Netzwerke aufgefordert, Inhalte mit diesem Begriff zu entfernen. Die Regierung beruft sich dabei auf die Weltgesundheitsbehörde WHO, die den Begriff in ihren Berichten nicht…

View On WordPress

#Asien #Corona

[newstodayreviews]

COVID B.1.617 VARIANT IS HERE

#youtube

[bioguardhygiene]

COVID-19 Hygiene

Cases infected with the virus may be low, but the threat continues due to emerging variants such as SARS-CoV-2 B.1.617 and Delta.

Bioguard disinfectants are proven effective in protecting against the virus and its genetically-modified forms.

Remember to Stay Alert, while COVID-19 variants still lurk around.

#bioguard #bioguardhygiene #covid #covid19 #coronavirus #covidalert #virus #infection #protection #prevention #disinfectants #stayhome #staysafe #socialdistancing #maskup #healthcare #wellbeing #bioguardindia

[munispeaks]

India tells social media intermediaries

India tells social media intermediaries

ANI | Updated: May 22, 2021 19:07 IST New Delhi [India], May 22 (ANI): India took a strong objection to the use of the term so-called ‘Indian variant’ for the B.1.617 variant of the coronavirus on social media posts. It is learnt from reliable sources that the Ministry of Electronics and Information Technology (MIETY) has written an advisory to social media intermediaries to take down such…

View On WordPress

[bouxmounir]

Japon, Singapour, Taïwan... Ces pays asiatiques font face à une nouvelle vague épidémie

Japon, Singapour, Taïwan… Ces pays asiatiques font face à une nouvelle vague épidémie

Alors que l’Inde est en proie à une flambée dans l’affaire du Covid-19, provoquée notamment par la variante B.1.617 qui a sévi dans le pays, plusieurs pays asiatiques sont également touchés. La France a également mis en quarantaine pendant quatre jours les voyageurs en provenance du Bangladesh, de l’Inde, du Népal, du Pakistan et du Sri Lanka. Adeptes de la stratégie « zéro covid », des États…

View On WordPress

[tomorrowusa]

Crematories are so full of bodies, it’s as if a war just happened. Fires burn around the clock. Many places are holding mass cremations, dozens at a time, and at night, in certain areas of New Delhi, the sky glows.   Sickness and death are everywhere.   Dozens of houses in my neighborhood have sick people.   One of my colleagues is sick.   One of my son’s teachers is sick.   The neighbor two doors down, to the right of us: sick.   Two doors to the left: sick.

Correspondent Jeffrey Gettleman reporting for the New York Times from New Delhi.

India thought it had the pandemic under control in February. Now the country is in a state of catastrophe thanks to the B.1.617 variant.

B.1.617 has been found in the US, Canada, and the UK. We should not get complacent about efforts to stop the virus.

Vaccines offer an enormous amount of protection against B.1.617. So don’t delay your own vaccination. Get vaccinated with friends and family members. In the US, everybody over 16 is now eligible to be vaccinated. And the vaccinations are FREE.

Vaccines appear effective against India COVID variant

#pandemic #covid-19 #coronavirus #india #variants #B.1.617 #vaccines #vaccination #jeffrey gettleman #भारत #ഇന്ത്യ #ਭਾਰਤ #ভারত #ہندوستان #మహమ్మారి

[indizombie]

INSACOG was set up as a forum of scientific advisers by the government in late December specifically to detect genomic variants of the coronavirus that might threaten public health. INSACOG brings together 10 national laboratories capable of studying virus variants. INSACOG researchers first detected B.1.617, which is now known as the Indian variant of the virus, as early as February, Ajay Parida, director of the state-run Institute of Life Sciences and a member of INSACOG, said. INSACOG shared its findings with the health ministry’s National Center for Disease Control (NCDC) before March 10, warning that infections could quickly increase in parts of the country. The findings were then passed on to the Indian health ministry.

‘Scientists say India government ignored warnings amid coronavirus surge’, Arab News

#Arab News #India #INSACOG #Coronavirus #Covid-19 #B.1.617 #Ajay Parida #Institute of Life Sciences #National Center for Disease Control #NCDC

[pharmatimesng]

Covid: Concern Increases Over India Variant in UK

Covid: Concern Increases Over India Variant in UK

Public health experts have recommended one version of the Indian coronavirus variant be made a “variant of concern” in the UK, the BBC has been told. Public Health England (PHE) is tracking B.1.617.2 which appears to spread more quickly than two other identified subtypes of the Indian variant. Scientists also believe it is at least as transmissible than the variant detected in Kent last year. A…

View On WordPress

#B.1.617 #B.1.617.2 #BBC #E.484K mutation #Public Health England #South Africa and Brazil strains

[aazkanews]

Covaxin vaccine effectively neutralises Delta and Alpha variants of Covid-19: Top US body | India News - Times of India

Covaxin vaccine effectively neutralises Delta and Alpha variants of Covid-19: Top US body | India News – Times of India

HYDERABAD: In yet another booster shot of endorsement for India’s first indigenously developed Covid-19 vaccine Covaxin, the United States’ National Institutes of Health has said that the vaccine is able to effectively neutralise the Alpha and Delta variants of SARS-CoV-2. “Results from two studies of blood serum from people who had received Covaxin suggest that the vaccine generates antibodies…

View On WordPress

#anthony s fauci #B.1.617 #Breaking news #Covaxin #COVAXIN vaccine #covaxin vaccine india #Delta #Google news #India #India news #India news today #Lancet Infectious Diseases #National Institutes of Health #Today news

[hummingzone]

Covaxin effectively neutralises Delta and Alpha variants of Covid-19: Top US body | India News - Times of India

Covaxin effectively neutralises Delta and Alpha variants of Covid-19: Top US body | India News – Times of India

HYDERABAD: In yet another booster shot of endorsement for India’s first indigenously developed Covid-19 vaccine Covaxin, the United States’ National Institutes of Health has said that the vaccine is able to effectively neutralise the Alpha and Delta variants of SARS-CoV-2. “Results from two studies of blood serum from people who had received Covaxin suggest that the vaccine generates antibodies…

View On WordPress

#anthony s fauci #B.1.617 #Breaking news #covaxin #delta #Google news #India #India news #India news today #Lancet Infectious Diseases #National Institutes of Health #NIH #Ocugen #Today news

[candrasuciawan]

Waspadai Varian Baru Covid-19, Pemkot Pekalongan Perketat Mobilitas Warga

Waspadai Varian Baru Covid-19, Pemkot Pekalongan Perketat Mobilitas Warga

PUSKAPIK.COM, Kota Pekalongan – Pemkot Pekalongan mewaspadai persebaran virus corona varian India atau B.1.617 yang sudah masuk Cilacap, Jawa Tengah. Hal itu menyusul hasil tes Whole Genome sequencing (WGS) yang dilakukan terhadap 13 anak buah kapal berkewarganegaraan Filipina yang melakukan bongkar muat di Cilacap menunjukkan mereka terkonfirmasi Covid-19 varian dari India itu. Virus itu…

View On WordPress

#B.1.617 #Kasus Covid-19 #Kota Pekalongan #Virus Corona Varian India

[franklong12]

COVID Vaccines Protect Against Top Variants, WHO Says The COVID-19 vaccines licensed for usage... Read the rest on our site with the url below https://worldwidetweets.com/covid-vaccines-protect-against-top-variants-who-says/?feed_id=18269&_unique_id=60aa9efa74f14 #B.1.1.7 #B.1.351 #B.1.617 #coronavirusvariants #Covid19Vaccines #internationaltravel #P.1 #WorldHealthOrganization

#B.1.1.7 #B.1.351 #B.1.617 #coronavirusvariants #Covid19Vaccines #internationaltravel #P.1 #WorldHealthOrganization