ABCD2: age, blood pressure, clinical features, duration of symptoms, and diabetes; DAPT: dual antiplatelet therapy (eg, aspirin and clopidogrel, or aspirin and ticagrelor); BP: blood pressure; SBP: systolic blood pressure; DBP: diastolic blood pressure.
* Indications for long-term oral anticoagulation include embolism prevention for patients with atrial fibrillation, ventricular thrombus, mechanical heart valve, and treatment of venous thromboembolism.
OA: oral anticoagulants; IVT: intravenous thrombolysis; MT: mechanical thrombectomy; NIHSS: National Institutes of Health Stroke Scale; DAPT: dual antiplatelet therapy (eg, aspirin and clopidogrel, or aspirin and ticagrelor).
* Refer to text and associated algorithm for details.
¶ Brain and large vessel imaging, cardiac evaluation, and (for select patients) other laboratory tests.
Δ For severe systemic or symptomatic intracranial bleeding, withhold all anticoagulant and antiplatelet therapy for one to two weeks or until the patient is stable.
Tx of Acute Ischemic CVA from UpToDate:
Immediate treatment– All patients with acute ischemic stroke should be evaluated to determine eligibility for reperfusion therapy with intravenous thrombolysis and/or mechanical thrombectomy, and aspirin and other antithrombotic agents should not be given alone or in combination for the first 24 hours following treatment with intravenous thrombolysis.
Otherwise, antiplatelet agents should be started as soon as possible after the diagnosis of transient ischemic attack (TIA) or ischemic stroke is confirmed, even before the evaluation for ischemic mechanism is complete. For most patients with no indication for long-term oral anticoagulation who have TIA (algorithm 2 [first algorithm above]) or ischemic stroke (algorithm 3 [second algorithm above]), we start antiplatelet therapy as follows:
•Aspirin alone – For patients with a low-risk TIA, defined by an ABCD2 score <4 (table 2), or moderate to major ischemic stroke, defined by a National Institutes of Health Stroke Scale (NIHSS) score >5 (table 3), we start treatment with aspirin (162 to 325 mg daily) alone.
•DAPT – For patients with a high-risk TIA, defined by an ABCD2 score ≥4 (table 2), or minor ischemic stroke, defined by a NIHSS score ≤5 (table 3), we begin with dual antiplatelet therapy (DAPT) for 21 days using aspirin (160 to 325 mg loading dose, followed by 50 to 100 mg daily) plus clopidogrel (300 to 600 mg loading dose, followed by 75 mg daily) rather than aspirin alone.
●Treatment by ischemic mechanism – Once the evaluation for TIA or stroke is complete, early antithrombotic therapy can be modified if necessary (algorithm 4 and algorithm 5) according to the ischemic mechanism:
•Atrial fibrillation – For patients with TIA or ischemic stroke who have atrial fibrillation, oral anticoagulation with warfarin or a direct oral anticoagulant (DOAC) is recommended for secondary stroke prevention. Oral anticoagulation can be started immediately for patients with TIA, and soon after stroke onset for medically stable patients with a small- or moderate-sized infarct and no bleeding complications or uncontrolled hypertension. For patients with large infarctions, symptomatic hemorrhagic transformation, or poorly controlled hypertension, withholding oral anticoagulation for one to two weeks is generally recommended.
•Intracardiac thrombus – For patients with acute cardioembolic TIA or ischemic stroke who have intracardiac thrombus in the left ventricle or associated with mechanical or native heart valves, we suggest early parenteral anticoagulation rather than aspirin (Grade 2C). This approach is controversial.
•No indication for anticoagulation – For most patients without atrial fibrillation or another indication for long-term oral anticoagulation, the initial antiplatelet regimen can be continued; for patients with low-risk TIA or moderate to severe stroke, we recommend aspirin monotherapy (160 to 325 mg daily) (Grade 1A). For patients with high-risk TIA or minor ischemic stroke, we recommend DAPT using aspirin and clopidogrel for 21 days rather than aspirin alone (Grade 1A).
However, certain additional modifications may apply:
-Carotid revascularization – Aspirin monotherapy is preferred by some experts prior to carotid endarterectomy, while DAPT is preferred by others. DAPT is recommended prior to and continuing for 30 days after carotid artery stenting.
-Intracranial large artery atherosclerosis – For patients with TIA or ischemic stroke attributed to intracranial large artery atherosclerosis stenosis of 70 to 99 percent, we suggest DAPT for 90 days.
-Dissection – The antithrombotic treatment of TIA or ischemic stroke caused by large artery dissection is discussed in detail separately.
●Long-term antiplatelet therapy – Beyond the acute phase of TIA and ischemic stroke, and in the absence of an indication for oral anticoagulation, long-term single-agent antiplatelet therapy for secondary stroke prevention should be continued with aspirin, clopidogrel, or aspirin-extended-release dipyridamole. Long-term DAPT with aspirin and clopidogrel is not recommended.
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Ira Dubey
This Biography is about one of the best Actress Ira Dubey including her Height, weight, Age & Other Detail…
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Real Name
Ira Dubey
Nickname
Not Known
Profession
Actress
Age (as in 2023)
38 Years old
Physical Stats & More Info
Height
in centimeters- 163 cm
in meters- 1.63 m
in Feet Inches- 5' 4”
Weight
in Kilograms- 52 kg
in Pounds- 115 lbs
Figure Measurements
33-25-34
Eye Colour
Black
Hair Colour
Black
Personal Life of Ira Dubey
Date of Birth
1 August 1984
Birth Place
Mumbai, Maharashtra, India
Zodiac sign/Sun sign
Leo
Nationality
Indian
Hometown
Mumbai, Maharashtra, India
School
The Cathedral & John Connon School, Mumbai
College
St. Xavier's College, Mumbai
Yale University, New Haven, Connecticut, USA
Educational Qualifications
Bachelors in English Literature
Majored in Theater Studies
Debut
Film Debut: Marigold (2007)
Family
Father- Ravi Dubey (former senior vice-president, corporate communications, in the Tata Group)
Mother- Lillete Dubey (Actress)
Brother- N/A
Sister- Neha Dubey
Religion
Hindu
Hobbies
Travelling and yoga
Controversies
Not Known
Favourite Things of Ira Dubey
Favourite Food
Italian food, chocolates and gulab jamun
Favourite Actor
Akshay Kumar, Ranveer Singh, Shahid Kapoor, Hrithik Roshan and Arjun Rampal
Favourite Actress
Madhuri Dixit, Deepika Padukone and Aishwarya Rai
Favourite Films
Bollywood: ABCD2
Hollywood: The Japanese Wife
Favourite Colour
Black
Favourite Perfume
Chanel’s Coco Mademoiselle and Jean Paul Gaultier Classique
Favourite Restaurant
New Yorker in Mumbai
Boys, Affairs and More of Ira Dubey
Marital Status
Unmarried
Affairs/Boyfriends
Not Known
Husband
N/A
This Biography Written By www.welidot.com
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Varun Dhawan Week: Pick His Best Looks!
Varun Dhawan Week: Pick His Best Looks!
He doesn’t have that much variation in the looks, but there is some there! At least enough for us to be judgemental (it doesn’t take much).
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